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The map label for this gene is cat1 [H]

Identifier: 120608809

GI number: 120608809

Start: 104393

End: 105916

Strand: Reverse

Name: cat1 [H]

Synonym: Aave_0100

Alternate gene names: 120608809

Gene position: 105916-104393 (Counterclockwise)

Preceding gene: 120608811

Following gene: 120608808

Centisome position: 1.98

GC content: 69.62

Gene sequence:

>1524_bases
ATGTCCTCTCCCGAACCCTCCCGCATCCAATGCCCCGTCCTGCGGGACAAGCTCATGACGGCCGAGCAGGCCGCCGCCCT
GATTCCCAACGGCGCGCGCGTCGGCATGAGCGGCTTCACCGGCGCCGGCTACCCCAAGGTGGTCCCGCCCGCGCTCGCCG
CCCGCATCGAGACGCTGCACGCCGCGGGCGAGCCCTTCAGCATCGGCCTGTGGACGGGCGCCTCCACCGCGCCGGAACTC
GACGGCGCGCTCGCGAAGGTGGGCGGCGTGAACATGCGCATGCCCTACCAGTCCGACCCGACCTGCCGCGCGCAGATCAA
CGCGGGCAAGATGCAGTACGTGGACGCCCACCTCTCCCACGTGGCGCCGTACGTATGGTTCGGCTTCTGGGGCCGGCTCG
ACGTGGCGGTGATCGAGGTGGCCGGCGTGCTGCCCGACGGGCGGCTGATCCCGTCGTCCTCCGTGGGCAACAACAAGACC
TGGCTCGACCAGGCCGACAGGATCATCCTGGAGGTGAACGCATGGCAGCCCGAAGGGCTGGACGGCATGCACGACATCTA
CTACGGCACCGACCTGCCGCCCAACCGCGTGCCGATCCCGCTGGTCAAGCCCGGCGACCGCATCGGCGAACCCTACCTGC
GCTGCGACCCGGCCAAGGTGGTGGCCGTGGTGCCCACCCATTCGCCCGACCGCAACTCCGTCTTCAACCCGCCCGACGAC
ACCTCGCAGCGCATCGCGGGCCACATCATCGAGTTCCTGCAGCATGAAGTGCGTCACGGCCGGCTGCCGCCCACGCTGCT
GCCGCTGCAGTCGGGCGTGGGCAACATCGCCAACGCCGTGCTGGCGGGGCTGGACGCCGGCCCCTTCCAGCACCTCACGG
CCTACACCGAGGTGCTGCAGGACGGCATGCTGGACATGCTGCGCTCCGGCACGCTGGACAGTGCCTCGGCCACCGCCCTG
TCGCTGAGCCCCGCAGCCACCGAGGAATTCACCCGCAACATCGGCTTCTACCGCGAACGCATCGTGCTGCGCCCGCAGGA
GATCAGCAACCACCCCGAGCTGATCCGCCGGCTGGGCCTCATCTCGATGAACGGCATGATCGAGGCCGACATCTACGGCA
ACGTGAATTCCACGCACGTGATGGGCTCGTCCATCATGAACGGCATCGGCGGCTCGGGCGACTACGCGCGCAACGCGTAT
CTCTCGATCTTCATGACGCCGTCGCTGGCCAAGGGCGGCAGCATCTCGTGCATCGTGCCCATGGCCTCGCACGTGGACCA
CACCGAGCACGACGTGCAGATCCTCGTCACCGAACAGGGCCTGGCCGACCTGCGCGGCCTCTCGCCCTCGCAGCGCTCGG
AGGTGGTGATCGAACGCTGTGCCCACCCCGACTTCCGCCCCGCCCTGCGCGACTACGTGGCCCGCGCCCGCGCGAGCGGC
TGCGGCCTGCACACCCCGCACTTGCTGGGCGAGGCGCTGTCGTGGCATGAGCGATACGTGCGCACCGGCACCATGCGCGC
CTGA

Upstream 100 bases:

