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The map label for this gene is fadD [C]

Identifier: 120609481

GI number: 120609481

Start: 845380

End: 847326

Strand: Reverse

Name: fadD [C]

Synonym: Aave_0787

Alternate gene names: 120609481

Gene position: 847326-845380 (Counterclockwise)

Preceding gene: 120609484

Following gene: 120609480

Centisome position: 15.83

GC content: 70.01

Gene sequence:

>1947_bases
ATGAGCGATACCTTTCCCCGACTGCTGTTGCGCCACGCGGCCGAGCGCCCCCAGGCCGCCGCGCTGCGCGAGAAGGAATA
CGGCATCTGGCAGACCACCACCTGGGCGCGCCTCGCGCAGCTGGTGGAGCGGCTGGCCGCGGGCCTGGACGCCGCGGGCC
TGGCGCGCGGCGAGCACCTGGTGGTGATCGGCGCGAACCGGCCGCGGCTCTACGCCACGATGCTCGCGGCGCAGTCGCTG
GGCGCCATCCCCGTGCCGCTCTACCAGGACGCCGTGGCGGCCGAATGCGTCTATCCGCTGAACAACGCCGAGGTGCGCTT
CTGCGTGGTGGAGGACCAGGAGCAGGTGGACAAGCTGCTGGAGATCCGCGCGCAGTGCCCCGCCATCGCCCGCATCTTCT
ACGACGATCCGCGCGGACTGCGCAACTACGCCGAGCCGGGCCTGCAATCGATCGACGCGCTGCTGGAAGACGGCGCGCGC
ACCGCGGATGCCGCGCCGGGCTGGTTCGCCGCACGCGCCCAGGCCGTGCAGCCCGATGACGTGGCCGCGATGTTCTTCAC
CTCCGGCACCACGGGCAACCCCAAGGGCGTGGTGCACACGCACGCCACGCTGCTGGACCGCGCCACGGCCGGTGCCGAGT
TCGACCGACTCACCGCCGCCGAGGACGTGCTGGCCTACCTGCCACCCGCCTGGATCGGGCAGAACATCTTCAGCTATGCG
CAATGGCTGGCCTGCGGCTACGTGGTGAACTGCCCGGAATCGGCCGCCACGGTGTCGATCGACCTGAAGGAGATCGGCCC
CACCTACTACTTCGCGCCGCCGCGCATCTTCGAAGGCCTGCTCACGAGCGTGACGATCCGCATGGAAGACGCGGGCGCCT
TCAAGCGCTGGCTGTTCCGCACCTGCATGGCGCATGCGCGCCGCGTGGGGCCGGCGCTGCAGAGCGGCCAGGCGGTGGGC
TGGTGGGACCGGCTGCGCTACGCCGCGGGCGACCTGCTGGTCTATGGCCCGCTGCGCAATACGCTGGGCTTCTCGCGGGT
GCGCGTGGCCTACACGGCGGGCGAAGCGATCGGGCCGGACCTGTTCACCTTCTACCGCTCCATCGGCATCAACCTCAAGC
AGCTCTACGGCTCCACCGAGACGGCGGTGTTCGTGTGCCTGCAGCCCGACGACGCGGTGCATGCCGACACGGTGGGCGTG
CCGATCCGGGGCGTGGAGATCAGGGTGGACGGCAACGGCGAGATCCTCGTGAAGTCCGCGGGCCTGCTGCGCGGCTACTA
CAAGAACCCCGAGGCGACGGCCGAAGTGCTCACGCCGGACGGCTGGTACCGCACGAGCGACGCGGGCTTCCTGGACGCGA
GCGGGCAGCTCAAGATCATCGACCGCGTGAAGGATGTCGGCAGGCTCTCCGGTGGGCCGCACGACGGCGCGATGTTCGCG
CCCAAGTACGTGGAGAACAAGCTCAAGTTCTTCCCGCACATCAAGGAAGCGGTGGCGCTCGGCAACGGCCGCGACAAGGT
CTGCGCGCTGATCAACATCGATTTCGAGGCCGTGGGCAACTGGGCGGAGCGCCAGAACCTGCCGTATGCGGGCTACACCG
ACCTCGCGGCCAAGCCCGAGGTGCTGGCGCTGGTCCGCGACTGCGTGGAGAAGGTGAACGCCGACCTCGCGGCCGACGGC
CTGCTCGCGGGCAGCCAGGTCGCCCGCTTCCTGGTGCTGCACAAGGAGCTGGATGCCGACGACGGCGAGCTCACGCGCAC
CAACAAGGTCCGCCGCGGCTTCATCGCCGACAAGTACGGCGTGCTGGTCGATGCGCTCTACGCGGGCCGCACCGAGCAGT
TCATCGAGACGCAGGTGAAGTTCGAGGACGGGCGCACGGGCCGCGTGAGCGCCACGCTGCGCATCGAGGACGCGAAGACC
TTCCCGCCCGTGCGGCAGGCCGCCTGA

Upstream 100 bases:

>100_bases
TCAAAGCGGTTCCTACCATCCGTTGCATTCCCGCGGATGGCGTGCCTGCCGACAGGCTCCGCCCCCTCCCGCTTCCTCCA
CCCTTCGGCAGGAACCCGGC

Downstream 100 bases:

>100_bases
CCCCGCGCCGCAGCGCAACGTACAACGCCATGACCACTCCCAGCAAGAAGACCGGCGACGTGATCCTCGACGTGCGCAAC
ATCAGCCTGCGCTTCGGCGG

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 648; Mature: 647

Protein sequence:

>648_residues
MSDTFPRLLLRHAAERPQAAALREKEYGIWQTTTWARLAQLVERLAAGLDAAGLARGEHLVVIGANRPRLYATMLAAQSL
GAIPVPLYQDAVAAECVYPLNNAEVRFCVVEDQEQVDKLLEIRAQCPAIARIFYDDPRGLRNYAEPGLQSIDALLEDGAR
TADAAPGWFAARAQAVQPDDVAAMFFTSGTTGNPKGVVHTHATLLDRATAGAEFDRLTAAEDVLAYLPPAWIGQNIFSYA
QWLACGYVVNCPESAATVSIDLKEIGPTYYFAPPRIFEGLLTSVTIRMEDAGAFKRWLFRTCMAHARRVGPALQSGQAVG
WWDRLRYAAGDLLVYGPLRNTLGFSRVRVAYTAGEAIGPDLFTFYRSIGINLKQLYGSTETAVFVCLQPDDAVHADTVGV
PIRGVEIRVDGNGEILVKSAGLLRGYYKNPEATAEVLTPDGWYRTSDAGFLDASGQLKIIDRVKDVGRLSGGPHDGAMFA
PKYVENKLKFFPHIKEAVALGNGRDKVCALINIDFEAVGNWAERQNLPYAGYTDLAAKPEVLALVRDCVEKVNADLAADG
LLAGSQVARFLVLHKELDADDGELTRTNKVRRGFIADKYGVLVDALYAGRTEQFIETQVKFEDGRTGRVSATLRIEDAKT
FPPVRQAA

Sequences:

>Translated_648_residues
MSDTFPRLLLRHAAERPQAAALREKEYGIWQTTTWARLAQLVERLAAGLDAAGLARGEHLVVIGANRPRLYATMLAAQSL
GAIPVPLYQDAVAAECVYPLNNAEVRFCVVEDQEQVDKLLEIRAQCPAIARIFYDDPRGLRNYAEPGLQSIDALLEDGAR
TADAAPGWFAARAQAVQPDDVAAMFFTSGTTGNPKGVVHTHATLLDRATAGAEFDRLTAAEDVLAYLPPAWIGQNIFSYA
QWLACGYVVNCPESAATVSIDLKEIGPTYYFAPPRIFEGLLTSVTIRMEDAGAFKRWLFRTCMAHARRVGPALQSGQAVG
WWDRLRYAAGDLLVYGPLRNTLGFSRVRVAYTAGEAIGPDLFTFYRSIGINLKQLYGSTETAVFVCLQPDDAVHADTVGV
PIRGVEIRVDGNGEILVKSAGLLRGYYKNPEATAEVLTPDGWYRTSDAGFLDASGQLKIIDRVKDVGRLSGGPHDGAMFA
PKYVENKLKFFPHIKEAVALGNGRDKVCALINIDFEAVGNWAERQNLPYAGYTDLAAKPEVLALVRDCVEKVNADLAADG
LLAGSQVARFLVLHKELDADDGELTRTNKVRRGFIADKYGVLVDALYAGRTEQFIETQVKFEDGRTGRVSATLRIEDAKT
FPPVRQAA
>Mature_647_residues
SDTFPRLLLRHAAERPQAAALREKEYGIWQTTTWARLAQLVERLAAGLDAAGLARGEHLVVIGANRPRLYATMLAAQSLG
AIPVPLYQDAVAAECVYPLNNAEVRFCVVEDQEQVDKLLEIRAQCPAIARIFYDDPRGLRNYAEPGLQSIDALLEDGART
ADAAPGWFAARAQAVQPDDVAAMFFTSGTTGNPKGVVHTHATLLDRATAGAEFDRLTAAEDVLAYLPPAWIGQNIFSYAQ
WLACGYVVNCPESAATVSIDLKEIGPTYYFAPPRIFEGLLTSVTIRMEDAGAFKRWLFRTCMAHARRVGPALQSGQAVGW
WDRLRYAAGDLLVYGPLRNTLGFSRVRVAYTAGEAIGPDLFTFYRSIGINLKQLYGSTETAVFVCLQPDDAVHADTVGVP
IRGVEIRVDGNGEILVKSAGLLRGYYKNPEATAEVLTPDGWYRTSDAGFLDASGQLKIIDRVKDVGRLSGGPHDGAMFAP
KYVENKLKFFPHIKEAVALGNGRDKVCALINIDFEAVGNWAERQNLPYAGYTDLAAKPEVLALVRDCVEKVNADLAADGL
LAGSQVARFLVLHKELDADDGELTRTNKVRRGFIADKYGVLVDALYAGRTEQFIETQVKFEDGRTGRVSATLRIEDAKTF
PPVRQAA

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI40807491, Length=618, Percent_Identity=25.2427184466019, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI83745141, Length=618, Percent_Identity=23.3009708737864, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI27477105, Length=617, Percent_Identity=23.0145867098865, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI57165412, Length=610, Percent_Identity=25.2459016393443, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI42794756, Length=608, Percent_Identity=24.5065789473684, Blast_Score=145, Evalue=2e-34,
Organism=Homo sapiens, GI42794760, Length=608, Percent_Identity=24.5065789473684, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI42794758, Length=608, Percent_Identity=24.5065789473684, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI57165410, Length=607, Percent_Identity=24.8764415156507, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI4758332, Length=543, Percent_Identity=22.2836095764273, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI12669909, Length=534, Percent_Identity=22.4719101123595, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI42794754, Length=477, Percent_Identity=25.1572327044025, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI42794752, Length=477, Percent_Identity=25.1572327044025, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1788107, Length=379, Percent_Identity=24.5382585751979, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI145693145, Length=186, Percent_Identity=29.5698924731183, Blast_Score=63, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17510401, Length=603, Percent_Identity=23.8805970149254, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17541856, Length=607, Percent_Identity=23.5584843492586, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17556552, Length=570, Percent_Identity=21.5789473684211, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI193204819, Length=573, Percent_Identity=22.5130890052356, Blast_Score=115, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17553312, Length=642, Percent_Identity=24.4548286604361, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17564090, Length=641, Percent_Identity=21.996879875195, Blast_Score=102, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI25147511, Length=645, Percent_Identity=22.4806201550388, Blast_Score=102, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17558820, Length=162, Percent_Identity=34.5679012345679, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32563687, Length=164, Percent_Identity=33.5365853658537, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320852, Length=635, Percent_Identity=23.4645669291339, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323903, Length=348, Percent_Identity=27.8735632183908, Blast_Score=107, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6322182, Length=500, Percent_Identity=24.2, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324893, Length=475, Percent_Identity=25.8947368421053, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17933690, Length=642, Percent_Identity=23.0529595015576, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI19921316, Length=626, Percent_Identity=24.6006389776358, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24666501, Length=598, Percent_Identity=23.4113712374582, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24666497, Length=598, Percent_Identity=23.4113712374582, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI281366413, Length=598, Percent_Identity=23.4113712374582, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI62471679, Length=623, Percent_Identity=23.4349919743178, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI62471683, Length=623, Percent_Identity=23.4349919743178, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI62471685, Length=623, Percent_Identity=23.4349919743178, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24586636, Length=623, Percent_Identity=23.4349919743178, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI62471681, Length=623, Percent_Identity=23.4349919743178, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI62471687, Length=623, Percent_Identity=23.4349919743178, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24586634, Length=623, Percent_Identity=23.4349919743178, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI22026970, Length=623, Percent_Identity=23.4349919743178, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI62471689, Length=623, Percent_Identity=23.4349919743178, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21358303, Length=136, Percent_Identity=30.8823529411765, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281365686, Length=157, Percent_Identity=31.2101910828025, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 70788; Mature: 70657

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTFPRLLLRHAAERPQAAALREKEYGIWQTTTWARLAQLVERLAAGLDAAGLARGEHL
CCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCEE
VVIGANRPRLYATMLAAQSLGAIPVPLYQDAVAAECVYPLNNAEVRFCVVEDQEQVDKLL
EEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHH
EIRAQCPAIARIFYDDPRGLRNYAEPGLQSIDALLEDGARTADAAPGWFAARAQAVQPDD
HHHHCCCCEEEEEECCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCC
VAAMFFTSGTTGNPKGVVHTHATLLDRATAGAEFDRLTAAEDVLAYLPPAWIGQNIFSYA
EEEEEEECCCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
QWLACGYVVNCPESAATVSIDLKEIGPTYYFAPPRIFEGLLTSVTIRMEDAGAFKRWLFR
HHHHCCEEEECCCCCEEEEEEHHHCCCEEEECCHHHHHHHHHEEEEEEECCHHHHHHHHH
TCMAHARRVGPALQSGQAVGWWDRLRYAAGDLLVYGPLRNTLGFSRVRVAYTAGEAIGPD
HHHHHHHHCCHHHHCCCCCCHHHHHHHHHCCEEEECCCHHCCCCCCEEEEEECCCCCCHH
LFTFYRSIGINLKQLYGSTETAVFVCLQPDDAVHADTVGVPIRGVEIRVDGNGEILVKSA
HHHHHHHHCCCHHHHCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCEEEEECC
GLLRGYYKNPEATAEVLTPDGWYRTSDAGFLDASGQLKIIDRVKDVGRLSGGPHDGAMFA
CHHHHHCCCCCCCEEEECCCCCEECCCCCEECCCCCEEHHHHHHHHHHCCCCCCCCCEEC
PKYVENKLKFFPHIKEAVALGNGRDKVCALINIDFEAVGNWAERQNLPYAGYTDLAAKPE
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHCCHHHHCCCCCCCCCCCCCCHH
VLALVRDCVEKVNADLAADGLLAGSQVARFLVLHKELDADDGELTRTNKVRRGFIADKYG
HHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHH
VLVDALYAGRTEQFIETQVKFEDGRTGRVSATLRIEDAKTFPPVRQAA
HHHHHHHCCCHHHHHHHEEEECCCCCCEEEEEEEEECCCCCCCHHHCC
>Mature Secondary Structure 
SDTFPRLLLRHAAERPQAAALREKEYGIWQTTTWARLAQLVERLAAGLDAAGLARGEHL
CCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCEE
VVIGANRPRLYATMLAAQSLGAIPVPLYQDAVAAECVYPLNNAEVRFCVVEDQEQVDKLL
EEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHH
EIRAQCPAIARIFYDDPRGLRNYAEPGLQSIDALLEDGARTADAAPGWFAARAQAVQPDD
HHHHCCCCEEEEEECCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCC
VAAMFFTSGTTGNPKGVVHTHATLLDRATAGAEFDRLTAAEDVLAYLPPAWIGQNIFSYA
EEEEEEECCCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
QWLACGYVVNCPESAATVSIDLKEIGPTYYFAPPRIFEGLLTSVTIRMEDAGAFKRWLFR
HHHHCCEEEECCCCCEEEEEEHHHCCCEEEECCHHHHHHHHHEEEEEEECCHHHHHHHHH
TCMAHARRVGPALQSGQAVGWWDRLRYAAGDLLVYGPLRNTLGFSRVRVAYTAGEAIGPD
HHHHHHHHCCHHHHCCCCCCHHHHHHHHHCCEEEECCCHHCCCCCCEEEEEECCCCCCHH
LFTFYRSIGINLKQLYGSTETAVFVCLQPDDAVHADTVGVPIRGVEIRVDGNGEILVKSA
HHHHHHHHCCCHHHHCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCEEEEECC
GLLRGYYKNPEATAEVLTPDGWYRTSDAGFLDASGQLKIIDRVKDVGRLSGGPHDGAMFA
CHHHHHCCCCCCCEEEECCCCCEECCCCCEECCCCCEEHHHHHHHHHHCCCCCCCCCEEC
PKYVENKLKFFPHIKEAVALGNGRDKVCALINIDFEAVGNWAERQNLPYAGYTDLAAKPE
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHCCHHHHCCCCCCCCCCCCCCHH
VLALVRDCVEKVNADLAADGLLAGSQVARFLVLHKELDADDGELTRTNKVRRGFIADKYG
HHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHH
VLVDALYAGRTEQFIETQVKFEDGRTGRVSATLRIEDAKTFPPVRQAA
HHHHHHHCCCHHHHHHHEEEECCCCCCEEEEEEEEECCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]