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The map label for this gene is ppiD [H]

Identifier: 120610416

GI number: 120610416

Start: 1895393

End: 1897321

Strand: Direct

Name: ppiD [H]

Synonym: Aave_1733

Alternate gene names: 120610416

Gene position: 1895393-1897321 (Clockwise)

Preceding gene: 120610415

Following gene: 120610425

Centisome position: 35.41

GC content: 69.0

Gene sequence:

>1929_bases
ATGTTCGAATCCATCCGCAAGCACTCCAAGGTCGTCATGATCGTGCTGTTCTTGCTGATCATTCCGTCGTTTGTGCTCGT
GGGCATCGACCGGAACTACTTCACCAGCAAGAGCGCCGTGGTGGCGCGCGTGGATGGCCATGACATCACCCAGGATGACT
GGGACAACGCGCACCGGATGGAAACCGACCGCATCCGCGCGCAGTCGCCCTCGGTCGATGCCAGGCTGCTGGATTCGCCC
CGCGCCCGCTACGCCACGCTGGAGCGCCTGGTGCGCGACCGCGTGATGCAGGCCGCCGCCGTCAAGATGCACCTGGTCAC
GAGCGACGCCCAGCTGGCCCGCACGCTGCAGGGCATTCCCGCCATCGCCGCGCTCAAGCGCCCCGATGGCTCGCTGGACG
CAGAGGCCTATCGCGCACTGGTGGGCTCGCAGGGCCTCACGCCCGAGGGCTTCGAATCCAACGTACGCCGCGAACTCTCC
CTCAGCCAGGTGATGGGCGGCGTGCTGGGCTCCGCGTTCGCTGGCCAGGAGCCGGCGCGCCTCGCGCTGGACGCGCTCTA
CCAGCGCCGCGAGATCCAGGTCGCCCGTTTCGACGCCAAGGACTTCGCCGCCAAGGTCGCGCCCACCGACGACGAACTGC
AGTCCTACTACAAGGCCCACGAAGCGCAGTTCCGCCAGCCCGAGCATGCGGACGTGCAGTACGTGGTGCTCGACCTGGAC
GCCGTGCGCGCCAGCATCACGCTGAGCGAGGACGACCTGCGCAGCTACTACAAGGAAAACCTGGAGCGCCTCGCCGGCAA
GGAAGAGCGCCGCGCCAGCCACATCCTGATCAATGCCCCCAAGGACGCCCCCGCCGCCGACCGCGAGAAGGCCAGGGCCC
GCGCGCAGGCGCTGCTGGAGCAGGTGCGCAAGGCGCCCGGCACCTTCGCAGAGGTGGCCCGCAAGAATTCGCAGGACACC
GGCTCCGCGCCCTCCGGCGGCGACCTCGGCTTCTTCAAGCGCGGCGACATGGTCAAGCCGTTCGAGGACGCCGCCTTCTC
GATGAAGAAGGGCGACATCAGCGACCTGGTGGAAAGCGAGTACGGCTACCACATCATCCAGCTCAACGACGTCAAGACGC
CCAGGCAGCCGACCTTCGAGGAAGTGCGTGCCAAGCTGGAGACGGAAGCCAAGCAGCAGCAGGCGCAACGCAAGTTCGCC
GAACTGGCCGAGGTGTTCTCCAACACCGTGTACGAGCAGGCGGACAGCCTGCAGCCCGTGGCCGACAAGCTCAAGCTGAA
GGTGCAGACAGCCAGCGGCGTCGCGCGCACGCCGCTGCCCGGCGCCCAGGGCCCGCTGGCCAACGGCCGCTTCCTGGAGG
CGCTGTTCGCCGCCGACTCCGTGCAGAACAAGCGCAACACCGAAGCCATCGAAACGGCGCCCAGCACCCTGGTGGCCGGC
CGCGTCGCTGCCTACACGCCGGCTTCCACCCCGGCCTTCGACCAGGTGAAGGCCCGCGTGCGCGAGCTGTTCGTGGCCGA
TCGCTCCGCCGAACTGGCACGCAAGGAAGGCGAGGCCAGGCTGGCCGCCTGGAAGGCCGCGCCGGCCAGCGCCACCGGCC
TGGGCAACCTCGTCACCATCTCGCGCGACAAGCCCGAAGGCCAGCCGCGCCCCGTGGTGGACGCCGCCCTGCAGGTGAAT
GCCGACACGCTGCCCGCTTTCGCCGGCACCCCCCTGGGCGCCCAGGGCTACGCCGTCGTCAAGGTGACCCGCATCGTGCC
GCGCGACCCGTCGGACCCGGCCGTGGCCCGCCAGCAGCATCAGCAGTACGCCGAAGCCGAGGCCCAGGCCGAGGCCATGG
CCTACTACGAACTGCTCAAGGATCGCTTCAAGGTCCAGTTCAAGGTGGCCCGCCCGACGGGCGACGGCACCCCCGCCGCG
GAAAATTGA

