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The map label for this gene is nrdB [H]

Identifier: 120609557

GI number: 120609557

Start: 934186

End: 935349

Strand: Reverse

Name: nrdB [H]

Synonym: Aave_0863

Alternate gene names: 120609557

Gene position: 935349-934186 (Counterclockwise)

Preceding gene: 120609558

Following gene: 120609556

Centisome position: 17.47

GC content: 63.14

Gene sequence:

>1164_bases
ATGCTGAACTGGGACGAAGAAGTCAAGCCCTCATCGCAGAAACCTCTGGACGGCGGTCTGCAAGGCCACCGTCAGGACGT
GCTGCCCTCCGCGTCTTTCCAGAGCCCCGCGCCGCAGTCCGCAGCCGCCTCCGCGCCGGCCCAGCACCGCCGCGTGAATG
CCGCCGACAAGCGCATCATCAACGGCCAGACCGACGTCAACCAGCTCGTCCCCTTCAAGTACAAGTGGGCCTGGGAAAAG
TACCTGGCCACCTGCGCCAACCACTGGATGCCGCAGGAAGTGAACATGACCCGCGACATCGCGCTGTGGAAGGACCCGAA
CGGCCTGACCGAGGACGAGCGCCGCATCGTCAAGCGCAACCTCGGCTTCTTCGTGACCGCCGACTCGCTGGCCGCCAACA
ACATCGTGCTGGGCACGTACCGCCACATCACCGCGCCCGAGTGCCGCCAGTTCCTGCTGCGCCAGGCCTTCGAGGAAGCG
ATCCACACGCACGCCTACCAGTACATCGTCGAGTCGCTCGGCCTCGACGAGAGCGAGATCTTCAACGCCTACAACGAGGT
CGATTCGATCCGCCACAAGGACGAGTTCCTGATCCCCTTCATCGAGGCGATCATGGACCCGGACTTCAAGACCGGCACGC
CCGAGACCGACCAGACCCTGCTGAAGTCGCTCATCGTGTTCGCCTGCCTGATGGAAGGCCTGTTCTTCTACGTCGGCTTC
ACGCAGATCCTCGCGCTGGGCCGCCAGAACAAGATGACCGGCGCCGCCGAGCAGTACCAGTACATCCTGCGCGACGAGTC
GATGCACTGCAACTTCGGCATCGACCTGATCAACCAGCTCAAGCTCGAGAACCCGCACCTCTGGACCGCGGAGTTCAAGG
AAGAGATCAAGGGCCTGTTCATGAAGGCCGTCGAGCTGGAGTACCAGTACGCGGAGGACACCATGCCCCGCGGCGTGCTG
GGCATGAACGCTTCCATGTTCAAGGGCTACCTGCGCTACATCGCCAACCGGCGCGCCACGCAGATCGGCCTGGAGGCGCT
CTTCCCCAACGAAGAGAACCCCTTCCCCTGGATGAGCGAGATGATCGACCTGAAGAAGGAGCGCAACTTCTTCGAGACGC
GCGTCATCGAGTACCAGTCCGGCGGCGCACTGTCCTGGGATTAG

Upstream 100 bases:

>100_bases
TCCGCGCTTGTGCTCTGAAGCAACAAAAACATCGCTGCGCCACGCTGCGGCGCTTTTATTTTTGCAGCGCTGCTTTCATA
ATCCGACCATTGGAAGACCT

Downstream 100 bases:

>100_bases
TCGATCCCGTCATTCCAGGCCATGTATTTTCATTCCACGCCCCGCACCGGCAGCCCGCAAGGGCTCTGCCGTGCGGGGCG
TTCCCGCGTTCATGGCGGTG

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MLNWDEEVKPSSQKPLDGGLQGHRQDVLPSASFQSPAPQSAAASAPAQHRRVNAADKRIINGQTDVNQLVPFKYKWAWEK
YLATCANHWMPQEVNMTRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEA
IHTHAYQYIVESLGLDESEIFNAYNEVDSIRHKDEFLIPFIEAIMDPDFKTGTPETDQTLLKSLIVFACLMEGLFFYVGF
TQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQLKLENPHLWTAEFKEEIKGLFMKAVELEYQYAEDTMPRGVL
GMNASMFKGYLRYIANRRATQIGLEALFPNEENPFPWMSEMIDLKKERNFFETRVIEYQSGGALSWD

Sequences:

>Translated_387_residues
MLNWDEEVKPSSQKPLDGGLQGHRQDVLPSASFQSPAPQSAAASAPAQHRRVNAADKRIINGQTDVNQLVPFKYKWAWEK
YLATCANHWMPQEVNMTRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEA
IHTHAYQYIVESLGLDESEIFNAYNEVDSIRHKDEFLIPFIEAIMDPDFKTGTPETDQTLLKSLIVFACLMEGLFFYVGF
TQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQLKLENPHLWTAEFKEEIKGLFMKAVELEYQYAEDTMPRGVL
GMNASMFKGYLRYIANRRATQIGLEALFPNEENPFPWMSEMIDLKKERNFFETRVIEYQSGGALSWD
>Mature_387_residues
MLNWDEEVKPSSQKPLDGGLQGHRQDVLPSASFQSPAPQSAAASAPAQHRRVNAADKRIINGQTDVNQLVPFKYKWAWEK
YLATCANHWMPQEVNMTRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEA
IHTHAYQYIVESLGLDESEIFNAYNEVDSIRHKDEFLIPFIEAIMDPDFKTGTPETDQTLLKSLIVFACLMEGLFFYVGF
TQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQLKLENPHLWTAEFKEEIKGLFMKAVELEYQYAEDTMPRGVL
GMNASMFKGYLRYIANRRATQIGLEALFPNEENPFPWMSEMIDLKKERNFFETRVIEYQSGGALSWD

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI289177074, Length=375, Percent_Identity=25.8666666666667, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI260064013, Length=356, Percent_Identity=26.9662921348315, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI4557845, Length=374, Percent_Identity=27.2727272727273, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI42544136, Length=350, Percent_Identity=25.7142857142857, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI289177076, Length=296, Percent_Identity=27.7027027027027, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1788567, Length=292, Percent_Identity=26.7123287671233, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17551968, Length=351, Percent_Identity=26.7806267806268, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI193206379, Length=304, Percent_Identity=22.3684210526316, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322434, Length=331, Percent_Identity=30.2114803625378, Blast_Score=149, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6321619, Length=320, Percent_Identity=24.375, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI18079279, Length=320, Percent_Identity=27.1875, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 44517; Mature: 44517

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNWDEEVKPSSQKPLDGGLQGHRQDVLPSASFQSPAPQSAAASAPAQHRRVNAADKRII
CCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHCCCCHHHHHCCHHHHHHC
NGQTDVNQLVPFKYKWAWEKYLATCANHWMPQEVNMTRDIALWKDPNGLTEDERRIVKRN
CCCCCHHHHCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHC
LGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAIHTHAYQYIVESLGLDESEI
CCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
FNAYNEVDSIRHKDEFLIPFIEAIMDPDFKTGTPETDQTLLKSLIVFACLMEGLFFYVGF
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQLKLENPHLWTAEFKEEIKGLF
HHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCEEHHHHHHHHHHHH
MKAVELEYQYAEDTMPRGVLGMNASMFKGYLRYIANRRATQIGLEALFPNEENPFPWMSE
HHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHH
MIDLKKERNFFETRVIEYQSGGALSWD
HHHHHHHCCHHHHHEEEECCCCCCCCC
>Mature Secondary Structure
MLNWDEEVKPSSQKPLDGGLQGHRQDVLPSASFQSPAPQSAAASAPAQHRRVNAADKRII
CCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHCCCCHHHHHCCHHHHHHC
NGQTDVNQLVPFKYKWAWEKYLATCANHWMPQEVNMTRDIALWKDPNGLTEDERRIVKRN
CCCCCHHHHCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHC
LGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAIHTHAYQYIVESLGLDESEI
CCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
FNAYNEVDSIRHKDEFLIPFIEAIMDPDFKTGTPETDQTLLKSLIVFACLMEGLFFYVGF
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQLKLENPHLWTAEFKEEIKGLF
HHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCEEHHHHHHHHHHHH
MKAVELEYQYAEDTMPRGVLGMNASMFKGYLRYIANRRATQIGLEALFPNEENPFPWMSE
HHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHH
MIDLKKERNFFETRVIEYQSGGALSWD
HHHHHHHCCHHHHHEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]