>100_bases
CAGCGGGGGGGCTGCCCGGGCAACGGCTCGGCCGTGCAGTGGCGCTAAGATTTTTGCATCCGCTTCCCCCGGCCCCTGCG
ACCCTCCACCCGGCTCTTCC

Downstream 100 bases:

>100_bases
AGGGGCGCGGGCAGTCCGGGAACGCCGGGATGTCACGGCCGGGCCTGCAGGAAAACCGGCGCCTCCCATAATCACCGGAT
CGCACCTGAAGGAGACATCG

Product: Acetyl-CoA hydrolase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MSSPEPSRIQCPVLRDKLMTAEQAAALIPNGARVGMSGFTGAGYPKVVPPALAARIETLHAAGEPFSIGLWTGASTAPEL
DGALAKVGGVNMRMPYQSDPTCRAQINAGKMQYVDAHLSHVAPYVWFGFWGRLDVAVIEVAGVLPDGRLIPSSSVGNNKT
WLDQADRIILEVNAWQPEGLDGMHDIYYGTDLPPNRVPIPLVKPGDRIGEPYLRCDPAKVVAVVPTHSPDRNSVFNPPDD
TSQRIAGHIIEFLQHEVRHGRLPPTLLPLQSGVGNIANAVLAGLDAGPFQHLTAYTEVLQDGMLDMLRSGTLDSASATAL
SLSPAATEEFTRNIGFYRERIVLRPQEISNHPELIRRLGLISMNGMIEADIYGNVNSTHVMGSSIMNGIGGSGDYARNAY
LSIFMTPSLAKGGSISCIVPMASHVDHTEHDVQILVTEQGLADLRGLSPSQRSEVVIERCAHPDFRPALRDYVARARASG
CGLHTPHLLGEALSWHERYVRTGTMRA

Sequences:

>Translated_507_residues
MSSPEPSRIQCPVLRDKLMTAEQAAALIPNGARVGMSGFTGAGYPKVVPPALAARIETLHAAGEPFSIGLWTGASTAPEL
DGALAKVGGVNMRMPYQSDPTCRAQINAGKMQYVDAHLSHVAPYVWFGFWGRLDVAVIEVAGVLPDGRLIPSSSVGNNKT
WLDQADRIILEVNAWQPEGLDGMHDIYYGTDLPPNRVPIPLVKPGDRIGEPYLRCDPAKVVAVVPTHSPDRNSVFNPPDD
TSQRIAGHIIEFLQHEVRHGRLPPTLLPLQSGVGNIANAVLAGLDAGPFQHLTAYTEVLQDGMLDMLRSGTLDSASATAL
SLSPAATEEFTRNIGFYRERIVLRPQEISNHPELIRRLGLISMNGMIEADIYGNVNSTHVMGSSIMNGIGGSGDYARNAY
LSIFMTPSLAKGGSISCIVPMASHVDHTEHDVQILVTEQGLADLRGLSPSQRSEVVIERCAHPDFRPALRDYVARARASG
CGLHTPHLLGEALSWHERYVRTGTMRA
>Mature_506_residues
SSPEPSRIQCPVLRDKLMTAEQAAALIPNGARVGMSGFTGAGYPKVVPPALAARIETLHAAGEPFSIGLWTGASTAPELD
GALAKVGGVNMRMPYQSDPTCRAQINAGKMQYVDAHLSHVAPYVWFGFWGRLDVAVIEVAGVLPDGRLIPSSSVGNNKTW
LDQADRIILEVNAWQPEGLDGMHDIYYGTDLPPNRVPIPLVKPGDRIGEPYLRCDPAKVVAVVPTHSPDRNSVFNPPDDT
SQRIAGHIIEFLQHEVRHGRLPPTLLPLQSGVGNIANAVLAGLDAGPFQHLTAYTEVLQDGMLDMLRSGTLDSASATALS
LSPAATEEFTRNIGFYRERIVLRPQEISNHPELIRRLGLISMNGMIEADIYGNVNSTHVMGSSIMNGIGGSGDYARNAYL
SIFMTPSLAKGGSISCIVPMASHVDHTEHDVQILVTEQGLADLRGLSPSQRSEVVIERCAHPDFRPALRDYVARARASGC
GLHTPHLLGEALSWHERYVRTGTMRA