Upstream 100 bases:

>100_bases
AAGGCGTAGGTCGGCGGTTCGACCCCGTCAGCACCCACCACCGATCAAAAGGCGAACGAGAGTTCGCCTTTTCTTTTGTC
GCCACTGAAAGATCGAAACC

Downstream 100 bases:

>100_bases
TGCTGTGAACATGGCCGGAGGGGTTTTTATCCGGCTATAATTCAAGGCTACGGTGGCTGTAGCTCAGTTGGTAGAGTCCA
GGATTGTGATTCCTGTCGTC

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 642; Mature: 642

Protein sequence:

>642_residues
MFESIRKHSKVVMIVLFLLIIPSFVLVGIDRNYFTSKSAVVARVDGHDITQDDWDNAHRMETDRIRAQSPSVDARLLDSP
RARYATLERLVRDRVMQAAAVKMHLVTSDAQLARTLQGIPAIAALKRPDGSLDAEAYRALVGSQGLTPEGFESNVRRELS
LSQVMGGVLGSAFAGQEPARLALDALYQRREIQVARFDAKDFAAKVAPTDDELQSYYKAHEAQFRQPEHADVQYVVLDLD
AVRASITLSEDDLRSYYKENLERLAGKEERRASHILINAPKDAPAADREKARARAQALLEQVRKAPGTFAEVARKNSQDT
GSAPSGGDLGFFKRGDMVKPFEDAAFSMKKGDISDLVESEYGYHIIQLNDVKTPRQPTFEEVRAKLETEAKQQQAQRKFA
ELAEVFSNTVYEQADSLQPVADKLKLKVQTASGVARTPLPGAQGPLANGRFLEALFAADSVQNKRNTEAIETAPSTLVAG
RVAAYTPASTPAFDQVKARVRELFVADRSAELARKEGEARLAAWKAAPASATGLGNLVTISRDKPEGQPRPVVDAALQVN
ADTLPAFAGTPLGAQGYAVVKVTRIVPRDPSDPAVARQQHQQYAEAEAQAEAMAYYELLKDRFKVQFKVARPTGDGTPAA
EN

Sequences:

>Translated_642_residues
MFESIRKHSKVVMIVLFLLIIPSFVLVGIDRNYFTSKSAVVARVDGHDITQDDWDNAHRMETDRIRAQSPSVDARLLDSP
RARYATLERLVRDRVMQAAAVKMHLVTSDAQLARTLQGIPAIAALKRPDGSLDAEAYRALVGSQGLTPEGFESNVRRELS
LSQVMGGVLGSAFAGQEPARLALDALYQRREIQVARFDAKDFAAKVAPTDDELQSYYKAHEAQFRQPEHADVQYVVLDLD
AVRASITLSEDDLRSYYKENLERLAGKEERRASHILINAPKDAPAADREKARARAQALLEQVRKAPGTFAEVARKNSQDT
GSAPSGGDLGFFKRGDMVKPFEDAAFSMKKGDISDLVESEYGYHIIQLNDVKTPRQPTFEEVRAKLETEAKQQQAQRKFA
ELAEVFSNTVYEQADSLQPVADKLKLKVQTASGVARTPLPGAQGPLANGRFLEALFAADSVQNKRNTEAIETAPSTLVAG
RVAAYTPASTPAFDQVKARVRELFVADRSAELARKEGEARLAAWKAAPASATGLGNLVTISRDKPEGQPRPVVDAALQVN
ADTLPAFAGTPLGAQGYAVVKVTRIVPRDPSDPAVARQQHQQYAEAEAQAEAMAYYELLKDRFKVQFKVARPTGDGTPAA
EN
>Mature_642_residues
MFESIRKHSKVVMIVLFLLIIPSFVLVGIDRNYFTSKSAVVARVDGHDITQDDWDNAHRMETDRIRAQSPSVDARLLDSP
RARYATLERLVRDRVMQAAAVKMHLVTSDAQLARTLQGIPAIAALKRPDGSLDAEAYRALVGSQGLTPEGFESNVRRELS
LSQVMGGVLGSAFAGQEPARLALDALYQRREIQVARFDAKDFAAKVAPTDDELQSYYKAHEAQFRQPEHADVQYVVLDLD
AVRASITLSEDDLRSYYKENLERLAGKEERRASHILINAPKDAPAADREKARARAQALLEQVRKAPGTFAEVARKNSQDT
GSAPSGGDLGFFKRGDMVKPFEDAAFSMKKGDISDLVESEYGYHIIQLNDVKTPRQPTFEEVRAKLETEAKQQQAQRKFA
ELAEVFSNTVYEQADSLQPVADKLKLKVQTASGVARTPLPGAQGPLANGRFLEALFAADSVQNKRNTEAIETAPSTLVAG
RVAAYTPASTPAFDQVKARVRELFVADRSAELARKEGEARLAAWKAAPASATGLGNLVTISRDKPEGQPRPVVDAALQVN
ADTLPAFAGTPLGAQGYAVVKVTRIVPRDPSDPAVARQQHQQYAEAEAQAEAMAYYELLKDRFKVQFKVARPTGDGTPAA
EN

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein; Periplasmic side (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=557, Percent_Identity=24.5960502692998, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1786238, Length=136, Percent_Identity=34.5588235294118, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 70336; Mature: 70336

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESIRKHSKVVMIVLFLLIIPSFVLVGIDRNYFTSKSAVVARVDGHDITQDDWDNAHRM
CCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEECCCCCCCCCCCCCHHC
ETDRIRAQSPSVDARLLDSPRARYATLERLVRDRVMQAAAVKMHLVTSDAQLARTLQGIP
CHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCC
AIAALKRPDGSLDAEAYRALVGSQGLTPEGFESNVRRELSLSQVMGGVLGSAFAGQEPAR
HHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LALDALYQRREIQVARFDAKDFAAKVAPTDDELQSYYKAHEAQFRQPEHADVQYVVLDLD
HHHHHHHHHHHHEEEEECHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEE
AVRASITLSEDDLRSYYKENLERLAGKEERRASHILINAPKDAPAADREKARARAQALLE
HHHEEEEECHHHHHHHHHHHHHHHHCCHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
QVRKAPGTFAEVARKNSQDTGSAPSGGDLGFFKRGDMVKPFEDAAFSMKKGDISDLVESE
HHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHC
YGYHIIQLNDVKTPRQPTFEEVRAKLETEAKQQQAQRKFAELAEVFSNTVYEQADSLQPV
CCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ADKLKLKVQTASGVARTPLPGAQGPLANGRFLEALFAADSVQNKRNTEAIETAPSTLVAG
HHHHEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHC
RVAAYTPASTPAFDQVKARVRELFVADRSAELARKEGEARLAAWKAAPASATGLGNLVTI
CHHEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHCCCCCCCCCCCCEEEE
SRDKPEGQPRPVVDAALQVNADTLPAFAGTPLGAQGYAVVKVTRIVPRDPSDPAVARQQH
ECCCCCCCCCCHHHHHHEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHH
QQYAEAEAQAEAMAYYELLKDRFKVQFKVARPTGDGTPAAEN
HHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MFESIRKHSKVVMIVLFLLIIPSFVLVGIDRNYFTSKSAVVARVDGHDITQDDWDNAHRM
CCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEECCCCCCCCCCCCCHHC
ETDRIRAQSPSVDARLLDSPRARYATLERLVRDRVMQAAAVKMHLVTSDAQLARTLQGIP
CHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCC
AIAALKRPDGSLDAEAYRALVGSQGLTPEGFESNVRRELSLSQVMGGVLGSAFAGQEPAR
HHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LALDALYQRREIQVARFDAKDFAAKVAPTDDELQSYYKAHEAQFRQPEHADVQYVVLDLD
HHHHHHHHHHHHEEEEECHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEE
AVRASITLSEDDLRSYYKENLERLAGKEERRASHILINAPKDAPAADREKARARAQALLE
HHHEEEEECHHHHHHHHHHHHHHHHCCHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
QVRKAPGTFAEVARKNSQDTGSAPSGGDLGFFKRGDMVKPFEDAAFSMKKGDISDLVESE
HHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHC
YGYHIIQLNDVKTPRQPTFEEVRAKLETEAKQQQAQRKFAELAEVFSNTVYEQADSLQPV
CCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ADKLKLKVQTASGVARTPLPGAQGPLANGRFLEALFAADSVQNKRNTEAIETAPSTLVAG
HHHHEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHC
RVAAYTPASTPAFDQVKARVRELFVADRSAELARKEGEARLAAWKAAPASATGLGNLVTI
CHHEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHCCCCCCCCCCCCEEEE
SRDKPEGQPRPVVDAALQVNADTLPAFAGTPLGAQGYAVVKVTRIVPRDPSDPAVARQQH
ECCCCCCCCCCHHHHHHEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHH
QQYAEAEAQAEAMAYYELLKDRFKVQFKVARPTGDGTPAAEN
HHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA