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The map label for this gene is cpg2 [H]

Identifier: 120610594

GI number: 120610594

Start: 2072046

End: 2073275

Strand: Reverse

Name: cpg2 [H]

Synonym: Aave_1914

Alternate gene names: 120610594

Gene position: 2073275-2072046 (Counterclockwise)

Preceding gene: 120610597

Following gene: 120610593

Centisome position: 38.73

GC content: 71.06

Gene sequence:

>1230_bases
ATGAAATTTCCGTTTCAATCATTCTTTCATCCCGCCTCACTGCCCGCCATGTCCACCACCGTGCCCGAGCCTGCCGCCGT
CCCCGCCTCCGCCCAGCCCCTGCTCGACTGGCTCGCCTCGCAGGAGCAGGCCATGGCCGACCTGCTGGCGCAGGTCGTGA
ACATCGACAGCGGCAGCGGCCATGAAGAGGGCGTGCGCCAGGTCGCGGCGGTGCTGCGCGGCCGCCTGGAATCCGCCGGC
ATCGCCGTGCAGACCCTGCCCGAGCCGGGCTGGGGCGAATGCCTCCTGGCCAAGGTGCCCGGCAGCAATCCCGGGGCGGC
GGGCCACCACCAGCTCATGGGGCACATGGATACGGTCTTCCCGCTGGGCACGGCGGCGCAGCGCCCGTGGCGCGTGGAAG
GCGGCAAGGCCTTCGGCCCCGGCGTGGCGGACATGAAGTCGGGCCTGGTGATGAACGTGTTCGTGGCCGAGGCCCTGGCA
CGCTTCGGCGGCAACGCCACCCCGGTGCACCTGCTGTTCACCGCCGACGAAGAGGTGGGATCGCCCGCCTGCCGCAACGT
CATCCGCGAGCACGTGCAGGGCGCCCGCGCCGTGCTCAATGCCGAGCCGGGCCGCATCAGCGGCAACGTGGTCAACGAGC
GCAAGGGCTCCTACCGCATCGATTTCGAAGTGCAGGGCGTGGCCGCGCACGCGGGCATCAACCCCGCCCAGGGCGCGAGC
GCCATCGACGCTCTGGCCCGCAAGATCCTGGCGCTGCACGCCCTCAACGGCTGCGAGCCCGGCATCACGGTGAACGTGGG
CTTCATCCAGGGCGGCATGGCCTCCAACGTGGTGGCCCCGCTGGCCTCGGCGCACGTGGACCTGCGCTACACCGCCGGCA
ACGACCTGGAAGGCGTCCTGGCACGCATCCAGGCCATCATCGAGGAAGAATCCCTGCCCCGCACCAGCGGCCGCATCGTC
GCCAAGACAGGCACCCTGCCCATGGCCCGCACGCCCGACGCGCTGCTGCAGACCTACCAGCGCTGCGCGCAACAGGTCGG
CTTCACGGTCGAGGGCGAGGCCACCGGCGGCGCGGCCGACAGCGGCATCACGTCGAACATGGGCATTCCCTCGCTGTGCG
CCCTGGGCCCCGTGGGCGGCTATGCGCACAGCGAGCGCGAGTTCTGCGACCTCACCACCTTCGTTCCCCGCGCCCAGGCG
CTCGCGCTCACGCTGCTGGCGCTGGGTTGA

Upstream 100 bases:

>100_bases
CGCAAGGCGCGGGGAGCGCCCCGTGGCGTCGATTGTGCATGGCGCGCCACCCCCGAGGAATGGAATGGATTGCAACAACT
ATTGCAAGGCAATATGATTT

Downstream 100 bases:

>100_bases
GCCGGCTTCCAACCTTTTTGTTTTCCTGACCTTTCCGAGACCTATGTCCTTCGAACGCACCCCCACCACCCGCCGCCAAC
TGCTGGCCACCGGCCTGGGC

Product: peptidase M20

Products: NA

Alternate protein names: CPDG2; Folate hydrolase G2; Glutamate carboxypeptidase; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MKFPFQSFFHPASLPAMSTTVPEPAAVPASAQPLLDWLASQEQAMADLLAQVVNIDSGSGHEEGVRQVAAVLRGRLESAG
IAVQTLPEPGWGECLLAKVPGSNPGAAGHHQLMGHMDTVFPLGTAAQRPWRVEGGKAFGPGVADMKSGLVMNVFVAEALA
RFGGNATPVHLLFTADEEVGSPACRNVIREHVQGARAVLNAEPGRISGNVVNERKGSYRIDFEVQGVAAHAGINPAQGAS
AIDALARKILALHALNGCEPGITVNVGFIQGGMASNVVAPLASAHVDLRYTAGNDLEGVLARIQAIIEEESLPRTSGRIV
AKTGTLPMARTPDALLQTYQRCAQQVGFTVEGEATGGAADSGITSNMGIPSLCALGPVGGYAHSEREFCDLTTFVPRAQA
LALTLLALG

