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The map label for this gene is cynR [H]

Identifier: 120608906

GI number: 120608906

Start: 222681

End: 223607

Strand: Reverse

Name: cynR [H]

Synonym: Aave_0198

Alternate gene names: 120608906

Gene position: 223607-222681 (Counterclockwise)

Preceding gene: 120608910

Following gene: 120608905

Centisome position: 4.18

GC content: 74.87

Gene sequence:

>927_bases
ATGGAATTGCGCCAGTTGCGCTACTTCCTGAGCGTGGCCGAGACCGAGCACCTCACGCAATCGGCCGACGCGCTCTTCGT
CACCCAGTCCACCCTGTCGCACGGCCTGCGGCAGCTGGAGGCCGAACTGGGGCTGCCCCTGTTCGACCGGCTGGGACGGG
GGCTGAAGCTCTCGCAGGCAGGCATGGCCTTCCGCAGCCACGCGGCGCGTGCGCTGCAGGAACTGGAGGCCGGCCGCATG
GCGCTGGCCGACATGGCAGGGCTGCAGGCGGGCACGCTCACGGTGGGCGTGATCCCCACCTTCCTGACCCACCTGGTGCC
GGACGCGGTGGCCGCCTTCAGCGCGGACTACCCCGGCGTGCAGGTGGTGGTGCGCGACCTGCGCGGCGGCCCGATCGAAG
AGCAGCTCATTGCCGGCCGGCTGGACGTGGGCATCTCCTTCCACCCCGCGCACCGCGAGGAGATCGAGGCCGAGCCGCTG
TTCGAGGAGCGCCTGCAACTGGTGGTGCACGCGGGCCACGCGCTGGCGCGCCGCCGCACCTTGCGCACGCGCGAGCTGGC
CGGCGTGCCGCTGGCGCTGCTGCCCCGGAGCTTCGCCACGCGCCGCATGATCGACGCGGCCTTCGCCCAGGCCGGCGTGG
TGCCCGTGGTGCGGGTGGAGATGGAATCGGTGGACGCGCTGCTGCACGCCTGCCGCGGCGGGCCGCTGGCCACCATCGCG
GCCGAGCGCGCGGCCGGCCAGGCCGGGCCGGACATGCGCGCGATCACGCTGACCGAGCCCGCCACCGTGCGCCGCGCGGG
CGTGCTGTGGCGCCGGGGTGCGTCGCGCAGCGCGGCAGCGCGGGAGTTCGTGGCGCGGCTGCGGCCCATCGTGGGCGCCA
CGGCCACCGCTGCCCGCCGTCCGGCAGCGTGCCGGACAATGCGGTGA

Upstream 100 bases:

>100_bases
CCTGCGATCCAATGGTATATATGACACGATTCATTCGATGCCATCGAACGATAATGCGCACCTTCCATTCACCCGTTCCA
CCCGTTCCCCAGGAGCCGCC

Downstream 100 bases:

>100_bases
TGAACGACTCCCCCATGCAGAAGACCGCAGAGGCATCTCCCGATACCTCCGAAGCGCCCATCCAGGAAGCGCGCCTGTGG
AGCGACGGACGCTGGACGGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MELRQLRYFLSVAETEHLTQSADALFVTQSTLSHGLRQLEAELGLPLFDRLGRGLKLSQAGMAFRSHAARALQELEAGRM
ALADMAGLQAGTLTVGVIPTFLTHLVPDAVAAFSADYPGVQVVVRDLRGGPIEEQLIAGRLDVGISFHPAHREEIEAEPL
FEERLQLVVHAGHALARRRTLRTRELAGVPLALLPRSFATRRMIDAAFAQAGVVPVVRVEMESVDALLHACRGGPLATIA
AERAAGQAGPDMRAITLTEPATVRRAGVLWRRGASRSAAAREFVARLRPIVGATATAARRPAACRTMR

Sequences:

>Translated_308_residues
MELRQLRYFLSVAETEHLTQSADALFVTQSTLSHGLRQLEAELGLPLFDRLGRGLKLSQAGMAFRSHAARALQELEAGRM
ALADMAGLQAGTLTVGVIPTFLTHLVPDAVAAFSADYPGVQVVVRDLRGGPIEEQLIAGRLDVGISFHPAHREEIEAEPL
FEERLQLVVHAGHALARRRTLRTRELAGVPLALLPRSFATRRMIDAAFAQAGVVPVVRVEMESVDALLHACRGGPLATIA
AERAAGQAGPDMRAITLTEPATVRRAGVLWRRGASRSAAAREFVARLRPIVGATATAARRPAACRTMR
>Mature_308_residues
MELRQLRYFLSVAETEHLTQSADALFVTQSTLSHGLRQLEAELGLPLFDRLGRGLKLSQAGMAFRSHAARALQELEAGRM
ALADMAGLQAGTLTVGVIPTFLTHLVPDAVAAFSADYPGVQVVVRDLRGGPIEEQLIAGRLDVGISFHPAHREEIEAEPL
FEERLQLVVHAGHALARRRTLRTRELAGVPLALLPRSFATRRMIDAAFAQAGVVPVVRVEMESVDALLHACRGGPLATIA
AERAAGQAGPDMRAITLTEPATVRRAGVLWRRGASRSAAAREFVARLRPIVGATATAARRPAACRTMR

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=281, Percent_Identity=40.9252669039146, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI145693105, Length=291, Percent_Identity=24.7422680412371, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788887, Length=189, Percent_Identity=32.8042328042328, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790399, Length=201, Percent_Identity=29.8507462686567, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787530, Length=295, Percent_Identity=25.0847457627119, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788748, Length=211, Percent_Identity=28.9099526066351, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787806, Length=278, Percent_Identity=28.0575539568345, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788297, Length=247, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788481, Length=296, Percent_Identity=28.0405405405405, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787879, Length=286, Percent_Identity=25.8741258741259, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI87081904, Length=215, Percent_Identity=29.3023255813954, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788296, Length=233, Percent_Identity=30.0429184549356, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789173, Length=164, Percent_Identity=32.3170731707317, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789204, Length=237, Percent_Identity=27.4261603375527, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787601, Length=184, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790208, Length=149, Percent_Identity=30.8724832214765, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33216; Mature: 33216

Theoretical pI: Translated: 11.13; Mature: 11.13

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRQLRYFLSVAETEHLTQSADALFVTQSTLSHGLRQLEAELGLPLFDRLGRGLKLSQA
CCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHCCCCCEEHHH
GMAFRSHAARALQELEAGRMALADMAGLQAGTLTVGVIPTFLTHLVPDAVAAFSADYPGV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
QVVVRDLRGGPIEEQLIAGRLDVGISFHPAHREEIEAEPLFEERLQLVVHAGHALARRRT
HHHHHHHCCCCCHHHHHHHHHCCCEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LRTRELAGVPLALLPRSFATRRMIDAAFAQAGVVPVVRVEMESVDALLHACRGGPLATIA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCEEHHH
AERAAGQAGPDMRAITLTEPATVRRAGVLWRRGASRSAAAREFVARLRPIVGATATAARR
HHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHCC
PAACRTMR
CCHHCCCC
>Mature Secondary Structure
MELRQLRYFLSVAETEHLTQSADALFVTQSTLSHGLRQLEAELGLPLFDRLGRGLKLSQA
CCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHCCCCCEEHHH
GMAFRSHAARALQELEAGRMALADMAGLQAGTLTVGVIPTFLTHLVPDAVAAFSADYPGV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
QVVVRDLRGGPIEEQLIAGRLDVGISFHPAHREEIEAEPLFEERLQLVVHAGHALARRRT
HHHHHHHCCCCCHHHHHHHHHCCCEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LRTRELAGVPLALLPRSFATRRMIDAAFAQAGVVPVVRVEMESVDALLHACRGGPLATIA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCEEHHH
AERAAGQAGPDMRAITLTEPATVRRAGVLWRRGASRSAAAREFVARLRPIVGATATAARR
HHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHCC
PAACRTMR
CCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]