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The map label for this gene is argH [H]

Identifier: 120610629

GI number: 120610629

Start: 2111250

End: 2112707

Strand: Direct

Name: argH [H]

Synonym: Aave_1949

Alternate gene names: 120610629

Gene position: 2111250-2112707 (Clockwise)

Preceding gene: 120610626

Following gene: 120610630

Centisome position: 39.44

GC content: 68.11

Gene sequence:

>1458_bases
ATGTCCTCCAGCCCCACCGCGCAACCTTCCCAAGACCAGCTCGCCACCAAGGCCCAGGCCTGGTCGGCCCTGTTTTCCGA
ACCCATGAGCGACCTGGTCAAGCGCTACACGTCGAGCGTGTTCTTCGACAAGCGCCTGTGGCAGGCCGACATCGCCGGCA
GCCTGGCGCATGCCGACATGCTGGCGGCGCAGGGCATCATCAGTGCGGACGACCATGCCGCCATCCGGCGCGGCATGGCC
ACGATCACCCAGGAAATCGAGTCCGGCGCCTTCGAATGGAAGCTCGACCTGGAAGACGTGCACCTGAACATCGAGGCCCG
CCTGACCCAGCTGGTGGGCGATGCCGGCAAGCGCCTGCACACCGGCCGCAGCCGCAACGACCAGGTCGCCACCGACGTGC
GCCTCTGGCTGCGCGGCGAGATCGACATGATCGCCGACCTGCTCAAGGAACTGCAGCGCTCCCTGGTGGATGTGGCCGAA
CAGAACGTGGAGGTGATCCTGCCCGGCTTCACCCACCTGCAGGTCGCCCAGCCGGTGAGCTTCGCCCACCACATGCTGGC
CTACGTGGAAATGTTCGCCCGCGACGCCGAGCGCATGCAGGACGTGCGCCGCCGCACCAACGTGCTGCCGCTGGGCAGCG
CCGCGCTGGCCGGCACGACCTATCCGCTGGACCGCGAGCGCGTGGCGCGCACGCTGGGCATGGAAGGTGTCTGCCAGAAC
AGCCTGGACGCCGTGAGCGACCGCGACTTCGCCATCGAATTCACGGCCGCCGCGAGCCTGTGCATGGTGCACGTGAGCCG
CCTGTCCGAGGAGCTCATCATCTGGATGAGCCAGAACTTCGGCTTCATCCGGATCGCCGACCGCTTCACCACCGGCTCGT
CCATCATGCCGCAGAAGAAGAACCCCGACGTGCCCGAACTGGCCCGCGGCAAGACCGGCCGGGTGGTGGGCCACCTGATG
GGCCTCATCACGCTGATGAAGGGCCAGCCCCTGGCCTACAACAAGGACAACCAGGAAGACAAGGAGCCGCTGTTCGACAC
CGTCGATACGCTCAAGGACACGCTGCGCATCTTCGCCGAGATGGTCGGAGGCCAGCGCGACCCGGCCACCGGCAGGAAGG
AGGGTGGCATCACCGTCAACCCGCAGGCCATGGAGCAGGCCGCGCAGAAGGGCTATGCCACCGCCACGGATCTGGCCGAC
TACCTCGTCAAGAAGGGCCTGCCGTTCCGCGATGCCCACGAAACCGTGGCCCATGCCGTGAAGGCCGCCACGTCCCACGG
CGTGGACCTGTCCGAGCTGCCGCTCACGGTGCTGCAGGGCTTCCATCCGGCCATCGGGAAGGACGTGTTCGACGCCCTGA
GCCTGCGCGGATCGCTGAACGCCCGCAACACGCTGGGCGGCACGGCGCCGGCCCAGGTGCGCACCCAGCTGGCGCGCCAC
CGCGCGCGCCTGGGCTGA

Upstream 100 bases:

>100_bases
GCTCTGCCAGGGGCTGGGGCCGGGTCGATAAAATTTGGGTCTCTTGCATCGCGGCATCCGGGCGTTCCGGGTGGCCGAAA
CCTCCGGATTATTGCCCTCC

Downstream 100 bases:

>100_bases
ACACTTCGTTTTCTTCCCGACCGGAGCCCCGCCATGACCCTGTCCCGCCGCCGCCTGCTCTCCCATGCCTCCCTTGCCGG
CGCCGCGCTGGCAGCGGGCC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSSSPTAQPSQDQLATKAQAWSALFSEPMSDLVKRYTSSVFFDKRLWQADIAGSLAHADMLAAQGIISADDHAAIRRGMA
TITQEIESGAFEWKLDLEDVHLNIEARLTQLVGDAGKRLHTGRSRNDQVATDVRLWLRGEIDMIADLLKELQRSLVDVAE
QNVEVILPGFTHLQVAQPVSFAHHMLAYVEMFARDAERMQDVRRRTNVLPLGSAALAGTTYPLDRERVARTLGMEGVCQN
SLDAVSDRDFAIEFTAAASLCMVHVSRLSEELIIWMSQNFGFIRIADRFTTGSSIMPQKKNPDVPELARGKTGRVVGHLM
GLITLMKGQPLAYNKDNQEDKEPLFDTVDTLKDTLRIFAEMVGGQRDPATGRKEGGITVNPQAMEQAAQKGYATATDLAD
YLVKKGLPFRDAHETVAHAVKAATSHGVDLSELPLTVLQGFHPAIGKDVFDALSLRGSLNARNTLGGTAPAQVRTQLARH
RARLG

Sequences:

>Translated_485_residues
MSSSPTAQPSQDQLATKAQAWSALFSEPMSDLVKRYTSSVFFDKRLWQADIAGSLAHADMLAAQGIISADDHAAIRRGMA
TITQEIESGAFEWKLDLEDVHLNIEARLTQLVGDAGKRLHTGRSRNDQVATDVRLWLRGEIDMIADLLKELQRSLVDVAE
QNVEVILPGFTHLQVAQPVSFAHHMLAYVEMFARDAERMQDVRRRTNVLPLGSAALAGTTYPLDRERVARTLGMEGVCQN
SLDAVSDRDFAIEFTAAASLCMVHVSRLSEELIIWMSQNFGFIRIADRFTTGSSIMPQKKNPDVPELARGKTGRVVGHLM
GLITLMKGQPLAYNKDNQEDKEPLFDTVDTLKDTLRIFAEMVGGQRDPATGRKEGGITVNPQAMEQAAQKGYATATDLAD
YLVKKGLPFRDAHETVAHAVKAATSHGVDLSELPLTVLQGFHPAIGKDVFDALSLRGSLNARNTLGGTAPAQVRTQLARH
RARLG
>Mature_484_residues
SSSPTAQPSQDQLATKAQAWSALFSEPMSDLVKRYTSSVFFDKRLWQADIAGSLAHADMLAAQGIISADDHAAIRRGMAT
ITQEIESGAFEWKLDLEDVHLNIEARLTQLVGDAGKRLHTGRSRNDQVATDVRLWLRGEIDMIADLLKELQRSLVDVAEQ
NVEVILPGFTHLQVAQPVSFAHHMLAYVEMFARDAERMQDVRRRTNVLPLGSAALAGTTYPLDRERVARTLGMEGVCQNS
LDAVSDRDFAIEFTAAASLCMVHVSRLSEELIIWMSQNFGFIRIADRFTTGSSIMPQKKNPDVPELARGKTGRVVGHLMG
LITLMKGQPLAYNKDNQEDKEPLFDTVDTLKDTLRIFAEMVGGQRDPATGRKEGGITVNPQAMEQAAQKGYATATDLADY
LVKKGLPFRDAHETVAHAVKAATSHGVDLSELPLTVLQGFHPAIGKDVFDALSLRGSLNARNTLGGTAPAQVRTQLARHR
ARLG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=464, Percent_Identity=40.7327586206897, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI68303542, Length=464, Percent_Identity=40.7327586206897, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI68303547, Length=464, Percent_Identity=38.5775862068966, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI68303549, Length=464, Percent_Identity=38.5775862068966, Blast_Score=323, Evalue=3e-88,
Organism=Escherichia coli, GI1790398, Length=469, Percent_Identity=46.2686567164179, Blast_Score=417, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6321806, Length=469, Percent_Identity=39.4456289978678, Blast_Score=336, Evalue=5e-93,
Organism=Drosophila melanogaster, GI221473854, Length=459, Percent_Identity=38.7799564270153, Blast_Score=322, Evalue=5e-88,
Organism=Drosophila melanogaster, GI78706858, Length=459, Percent_Identity=38.7799564270153, Blast_Score=322, Evalue=5e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 53203; Mature: 53072

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSPTAQPSQDQLATKAQAWSALFSEPMSDLVKRYTSSVFFDKRLWQADIAGSLAHADM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAQGIISADDHAAIRRGMATITQEIESGAFEWKLDLEDVHLNIEARLTQLVGDAGKRLH
HHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEHHHEEECHHHHHHHHHHHHHHHHH
TGRSRNDQVATDVRLWLRGEIDMIADLLKELQRSLVDVAEQNVEVILPGFTHLQVAQPVS
CCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHH
FAHHMLAYVEMFARDAERMQDVRRRTNVLPLGSAALAGTTYPLDRERVARTLGMEGVCQN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHCCCHHHHH
SLDAVSDRDFAIEFTAAASLCMVHVSRLSEELIIWMSQNFGFIRIADRFTTGSSIMPQKK
HHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCCCCCCCCCCCCC
NPDVPELARGKTGRVVGHLMGLITLMKGQPLAYNKDNQEDKEPLFDTVDTLKDTLRIFAE
CCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MVGGQRDPATGRKEGGITVNPQAMEQAAQKGYATATDLADYLVKKGLPFRDAHETVAHAV
HHCCCCCCCCCCCCCCEEECHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
KAATSHGVDLSELPLTVLQGFHPAIGKDVFDALSLRGSLNARNTLGGTAPAQVRTQLARH
HHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
RARLG
HHCCC
>Mature Secondary Structure 
SSSPTAQPSQDQLATKAQAWSALFSEPMSDLVKRYTSSVFFDKRLWQADIAGSLAHADM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAQGIISADDHAAIRRGMATITQEIESGAFEWKLDLEDVHLNIEARLTQLVGDAGKRLH
HHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEHHHEEECHHHHHHHHHHHHHHHHH
TGRSRNDQVATDVRLWLRGEIDMIADLLKELQRSLVDVAEQNVEVILPGFTHLQVAQPVS
CCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHH
FAHHMLAYVEMFARDAERMQDVRRRTNVLPLGSAALAGTTYPLDRERVARTLGMEGVCQN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHCCCHHHHH
SLDAVSDRDFAIEFTAAASLCMVHVSRLSEELIIWMSQNFGFIRIADRFTTGSSIMPQKK
HHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCCCCCCCCCCCCC
NPDVPELARGKTGRVVGHLMGLITLMKGQPLAYNKDNQEDKEPLFDTVDTLKDTLRIFAE
CCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MVGGQRDPATGRKEGGITVNPQAMEQAAQKGYATATDLADYLVKKGLPFRDAHETVAHAV
HHCCCCCCCCCCCCCCEEECHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
KAATSHGVDLSELPLTVLQGFHPAIGKDVFDALSLRGSLNARNTLGGTAPAQVRTQLARH
HHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
RARLG
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA