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The map label for this gene is uvrD [H]

Identifier: 120610596

GI number: 120610596

Start: 2074331

End: 2076787

Strand: Direct

Name: uvrD [H]

Synonym: Aave_1916

Alternate gene names: 120610596

Gene position: 2074331-2076787 (Clockwise)

Preceding gene: 120610595

Following gene: 120610610

Centisome position: 38.75

GC content: 68.82

Gene sequence:

>2457_bases
ATGCTCCCACACGACCTGTTTTCCGGCGCGCCAGCGCCCTTCGGCGCTGCCGAGCCGGGCCCGGCCTCGCCGTCGGCGGC
CGCATCGCCCCTGCTGCAGAACCTGAACGACGAGCAGCTTGCCGCCGTCACGCTGCCCGCGGGCCACGCCCTGATCCTGG
CCGGCGCGGGCTCCGGCAAGACCCGCGTGCTCACCACGCGCATCGCCTGGCTGCTGCAGAACGGCTATGCCTCGCCCGGC
AGCATCCTGGCCGTCACCTTCACCAACAAGGCCGCCAAGGAAATGACCGCGCGCCTCTCGGCCATGCTGCCGGTGAACGT
GCGCGGCATGTGGATCGGTACCTTCCACGGCCTGTGCAACCGGCTGCTGCGCGCCCACCACAAGTCGGCAGGGCTGCCCG
CCACCTTCCAGATCCTGGACACGCAGGACCAGCTCTCGGCCGTGAAGCGGCTGTGCAAGCAGTTCAACATCGACGAGGAG
CGCTTTCCCCCGAAGCAGATGGCCTACTTCATCAGCGGCTGCAAGGAAGAGGGCCTGCGGCCCGGCGACGTGGATGCGCG
CGATGCGGACGGGCGCAAGAAGGTGGAGCTCTACCAGCTGTACGAGGAGCAGTGCCAGCGCGAGGGCGTGGTGGACTTCG
GCGAGCTGATGCTGCGCAGCTACGAACTGCTGCGCGACAACGATCCGATCCGCGCGCACTACCAGCGGCGCTTCCAGCAC
ATCCTGGTGGACGAGTTCCAGGACACGAACAAGCTGCAGTACGCCTGGCTCAAGCAGATCGCGGGCGACGTGGTGGACGG
CCGCCTCGTCACGCATGGCAGCGTGCTGGCGGTGGGCGACGACGACCAGAGCATCTACGCGTTCCGCGGCGCGCGGGTGG
GCAACATGCAGGACTTCGTGCGCGAGTTCGACGTGCGCCACCAGATCAAGCTGGAGCAGAACTACCGCAGCTACAGCAAC
ATCCTCGATTCGGCCAACGCCCTCATCAGCCACAACAGCCGCCGCCTGGGCAAGAACCTGCGCACCACGCAGGGGCCGGG
CGAGCCGGTGCGCGTCTATGAAGCGCCCACCGACCTGGCGGAAGCGCAATGGATGGTGGACGAGATCCGCCAGCTCGCGC
GCAATGACGGCTTCGAGCGGCGCGAGATCGCCGTGCTCTACCGCAGCAACGCGCAAAGCCGGGTGATCGAGTCGGCGCTG
TTCAATGCCGCGGTGCCCTACCGCGTGTACGGCGGCCTGCGCTTTTTCGAGCGGGCGGAAATCAAGCATGCGCTGGCCTA
CCTGCGCCTGCTGGAGAACCCGCACGACGACACGAGCTTCATGCGCGTGGTGAACTTCCCGCCGCGCGGCATCGGGGCGC
GCACGGTCGAGGTGCTGCAGGACGCGGCACGGCAGGCCGGCTGCTCGCTGCACGATGCCGTGAGCGCCGTGCCCGGCAAG
GCGGGGGCGAACCTGGGCGCCTTCGTCGCCATGGTGGATGTGATGCGCGAGCAGACGCAGGGCCAGACGCTGCGCGGCAT
CATCGGCCAGATGCTCGAATCGAGCGGACTGGTGGAGCACTACCGTGCCGAAAAGGAAGGCGCGGACCGTCTGGAGAACC
TGGACGAACTGATCAATGCCGCCGAGAGCTTCGTCACGCAGGAAGGATTCGGCCGCGACGCCGTCGCGCTGCCGGTGGAC
GAACACGGCGCCAGCCTGCGCCAGAGCCCGGCGAGCCAGGGCATCGATCCCTCGTTGCCCGTGGTGGATGAACCGCTGCC
GGGCGGCGTGGATGCCGACACCGGCGAGACGCTGTCACCCCTGGCCGCCTTCCTCACGCACGCCGCGCTGGAAGCCGGCG
ACAACCAGGCCCAGGCCGGGCAGGATGCCGTGCAGCTCATGACCGTGCATGCCTCCAAGGGGCTGGAGTTCGATGCCGTG
TTCATCGGCGGCATGGAGGAGGGCCTGTTCCCGCACGAGAACTCCATGAGCGACCGGGACGGCCTGGAGGAGGAGCGCCG
CCTGATGTACGTGGCGATCACGCGCGCGCGCAAGCGGCTCTACCTGAGCCATTCGCAGACCCGGCTGCTGCACGGGCAGA
CGCGCTACAACATCAAGAGTCGCTTCTTCGACGAGCTGCCCGAGGCGGCGCTGAAATGGATCACGCCCAAGCAGCAGGGC
TTCGGCAGCTTCGCGCCGCAGTCCGGCGGACGGGGCGGGAGTGCGGGGACGCCGTGGGGCGGCTTCGGGTCGGGCGGCAA
ATCAGAGACCTTCGCGAGCCCGCCCGTGCCGGCGCAGAAGGCGCCGCCCGCGCATGGGCTGCGCGTGGGGCTGGCGGTGT
TCCACACCAAGTTCGGCGAGGGCAAGGTGCTGTCGCTCGAAGGCTCGGGCGACGATGCGCGCGCGCAGGTGAACTTCCCG
CGGCACGGCACCAAGTGGCTGGCGCTGTCCGTGGCCAAGCTGACGGTGGTGGACTGA

Upstream 100 bases:

>100_bases
TCCGACGCGCTGGACGGCCTGTTGACGTAGGGGCGGGACAGATTCCGGGGGCTTGACCCCGCCGGCCGGGCGGAGGCGGC
CGGGTTCCTACAATGGCGGG

Downstream 100 bases:

>100_bases
CGCGCCGCGCGGCGGCCGGGTCCCGAAGCCCGGCCGATCAGTTGCGTGACGGGTAAACGCCTTCCAGGGCGATGATGAAG
TTGATGCAGAGGTAGGGCTG

Product: ATP-dependent DNA helicase UvrD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 818; Mature: 818

Protein sequence:

>818_residues
MLPHDLFSGAPAPFGAAEPGPASPSAAASPLLQNLNDEQLAAVTLPAGHALILAGAGSGKTRVLTTRIAWLLQNGYASPG
SILAVTFTNKAAKEMTARLSAMLPVNVRGMWIGTFHGLCNRLLRAHHKSAGLPATFQILDTQDQLSAVKRLCKQFNIDEE
RFPPKQMAYFISGCKEEGLRPGDVDARDADGRKKVELYQLYEEQCQREGVVDFGELMLRSYELLRDNDPIRAHYQRRFQH
ILVDEFQDTNKLQYAWLKQIAGDVVDGRLVTHGSVLAVGDDDQSIYAFRGARVGNMQDFVREFDVRHQIKLEQNYRSYSN
ILDSANALISHNSRRLGKNLRTTQGPGEPVRVYEAPTDLAEAQWMVDEIRQLARNDGFERREIAVLYRSNAQSRVIESAL
FNAAVPYRVYGGLRFFERAEIKHALAYLRLLENPHDDTSFMRVVNFPPRGIGARTVEVLQDAARQAGCSLHDAVSAVPGK
AGANLGAFVAMVDVMREQTQGQTLRGIIGQMLESSGLVEHYRAEKEGADRLENLDELINAAESFVTQEGFGRDAVALPVD
EHGASLRQSPASQGIDPSLPVVDEPLPGGVDADTGETLSPLAAFLTHAALEAGDNQAQAGQDAVQLMTVHASKGLEFDAV
FIGGMEEGLFPHENSMSDRDGLEEERRLMYVAITRARKRLYLSHSQTRLLHGQTRYNIKSRFFDELPEAALKWITPKQQG
FGSFAPQSGGRGGSAGTPWGGFGSGGKSETFASPPVPAQKAPPAHGLRVGLAVFHTKFGEGKVLSLEGSGDDARAQVNFP
RHGTKWLALSVAKLTVVD

Sequences:

