Click here to switch to the map view.

The map label for this gene is mmgC [H]

Identifier: 120610662

GI number: 120610662

Start: 2150957

End: 2152156

Strand: Reverse

Name: mmgC [H]

Synonym: Aave_1982

Alternate gene names: 120610662

Gene position: 2152156-2150957 (Counterclockwise)

Preceding gene: 120610666

Following gene: 120610661

Centisome position: 40.21

GC content: 67.58

Gene sequence:

>1200_bases
ATGGCCCGCCCTGCAGCCTTCCACTGGGAAGATCCCTTCCTGCTCGACCAGCAGCTCAGCGACGACGAGCGCATGGTGCG
CGATGCCGCGGCGGCCTACTGCCGCGACCGGCTGGCGACCCGCGTGCTGGAACAGTTCCGCCACGAAAAGACCGATACGG
CCATCTTCCGCGAGATGGGCGAGCTGGGCCTGCTGGGCCCGACCATCCCTGAGCAGTACGGCGGTCCCGGGCTGAACTAT
GTGGCCTACGGCCTGATCGCCCGCGAGATCGAACGCATCGATTCGGGCTACCGCTCCATGGCCAGCGTGCAGAGCTCGCT
GGTGATGGTGCCGATCTTCGAGTTCGGCACCGAGGCGCAGAAGCAGAAGTACCTGCCGAAGCTGGCGAGCGGCGAATGGA
TCGGCTGCTTCGGACTGACCGAACCCGACCACGGATCCGACCCCGGCAGCATGGCCACGCGCGCCCACAAGACCGCGGGC
GGCTACAAGCTCAAGGGCAGCAAGATGTGGATCACCAACAGCCCCATCGCCGACGTGTTCGTCGTCTGGGCCAAGGAGGT
GAGCGAATCCGGCGCCGTGGGCCCGATCCGCGGCTTCGTGCTGGAAAAGGGCATGCAGGGCCTCACGGCGCCGGCCATCC
ACGGCAAGGTGGGCCTGCGTGCCTCCATCACCGGCGAGATCGTGATGGACGATGTGTTCGTGCCCGAGGAGAACGCCTTC
CCCGAGGTACAGGGCCTCAAGGGTCCGTTCACCTGCCTGAACAGCGCGCGCTACGGCATCGCCTGGGGCGCGCTGGGCGC
GGCCGAGTTCTGCTGGCACACGGCGCGCCAGTACACGCTGGACCGCAAGCAGTTCGGCCGGCCGCTCGCCGCCAACCAGC
TCATCCAGAAGAAGCTGGCCGACATGCAGACCGAGATCGCCATCGGCCTGCAGGCCTGCCTGCGCCTGGGCCGCATGAAG
GACGAAGGCACGGCCGCCGTGGAGGCCACTTCCATCATCAAGCGCAACAGCTGCGGCAAGGCGCTGGACATCGCCCGCAT
GGCGCGCGACATGATGGGCGGCAACGGCATCAGCGACGAGTTCGGCGTGGCACGGCACCTGGTGAACCTGGAGGTGGTCA
ACACCTACGAGGGCACGCACGACGTGCATGCGCTCATCCTGGGCCGCGCCCAGACGGGCATCGCCGCGTTCGCGAACTGA

Upstream 100 bases:

>100_bases
GCTTGCCGCAGCCCATCCACAAGGCATAGCATCCATGCATTCCGAGTGACATGCCGAACCGGCAAATCACATCTTTCGCC
CGATTTCAAGGAGACACACC

Downstream 100 bases:

>100_bases
CGGCGCCATGGACGCGGCTCCCCTGCCCTCCCCCGCGCCCGCGGCCGGCGCGCTCGCCGGTATCCGGGTACTCGACCTCT
CGCGCGTGCTGGCCGGACCG

Product: acyl-CoA dehydrogenase domain-containing protein

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MARPAAFHWEDPFLLDQQLSDDERMVRDAAAAYCRDRLATRVLEQFRHEKTDTAIFREMGELGLLGPTIPEQYGGPGLNY
VAYGLIAREIERIDSGYRSMASVQSSLVMVPIFEFGTEAQKQKYLPKLASGEWIGCFGLTEPDHGSDPGSMATRAHKTAG
GYKLKGSKMWITNSPIADVFVVWAKEVSESGAVGPIRGFVLEKGMQGLTAPAIHGKVGLRASITGEIVMDDVFVPEENAF
PEVQGLKGPFTCLNSARYGIAWGALGAAEFCWHTARQYTLDRKQFGRPLAANQLIQKKLADMQTEIAIGLQACLRLGRMK
DEGTAAVEATSIIKRNSCGKALDIARMARDMMGGNGISDEFGVARHLVNLEVVNTYEGTHDVHALILGRAQTGIAAFAN

Sequences:

>Translated_399_residues
MARPAAFHWEDPFLLDQQLSDDERMVRDAAAAYCRDRLATRVLEQFRHEKTDTAIFREMGELGLLGPTIPEQYGGPGLNY
VAYGLIAREIERIDSGYRSMASVQSSLVMVPIFEFGTEAQKQKYLPKLASGEWIGCFGLTEPDHGSDPGSMATRAHKTAG
GYKLKGSKMWITNSPIADVFVVWAKEVSESGAVGPIRGFVLEKGMQGLTAPAIHGKVGLRASITGEIVMDDVFVPEENAF
PEVQGLKGPFTCLNSARYGIAWGALGAAEFCWHTARQYTLDRKQFGRPLAANQLIQKKLADMQTEIAIGLQACLRLGRMK
DEGTAAVEATSIIKRNSCGKALDIARMARDMMGGNGISDEFGVARHLVNLEVVNTYEGTHDVHALILGRAQTGIAAFAN
>Mature_398_residues
ARPAAFHWEDPFLLDQQLSDDERMVRDAAAAYCRDRLATRVLEQFRHEKTDTAIFREMGELGLLGPTIPEQYGGPGLNYV
AYGLIAREIERIDSGYRSMASVQSSLVMVPIFEFGTEAQKQKYLPKLASGEWIGCFGLTEPDHGSDPGSMATRAHKTAGG
YKLKGSKMWITNSPIADVFVVWAKEVSESGAVGPIRGFVLEKGMQGLTAPAIHGKVGLRASITGEIVMDDVFVPEENAFP
EVQGLKGPFTCLNSARYGIAWGALGAAEFCWHTARQYTLDRKQFGRPLAANQLIQKKLADMQTEIAIGLQACLRLGRMKD
EGTAAVEATSIIKRNSCGKALDIARMARDMMGGNGISDEFGVARHLVNLEVVNTYEGTHDVHALILGRAQTGIAAFAN

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=398, Percent_Identity=65.0753768844221, Blast_Score=527, Evalue=1e-150,
Organism=Homo sapiens, GI7669494, Length=378, Percent_Identity=64.021164021164, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=34.3915343915344, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=34.971098265896, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI4557233, Length=335, Percent_Identity=34.0298507462687, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI76496475, Length=347, Percent_Identity=34.0057636887608, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI4557235, Length=347, Percent_Identity=34.0057636887608, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI4501859, Length=368, Percent_Identity=28.804347826087, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI21361497, Length=336, Percent_Identity=33.9285714285714, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI4557231, Length=397, Percent_Identity=28.7153652392947, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI187960098, Length=397, Percent_Identity=28.7153652392947, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=30.4232804232804, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI4501857, Length=384, Percent_Identity=27.8645833333333, Blast_Score=135, Evalue=9e-32,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=25.3926701570681, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI87081958, Length=340, Percent_Identity=25.2941176470588, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87081702, Length=335, Percent_Identity=24.1791044776119, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17534353, Length=397, Percent_Identity=62.4685138539043, Blast_Score=514, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17508101, Length=368, Percent_Identity=31.7934782608696, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=31.6622691292876, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17506239, Length=366, Percent_Identity=29.7814207650273, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17569725, Length=378, Percent_Identity=29.8941798941799, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI71990804, Length=289, Percent_Identity=34.6020761245675, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71985184, Length=341, Percent_Identity=31.6715542521994, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17534899, Length=375, Percent_Identity=29.6, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71985192, Length=259, Percent_Identity=33.976833976834, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=27.7777777777778, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=34.051724137931, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=30.6569343065693, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=25.6, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17505929, Length=347, Percent_Identity=25.9365994236311, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17551932, Length=359, Percent_Identity=25.6267409470752, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19920834, Length=397, Percent_Identity=60.7052896725441, Blast_Score=480, Evalue=1e-136,
Organism=Drosophila melanogaster, GI21356377, Length=373, Percent_Identity=31.0991957104558, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24666513, Length=366, Percent_Identity=32.5136612021858, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=31.6353887399464, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=30.3430079155673, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI281363737, Length=356, Percent_Identity=32.5842696629214, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=31.1345646437995, Blast_Score=161, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43500; Mature: 43369

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARPAAFHWEDPFLLDQQLSDDERMVRDAAAAYCRDRLATRVLEQFRHEKTDTAIFREMG
CCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ELGLLGPTIPEQYGGPGLNYVAYGLIAREIERIDSGYRSMASVQSSLVMVPIFEFGTEAQ
HCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHCCHHH
KQKYLPKLASGEWIGCFGLTEPDHGSDPGSMATRAHKTAGGYKLKGSKMWITNSPIADVF
HHHHCCHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEECCCEEEEECCCHHHHH
VVWAKEVSESGAVGPIRGFVLEKGMQGLTAPAIHGKVGLRASITGEIVMDDVFVPEENAF
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCEEEEECEECCCCCCC
PEVQGLKGPFTCLNSARYGIAWGALGAAEFCWHTARQYTLDRKQFGRPLAANQLIQKKLA
CCCCCCCCHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHH
DMQTEIAIGLQACLRLGRMKDEGTAAVEATSIIKRNSCGKALDIARMARDMMGGNGISDE
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHH
FGVARHLVNLEVVNTYEGTHDVHALILGRAQTGIAAFAN
HHHHHHHHEEEEEECCCCCHHHHHHEEECCCCCHHHCCC
>Mature Secondary Structure 
ARPAAFHWEDPFLLDQQLSDDERMVRDAAAAYCRDRLATRVLEQFRHEKTDTAIFREMG
CCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ELGLLGPTIPEQYGGPGLNYVAYGLIAREIERIDSGYRSMASVQSSLVMVPIFEFGTEAQ
HCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHCCHHH
KQKYLPKLASGEWIGCFGLTEPDHGSDPGSMATRAHKTAGGYKLKGSKMWITNSPIADVF
HHHHCCHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEECCCEEEEECCCHHHHH
VVWAKEVSESGAVGPIRGFVLEKGMQGLTAPAIHGKVGLRASITGEIVMDDVFVPEENAF
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCEEEEECEECCCCCCC
PEVQGLKGPFTCLNSARYGIAWGALGAAEFCWHTARQYTLDRKQFGRPLAANQLIQKKLA
CCCCCCCCHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHH
DMQTEIAIGLQACLRLGRMKDEGTAAVEATSIIKRNSCGKALDIARMARDMMGGNGISDE
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHH
FGVARHLVNLEVVNTYEGTHDVHALILGRAQTGIAAFAN
HHHHHHHHEEEEEECCCCCHHHHHHEEECCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]