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The map label for this gene is livH [H]

Identifier: 120609479

GI number: 120609479

Start: 843602

End: 844531

Strand: Reverse

Name: livH [H]

Synonym: Aave_0785

Alternate gene names: 120609479

Gene position: 844531-843602 (Counterclockwise)

Preceding gene: 120609480

Following gene: 120609478

Centisome position: 15.78

GC content: 67.53

Gene sequence:

>930_bases
ATGGGTTTCTTTCTCGAAACGGTGTTCGGCGGCCTGATGGCCGGCATGCTCTATGCGCTGGTGGCGCTGGGGTTCGTGCT
GATCTTCAAGGCCTCGGGCGTGTTCAATTTCGCGCAGGGCGCGATGGTGCTGTTCGCGGCGCTCGCGATGGCGCGCTTCG
CCGAATGGCTGCCGCGCTGGCTGGGCTTCGACAGCCTGCTGCTCGCGAATGTGCTGGCCTTCTGCGCGGCGGTGGCGTGC
ATGGTGGGCGTGGCCTGGCTGGTGGAGCGGCTGGCGCTGCGCCACCTCGTGAACCAGGAGCCGATCGCGCTGCTGATGGC
CACGCTGGGCATCACCTACTTCCTCGACGGCGCGGGCCAGCTCATCTTCGGCAGCAGCACCTACAAGATCGACGTGGGCA
TGCCCAAGGACCCGATGATCGTGCTGGAGAACGTCTTCGAGGGCGGCCTGCTGCTCTCCAAGGAAGACCTCTACGCCGCC
GTGGTGGCCGCCGCGCTCGTGGCGCTGCTCTCGCTGTTCTTCCAGAAGACGCGCACCGGCCGCGCGCTGCGCGCCGTGGC
GGACGACCACCAGGCCGCGCAGTCCATCGGCATCCCGCTCTCGCGCATCTGGGTGATCGTGTGGTCGGTGGGCGGCATCG
TCGCGCTCGTGGCCGGCATCATCTGGGGCAGCAAGCTGGGTGTGCAGTTCTCCATCTCGCTCGTGGCGCTCAAGGCCTTC
CCGGTGGTGATCCTCGGCGGGCTCACCTCGGTGCCCGGCGCCATCGTGGGCGGCCTGCTGATCGGCGTGGGCGAGAAGGT
GTCCGAGATCTACCTCGGGCCGTTCCTCGGCGGCGGCATCGAGAACTGGTTCGCCTACGTGCTCGCGCTGGGCTTCCTCC
TCATCCGGCCGCAAGGGTTGTTTGGGGACAAGATCATCGACCGCGTGTAA

Upstream 100 bases:

>100_bases
CGGCGACGGCACGCCGCAAGCGGTGCGCGAGAACGAAGACGTCATCCGCGCCTACCTCGGCGCCGGCCACTAGACACGCA
GGACATCGGAGGCATACGCC

Downstream 100 bases:

>100_bases
CCGGTAGAAGGAGGCAAGCACCATGTTCTACCGTGAAAACGGCCAGTTCAAGACCAGCTACCAGGCCGACCTGGCGCTGT
TTCCCGTCGCCCAGGACCGC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MGFFLETVFGGLMAGMLYALVALGFVLIFKASGVFNFAQGAMVLFAALAMARFAEWLPRWLGFDSLLLANVLAFCAAVAC
MVGVAWLVERLALRHLVNQEPIALLMATLGITYFLDGAGQLIFGSSTYKIDVGMPKDPMIVLENVFEGGLLLSKEDLYAA
VVAAALVALLSLFFQKTRTGRALRAVADDHQAAQSIGIPLSRIWVIVWSVGGIVALVAGIIWGSKLGVQFSISLVALKAF
PVVILGGLTSVPGAIVGGLLIGVGEKVSEIYLGPFLGGGIENWFAYVLALGFLLIRPQGLFGDKIIDRV

Sequences:

>Translated_309_residues
MGFFLETVFGGLMAGMLYALVALGFVLIFKASGVFNFAQGAMVLFAALAMARFAEWLPRWLGFDSLLLANVLAFCAAVAC
MVGVAWLVERLALRHLVNQEPIALLMATLGITYFLDGAGQLIFGSSTYKIDVGMPKDPMIVLENVFEGGLLLSKEDLYAA
VVAAALVALLSLFFQKTRTGRALRAVADDHQAAQSIGIPLSRIWVIVWSVGGIVALVAGIIWGSKLGVQFSISLVALKAF
PVVILGGLTSVPGAIVGGLLIGVGEKVSEIYLGPFLGGGIENWFAYVLALGFLLIRPQGLFGDKIIDRV
>Mature_308_residues
GFFLETVFGGLMAGMLYALVALGFVLIFKASGVFNFAQGAMVLFAALAMARFAEWLPRWLGFDSLLLANVLAFCAAVACM
VGVAWLVERLALRHLVNQEPIALLMATLGITYFLDGAGQLIFGSSTYKIDVGMPKDPMIVLENVFEGGLLLSKEDLYAAV
VAAALVALLSLFFQKTRTGRALRAVADDHQAAQSIGIPLSRIWVIVWSVGGIVALVAGIIWGSKLGVQFSISLVALKAFP
VVILGGLTSVPGAIVGGLLIGVGEKVSEIYLGPFLGGGIENWFAYVLALGFLLIRPQGLFGDKIIDRV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=329, Percent_Identity=27.9635258358663, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 32828; Mature: 32697

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFFLETVFGGLMAGMLYALVALGFVLIFKASGVFNFAQGAMVLFAALAMARFAEWLPRW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LGFDSLLLANVLAFCAAVACMVGVAWLVERLALRHLVNQEPIALLMATLGITYFLDGAGQ
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
LIFGSSTYKIDVGMPKDPMIVLENVFEGGLLLSKEDLYAAVVAAALVALLSLFFQKTRTG
EEECCCEEEEECCCCCCHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCC
RALRAVADDHQAAQSIGIPLSRIWVIVWSVGGIVALVAGIIWGSKLGVQFSISLVALKAF
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHH
PVVILGGLTSVPGAIVGGLLIGVGEKVSEIYLGPFLGGGIENWFAYVLALGFLLIRPQGL
HHHHHCCHHHCHHHHHHHHHHHCCHHHHHHHHCHHCCCCHHHHHHHHHHHHHHHHCCCCC
FGDKIIDRV
CHHHHHHCC
>Mature Secondary Structure 
GFFLETVFGGLMAGMLYALVALGFVLIFKASGVFNFAQGAMVLFAALAMARFAEWLPRW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LGFDSLLLANVLAFCAAVACMVGVAWLVERLALRHLVNQEPIALLMATLGITYFLDGAGQ
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
LIFGSSTYKIDVGMPKDPMIVLENVFEGGLLLSKEDLYAAVVAAALVALLSLFFQKTRTG
EEECCCEEEEECCCCCCHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCC
RALRAVADDHQAAQSIGIPLSRIWVIVWSVGGIVALVAGIIWGSKLGVQFSISLVALKAF
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHH
PVVILGGLTSVPGAIVGGLLIGVGEKVSEIYLGPFLGGGIENWFAYVLALGFLLIRPQGL
HHHHHCCHHHCHHHHHHHHHHHCCHHHHHHHHCHHCCCCHHHHHHHHHHHHHHHHCCCCC
FGDKIIDRV
CHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]