Specific function: Forms succinyl-CoA from succinate and acetyl-CoA [H]

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=488, Percent_Identity=46.5163934426229, Blast_Score=446, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17538151, Length=474, Percent_Identity=25.1054852320675, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319456, Length=511, Percent_Identity=43.8356164383562, Blast_Score=412, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702
- InterPro:   IPR006472
- InterPro:   IPR017821 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro; PF04223 CitF [H]

EC number: NA

Molecular weight: Translated: 54766; Mature: 54635

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPEPSRIQCPVLRDKLMTAEQAAALIPNGARVGMSGFTGAGYPKVVPPALAARIETLH
CCCCCCCCEECHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHH
AAGEPFSIGLWTGASTAPELDGALAKVGGVNMRMPYQSDPTCRAQINAGKMQYVDAHLSH
HCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEECCCCCCCCEEEEECCCCEEHHHHHHHH
VAPYVWFGFWGRLDVAVIEVAGVLPDGRLIPSSSVGNNKTWLDQADRIILEVNAWQPEGL
HHHHHHHHHHCCHHEEEEEHHHCCCCCCCCCCCCCCCCCHHHHCCCEEEEEEECCCCCCC
DGMHDIYYGTDLPPNRVPIPLVKPGDRIGEPYLRCDPAKVVAVVPTHSPDRNSVFNPPDD
CCCHHHEECCCCCCCCCCCCEECCCHHHCCCCEEECCCEEEEEEECCCCCCCCCCCCCCC
TSQRIAGHIIEFLQHEVRHGRLPPTLLPLQSGVGNIANAVLAGLDAGPFQHLTAYTEVLQ
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DGMLDMLRSGTLDSASATALSLSPAATEEFTRNIGFYRERIVLRPQEISNHPELIRRLGL
HHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHEEECCHHHCCCHHHHHHHCC
ISMNGMIEADIYGNVNSTHVMGSSIMNGIGGSGDYARNAYLSIFMTPSLAKGGSISCIVP
EEECCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEE
MASHVDHTEHDVQILVTEQGLADLRGLSPSQRSEVVIERCAHPDFRPALRDYVARARASG
CHHCCCCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
CGLHTPHLLGEALSWHERYVRTGTMRA
CCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SSPEPSRIQCPVLRDKLMTAEQAAALIPNGARVGMSGFTGAGYPKVVPPALAARIETLH
CCCCCCCEECHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHH
AAGEPFSIGLWTGASTAPELDGALAKVGGVNMRMPYQSDPTCRAQINAGKMQYVDAHLSH
HCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEECCCCCCCCEEEEECCCCEEHHHHHHHH
VAPYVWFGFWGRLDVAVIEVAGVLPDGRLIPSSSVGNNKTWLDQADRIILEVNAWQPEGL
HHHHHHHHHHCCHHEEEEEHHHCCCCCCCCCCCCCCCCCHHHHCCCEEEEEEECCCCCCC
DGMHDIYYGTDLPPNRVPIPLVKPGDRIGEPYLRCDPAKVVAVVPTHSPDRNSVFNPPDD
CCCHHHEECCCCCCCCCCCCEECCCHHHCCCCEEECCCEEEEEEECCCCCCCCCCCCCCC
TSQRIAGHIIEFLQHEVRHGRLPPTLLPLQSGVGNIANAVLAGLDAGPFQHLTAYTEVLQ
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DGMLDMLRSGTLDSASATALSLSPAATEEFTRNIGFYRERIVLRPQEISNHPELIRRLGL
HHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHEEECCHHHCCCHHHHHHHCC
ISMNGMIEADIYGNVNSTHVMGSSIMNGIGGSGDYARNAYLSIFMTPSLAKGGSISCIVP
EEECCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEE
MASHVDHTEHDVQILVTEQGLADLRGLSPSQRSEVVIERCAHPDFRPALRDYVARARASG
CHHCCCCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
CGLHTPHLLGEALSWHERYVRTGTMRA
CCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]