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The map label for this gene is ydgK [H]

Identifier: 120610547

GI number: 120610547

Start: 2023924

End: 2025144

Strand: Direct

Name: ydgK [H]

Synonym: Aave_1867

Alternate gene names: 120610547

Gene position: 2023924-2025144 (Clockwise)

Preceding gene: 120610546

Following gene: 120610548

Centisome position: 37.81

GC content: 71.42

Gene sequence:

>1221_bases
ATGCCTTCTTCGCCTTTCCTGCGCATGGCCCTGGTACTGGGCCTGCTTTCCGCCATCGGCCCCTTCGCGATCGACATGTA
CCTGCCTGCGCTGCCCGAGATCGGGCATGGCCTGGGCGCGCCCGTGGGCGCGGTGCAGTGGAGCCTGACGGCCTTCTTCC
TCTCGCTCGGCGTGGGCCAGTTGCTCTACGGCCCGCTGTCGGACATGGCCGGGCGCAAGCCGCCGCTCTATTTCGGGCTG
GTGCTGTTCACCGTGGCGAGCGTCGGCTGTGCGCTGGCGACCACCATCGAGACCCTGCTCGTGCTGCGCTTCCTGCAGGG
ATTGGGCGCGGCCGCGGGGATGGTGGTGCCGCGCGCCGTGGTGCGGGACCTGCACACGGGCCACGAGGCCGCACGGCTGA
TGTCGCTGCTGATGCTGGTGTTCAGCGTGTCGCCATTGCTGGCGCCGCTCGCCGGCAGCGGCGTGATCGCTCTCGCGGGC
TGGCGTGGCGTGTTCTGGGCGGTGGCGATCGCCGCGCTGGCCGGACTGCTGCTGGTGCGCTTTGCGCTCGCCGAGACCCG
GCCCGCCGCGGAGCGGACGCAAAGCACCCTGGGCAGCGCGCTGCGGGGCTACGGCCTGCTGCTGCGCGACCCGCATTACC
TGGGCCTGGTGTTCATCGGCGGCTGCGCGATGGCGGGCTTCTTCGTGTACCTGGCGGGCTCGCCCTTCGTGCTCATCAAC
CACTACGGGCTCACGCCCACGCAGTACAGCCTGGCGTTCTCGTTCAATGCCGCGGCGTTTTTCGCCATGGCGCAGTTCAA
CGGCATGCTGGCCGCCCGCTTCGGGCTGGAGCCGATCGTGAAGGTGGCGGCCACCGCCTCGTCGGCGGTGATGGCCGTGA
TGCTCGGCTACTACCTGCTGGGCGGTGACCGGCTCGCGGTGCTGATCGGCCTGTACTTCATGGCGAGCGCGCTCATGGGG
CTGGTGATTCCCACGACCTCGGTGCTGGCGCTGGAGGAGCACGGCGCGATCGCGGGCACGGCCTCTGCGCTGATGGGCAC
GCTGCAGATGCTCACGGGTGCCGTGGCGATGGGGCTGGTGGGGCTGTTCGCCGATGGCCGGCCGCTGCCGATGGTCGCGG
GGATGGCGACGGGGGCGTTTCTCGGCACGGCGCTGTGCTGGACCACGCTGGGCCGCGCCCGCGTGGCGCCCGGCCGGGGC
CGCCGGGGAGCCCGGGCGTGA

Upstream 100 bases:

>100_bases
GGGTCCGGGCGCATGCCGGCCAAGCTTTCCGCACAGGGGCATCTGCGCGCGCGCTTCGGCGAGGGCCGGCGCGGGGCTTT
TCTCCTGGCGACAATGCGGG

Downstream 100 bases:

>100_bases
GCGGTGTGACACCTGGCACGGCTTCCGGCGCGGGGCAGCGCAGTTCCGCGGAAGCCGCCGTGTCGCGGCCTGCAGGCGTG
GCGGACGGACTGGAGCCGCC

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MPSSPFLRMALVLGLLSAIGPFAIDMYLPALPEIGHGLGAPVGAVQWSLTAFFLSLGVGQLLYGPLSDMAGRKPPLYFGL
VLFTVASVGCALATTIETLLVLRFLQGLGAAAGMVVPRAVVRDLHTGHEAARLMSLLMLVFSVSPLLAPLAGSGVIALAG
WRGVFWAVAIAALAGLLLVRFALAETRPAAERTQSTLGSALRGYGLLLRDPHYLGLVFIGGCAMAGFFVYLAGSPFVLIN
HYGLTPTQYSLAFSFNAAAFFAMAQFNGMLAARFGLEPIVKVAATASSAVMAVMLGYYLLGGDRLAVLIGLYFMASALMG
LVIPTTSVLALEEHGAIAGTASALMGTLQMLTGAVAMGLVGLFADGRPLPMVAGMATGAFLGTALCWTTLGRARVAPGRG
RRGARA

Sequences:

>Translated_406_residues
MPSSPFLRMALVLGLLSAIGPFAIDMYLPALPEIGHGLGAPVGAVQWSLTAFFLSLGVGQLLYGPLSDMAGRKPPLYFGL
VLFTVASVGCALATTIETLLVLRFLQGLGAAAGMVVPRAVVRDLHTGHEAARLMSLLMLVFSVSPLLAPLAGSGVIALAG
WRGVFWAVAIAALAGLLLVRFALAETRPAAERTQSTLGSALRGYGLLLRDPHYLGLVFIGGCAMAGFFVYLAGSPFVLIN
HYGLTPTQYSLAFSFNAAAFFAMAQFNGMLAARFGLEPIVKVAATASSAVMAVMLGYYLLGGDRLAVLIGLYFMASALMG
LVIPTTSVLALEEHGAIAGTASALMGTLQMLTGAVAMGLVGLFADGRPLPMVAGMATGAFLGTALCWTTLGRARVAPGRG
RRGARA
>Mature_405_residues
PSSPFLRMALVLGLLSAIGPFAIDMYLPALPEIGHGLGAPVGAVQWSLTAFFLSLGVGQLLYGPLSDMAGRKPPLYFGLV
LFTVASVGCALATTIETLLVLRFLQGLGAAAGMVVPRAVVRDLHTGHEAARLMSLLMLVFSVSPLLAPLAGSGVIALAGW
RGVFWAVAIAALAGLLLVRFALAETRPAAERTQSTLGSALRGYGLLLRDPHYLGLVFIGGCAMAGFFVYLAGSPFVLINH
YGLTPTQYSLAFSFNAAAFFAMAQFNGMLAARFGLEPIVKVAATASSAVMAVMLGYYLLGGDRLAVLIGLYFMASALMGL
VIPTTSVLALEEHGAIAGTASALMGTLQMLTGAVAMGLVGLFADGRPLPMVAGMATGAFLGTALCWTTLGRARVAPGRGR
RGARA

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=381, Percent_Identity=34.1207349081365, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI48994889, Length=355, Percent_Identity=33.8028169014084, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1790146, Length=237, Percent_Identity=32.9113924050633, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI87082312, Length=336, Percent_Identity=30.3571428571429, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1787065, Length=238, Percent_Identity=30.2521008403361, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790794, Length=374, Percent_Identity=23.7967914438503, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87081983, Length=183, Percent_Identity=29.5081967213115, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790195, Length=179, Percent_Identity=29.0502793296089, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319517, Length=184, Percent_Identity=28.2608695652174, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324264, Length=162, Percent_Identity=24.6913580246914, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41998; Mature: 41867

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSPFLRMALVLGLLSAIGPFAIDMYLPALPEIGHGLGAPVGAVQWSLTAFFLSLGVGQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
LLYGPLSDMAGRKPPLYFGLVLFTVASVGCALATTIETLLVLRFLQGLGAAAGMVVPRAV
HHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
VRDLHTGHEAARLMSLLMLVFSVSPLLAPLAGSGVIALAGWRGVFWAVAIAALAGLLLVR
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHH
FALAETRPAAERTQSTLGSALRGYGLLLRDPHYLGLVFIGGCAMAGFFVYLAGSPFVLIN
HHHHHCCCHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
HYGLTPTQYSLAFSFNAAAFFAMAQFNGMLAARFGLEPIVKVAATASSAVMAVMLGYYLL
ECCCCCCCEEEEEEECHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
GGDRLAVLIGLYFMASALMGLVIPTTSVLALEEHGAIAGTASALMGTLQMLTGAVAMGLV
CCCHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLFADGRPLPMVAGMATGAFLGTALCWTTLGRARVAPGRGRRGARA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PSSPFLRMALVLGLLSAIGPFAIDMYLPALPEIGHGLGAPVGAVQWSLTAFFLSLGVGQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
LLYGPLSDMAGRKPPLYFGLVLFTVASVGCALATTIETLLVLRFLQGLGAAAGMVVPRAV
HHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
VRDLHTGHEAARLMSLLMLVFSVSPLLAPLAGSGVIALAGWRGVFWAVAIAALAGLLLVR
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHH
FALAETRPAAERTQSTLGSALRGYGLLLRDPHYLGLVFIGGCAMAGFFVYLAGSPFVLIN
HHHHHCCCHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
HYGLTPTQYSLAFSFNAAAFFAMAQFNGMLAARFGLEPIVKVAATASSAVMAVMLGYYLL
ECCCCCCCEEEEEEECHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
GGDRLAVLIGLYFMASALMGLVIPTTSVLALEEHGAIAGTASALMGTLQMLTGAVAMGLV
CCCHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLFADGRPLPMVAGMATGAFLGTALCWTTLGRARVAPGRGRRGARA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]