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The map label for this gene is relA [H]

Identifier: 120610273

GI number: 120610273

Start: 1753706

End: 1755967

Strand: Direct

Name: relA [H]

Synonym: Aave_1588

Alternate gene names: 120610273

Gene position: 1753706-1755967 (Clockwise)

Preceding gene: 120610272

Following gene: 120610274

Centisome position: 32.76

GC content: 69.67

Gene sequence:

>2262_bases
ATGAGAAGCATCGCCGCGCCCCAGCCACCGCACGCCGCCGCCGGCCAGGAGGCCGTGCCCCAGCTCATCGCAGCCACCTC
CCTCGCGTTGCCCGAGCAGGCCGGCGCCCTGGCGCGCGCCCGGGCGTTCGCCGAACCGCTGCTCTCCGGCGAGACGCTGG
AGACCGGCGAGAACACCTTCGCCCATGCCGAGGCCGTCGCCGCCATCCTGAAGACCATCGGCGGCTCGGAGGCCATGCAG
GCCGCCAGCTACCTCGTGCATGCCTGCTCGCACCTGAACAAGCCCGAAGAGGTCATCGCCAAGGCCTTCGGCCAGAACTT
CGCCACGCTCGCCGTCGAAACCACCAAGCTCATGCGCGTGCAGCACCATGCGCGCGAGGCACAGCTCGCCGGCCATGCGG
TGGACGACCCGGCCACCCACACCGAGAACGTGCGCAAGATGCTGCTGGCCTTCTCGCGCGACCTGCGCGTGGTCATGCTG
CGCCTGGCGTCGCGCCTGCAGACGCTGCGCTTCTACGCGGCCAGCAAGCGGCCCGTCTCGCCCTCCATCGCCCGCGAGGC
GCTGCAGGTGTTCGCGCCGCTCGCCAACCGCCTCGGCATCTGGCAGATGAAGTGGGAGCTGGAAGACCTGTCCTTCCGCT
TCCTGGAGCCCGACACCTACAAGCAGATCGCCCGCCTGCTCGACGAGAAGCGCGCCGAGCGCGAGGTGTACATGGAGCAG
CTGCGCGGCCGGCTCGAATCCGAACTGCGCGCGCGCAGCATCAGCGCCACCGTGCAGGGGCGGCCCAAGCACATCTACAG
CATCGTCAAGAAGATGCGCGGCAAGTCGCTCGACTTCGACCAGGTGTTCGACATCCGCGCGCTGCGTGTGGTCGTTCCCA
CGGTGAAGGACTGCTATGCCGCGCTGTCATGGGTGCATTCGCACTTCAAGCCCATCGACGCCGAGTTCGACGACTACATC
GCCAAACCCAAGCCCAACGGCTACCAGTCGCTGCACACCGTGGTGCGCGACGAGGCGGGCAAGGCCATCGAGATCCAGAT
CCGCACCCAGGCCATGCACGACCATGCCGAGCACGGCGTGGCGGCGCACTGGGCGTACAAGGAAGCCGGCGCCAAGGGCT
ATGCGGGAGTTTCTGCCAGCAGCGAGTACGACGCCAAGATCGCCGTGCTGCGGCAGCTGCTGGCCTGGGAGCGCGACATG
GCCGGCGCGGTGCAGCACCGCGGCCTGTTCGAGGACCGCATCTACGTGCTGACGCCCAATGCCGAGGTGGTGGAACTGCC
CCAGGGCGCCACCCCGGTGGACTTCGCCTACGCCGTGCACACCAGCGTGGGGCACCGCTGCCGGGGTGCGCGCGTGGACG
GCGCCATGGTTCCGCTCAACACGCCGCTGCACAACGGCCAGACGGTGGAGATCACCACGGTGAAGGAGGGCCGGCCCTCG
CGCGACTGGCTCAATCCCGAACTGGGCTATCTCACCAGCCACCGCGCCCGCGCCAAGGTGCGCGCCTGGTTCAACGCCCA
GGCCACGCACGAGACCGTGGCGCGCGGCCGCGAGGCCGTCGAAAAGCTGCTGCAGCGCGAAGGCAAGACCGCCATCCGGC
TGGAAGACCTGGCCGTGCAACTGGGCTTCAAGACCGCCGATGCGCTCTTCGAAGTGGTGGGCAAGGACGAATTCTCCCTG
CGCACCATCGAGACCCTGCTGCGCCCGCCCGAGCCCGTGCTGCAGCCCGACGACTACCTGCTGCTCAAGAAGGCGCGCAC
GAACGAGAGCGCTCCCAAGGGCGGCGTGCTGGTGGTGGGCATCGACTCCCTCATGACCCAGCTGGCCAAGTGCTGCCGCC
CCGCGCCGCCGGACCCGATCCGCGGCTTCGTCACGCGCGGCAAGGGCGTGAGCGTGCACCGCGCGGACTGCAGCAACTTC
CGCGAGATGGCCGCCCGCAGCGCCGAGCGCGTGATCGACGTCGAATGGGGCAGCGCGGGTGGATCCGGTGGCGGAGCGCA
GGGAGGCGGGCAGGGCGGCCACCCAGCCCTCCTCTACCCCGTGGACGTGGCCGTCGAGGCCGCCGACCGCCAGGGCCTGC
TGCGCGACATCTCCGAAGTCTTCGCGCGCGAGAAGACCAACGTCATCGGCGTGCAGACGCAGTCGGTGAAGGGCACGGCG
TGGATGACGTTCACCGTGGAGGTGTCGGACTCCGGACGCCTGAACAAGGTGCTGTCGATCGTCGCCGCGGTGCAGGGCGT
GCGCTCCGCGCGGCGGCGCTGA

