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The map label for this gene is uraA [H]

Identifier: 120599140

GI number: 120599140

Start: 2690799

End: 2692037

Strand: Direct

Name: uraA [H]

Synonym: Sputw3181_2336

Alternate gene names: 120599140

Gene position: 2690799-2692037 (Clockwise)

Preceding gene: 120599137

Following gene: 120599142

Centisome position: 57.15

GC content: 46.49

Gene sequence:

>1239_bases
ATGAGACGACTCACCATCCCCCTACAGGGTGCACAAATGCTATTTGTAGCTTTTGGTGCCTTAGTATTGATGCCACTACT
GACTGGGCTAGACACCAGTGTCGCCCTATTCACTGCAGGTATCGGTACGCTACTGTTCCAATTGATTACTAAACGTCAAG
TGCCTATCTTCCTTGCTTCTTCCTTCGCTTTTATTGCCCCCATTCTTTATGGTGTGCAAACTTGGGGGATACCATCCACC
ATGGGAGGGATCATGGCAGCAGGTGTCGTTTATGTGCTGCTCGGTGCCCTAGTTAAAGTACGGGGTACCGACTTTATCCA
TAAGCTATTACCGCCTGTGGTAGTTGGTCCAGTGATCATTATTATCGGTCTTGGATTAGCCCCAGTTGCCGTTAATATGG
CATTAGGTAAGAGTGGCGATGGTAGCTTGACGTTAGTTGCCACCAATACTGCGTTATTTATTTCGCTTGCATCGCTTTGT
ACTACGATCGCCGTGGCAATTTTTGCGAAAGGATTACTGAAGGTAATGCCGATTTTAGCTGGTATTGTCGTAGGTTACGG
CTTAAGTCTTGCCTTTGGTATTGTTGATTTTGCCGTAGTGACTGCTGCAAGTTGGATTGCCATTCCTAAATTTGTCGCGC
CAGAATTTAACTGGCATGCCATCGCCTTTATGATCCCTGTCGCCATTGCACCTGCGGTTGAACATATTGGTGATATTTTG
GCAATATCCAATGTCACTGGTAAGGATTTCATGAAAAAACCAGGCCTTCATCGCACACTAACCGGCGATGGCGTAGCAAC
TATCGCTGCAGCCGCCTTTGGTGGACCGCCTAATACTACCTATTCAGAAGTCACAGGCGCAGTCACATTAACCCGTAACT
TTGATCCTAAAATCATGACTTGGACCGCGATTACTGCCATTACCTTAGCTTTCGTTGGTAAGCTAGGTGCACTCATGCAG
ACAATTCCGGTTCCTGTTATGGGCGGCATTATGTGTTTACTCTTTGGGTCTATCGCGGCAGTGGGCCTCAATACCTTGAT
CCGCAATCATGTGGATTTATCAGAGGCTCGCAATTTAAGTATTGTTGGCGTAACACTCGTATTTGGTATTGGAGGGATGG
CATTTGGTATTGGCTCATTCAGTTTAACTGGGATCAGTTTGTGCGGTATTGTGGCCATCACAATGAACTTACTCTTACCC
GCGACTAAACATCACGAACGTGATGCGGCATCACACTAA

Upstream 100 bases:

>100_bases
AACAGTGATCCACCCCCATAAAAGTGAACATTTTATTCTGTCTGGATTTCAACAAACTGATATCATCTGGCGGTTTACCC
TAAATTAACGAGAATAATAA

Downstream 100 bases:

>100_bases
GTTCCGCCTTTAAATCAGTCAAAATTTGGCAATAAAAAAGCCGATAAGTCATCAGCTTAGCGGCTTTTTGTTATTCTTTC
ATCACTCTGTTACGAGGGAT

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MRRLTIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLASSFAFIAPILYGVQTWGIPST
MGGIMAAGVVYVLLGALVKVRGTDFIHKLLPPVVVGPVIIIIGLGLAPVAVNMALGKSGDGSLTLVATNTALFISLASLC
TTIAVAIFAKGLLKVMPILAGIVVGYGLSLAFGIVDFAVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
AISNVTGKDFMKKPGLHRTLTGDGVATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMTWTAITAITLAFVGKLGALMQ
TIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEARNLSIVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLP
ATKHHERDAASH

Sequences:

>Translated_412_residues
MRRLTIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLASSFAFIAPILYGVQTWGIPST
MGGIMAAGVVYVLLGALVKVRGTDFIHKLLPPVVVGPVIIIIGLGLAPVAVNMALGKSGDGSLTLVATNTALFISLASLC
TTIAVAIFAKGLLKVMPILAGIVVGYGLSLAFGIVDFAVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
AISNVTGKDFMKKPGLHRTLTGDGVATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMTWTAITAITLAFVGKLGALMQ
TIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEARNLSIVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLP
ATKHHERDAASH
>Mature_412_residues
MRRLTIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLASSFAFIAPILYGVQTWGIPST
MGGIMAAGVVYVLLGALVKVRGTDFIHKLLPPVVVGPVIIIIGLGLAPVAVNMALGKSGDGSLTLVATNTALFISLASLC
TTIAVAIFAKGLLKVMPILAGIVVGYGLSLAFGIVDFAVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
AISNVTGKDFMKKPGLHRTLTGDGVATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMTWTAITAITLAFVGKLGALMQ
TIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEARNLSIVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLP
ATKHHERDAASH

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=387, Percent_Identity=25.3229974160207, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI44680143, Length=391, Percent_Identity=25.0639386189258, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI44680148, Length=393, Percent_Identity=24.9363867684478, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI40316845, Length=393, Percent_Identity=24.9363867684478, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1788843, Length=394, Percent_Identity=39.5939086294416, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI87081818, Length=421, Percent_Identity=37.5296912114014, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI87082181, Length=425, Percent_Identity=28, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790087, Length=370, Percent_Identity=24.3243243243243, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082178, Length=322, Percent_Identity=26.7080745341615, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=180, Percent_Identity=27.2222222222222, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356175, Length=392, Percent_Identity=25.5102040816327, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 42654; Mature: 42654

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLTIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLAS
CCEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHH
SFAFIAPILYGVQTWGIPSTMGGIMAAGVVYVLLGALVKVRGTDFIHKLLPPVVVGPVII
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHH
IIGLGLAPVAVNMALGKSGDGSLTLVATNTALFISLASLCTTIAVAIFAKGLLKVMPILA
HHHCCHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIVVGYGLSLAFGIVDFAVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AISNVTGKDFMKKPGLHRTLTGDGVATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMT
HCCCCCCHHHHHCCCCCEEECCCCHHHHHHHHCCCCCCCCHHHHCCEEEEEECCCCCEEH
WTAITAITLAFVGKLGALMQTIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEARNLS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCE
IVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLPATKHHERDAASH
EEHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCC
>Mature Secondary Structure
MRRLTIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLAS
CCEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHH
SFAFIAPILYGVQTWGIPSTMGGIMAAGVVYVLLGALVKVRGTDFIHKLLPPVVVGPVII
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHH
IIGLGLAPVAVNMALGKSGDGSLTLVATNTALFISLASLCTTIAVAIFAKGLLKVMPILA
HHHCCHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIVVGYGLSLAFGIVDFAVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AISNVTGKDFMKKPGLHRTLTGDGVATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMT
HCCCCCCHHHHHCCCCCEEECCCCHHHHHHHHCCCCCCCCHHHHCCEEEEEECCCCCEEH
WTAITAITLAFVGKLGALMQTIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEARNLS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCE
IVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLPATKHHERDAASH
EEHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]