Sequences:

>Translated_409_residues
MKFPFQSFFHPASLPAMSTTVPEPAAVPASAQPLLDWLASQEQAMADLLAQVVNIDSGSGHEEGVRQVAAVLRGRLESAG
IAVQTLPEPGWGECLLAKVPGSNPGAAGHHQLMGHMDTVFPLGTAAQRPWRVEGGKAFGPGVADMKSGLVMNVFVAEALA
RFGGNATPVHLLFTADEEVGSPACRNVIREHVQGARAVLNAEPGRISGNVVNERKGSYRIDFEVQGVAAHAGINPAQGAS
AIDALARKILALHALNGCEPGITVNVGFIQGGMASNVVAPLASAHVDLRYTAGNDLEGVLARIQAIIEEESLPRTSGRIV
AKTGTLPMARTPDALLQTYQRCAQQVGFTVEGEATGGAADSGITSNMGIPSLCALGPVGGYAHSEREFCDLTTFVPRAQA
LALTLLALG
>Mature_409_residues
MKFPFQSFFHPASLPAMSTTVPEPAAVPASAQPLLDWLASQEQAMADLLAQVVNIDSGSGHEEGVRQVAAVLRGRLESAG
IAVQTLPEPGWGECLLAKVPGSNPGAAGHHQLMGHMDTVFPLGTAAQRPWRVEGGKAFGPGVADMKSGLVMNVFVAEALA
RFGGNATPVHLLFTADEEVGSPACRNVIREHVQGARAVLNAEPGRISGNVVNERKGSYRIDFEVQGVAAHAGINPAQGAS
AIDALARKILALHALNGCEPGITVNVGFIQGGMASNVVAPLASAHVDLRYTAGNDLEGVLARIQAIIEEESLPRTSGRIV
AKTGTLPMARTPDALLQTYQRCAQQVGFTVEGEATGGAADSGITSNMGIPSLCALGPVGGYAHSEREFCDLTTFVPRAQA
LALTLLALG

Specific function: Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity [H]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Escherichia coli, GI1790395, Length=287, Percent_Identity=28.9198606271777, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR017150
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.17.11 [H]

Molecular weight: Translated: 42466; Mature: 42466

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFPFQSFFHPASLPAMSTTVPEPAAVPASAQPLLDWLASQEQAMADLLAQVVNIDSGSG
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
HEEGVRQVAAVLRGRLESAGIAVQTLPEPGWGECLLAKVPGSNPGAAGHHQLMGHMDTVF
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHC
PLGTAAQRPWRVEGGKAFGPGVADMKSGLVMNVFVAEALARFGGNATPVHLLFTADEEVG
CCCCCCCCCEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHC
SPACRNVIREHVQGARAVLNAEPGRISGNVVNERKGSYRIDFEVQGVAAHAGINPAQGAS
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEEEEEEEEEECCCCCCCCHH
AIDALARKILALHALNGCEPGITVNVGFIQGGMASNVVAPLASAHVDLRYTAGNDLEGVL
HHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHCCEEEEEECCCCHHHHH
ARIQAIIEEESLPRTSGRIVAKTGTLPMARTPDALLQTYQRCAQQVGFTVEGEATGGAAD
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCC
SGITSNMGIPSLCALGPVGGYAHSEREFCDLTTFVPRAQALALTLLALG
CCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFPFQSFFHPASLPAMSTTVPEPAAVPASAQPLLDWLASQEQAMADLLAQVVNIDSGSG
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
HEEGVRQVAAVLRGRLESAGIAVQTLPEPGWGECLLAKVPGSNPGAAGHHQLMGHMDTVF
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHC
PLGTAAQRPWRVEGGKAFGPGVADMKSGLVMNVFVAEALARFGGNATPVHLLFTADEEVG
CCCCCCCCCEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHC
SPACRNVIREHVQGARAVLNAEPGRISGNVVNERKGSYRIDFEVQGVAAHAGINPAQGAS
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEEEEEEEEEECCCCCCCCHH
AIDALARKILALHALNGCEPGITVNVGFIQGGMASNVVAPLASAHVDLRYTAGNDLEGVL
HHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHCCEEEEEECCCCHHHHH
ARIQAIIEEESLPRTSGRIVAKTGTLPMARTPDALLQTYQRCAQQVGFTVEGEATGGAAD
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCC
SGITSNMGIPSLCALGPVGGYAHSEREFCDLTTFVPRAQALALTLLALG
CCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6396165; 3838935; 9083113 [H]