Upstream 100 bases:

>100_bases
GCCATGCCCCCACCCTGGTGGCCGCGGAGCAGGTCGATGTGGTGGAACAGTTCCTGTTCGGCGCCGGGCAGGGTGGCCCA
GGAGCGGTGGAGGCGCGCCC

Downstream 100 bases:

>100_bases
GGTGAGGTGTTTGGAGCGAGATTTCGCGACTTTGTCCGGCGACCGGTTTTTTGCTGCTATACTCTCGCTTCTCGAATACA
CACAGGCGCGTAGCTCAGCT

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 753; Mature: 753

Protein sequence:

>753_residues
MRSIAAPQPPHAAAGQEAVPQLIAATSLALPEQAGALARARAFAEPLLSGETLETGENTFAHAEAVAAILKTIGGSEAMQ
AASYLVHACSHLNKPEEVIAKAFGQNFATLAVETTKLMRVQHHAREAQLAGHAVDDPATHTENVRKMLLAFSRDLRVVML
RLASRLQTLRFYAASKRPVSPSIAREALQVFAPLANRLGIWQMKWELEDLSFRFLEPDTYKQIARLLDEKRAEREVYMEQ
LRGRLESELRARSISATVQGRPKHIYSIVKKMRGKSLDFDQVFDIRALRVVVPTVKDCYAALSWVHSHFKPIDAEFDDYI
AKPKPNGYQSLHTVVRDEAGKAIEIQIRTQAMHDHAEHGVAAHWAYKEAGAKGYAGVSASSEYDAKIAVLRQLLAWERDM
AGAVQHRGLFEDRIYVLTPNAEVVELPQGATPVDFAYAVHTSVGHRCRGARVDGAMVPLNTPLHNGQTVEITTVKEGRPS
RDWLNPELGYLTSHRARAKVRAWFNAQATHETVARGREAVEKLLQREGKTAIRLEDLAVQLGFKTADALFEVVGKDEFSL
RTIETLLRPPEPVLQPDDYLLLKKARTNESAPKGGVLVVGIDSLMTQLAKCCRPAPPDPIRGFVTRGKGVSVHRADCSNF
REMAARSAERVIDVEWGSAGGSGGGAQGGGQGGHPALLYPVDVAVEAADRQGLLRDISEVFAREKTNVIGVQTQSVKGTA
WMTFTVEVSDSGRLNKVLSIVAAVQGVRSARRR

Sequences:

>Translated_753_residues
MRSIAAPQPPHAAAGQEAVPQLIAATSLALPEQAGALARARAFAEPLLSGETLETGENTFAHAEAVAAILKTIGGSEAMQ
AASYLVHACSHLNKPEEVIAKAFGQNFATLAVETTKLMRVQHHAREAQLAGHAVDDPATHTENVRKMLLAFSRDLRVVML
RLASRLQTLRFYAASKRPVSPSIAREALQVFAPLANRLGIWQMKWELEDLSFRFLEPDTYKQIARLLDEKRAEREVYMEQ
LRGRLESELRARSISATVQGRPKHIYSIVKKMRGKSLDFDQVFDIRALRVVVPTVKDCYAALSWVHSHFKPIDAEFDDYI
AKPKPNGYQSLHTVVRDEAGKAIEIQIRTQAMHDHAEHGVAAHWAYKEAGAKGYAGVSASSEYDAKIAVLRQLLAWERDM
AGAVQHRGLFEDRIYVLTPNAEVVELPQGATPVDFAYAVHTSVGHRCRGARVDGAMVPLNTPLHNGQTVEITTVKEGRPS
RDWLNPELGYLTSHRARAKVRAWFNAQATHETVARGREAVEKLLQREGKTAIRLEDLAVQLGFKTADALFEVVGKDEFSL
RTIETLLRPPEPVLQPDDYLLLKKARTNESAPKGGVLVVGIDSLMTQLAKCCRPAPPDPIRGFVTRGKGVSVHRADCSNF
REMAARSAERVIDVEWGSAGGSGGGAQGGGQGGHPALLYPVDVAVEAADRQGLLRDISEVFAREKTNVIGVQTQSVKGTA
WMTFTVEVSDSGRLNKVLSIVAAVQGVRSARRR
>Mature_753_residues
MRSIAAPQPPHAAAGQEAVPQLIAATSLALPEQAGALARARAFAEPLLSGETLETGENTFAHAEAVAAILKTIGGSEAMQ
AASYLVHACSHLNKPEEVIAKAFGQNFATLAVETTKLMRVQHHAREAQLAGHAVDDPATHTENVRKMLLAFSRDLRVVML
RLASRLQTLRFYAASKRPVSPSIAREALQVFAPLANRLGIWQMKWELEDLSFRFLEPDTYKQIARLLDEKRAEREVYMEQ
LRGRLESELRARSISATVQGRPKHIYSIVKKMRGKSLDFDQVFDIRALRVVVPTVKDCYAALSWVHSHFKPIDAEFDDYI
AKPKPNGYQSLHTVVRDEAGKAIEIQIRTQAMHDHAEHGVAAHWAYKEAGAKGYAGVSASSEYDAKIAVLRQLLAWERDM
AGAVQHRGLFEDRIYVLTPNAEVVELPQGATPVDFAYAVHTSVGHRCRGARVDGAMVPLNTPLHNGQTVEITTVKEGRPS
RDWLNPELGYLTSHRARAKVRAWFNAQATHETVARGREAVEKLLQREGKTAIRLEDLAVQLGFKTADALFEVVGKDEFSL
RTIETLLRPPEPVLQPDDYLLLKKARTNESAPKGGVLVVGIDSLMTQLAKCCRPAPPDPIRGFVTRGKGVSVHRADCSNF
REMAARSAERVIDVEWGSAGGSGGGAQGGGQGGHPALLYPVDVAVEAADRQGLLRDISEVFAREKTNVIGVQTQSVKGTA
WMTFTVEVSDSGRLNKVLSIVAAVQGVRSARRR

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=639, Percent_Identity=43.0359937402191, Blast_Score=522, Evalue=1e-149,
Organism=Escherichia coli, GI1790082, Length=726, Percent_Identity=33.3333333333333, Blast_Score=356, Evalue=3e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 82608; Mature: 82608

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSIAAPQPPHAAAGQEAVPQLIAATSLALPEQAGALARARAFAEPLLSGETLETGENTF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AHAEAVAAILKTIGGSEAMQAASYLVHACSHLNKPEEVIAKAFGQNFATLAVETTKLMRV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHH
QHHAREAQLAGHAVDDPATHTENVRKMLLAFSRDLRVVMLRLASRLQTLRFYAASKRPVS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PSIAREALQVFAPLANRLGIWQMKWELEDLSFRFLEPDTYKQIARLLDEKRAEREVYMEQ
HHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
LRGRLESELRARSISATVQGRPKHIYSIVKKMRGKSLDFDQVFDIRALRVVVPTVKDCYA
HHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHH
ALSWVHSHFKPIDAEFDDYIAKPKPNGYQSLHTVVRDEAGKAIEIQIRTQAMHDHAEHGV
HHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHCCC
AAHWAYKEAGAKGYAGVSASSEYDAKIAVLRQLLAWERDMAGAVQHRGLFEDRIYVLTPN
CCEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
AEVVELPQGATPVDFAYAVHTSVGHRCRGARVDGAMVPLNTPLHNGQTVEITTVKEGRPS
CCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCC
RDWLNPELGYLTSHRARAKVRAWFNAQATHETVARGREAVEKLLQREGKTAIRLEDLAVQ
CCCCCCCHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHH
LGFKTADALFEVVGKDEFSLRTIETLLRPPEPVLQPDDYLLLKKARTNESAPKGGVLVVG
HCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEE
IDSLMTQLAKCCRPAPPDPIRGFVTRGKGVSVHRADCSNFREMAARSAERVIDVEWGSAG
HHHHHHHHHHHCCCCCCCCHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHEEEEEECCCC
GSGGGAQGGGQGGHPALLYPVDVAVEAADRQGLLRDISEVFAREKTNVIGVQTQSVKGTA
CCCCCCCCCCCCCCCEEEEEHHHEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
WMTFTVEVSDSGRLNKVLSIVAAVQGVRSARRR
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRSIAAPQPPHAAAGQEAVPQLIAATSLALPEQAGALARARAFAEPLLSGETLETGENTF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AHAEAVAAILKTIGGSEAMQAASYLVHACSHLNKPEEVIAKAFGQNFATLAVETTKLMRV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHH
QHHAREAQLAGHAVDDPATHTENVRKMLLAFSRDLRVVMLRLASRLQTLRFYAASKRPVS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PSIAREALQVFAPLANRLGIWQMKWELEDLSFRFLEPDTYKQIARLLDEKRAEREVYMEQ
HHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
LRGRLESELRARSISATVQGRPKHIYSIVKKMRGKSLDFDQVFDIRALRVVVPTVKDCYA
HHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHH
ALSWVHSHFKPIDAEFDDYIAKPKPNGYQSLHTVVRDEAGKAIEIQIRTQAMHDHAEHGV
HHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHCCC
AAHWAYKEAGAKGYAGVSASSEYDAKIAVLRQLLAWERDMAGAVQHRGLFEDRIYVLTPN
CCEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
AEVVELPQGATPVDFAYAVHTSVGHRCRGARVDGAMVPLNTPLHNGQTVEITTVKEGRPS
CCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCC
RDWLNPELGYLTSHRARAKVRAWFNAQATHETVARGREAVEKLLQREGKTAIRLEDLAVQ
CCCCCCCHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHH
LGFKTADALFEVVGKDEFSLRTIETLLRPPEPVLQPDDYLLLKKARTNESAPKGGVLVVG
HCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEE
IDSLMTQLAKCCRPAPPDPIRGFVTRGKGVSVHRADCSNFREMAARSAERVIDVEWGSAG
HHHHHHHHHHHCCCCCCCCHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHEEEEEECCCC
GSGGGAQGGGQGGHPALLYPVDVAVEAADRQGLLRDISEVFAREKTNVIGVQTQSVKGTA
CCCCCCCCCCCCCCCEEEEEHHHEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
WMTFTVEVSDSGRLNKVLSIVAAVQGVRSARRR
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928955 [H]