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The map label for this gene is yngG [H]

Identifier: 120610335

GI number: 120610335

Start: 1811321

End: 1812301

Strand: Direct

Name: yngG [H]

Synonym: Aave_1652

Alternate gene names: 120610335

Gene position: 1811321-1812301 (Clockwise)

Preceding gene: 120610334

Following gene: 120610336

Centisome position: 33.84

GC content: 74.41

Gene sequence:

>981_bases
ATGAACGCCGGCGGCACGGTGTGGCACGGCGCCGGGCGCCGCATCCACATGCAGGAAGTGGGCACGCGCGACGGCCTGCA
GATGGAGCAGGCCTTCGTGCCCACCGAAGACAAGATCGCGCTGGTGGACGCGCTGTCCGCCGCGGGCCTGGCCAAGATCG
AGGTGACGGCCTTCGTGTCGCCCGCGGCGATCCCGGCGCTGCGCGACGCGGAGATCGTGATGCGCGAGATCGCGCGCCGC
CCCGGCGTCGTCTATGCCGCGCTGGTGCCGAACGTGCGCGGCGCGGAGCGCGCGATCGAGGCGCGCACCGACGAGCTGAA
CCTGGTGATGTCCGCCAGCGAGACGCACAACCTCGCCAACCTGCGCATGACGCGCGCGCAGTCCTTCGCGGCCCTCGCGC
AGGTGGTGGCCACGGCGCAGGGCGCGGGCGTGGCGGTGAACGTGTCGCTCTCGTGCGTGTTCGGCTGCCCGATGGAGGGC
GACGTCGCCGGGGCGGAGGTGTTCGGATGGGTGCAGCGCTTCGCCGACCTGGGCGTGGGCGGCATCACGCTGTGCGACAC
CACCGGCATGGCGTACCCCGCGCAGGTGGCGGCGCTGGTGGCCGCGGCGCGCGCCCGCTGGCCGGCAATGGCCTTCACGC
TGCACTTCCACAACACGCGCGGCATGGGCCTGGCCAACGTGCTGGCGGCGATCGACGCGGGCGCGGACCGGTTCGACGCC
TCGCTGGGCGGGCTGGGCGGCTGCCCGTACGCGCCGGGTGCCTCGGGCAACGTCTGCAGCGAGGAGGTCGTCCATGCGCT
GGAGCTCATGGGCTACGACACGGGCGTGGACCTGCCGGCGCTGCTCGCGGCCGCGCGGCGGCTGCCCGCGCTCATCGGGC
ACGACATCCCGGGCCAGATCGCCAAGGCGGGCGCGCGCCTGGACCTGCACCCGGTGCCTGCGGACTTCGCGGCCATCCGC
GAGCGGGCGCTCGCGCGCTGA

Upstream 100 bases:

>100_bases
CCAGCGCCCCGCAGCTGGGTGACGACACGGACGCGGTGCTGCGCGAGGCCGGCCTGAGCGATGCCCAGATCGCGCTGCTG
CGCGAAAAGGGGGTGGTGCA

Downstream 100 bases:

>100_bases
CGCCGGCGGCGCGGCCCGGGCAGAACCACGACCACCACGATAACCACGACAGGAGACACACCATGCACACGCCGACCATC
CCCGGAGCCGGCCTGCCGCG

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MNAGGTVWHGAGRRIHMQEVGTRDGLQMEQAFVPTEDKIALVDALSAAGLAKIEVTAFVSPAAIPALRDAEIVMREIARR
PGVVYAALVPNVRGAERAIEARTDELNLVMSASETHNLANLRMTRAQSFAALAQVVATAQGAGVAVNVSLSCVFGCPMEG
DVAGAEVFGWVQRFADLGVGGITLCDTTGMAYPAQVAALVAAARARWPAMAFTLHFHNTRGMGLANVLAAIDAGADRFDA
SLGGLGGCPYAPGASGNVCSEEVVHALELMGYDTGVDLPALLAAARRLPALIGHDIPGQIAKAGARLDLHPVPADFAAIR
ERALAR

Sequences:

>Translated_326_residues
MNAGGTVWHGAGRRIHMQEVGTRDGLQMEQAFVPTEDKIALVDALSAAGLAKIEVTAFVSPAAIPALRDAEIVMREIARR
PGVVYAALVPNVRGAERAIEARTDELNLVMSASETHNLANLRMTRAQSFAALAQVVATAQGAGVAVNVSLSCVFGCPMEG
DVAGAEVFGWVQRFADLGVGGITLCDTTGMAYPAQVAALVAAARARWPAMAFTLHFHNTRGMGLANVLAAIDAGADRFDA
SLGGLGGCPYAPGASGNVCSEEVVHALELMGYDTGVDLPALLAAARRLPALIGHDIPGQIAKAGARLDLHPVPADFAAIR
ERALAR
>Mature_326_residues
MNAGGTVWHGAGRRIHMQEVGTRDGLQMEQAFVPTEDKIALVDALSAAGLAKIEVTAFVSPAAIPALRDAEIVMREIARR
PGVVYAALVPNVRGAERAIEARTDELNLVMSASETHNLANLRMTRAQSFAALAQVVATAQGAGVAVNVSLSCVFGCPMEG
DVAGAEVFGWVQRFADLGVGGITLCDTTGMAYPAQVAALVAAARARWPAMAFTLHFHNTRGMGLANVLAAIDAGADRFDA
SLGGLGGCPYAPGASGNVCSEEVVHALELMGYDTGVDLPALLAAARRLPALIGHDIPGQIAKAGARLDLHPVPADFAAIR
ERALAR

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=295, Percent_Identity=38.3050847457627, Blast_Score=215, Evalue=4e-56,
Organism=Homo sapiens, GI109150422, Length=289, Percent_Identity=35.2941176470588, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI109150427, Length=289, Percent_Identity=35.2941176470588, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI260654708, Length=136, Percent_Identity=37.5, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17510563, Length=289, Percent_Identity=35.6401384083045, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24582381, Length=303, Percent_Identity=36.963696369637, Blast_Score=198, Evalue=4e-51,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 33836; Mature: 33836

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAGGTVWHGAGRRIHMQEVGTRDGLQMEQAFVPTEDKIALVDALSAAGLAKIEVTAFVS
CCCCCCEEECCCCEEEHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHCCCEEEEEEEEEC
PAAIPALRDAEIVMREIARRPGVVYAALVPNVRGAERAIEARTDELNLVMSASETHNLAN
CHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCHHH
LRMTRAQSFAALAQVVATAQGAGVAVNVSLSCVFGCPMEGDVAGAEVFGWVQRFADLGVG
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCC
GITLCDTTGMAYPAQVAALVAAARARWPAMAFTLHFHNTRGMGLANVLAAIDAGADRFDA
CEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHCCCHHHHH
SLGGLGGCPYAPGASGNVCSEEVVHALELMGYDTGVDLPALLAAARRLPALIGHDIPGQI
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
AKAGARLDLHPVPADFAAIRERALAR
HHCCCCEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNAGGTVWHGAGRRIHMQEVGTRDGLQMEQAFVPTEDKIALVDALSAAGLAKIEVTAFVS
CCCCCCEEECCCCEEEHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHCCCEEEEEEEEEC
PAAIPALRDAEIVMREIARRPGVVYAALVPNVRGAERAIEARTDELNLVMSASETHNLAN
CHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCHHH
LRMTRAQSFAALAQVVATAQGAGVAVNVSLSCVFGCPMEGDVAGAEVFGWVQRFADLGVG
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCC
GITLCDTTGMAYPAQVAALVAAARARWPAMAFTLHFHNTRGMGLANVLAAIDAGADRFDA
CEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHCCCHHHHH
SLGGLGGCPYAPGASGNVCSEEVVHALELMGYDTGVDLPALLAAARRLPALIGHDIPGQI
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
AKAGARLDLHPVPADFAAIRERALAR
HHCCCCEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]