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The map label for this gene is hemB [H]

Identifier: 120609030

GI number: 120609030

Start: 360087

End: 361094

Strand: Reverse

Name: hemB [H]

Synonym: Aave_0327

Alternate gene names: 120609030

Gene position: 361094-360087 (Counterclockwise)

Preceding gene: 120609052

Following gene: 120609029

Centisome position: 6.75

GC content: 68.25

Gene sequence:

>1008_bases
ATGCATCTCTCCAGCCCCCCGCCCTTTCCCCAGCACCGTCCCCGCCGGCTGCGGCGCGACGCGTTCACCCGCAACCTCGT
GCGCGAGCACCGGCTGTCACCGCACGATTTCATCTATCCGGTGTTCGTGCATGAAGGCGCGAACCACCGCCAGGCCGTGC
CCTCGATGCCGGGGGTGGACCGGCTGAGCCTGGACCTGCTGCTGCCCGTGGCGGAGGACTGCGTGCGCCTGGGCATCCCG
GTGCTGGCGCTGTTTCCCTCGATCGACCCGGCACTCAAGACGCCGGACGGCAAGGAGGCGCTGAACCCTGACGGCCTGAT
CCCCCGCGTGGTGCGGGCGCTGAAGAAGGAATTCCCCGACCTGGGCGTGCTCACCGATGTGGCGCTGGACCCCTACACCA
GCCACGGCCAGGACGGCATGCTCGACGAGACCGGCTACATCCTGAACGACGAGACGGTGGAAATCCTCGTCGGACAGGTG
CTCACGCATGCCGAGGCGGGGGTGGATATCGTGGCACCCAGCGACATGATGGACGGCCGGATCGGCGCGATCCGCGAGGC
TCTGGAGGCGCAGGGCCATGTCCACACCCGCATCATGGCCTACAGCGCGAAGTACGCGAGCGCGTTCTACGGCCCGTTCC
GCGATGCCGTGGGCACGCGTGGGGCGCTGGGCAAGGCCGACAAGAACGTCTACCAGATGGACCCGGGCAACACCGACGAG
GCGCTGCGCGAGGTGGCGCTGGACATCGCAGAGGGCGCGGACATGGTCATGGTCAAGCCCGGCATGCCGTACCTGGACGT
CGTGCGCCGCGTGAAGGACGAGTTCCGCGTGCCGACCTTCGCCTACCAGGTGAGCGGCGAATACGCCATGCTGAAGGCCG
CCGCCGCCAACGGCTGGCTCGACCACGATGCCGTGATGATGGAATCCCTGCTCGCCTTCAAGCGCGCCGGCGCGGACGGC
ATCCTCACGTATTTCGCGCGCGATGCCGCGCGGCTGCTGACGAAGTAA

Upstream 100 bases:

>100_bases
CGATATGGAAGGCTTTGACCCAGAGCATGGACCGCAGTGTACGTGCCGCGGGGAGCCCGCCGGTGGCACGCACGTCCCGA
AACGGGAGCACAATTTCGGG

Downstream 100 bases:

>100_bases
GGGTCCCATGTCGCCGATCTGGACAGGGCCAGAGAAAGAAGAAGACCAACGCGGGGGGCGGCCTTGAGCGAAGACTCCAA
CGGTACGGTCCGCGTCTTCC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MHLSSPPPFPQHRPRRLRRDAFTRNLVREHRLSPHDFIYPVFVHEGANHRQAVPSMPGVDRLSLDLLLPVAEDCVRLGIP
VLALFPSIDPALKTPDGKEALNPDGLIPRVVRALKKEFPDLGVLTDVALDPYTSHGQDGMLDETGYILNDETVEILVGQV
LTHAEAGVDIVAPSDMMDGRIGAIREALEAQGHVHTRIMAYSAKYASAFYGPFRDAVGTRGALGKADKNVYQMDPGNTDE
ALREVALDIAEGADMVMVKPGMPYLDVVRRVKDEFRVPTFAYQVSGEYAMLKAAAANGWLDHDAVMMESLLAFKRAGADG
ILTYFARDAARLLTK

Sequences:

>Translated_335_residues
MHLSSPPPFPQHRPRRLRRDAFTRNLVREHRLSPHDFIYPVFVHEGANHRQAVPSMPGVDRLSLDLLLPVAEDCVRLGIP
VLALFPSIDPALKTPDGKEALNPDGLIPRVVRALKKEFPDLGVLTDVALDPYTSHGQDGMLDETGYILNDETVEILVGQV
LTHAEAGVDIVAPSDMMDGRIGAIREALEAQGHVHTRIMAYSAKYASAFYGPFRDAVGTRGALGKADKNVYQMDPGNTDE
ALREVALDIAEGADMVMVKPGMPYLDVVRRVKDEFRVPTFAYQVSGEYAMLKAAAANGWLDHDAVMMESLLAFKRAGADG
ILTYFARDAARLLTK
>Mature_335_residues
MHLSSPPPFPQHRPRRLRRDAFTRNLVREHRLSPHDFIYPVFVHEGANHRQAVPSMPGVDRLSLDLLLPVAEDCVRLGIP
VLALFPSIDPALKTPDGKEALNPDGLIPRVVRALKKEFPDLGVLTDVALDPYTSHGQDGMLDETGYILNDETVEILVGQV
LTHAEAGVDIVAPSDMMDGRIGAIREALEAQGHVHTRIMAYSAKYASAFYGPFRDAVGTRGALGKADKNVYQMDPGNTDE
ALREVALDIAEGADMVMVKPGMPYLDVVRRVKDEFRVPTFAYQVSGEYAMLKAAAANGWLDHDAVMMESLLAFKRAGADG
ILTYFARDAARLLTK

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=298, Percent_Identity=45.3020134228188, Blast_Score=231, Evalue=7e-61,
Organism=Escherichia coli, GI87081728, Length=319, Percent_Identity=46.0815047021944, Blast_Score=249, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6321398, Length=307, Percent_Identity=36.8078175895765, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI21358291, Length=295, Percent_Identity=41.3559322033898, Blast_Score=228, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36836; Mature: 36836

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLSSPPPFPQHRPRRLRRDAFTRNLVREHRLSPHDFIYPVFVHEGANHRQAVPSMPGVD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCC
RLSLDLLLPVAEDCVRLGIPVLALFPSIDPALKTPDGKEALNPDGLIPRVVRALKKEFPD
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
LGVLTDVALDPYTSHGQDGMLDETGYILNDETVEILVGQVLTHAEAGVDIVAPSDMMDGR
CCCHHHHHCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCCEEEECCCHHHCCH
IGAIREALEAQGHVHTRIMAYSAKYASAFYGPFRDAVGTRGALGKADKNVYQMDPGNTDE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHH
ALREVALDIAEGADMVMVKPGMPYLDVVRRVKDEFRVPTFAYQVSGEYAMLKAAAANGWL
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHEEEHHHHCCCC
DHDAVMMESLLAFKRAGADGILTYFARDAARLLTK
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHLSSPPPFPQHRPRRLRRDAFTRNLVREHRLSPHDFIYPVFVHEGANHRQAVPSMPGVD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCC
RLSLDLLLPVAEDCVRLGIPVLALFPSIDPALKTPDGKEALNPDGLIPRVVRALKKEFPD
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
LGVLTDVALDPYTSHGQDGMLDETGYILNDETVEILVGQVLTHAEAGVDIVAPSDMMDGR
CCCHHHHHCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCCEEEECCCHHHCCH
IGAIREALEAQGHVHTRIMAYSAKYASAFYGPFRDAVGTRGALGKADKNVYQMDPGNTDE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHH
ALREVALDIAEGADMVMVKPGMPYLDVVRRVKDEFRVPTFAYQVSGEYAMLKAAAANGWL
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHEEEHHHHCCCC
DHDAVMMESLLAFKRAGADGILTYFARDAARLLTK
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]