>Translated_818_residues
MLPHDLFSGAPAPFGAAEPGPASPSAAASPLLQNLNDEQLAAVTLPAGHALILAGAGSGKTRVLTTRIAWLLQNGYASPG
SILAVTFTNKAAKEMTARLSAMLPVNVRGMWIGTFHGLCNRLLRAHHKSAGLPATFQILDTQDQLSAVKRLCKQFNIDEE
RFPPKQMAYFISGCKEEGLRPGDVDARDADGRKKVELYQLYEEQCQREGVVDFGELMLRSYELLRDNDPIRAHYQRRFQH
ILVDEFQDTNKLQYAWLKQIAGDVVDGRLVTHGSVLAVGDDDQSIYAFRGARVGNMQDFVREFDVRHQIKLEQNYRSYSN
ILDSANALISHNSRRLGKNLRTTQGPGEPVRVYEAPTDLAEAQWMVDEIRQLARNDGFERREIAVLYRSNAQSRVIESAL
FNAAVPYRVYGGLRFFERAEIKHALAYLRLLENPHDDTSFMRVVNFPPRGIGARTVEVLQDAARQAGCSLHDAVSAVPGK
AGANLGAFVAMVDVMREQTQGQTLRGIIGQMLESSGLVEHYRAEKEGADRLENLDELINAAESFVTQEGFGRDAVALPVD
EHGASLRQSPASQGIDPSLPVVDEPLPGGVDADTGETLSPLAAFLTHAALEAGDNQAQAGQDAVQLMTVHASKGLEFDAV
FIGGMEEGLFPHENSMSDRDGLEEERRLMYVAITRARKRLYLSHSQTRLLHGQTRYNIKSRFFDELPEAALKWITPKQQG
FGSFAPQSGGRGGSAGTPWGGFGSGGKSETFASPPVPAQKAPPAHGLRVGLAVFHTKFGEGKVLSLEGSGDDARAQVNFP
RHGTKWLALSVAKLTVVD
>Mature_818_residues
MLPHDLFSGAPAPFGAAEPGPASPSAAASPLLQNLNDEQLAAVTLPAGHALILAGAGSGKTRVLTTRIAWLLQNGYASPG
SILAVTFTNKAAKEMTARLSAMLPVNVRGMWIGTFHGLCNRLLRAHHKSAGLPATFQILDTQDQLSAVKRLCKQFNIDEE
RFPPKQMAYFISGCKEEGLRPGDVDARDADGRKKVELYQLYEEQCQREGVVDFGELMLRSYELLRDNDPIRAHYQRRFQH
ILVDEFQDTNKLQYAWLKQIAGDVVDGRLVTHGSVLAVGDDDQSIYAFRGARVGNMQDFVREFDVRHQIKLEQNYRSYSN
ILDSANALISHNSRRLGKNLRTTQGPGEPVRVYEAPTDLAEAQWMVDEIRQLARNDGFERREIAVLYRSNAQSRVIESAL
FNAAVPYRVYGGLRFFERAEIKHALAYLRLLENPHDDTSFMRVVNFPPRGIGARTVEVLQDAARQAGCSLHDAVSAVPGK
AGANLGAFVAMVDVMREQTQGQTLRGIIGQMLESSGLVEHYRAEKEGADRLENLDELINAAESFVTQEGFGRDAVALPVD
EHGASLRQSPASQGIDPSLPVVDEPLPGGVDADTGETLSPLAAFLTHAALEAGDNQAQAGQDAVQLMTVHASKGLEFDAV
FIGGMEEGLFPHENSMSDRDGLEEERRLMYVAITRARKRLYLSHSQTRLLHGQTRYNIKSRFFDELPEAALKWITPKQQG
FGSFAPQSGGRGGSAGTPWGGFGSGGKSETFASPPVPAQKAPPAHGLRVGLAVFHTKFGEGKVLSLEGSGDDARAQVNFP
RHGTKWLALSVAKLTVVD

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=799, Percent_Identity=44.6808510638298, Blast_Score=633, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=692, Percent_Identity=35.1156069364162, Blast_Score=344, Evalue=1e-95,
Organism=Escherichia coli, GI1787196, Length=359, Percent_Identity=27.5766016713092, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6322369, Length=774, Percent_Identity=28.9405684754522, Blast_Score=234, Evalue=4e-62,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 89466; Mature: 89466

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPHDLFSGAPAPFGAAEPGPASPSAAASPLLQNLNDEQLAAVTLPAGHALILAGAGSGK
CCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCC
TRVLTTRIAWLLQNGYASPGSILAVTFTNKAAKEMTARLSAMLPVNVRGMWIGTFHGLCN
CCHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHH
RLLRAHHKSAGLPATFQILDTQDQLSAVKRLCKQFNIDEERFPPKQMAYFISGCKEEGLR
HHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCC
PGDVDARDADGRKKVELYQLYEEQCQREGVVDFGELMLRSYELLRDNDPIRAHYQRRFQH
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ILVDEFQDTNKLQYAWLKQIAGDVVDGRLVTHGSVLAVGDDDQSIYAFRGARVGNMQDFV
HHHHHHCCCCHHHHHHHHHHHHHHHCCEEEECCCEEEECCCCCCEEEECCCCCCCHHHHH
REFDVRHQIKLEQNYRSYSNILDSANALISHNSRRLGKNLRTTQGPGEPVRVYEAPTDLA
HHHCCHHEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEECCCHHH
EAQWMVDEIRQLARNDGFERREIAVLYRSNAQSRVIESALFNAAVPYRVYGGLRFFERAE
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHCCHHHHHHHH
IKHALAYLRLLENPHDDTSFMRVVNFPPRGIGARTVEVLQDAARQAGCSLHDAVSAVPGK
HHHHHHHHHHHCCCCCCCHHEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCC
AGANLGAFVAMVDVMREQTQGQTLRGIIGQMLESSGLVEHYRAEKEGADRLENLDELINA
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
AESFVTQEGFGRDAVALPVDEHGASLRQSPASQGIDPSLPVVDEPLPGGVDADTGETLSP
HHHHHHHCCCCCCEEEECCHHCCCHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LAAFLTHAALEAGDNQAQAGQDAVQLMTVHASKGLEFDAVFIGGMEEGLFPHENSMSDRD
HHHHHHHHHHHCCCCHHHCCHHHHHHHEEECCCCCEEEEEEECCHHHCCCCCCCCCCCCC
GLEEERRLMYVAITRARKRLYLSHSQTRLLHGQTRYNIKSRFFDELPEAALKWITPKQQG
CCHHHHHEEHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
FGSFAPQSGGRGGSAGTPWGGFGSGGKSETFASPPVPAQKAPPAHGLRVGLAVFHTKFGE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCC
GKVLSLEGSGDDARAQVNFPRHGTKWLALSVAKLTVVD
CEEEEEECCCCCCEEEECCCCCCCEEEEEEEEEEEECC
>Mature Secondary Structure
MLPHDLFSGAPAPFGAAEPGPASPSAAASPLLQNLNDEQLAAVTLPAGHALILAGAGSGK
CCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCC
TRVLTTRIAWLLQNGYASPGSILAVTFTNKAAKEMTARLSAMLPVNVRGMWIGTFHGLCN
CCHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHH
RLLRAHHKSAGLPATFQILDTQDQLSAVKRLCKQFNIDEERFPPKQMAYFISGCKEEGLR
HHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCC
PGDVDARDADGRKKVELYQLYEEQCQREGVVDFGELMLRSYELLRDNDPIRAHYQRRFQH
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ILVDEFQDTNKLQYAWLKQIAGDVVDGRLVTHGSVLAVGDDDQSIYAFRGARVGNMQDFV
HHHHHHCCCCHHHHHHHHHHHHHHHCCEEEECCCEEEECCCCCCEEEECCCCCCCHHHHH
REFDVRHQIKLEQNYRSYSNILDSANALISHNSRRLGKNLRTTQGPGEPVRVYEAPTDLA
HHHCCHHEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEECCCHHH
EAQWMVDEIRQLARNDGFERREIAVLYRSNAQSRVIESALFNAAVPYRVYGGLRFFERAE
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHCCHHHHHHHH
IKHALAYLRLLENPHDDTSFMRVVNFPPRGIGARTVEVLQDAARQAGCSLHDAVSAVPGK
HHHHHHHHHHHCCCCCCCHHEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCC
AGANLGAFVAMVDVMREQTQGQTLRGIIGQMLESSGLVEHYRAEKEGADRLENLDELINA
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
AESFVTQEGFGRDAVALPVDEHGASLRQSPASQGIDPSLPVVDEPLPGGVDADTGETLSP
HHHHHHHCCCCCCEEEECCHHCCCHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LAAFLTHAALEAGDNQAQAGQDAVQLMTVHASKGLEFDAVFIGGMEEGLFPHENSMSDRD
HHHHHHHHHHHCCCCHHHCCHHHHHHHEEECCCCCEEEEEEECCHHHCCCCCCCCCCCCC
GLEEERRLMYVAITRARKRLYLSHSQTRLLHGQTRYNIKSRFFDELPEAALKWITPKQQG
CCHHHHHEEHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
FGSFAPQSGGRGGSAGTPWGGFGSGGKSETFASPPVPAQKAPPAHGLRVGLAVFHTKFGE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCC
GKVLSLEGSGDDARAQVNFPRHGTKWLALSVAKLTVVD
CEEEEEECCCCCCEEEECCCCCCCEEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]