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The map label for this gene is 120608959

Identifier: 120608959

GI number: 120608959

Start: 286027

End: 287292

Strand: Reverse

Name: 120608959

Synonym: Aave_0256

Alternate gene names: NA

Gene position: 287292-286027 (Counterclockwise)

Preceding gene: 120608960

Following gene: 120608955

Centisome position: 5.37

GC content: 72.83

Gene sequence:

>1266_bases
ATGCCACAGCACACCGACGCCACCCATGACCCGTCCCTGCGCAGCTGGGTCGAATCCGCCAACGCCGCGGGCTGCGATTT
TCCCATCCAGAACCTGCCCTTCGGCCGCTTCCGCGCGCACGACGGCAGCGCCCGCATCGGCGTGGCCATCGGCGACCGGA
TCCTGGATATCCAGGCCGCCGGCCTCGTGGCCGGCGACGACATGAACGCGCTGATGGCCGCAGGGCCGCAGGCGCGCCGG
GCCTTGCGGACGCGCCTTTCGCAGGGCCTCGCCGCCGGCAGCGCGCAGCAGGCCGCATGGCAGGACGCGCTGCTGCCGCA
GGCGGGCACCGGGATGCTCATGCCCTGCCGCATCGGTGACTACACCGACTTCTACACCAGCGTGCACCACGCCACCAACG
TGGGCCGGCAGTTCCGCCCCGACAACCCGCTGCTGCCCAACTACCAGTGGGTGCCGATCGGCTACCACGGCCGCGCGTCC
TCCATCGGCGTGAGCGGCGCGGCGGTGCGGCGTCCCCGCGGCCAGCTCAAGGCCCCCGAGGCCGCGGCCCCCGTGCTCGC
GCCCAGCCGGCGGCTGGACTACGAACTGGAGCTGGGCTGGTTCGTCGGCACGGGCAATGCGCAGGGCGAGCCCATCGGCA
TCGGCGAGGCGGAGGACCACCTGTTCGGCGTCGCGCTCTTCAACGACTGGAGCGCGCGCGACATCCAGGGCTGGGAATAC
CAGCCGCTGGGCCCTTTTCTCTCGAAGAATTTCGCGAGCACCCTCTCGCCCTGGGTGGTGACGCTGGAGGCGCTCGCGCC
CTTCCGCGCGCCCTTCACAAGACCCGACGAAGATCCGCAGCCGCTGCCCTACCTGGATTCTCCCGACCACCGCGCCGCGG
GCGCTTTCGCGATCACGCTCGAAGTGCTGCTGCAGACGGAGCGCATGCGCACCGAGGGCCTGCCGCCCGCGGTGCTCTCG
CGCACCGACACCACGCGCGCCGCCTACTGGACACCCGCGCAACTGGTGGCGCACCACACGGTGAACGGCTGCAACCTGCA
CAGTGGCGACCTGCTCGGCTCGGGCACGCTGTCGGGCCCCGGCCCGCAGGAGGCAGGCTCCCTGCTGGAGCTGGCCGCGG
CCGGCCGTCAGCCCGTGCGCCTGCCGTCCGGCGAGGAGCGCAGCTTCCTGGAGGACGGCGACACCGTCACGCTGCGCGGC
TGGTGCGAGCGCGAAGGCGCGGCGCGCATCGGGCTGGGCGAGGCCAGCGGCACGGTCACCGGCTGA

Upstream 100 bases:

>100_bases
GGGAGCACTGACGCTGCGCGAGTACGACCGCCTGGGTCAGGTGGCCCGCGCGGCCGGGATGACCGCCGACTGACCGGACC
CTGTCCAGCAAGGCCCCGCC

Downstream 100 bases:

>100_bases
CGGCGGCCACCACCGGCGTCGAGCGCCCCGTACGCCGGCCGCTTACTTCGCCACCTTCAGCACGCGCCAGTCGATGCGGT
TGTCGGCGCGGTGCGGCAGT

Product: fumarylacetoacetate hydrolase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MPQHTDATHDPSLRSWVESANAAGCDFPIQNLPFGRFRAHDGSARIGVAIGDRILDIQAAGLVAGDDMNALMAAGPQARR
ALRTRLSQGLAAGSAQQAAWQDALLPQAGTGMLMPCRIGDYTDFYTSVHHATNVGRQFRPDNPLLPNYQWVPIGYHGRAS
SIGVSGAAVRRPRGQLKAPEAAAPVLAPSRRLDYELELGWFVGTGNAQGEPIGIGEAEDHLFGVALFNDWSARDIQGWEY
QPLGPFLSKNFASTLSPWVVTLEALAPFRAPFTRPDEDPQPLPYLDSPDHRAAGAFAITLEVLLQTERMRTEGLPPAVLS
RTDTTRAAYWTPAQLVAHHTVNGCNLHSGDLLGSGTLSGPGPQEAGSLLELAAAGRQPVRLPSGEERSFLEDGDTVTLRG
WCEREGAARIGLGEASGTVTG

Sequences:

>Translated_421_residues
MPQHTDATHDPSLRSWVESANAAGCDFPIQNLPFGRFRAHDGSARIGVAIGDRILDIQAAGLVAGDDMNALMAAGPQARR
ALRTRLSQGLAAGSAQQAAWQDALLPQAGTGMLMPCRIGDYTDFYTSVHHATNVGRQFRPDNPLLPNYQWVPIGYHGRAS
SIGVSGAAVRRPRGQLKAPEAAAPVLAPSRRLDYELELGWFVGTGNAQGEPIGIGEAEDHLFGVALFNDWSARDIQGWEY
QPLGPFLSKNFASTLSPWVVTLEALAPFRAPFTRPDEDPQPLPYLDSPDHRAAGAFAITLEVLLQTERMRTEGLPPAVLS
RTDTTRAAYWTPAQLVAHHTVNGCNLHSGDLLGSGTLSGPGPQEAGSLLELAAAGRQPVRLPSGEERSFLEDGDTVTLRG
WCEREGAARIGLGEASGTVTG
>Mature_420_residues
PQHTDATHDPSLRSWVESANAAGCDFPIQNLPFGRFRAHDGSARIGVAIGDRILDIQAAGLVAGDDMNALMAAGPQARRA
LRTRLSQGLAAGSAQQAAWQDALLPQAGTGMLMPCRIGDYTDFYTSVHHATNVGRQFRPDNPLLPNYQWVPIGYHGRASS
IGVSGAAVRRPRGQLKAPEAAAPVLAPSRRLDYELELGWFVGTGNAQGEPIGIGEAEDHLFGVALFNDWSARDIQGWEYQ
PLGPFLSKNFASTLSPWVVTLEALAPFRAPFTRPDEDPQPLPYLDSPDHRAAGAFAITLEVLLQTERMRTEGLPPAVLSR
TDTTRAAYWTPAQLVAHHTVNGCNLHSGDLLGSGTLSGPGPQEAGSLLELAAAGRQPVRLPSGEERSFLEDGDTVTLRGW
CEREGAARIGLGEASGTVTG

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=420, Percent_Identity=46.1904761904762, Blast_Score=351, Evalue=8e-97,
Organism=Caenorhabditis elegans, GI17568863, Length=415, Percent_Identity=48.433734939759, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI24657182, Length=409, Percent_Identity=44.4987775061125, Blast_Score=331, Evalue=4e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 45002; Mature: 44871

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQHTDATHDPSLRSWVESANAAGCDFPIQNLPFGRFRAHDGSARIGVAIGDRILDIQAA
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCEEEEEECCEEEEEEEC
GLVAGDDMNALMAAGPQARRALRTRLSQGLAAGSAQQAAWQDALLPQAGTGMLMPCRIGD
CEEECCCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEECCC
YTDFYTSVHHATNVGRQFRPDNPLLPNYQWVPIGYHGRASSIGVSGAAVRRPRGQLKAPE
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHCCCCCCCCCCC
AAAPVLAPSRRLDYELELGWFVGTGNAQGEPIGIGEAEDHLFGVALFNDWSARDIQGWEY
CCCCCCCCCCCCCEEEEEEEEEECCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCCCCC
QPLGPFLSKNFASTLSPWVVTLEALAPFRAPFTRPDEDPQPLPYLDSPDHRAAGAFAITL
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
EVLLQTERMRTEGLPPAVLSRTDTTRAAYWTPAQLVAHHTVNGCNLHSGDLLGSGTLSGP
HHHHHHHHHHHCCCCHHHHCCCCCCCEEECCHHHHHHHHCCCCCCCCCCCEECCCCCCCC
GPQEAGSLLELAAAGRQPVRLPSGEERSFLEDGDTVTLRGWCEREGAARIGLGEASGTVT
CHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCEEEEEEECCCCCCCEEECCCCCCCCC
G
C
>Mature Secondary Structure 
PQHTDATHDPSLRSWVESANAAGCDFPIQNLPFGRFRAHDGSARIGVAIGDRILDIQAA
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCEEEEEECCEEEEEEEC
GLVAGDDMNALMAAGPQARRALRTRLSQGLAAGSAQQAAWQDALLPQAGTGMLMPCRIGD
CEEECCCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEECCC
YTDFYTSVHHATNVGRQFRPDNPLLPNYQWVPIGYHGRASSIGVSGAAVRRPRGQLKAPE
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHCCCCCCCCCCC
AAAPVLAPSRRLDYELELGWFVGTGNAQGEPIGIGEAEDHLFGVALFNDWSARDIQGWEY
CCCCCCCCCCCCCEEEEEEEEEECCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCCCCC
QPLGPFLSKNFASTLSPWVVTLEALAPFRAPFTRPDEDPQPLPYLDSPDHRAAGAFAITL
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
EVLLQTERMRTEGLPPAVLSRTDTTRAAYWTPAQLVAHHTVNGCNLHSGDLLGSGTLSGP
HHHHHHHHHHHCCCCHHHHCCCCCCCEEECCHHHHHHHHCCCCCCCCCCCEECCCCCCCC
GPQEAGSLLELAAAGRQPVRLPSGEERSFLEDGDTVTLRGWCEREGAARIGLGEASGTVT
CHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCEEEEEEECCCCCCCEEECCCCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA