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The map label for this gene is btuE [C]

Identifier: 120608953

GI number: 120608953

Start: 279275

End: 279769

Strand: Reverse

Name: btuE [C]

Synonym: Aave_0250

Alternate gene names: 120608953

Gene position: 279769-279275 (Counterclockwise)

Preceding gene: 120608954

Following gene: 120608944

Centisome position: 5.23

GC content: 69.49

Gene sequence:

>495_bases
ATGACCTCCGCCTACGACTTCGACGCCCTGCAGATGGACGGCCAGGCGGTGCCGCTGCGCCAGTACGCGGGCCGCGTGCT
GCTCATCGTGAACACCGCCAGCGCCTGCGGCTTCACGCCGCAGTTCGCGGGACTGCAGGAATTGCACCAGCGCTATGCGG
ACCGGGGGCTCGTCGTGCTGGGCTTTCCGTGCAACCAGTTCGGCCGGCAGGACCCCGGATCGAACGGGGAAATCGCCGCG
TTCTGCCAGCGCAACTACGGTGTCGATTTCCCGATGATGGCCAAGATCGACGTGAACGGATCCGGGGCGCCGCCGCTCTA
CCGCTGGCTGACCGCGGAGGCCCCGGGCCTGCTGGGCACCAAGGCGATCAAGTGGAACTTCACCAAGTTCCTGATCGGCC
GGGACGGCCAGGTGGTCCGCCGCTACGCGCCCACCGCCAAGCCCGCGTCGCTCGCCGGCGACATCGAGGCGGAACTCGCC
CGGCCCGCGCCCTGA

Upstream 100 bases:

>100_bases
CAGCGGCGCTGAAGCATCAGGCTGACAGGCTGCGGCGGTCCTTGCGACAATGGGCGCGAAACCCGCCGTCGCGGGCCCTT
CTTCGCCGGGAGATGCCGAG

Downstream 100 bases:

>100_bases
AGCACGCCGGCCAGGCGCTCAGTCGGACAGCTCGCGCTGGGGCCGCCCCGTGATCTCGAAACGCCGGGAGAACCCCAGCG
GCCTCGAAACCCCGCGCGCC

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MTSAYDFDALQMDGQAVPLRQYAGRVLLIVNTASACGFTPQFAGLQELHQRYADRGLVVLGFPCNQFGRQDPGSNGEIAA
FCQRNYGVDFPMMAKIDVNGSGAPPLYRWLTAEAPGLLGTKAIKWNFTKFLIGRDGQVVRRYAPTAKPASLAGDIEAELA
RPAP

Sequences:

>Translated_164_residues
MTSAYDFDALQMDGQAVPLRQYAGRVLLIVNTASACGFTPQFAGLQELHQRYADRGLVVLGFPCNQFGRQDPGSNGEIAA
FCQRNYGVDFPMMAKIDVNGSGAPPLYRWLTAEAPGLLGTKAIKWNFTKFLIGRDGQVVRRYAPTAKPASLAGDIEAELA
RPAP
>Mature_163_residues
TSAYDFDALQMDGQAVPLRQYAGRVLLIVNTASACGFTPQFAGLQELHQRYADRGLVVLGFPCNQFGRQDPGSNGEIAAF
CQRNYGVDFPMMAKIDVNGSGAPPLYRWLTAEAPGLLGTKAIKWNFTKFLIGRDGQVVRRYAPTAKPASLAGDIEAELAR
PAP

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=156, Percent_Identity=47.4358974358974, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI90903240, Length=156, Percent_Identity=47.4358974358974, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI15618997, Length=154, Percent_Identity=44.8051948051948, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI192455698, Length=158, Percent_Identity=37.9746835443038, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI90903238, Length=131, Percent_Identity=48.8549618320611, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI6006001, Length=181, Percent_Identity=37.0165745856354, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI4557629, Length=179, Percent_Identity=36.3128491620112, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI33186887, Length=179, Percent_Identity=31.8435754189944, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI41406084, Length=184, Percent_Identity=36.9565217391304, Blast_Score=97, Evalue=6e-21,
Organism=Homo sapiens, GI32967607, Length=181, Percent_Identity=34.8066298342541, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1788003, Length=156, Percent_Identity=45.5128205128205, Blast_Score=154, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17535473, Length=160, Percent_Identity=46.25, Blast_Score=150, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17506887, Length=162, Percent_Identity=43.8271604938272, Blast_Score=148, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71993584, Length=160, Percent_Identity=37.5, Blast_Score=122, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI193210707, Length=158, Percent_Identity=40.5063291139241, Blast_Score=121, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17550320, Length=187, Percent_Identity=33.6898395721925, Blast_Score=102, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI193209493, Length=184, Percent_Identity=32.6086956521739, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71993573, Length=95, Percent_Identity=35.7894736842105, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71999642, Length=76, Percent_Identity=39.4736842105263, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193210709, Length=74, Percent_Identity=45.945945945946, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319721, Length=160, Percent_Identity=52.5, Blast_Score=197, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6322228, Length=161, Percent_Identity=50.9316770186335, Blast_Score=189, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6322826, Length=162, Percent_Identity=41.9753086419753, Blast_Score=154, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24656777, Length=159, Percent_Identity=46.5408805031447, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24656767, Length=159, Percent_Identity=46.5408805031447, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24656772, Length=159, Percent_Identity=46.5408805031447, Blast_Score=150, Evalue=3e-37,
Organism=Drosophila melanogaster, GI85726443, Length=150, Percent_Identity=45.3333333333333, Blast_Score=122, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 17783; Mature: 17651

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1 ; PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAYDFDALQMDGQAVPLRQYAGRVLLIVNTASACGFTPQFAGLQELHQRYADRGLVVL
CCCCCCCCEEEECCCEECHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCEEEE
GFPCNQFGRQDPGSNGEIAAFCQRNYGVDFPMMAKIDVNGSGAPPLYRWLTAEAPGLLGT
ECCCHHHCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCHHHEEECCCCCCCCCC
KAIKWNFTKFLIGRDGQVVRRYAPTAKPASLAGDIEAELARPAP
EEEEEEEEEEEECCCCCEEEECCCCCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
TSAYDFDALQMDGQAVPLRQYAGRVLLIVNTASACGFTPQFAGLQELHQRYADRGLVVL
CCCCCCCEEEECCCEECHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCEEEE
GFPCNQFGRQDPGSNGEIAAFCQRNYGVDFPMMAKIDVNGSGAPPLYRWLTAEAPGLLGT
ECCCHHHCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCHHHEEECCCCCCCCCC
KAIKWNFTKFLIGRDGQVVRRYAPTAKPASLAGDIEAELARPAP
EEEEEEEEEEEECCCCCEEEECCCCCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]