Click here to switch to the map view.

The map label for this gene is guaC

Identifier: 120610591

GI number: 120610591

Start: 2068949

End: 2069926

Strand: Reverse

Name: guaC

Synonym: Aave_1911

Alternate gene names: 120610591

Gene position: 2069926-2068949 (Counterclockwise)

Preceding gene: 120610592

Following gene: 120610590

Centisome position: 38.67

GC content: 65.24

Gene sequence:

>978_bases
ATGGAAATCTTCGACTACGACAATGTCCTGCTGCTGCCGCGCAAATGCCGCGTGGAGAGCCGCTCCGAATGCGACGCCAG
CGTCACCCTCGGGCAGCGCAGCTTCCGCCTGCCGGTGGTGCCGGCGAACATGAAGACGGTGGTGGACGAGAAGATCTGCC
GCTGGCTCGCCAGCAACGGCTACTTCTACGTCATGCACCGCTTCGACCTCGACAACGTGCAGTTCGTGCGCGACATGCAC
GCGGCCGGCTGCTTCGCCTCCATCTCGCTGGGCGTGAAGCAGCCCGACTACGACACGGTGGACCGGCTCGTGGCGGAAGG
CCTCTGCCCCGAGTACATCACCATCGACATCGCCCACGGCCATGCGGACACCGTGAAGGCCATGATCGCCTACCTCAAGC
AGCACCTGCCGCAGGCCTTCGTGATCGCCGGCAACGTGGCCACGCCCGAAGCCATCATCGACCTGGAGAACTGGGGCGCG
GACGCGACCAAGGTGGGCGTGGGCCCGGGCAAGGTGTGCATCACCAAGCTCAAGACCGGCTTCGGCACCGGCGGCTGGCA
GCTCTCGGCGCTCAAGTGGTGCGCCCGCGTGGCCACGAAACCCATCATCGCCGACGGCGGCATCCGCAGCCATGGCGACA
TCGCCAAGAGCATCCGCTTCGGCGCCACCATGGTCATGATCGGCTCGCTGTTCGCAGGCCACGAGGAATCCCCCGGCAAG
ACCGTGGAAGTGGACGGCGAGCAGTTCAAGGAGTACTACGGCTCCGCCAGCGACTTCAACAAGGGCGAGTACAAGCACGT
GGAAGGCAAGCGCATCCTCGAACCCATCAAGGGCCGCCTGGCGGACACGCTGGTCGAGATGGAGCAGGACGTGCAGAGCT
CCATCAGCTACTCCGGCGGCCGCAGGCTCATGGACATCCGCAAGGTGAACTACGTGATCCTGGGCGGCGACAACGCGGGC
GAACACCTGCTCATGTGA

Upstream 100 bases:

>100_bases
GAGGCCTTTCACGGCCCGCCCACAAGACCGGCCTCCAAGCCAAGCGCCCCATCGCGGGGGAAACGGTCCTCCGCGACCTT
TCACAGGAGCTTGGAATCTC

Downstream 100 bases:

>100_bases
GGTGCCGAAAACTTTTTTGCCTGCCTGCTTGCAGACCGGTAAAAAAGTAGTGCATAATTCGAGGCTCTGCAGCGCTGCAG
ACACAGTTTCAAAGTTTACT

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MEIFDYDNVLLLPRKCRVESRSECDASVTLGQRSFRLPVVPANMKTVVDEKICRWLASNGYFYVMHRFDLDNVQFVRDMH
AAGCFASISLGVKQPDYDTVDRLVAEGLCPEYITIDIAHGHADTVKAMIAYLKQHLPQAFVIAGNVATPEAIIDLENWGA
DATKVGVGPGKVCITKLKTGFGTGGWQLSALKWCARVATKPIIADGGIRSHGDIAKSIRFGATMVMIGSLFAGHEESPGK
TVEVDGEQFKEYYGSASDFNKGEYKHVEGKRILEPIKGRLADTLVEMEQDVQSSISYSGGRRLMDIRKVNYVILGGDNAG
EHLLM

Sequences:

>Translated_325_residues
MEIFDYDNVLLLPRKCRVESRSECDASVTLGQRSFRLPVVPANMKTVVDEKICRWLASNGYFYVMHRFDLDNVQFVRDMH
AAGCFASISLGVKQPDYDTVDRLVAEGLCPEYITIDIAHGHADTVKAMIAYLKQHLPQAFVIAGNVATPEAIIDLENWGA
DATKVGVGPGKVCITKLKTGFGTGGWQLSALKWCARVATKPIIADGGIRSHGDIAKSIRFGATMVMIGSLFAGHEESPGK
TVEVDGEQFKEYYGSASDFNKGEYKHVEGKRILEPIKGRLADTLVEMEQDVQSSISYSGGRRLMDIRKVNYVILGGDNAG
EHLLM
>Mature_325_residues
MEIFDYDNVLLLPRKCRVESRSECDASVTLGQRSFRLPVVPANMKTVVDEKICRWLASNGYFYVMHRFDLDNVQFVRDMH
AAGCFASISLGVKQPDYDTVDRLVAEGLCPEYITIDIAHGHADTVKAMIAYLKQHLPQAFVIAGNVATPEAIIDLENWGA
DATKVGVGPGKVCITKLKTGFGTGGWQLSALKWCARVATKPIIADGGIRSHGDIAKSIRFGATMVMIGSLFAGHEESPGK
TVEVDGEQFKEYYGSASDFNKGEYKHVEGKRILEPIKGRLADTLVEMEQDVQSSISYSGGRRLMDIRKVNYVILGGDNAG
EHLLM

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily

Homologues:

Organism=Homo sapiens, GI50541954, Length=331, Percent_Identity=31.7220543806647, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI50541952, Length=331, Percent_Identity=31.7220543806647, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI50541948, Length=331, Percent_Identity=31.7220543806647, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI156104880, Length=328, Percent_Identity=32.0121951219512, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI50541956, Length=331, Percent_Identity=31.7220543806647, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI217035146, Length=170, Percent_Identity=35.8823529411765, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI217035148, Length=170, Percent_Identity=35.8823529411765, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI217035150, Length=170, Percent_Identity=35.8823529411765, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI156616279, Length=170, Percent_Identity=35.8823529411765, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI217035152, Length=170, Percent_Identity=35.8823529411765, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI34328930, Length=170, Percent_Identity=35.8823529411765, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI34328928, Length=170, Percent_Identity=35.8823529411765, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI66933016, Length=177, Percent_Identity=36.1581920903955, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1786293, Length=326, Percent_Identity=31.9018404907975, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1788855, Length=197, Percent_Identity=38.5786802030457, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17560440, Length=323, Percent_Identity=31.5789473684211, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=163, Percent_Identity=38.6503067484663, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71994389, Length=163, Percent_Identity=38.6503067484663, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323585, Length=177, Percent_Identity=34.4632768361582, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323464, Length=177, Percent_Identity=34.4632768361582, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322012, Length=177, Percent_Identity=34.4632768361582, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28571163, Length=173, Percent_Identity=38.150289017341, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24641071, Length=173, Percent_Identity=38.150289017341, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24641073, Length=173, Percent_Identity=38.150289017341, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): GUAC_ACIAC (A1TNF7)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_970269.1
- ProteinModelPortal:   A1TNF7
- SMR:   A1TNF7
- STRING:   A1TNF7
- GeneID:   4668745
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1911
- NMPDR:   fig|397945.5.peg.1653
- eggNOG:   COG0516
- HOGENOM:   HBG298985
- OMA:   PDYITID
- PhylomeDB:   A1TNF7
- ProtClustDB:   PRK05458
- BioCyc:   AAVE397945:AAVE_1911-MONOMER
- HAMAP:   MF_01511
- InterPro:   IPR013785
- InterPro:   IPR005994
- InterPro:   IPR015875
- InterPro:   IPR001093
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF036500
- TIGRFAMs:   TIGR01306

Pfam domain/function: PF00478 IMPDH

EC number: =1.7.1.7

Molecular weight: Translated: 35753; Mature: 35753

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: ACT_SITE 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFDYDNVLLLPRKCRVESRSECDASVTLGQRSFRLPVVPANMKTVVDEKICRWLASNG
CCEECCCCEEEECHHCCCCCCCCCCCEEEECCCCEECCEECCCHHHHHHHHHHHHHHCCC
YFYVMHRFDLDNVQFVRDMHAAGCFASISLGVKQPDYDTVDRLVAEGLCPEYITIDIAHG
EEEEEEEECCCHHHHHHHHHHHCCHHEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECC
HADTVKAMIAYLKQHLPQAFVIAGNVATPEAIIDLENWGADATKVGVGPGKVCITKLKTG
CHHHHHHHHHHHHHHCCCEEEEECCCCCCHHEEEEHHCCCCCEEECCCCCHHEEEEHHCC
FGTGGWQLSALKWCARVATKPIIADGGIRSHGDIAKSIRFGATMVMIGSLFAGHEESPGK
CCCCCCHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TVEVDGEQFKEYYGSASDFNKGEYKHVEGKRILEPIKGRLADTLVEMEQDVQSSISYSGG
EEEECHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RRLMDIRKVNYVILGGDNAGEHLLM
CEEEEEEEEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MEIFDYDNVLLLPRKCRVESRSECDASVTLGQRSFRLPVVPANMKTVVDEKICRWLASNG
CCEECCCCEEEECHHCCCCCCCCCCCEEEECCCCEECCEECCCHHHHHHHHHHHHHHCCC
YFYVMHRFDLDNVQFVRDMHAAGCFASISLGVKQPDYDTVDRLVAEGLCPEYITIDIAHG
EEEEEEEECCCHHHHHHHHHHHCCHHEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECC
HADTVKAMIAYLKQHLPQAFVIAGNVATPEAIIDLENWGADATKVGVGPGKVCITKLKTG
CHHHHHHHHHHHHHHCCCEEEEECCCCCCHHEEEEHHCCCCCEEECCCCCHHEEEEHHCC
FGTGGWQLSALKWCARVATKPIIADGGIRSHGDIAKSIRFGATMVMIGSLFAGHEESPGK
CCCCCCHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TVEVDGEQFKEYYGSASDFNKGEYKHVEGKRILEPIKGRLADTLVEMEQDVQSSISYSGG
EEEECHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RRLMDIRKVNYVILGGDNAGEHLLM
CEEEEEEEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA