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The map label for this gene is aroE

Identifier: 120609535

GI number: 120609535

Start: 910882

End: 911727

Strand: Reverse

Name: aroE

Synonym: Aave_0841

Alternate gene names: 120609535

Gene position: 911727-910882 (Counterclockwise)

Preceding gene: 120609536

Following gene: 120609534

Centisome position: 17.03

GC content: 75.41

Gene sequence:

>846_bases
ATGACGACGACATCCGCCCCGGACGTGTACTGCGTGATGGGCCATCCCGTGGAGCACAGCCGCTCGCCGTGGATCCATGC
GCGCTTCGCCGAACTCACCGGCCAGCGGATCGCCTACACGCGGCGGCTGGTGCCGCTCGACGGCTTCGCCCGGGCGCTCG
CCGATTTCGCGGCGGCCGGCGGGGCGGGCTGCAACGTGACGGTGCCGTTCAAGCACGACGCGGCCCGGCTCGCGACCCAC
GCCAGCGACCGCGTGCGGCGCGCGGGGGCAGCCAACACCCTGAGCTTCCGGGCCGACGGCACGGTGCATGCCGAGAACAC
CGATGGCCTGGGCCTGGTGGCCGACATCGTGGTCAATGCGGGCGTGGCGCTCGCGGGCCGCGACGTGCTGCTCGTGGGTG
CCGGCGGCGCGGCCGCGGGCGTGCTCGCCCCGCTGCTGGACCAGGCCCCCCGGCGGATCACCGTGGCGAACCGCACCGAA
GCGCGCGCGCAGGCCCTGGTGCAGGCGCACGCGGACCTCGCGGCCAGCCGGCAGGTGGTGCTCGAGGCGCTGCCGATCGG
CCAGCCCGGCACCGGCTTCGACGTGGTCATCAACGCCACGGCCAGCAGCCTGGCCGGTGGCGAGGTGCCCGTGCCGGACA
CGGTGCTGCGCGAGGGCACCCTGGCCTACGACATGATGTACGGCCCCGCCGCGCAGGGTTTCATGGACTGGGCGCGCGCC
CACGGCGCGGTGCCGCGCGACGGGCTGGGCATGCTGGTGGAGCAGGCCGCCGAGGCGTTCGCCGTCTGGCGCGGCGTGCG
CCCCCCGGCCGCGCAGGTGCTGCAGGAACTGCGCGCGCAGCTATGA

Upstream 100 bases:

>100_bases
CGCGCTTCAAGTTCACGCGCGAGCAGACGCTGGAGACCAGCGTGCGCTGACGCACCCCGGCCCGCCCGCTTTCCCGACGA
CTTTCCCGCCCTCTGCCGCC

Downstream 100 bases:

>100_bases
AGGCCTTGCTGCGCTGGATCGGCTGCCTGCTGCTGGCCGGCGTGGCCCTGCAGCTGTTCTTCGTGCTGCGCATCGCCGCG
ATGGCGGCCGTCGATCCGCA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MTTTSAPDVYCVMGHPVEHSRSPWIHARFAELTGQRIAYTRRLVPLDGFARALADFAAAGGAGCNVTVPFKHDAARLATH
ASDRVRRAGAANTLSFRADGTVHAENTDGLGLVADIVVNAGVALAGRDVLLVGAGGAAAGVLAPLLDQAPRRITVANRTE
ARAQALVQAHADLAASRQVVLEALPIGQPGTGFDVVINATASSLAGGEVPVPDTVLREGTLAYDMMYGPAAQGFMDWARA
HGAVPRDGLGMLVEQAAEAFAVWRGVRPPAAQVLQELRAQL

Sequences:

>Translated_281_residues
MTTTSAPDVYCVMGHPVEHSRSPWIHARFAELTGQRIAYTRRLVPLDGFARALADFAAAGGAGCNVTVPFKHDAARLATH
ASDRVRRAGAANTLSFRADGTVHAENTDGLGLVADIVVNAGVALAGRDVLLVGAGGAAAGVLAPLLDQAPRRITVANRTE
ARAQALVQAHADLAASRQVVLEALPIGQPGTGFDVVINATASSLAGGEVPVPDTVLREGTLAYDMMYGPAAQGFMDWARA
HGAVPRDGLGMLVEQAAEAFAVWRGVRPPAAQVLQELRAQL
>Mature_280_residues
TTTSAPDVYCVMGHPVEHSRSPWIHARFAELTGQRIAYTRRLVPLDGFARALADFAAAGGAGCNVTVPFKHDAARLATHA
SDRVRRAGAANTLSFRADGTVHAENTDGLGLVADIVVNAGVALAGRDVLLVGAGGAAAGVLAPLLDQAPRRITVANRTEA
RAQALVQAHADLAASRQVVLEALPIGQPGTGFDVVINATASSLAGGEVPVPDTVLREGTLAYDMMYGPAAQGFMDWARAH
GAVPRDGLGMLVEQAAEAFAVWRGVRPPAAQVLQELRAQL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=277, Percent_Identity=39.7111913357401, Blast_Score=191, Evalue=4e-50,
Organism=Escherichia coli, GI1787983, Length=290, Percent_Identity=28.2758620689655, Blast_Score=89, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_ACIAC (A1TKF1)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969213.1
- ProteinModelPortal:   A1TKF1
- SMR:   A1TKF1
- STRING:   A1TKF1
- GeneID:   4668655
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_0841
- NMPDR:   fig|397945.5.peg.730
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   DQYVVFG
- PhylomeDB:   A1TKF1
- ProtClustDB:   PRK00258
- BioCyc:   AAVE397945:AAVE_0841-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29219; Mature: 29087

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: ACT_SITE 71-71

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTSAPDVYCVMGHPVEHSRSPWIHARFAELTGQRIAYTRRLVPLDGFARALADFAAAG
CCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHCC
GAGCNVTVPFKHDAARLATHASDRVRRAGAANTLSFRADGTVHAENTDGLGLVADIVVNA
CCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHC
GVALAGRDVLLVGAGGAAAGVLAPLLDQAPRRITVANRTEARAQALVQAHADLAASRQVV
CEEEECCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LEALPIGQPGTGFDVVINATASSLAGGEVPVPDTVLREGTLAYDMMYGPAAQGFMDWARA
HHHCCCCCCCCCEEEEEECCHHHCCCCCCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHH
HGAVPRDGLGMLVEQAAEAFAVWRGVRPPAAQVLQELRAQL
CCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TTTSAPDVYCVMGHPVEHSRSPWIHARFAELTGQRIAYTRRLVPLDGFARALADFAAAG
CCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHCC
GAGCNVTVPFKHDAARLATHASDRVRRAGAANTLSFRADGTVHAENTDGLGLVADIVVNA
CCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHC
GVALAGRDVLLVGAGGAAAGVLAPLLDQAPRRITVANRTEARAQALVQAHADLAASRQVV
CEEEECCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LEALPIGQPGTGFDVVINATASSLAGGEVPVPDTVLREGTLAYDMMYGPAAQGFMDWARA
HHHCCCCCCCCCEEEEEECCHHHCCCCCCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHH
HGAVPRDGLGMLVEQAAEAFAVWRGVRPPAAQVLQELRAQL
CCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA