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The map label for this gene is lysN [H]

Identifier: 120610248

GI number: 120610248

Start: 1729326

End: 1730522

Strand: Direct

Name: lysN [H]

Synonym: Aave_1563

Alternate gene names: 120610248

Gene position: 1729326-1730522 (Clockwise)

Preceding gene: 120610246

Following gene: 120610249

Centisome position: 32.31

GC content: 70.68

Gene sequence:

>1197_bases
ATGCAATTCGCAGACCGCCTGAACAACGTCGAAACCTCCGCCATCCGGGAGCTGTTCAAGCTGCTGGGCAAGCCCGGCAT
CATCAGCTTCGCCGGCGGCTTTCCCGACAGCGCGATGTTCGACGTCGAGGGCATCCGCGAGGCGAGCGGGCGGGCGCTCG
CCGAGGAGCCCGGCACGGCGCTGCAGTACGGTGCCACCGAGGGCTACAACCCGCTGCGCGAACAGCTCTCGGCCTTCATG
GCCTCCAAGGGCGCGCAGGGCGTGCGGCCCGAGGACCTGATCGTCACCACCGGCAGCCAGCAGGCGCTGGACCTGCTGGG
CAAGACCCTCATCAGCCCCGGCGACAAGGTGATCGTGGAAGGGCCCACCTTCCTCGCCACCATCCAGTGCTTCCGCCTCT
ACGGCGCCGAACTGGTAAGCGCACCCGTGGACGGCCATGGTGTGGATGCCGACGCGCTCGAGCGGCTCATCGTGGAGCAC
CGGCCCAAGTTCGTCTATCTCATTCCCACGTTCGGCAACCCCAGCGGCGCGCTGCTGTCGCTGGAGCGCCGCCGCCGGAT
CCTGGAACTGGCGGTGCGCCACCAGGTGCTGGTCGTCGAGGACGATCCCTACGGCGACCTGTATTTCGGCGAGGCGCCGC
CGCCCAGCCTGCTGGCGCTGTCGGCCACGGTGCCCGGCAGCCGCGAACTGCTGGCCCACTGCGGCAGCCTCAGCAAGGTG
CTGAGCCCGGGCCTGCGCGTGGGCTGGCTGATCGCGCCCGCCGAGCTGCTGGCCAAGGCCACCATGTGCAAGCAGTTCAG
CGACGCGCACACCAGCACTTTCGCGCAGGCCACGGCCGCGCAGTACCTGCGTTCGGGCCGCATGCCGGCCACGCTGGCCA
AGGTACGCGCCGTGTATGCCGAGCGCGCGCAGGCCATGGGCGACACGCTGCGCCGCGAGCTGGGCGAGGCGATCGACTTC
GTGCAGCCCCAGGGCGGCCTGTTCGTGTGGGCGCGGCTCACGGGGGCGGGCGGCGCGGTGGCCGACGGCAACGTGCTGGC
CAAGCTGGCCATCGACAAAGGCGTGGCCTTCGTGCCGGGAACGCCGTTCTTCTGCGCGAACCCCGACCATGCCACGCTGC
GCCTGTCGTTCGCGACGGCCGACGTGGACAGGATCCGCGAAGGCGTGGCGCGCCTCGGCCAGGCGCTGCGAGGCTGA

Upstream 100 bases:

>100_bases
GCGGTTCGCCCGTGCATTGTCCCGCAGCGCACCGTACGCATGAAACATGCGCGGCCATTGGCGACAATGGGGTCTTTCGC
CAACACACCGTGAACACGCC

Downstream 100 bases:

>100_bases
GCCATGCCGGACACCGACCGCACCCCGTCCGAGCGCCTGGACGAGCTGGAGATCAAGGCCAGCTACGCCGAAGACCTGCT
GGACCAGCTCAACGTCACCG

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MQFADRLNNVETSAIRELFKLLGKPGIISFAGGFPDSAMFDVEGIREASGRALAEEPGTALQYGATEGYNPLREQLSAFM
ASKGAQGVRPEDLIVTTGSQQALDLLGKTLISPGDKVIVEGPTFLATIQCFRLYGAELVSAPVDGHGVDADALERLIVEH
RPKFVYLIPTFGNPSGALLSLERRRRILELAVRHQVLVVEDDPYGDLYFGEAPPPSLLALSATVPGSRELLAHCGSLSKV
LSPGLRVGWLIAPAELLAKATMCKQFSDAHTSTFAQATAAQYLRSGRMPATLAKVRAVYAERAQAMGDTLRRELGEAIDF
VQPQGGLFVWARLTGAGGAVADGNVLAKLAIDKGVAFVPGTPFFCANPDHATLRLSFATADVDRIREGVARLGQALRG

Sequences:

>Translated_398_residues
MQFADRLNNVETSAIRELFKLLGKPGIISFAGGFPDSAMFDVEGIREASGRALAEEPGTALQYGATEGYNPLREQLSAFM
ASKGAQGVRPEDLIVTTGSQQALDLLGKTLISPGDKVIVEGPTFLATIQCFRLYGAELVSAPVDGHGVDADALERLIVEH
RPKFVYLIPTFGNPSGALLSLERRRRILELAVRHQVLVVEDDPYGDLYFGEAPPPSLLALSATVPGSRELLAHCGSLSKV
LSPGLRVGWLIAPAELLAKATMCKQFSDAHTSTFAQATAAQYLRSGRMPATLAKVRAVYAERAQAMGDTLRRELGEAIDF
VQPQGGLFVWARLTGAGGAVADGNVLAKLAIDKGVAFVPGTPFFCANPDHATLRLSFATADVDRIREGVARLGQALRG
>Mature_398_residues
MQFADRLNNVETSAIRELFKLLGKPGIISFAGGFPDSAMFDVEGIREASGRALAEEPGTALQYGATEGYNPLREQLSAFM
ASKGAQGVRPEDLIVTTGSQQALDLLGKTLISPGDKVIVEGPTFLATIQCFRLYGAELVSAPVDGHGVDADALERLIVEH
RPKFVYLIPTFGNPSGALLSLERRRRILELAVRHQVLVVEDDPYGDLYFGEAPPPSLLALSATVPGSRELLAHCGSLSKV
LSPGLRVGWLIAPAELLAKATMCKQFSDAHTSTFAQATAAQYLRSGRMPATLAKVRAVYAERAQAMGDTLRRELGEAIDF
VQPQGGLFVWARLTGAGGAVADGNVLAKLAIDKGVAFVPGTPFFCANPDHATLRLSFATADVDRIREGVARLGQALRG

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=414, Percent_Identity=28.5024154589372, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI33469970, Length=414, Percent_Identity=28.5024154589372, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI4507369, Length=202, Percent_Identity=30.6930693069307, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1787710, Length=377, Percent_Identity=28.6472148541114, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1790797, Length=373, Percent_Identity=28.4182305630027, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788722, Length=380, Percent_Identity=29.2105263157895, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786816, Length=383, Percent_Identity=25.3263707571802, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788627, Length=398, Percent_Identity=21.608040201005, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17567369, Length=270, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321000, Length=432, Percent_Identity=26.3888888888889, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6321236, Length=484, Percent_Identity=21.6942148760331, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321929, Length=463, Percent_Identity=22.0302375809935, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6322401, Length=366, Percent_Identity=24.5901639344262, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356535, Length=402, Percent_Identity=28.1094527363184, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 42456; Mature: 42456

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFADRLNNVETSAIRELFKLLGKPGIISFAGGFPDSAMFDVEGIREASGRALAEEPGTA
CCHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCEECHHHHHHHCCCCCCCCCCCE
LQYGATEGYNPLREQLSAFMASKGAQGVRPEDLIVTTGSQQALDLLGKTLISPGDKVIVE
EECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEE
GPTFLATIQCFRLYGAELVSAPVDGHGVDADALERLIVEHRPKFVYLIPTFGNPSGALLS
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEE
LERRRRILELAVRHQVLVVEDDPYGDLYFGEAPPPSLLALSATVPGSRELLAHCGSLSKV
HHHHHHHHHHHHHCEEEEEECCCCCCEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHH
LSPGLRVGWLIAPAELLAKATMCKQFSDAHTSTFAQATAAQYLRSGRMPATLAKVRAVYA
HCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ERAQAMGDTLRRELGEAIDFVQPQGGLFVWARLTGAGGAVADGNVLAKLAIDKGVAFVPG
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEECCCEEEEEECCCCEEECCC
TPFFCANPDHATLRLSFATADVDRIREGVARLGQALRG
CCEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQFADRLNNVETSAIRELFKLLGKPGIISFAGGFPDSAMFDVEGIREASGRALAEEPGTA
CCHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCEECHHHHHHHCCCCCCCCCCCE
LQYGATEGYNPLREQLSAFMASKGAQGVRPEDLIVTTGSQQALDLLGKTLISPGDKVIVE
EECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEE
GPTFLATIQCFRLYGAELVSAPVDGHGVDADALERLIVEHRPKFVYLIPTFGNPSGALLS
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEE
LERRRRILELAVRHQVLVVEDDPYGDLYFGEAPPPSLLALSATVPGSRELLAHCGSLSKV
HHHHHHHHHHHHHCEEEEEECCCCCCEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHH
LSPGLRVGWLIAPAELLAKATMCKQFSDAHTSTFAQATAAQYLRSGRMPATLAKVRAVYA
HCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ERAQAMGDTLRRELGEAIDFVQPQGGLFVWARLTGAGGAVADGNVLAKLAIDKGVAFVPG
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEECCCEEEEEECCCCEEECCC
TPFFCANPDHATLRLSFATADVDRIREGVARLGQALRG
CCEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA