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The map label for this gene is csrD [H]

Identifier: 120598966

GI number: 120598966

Start: 2487294

End: 2489198

Strand: Direct

Name: csrD [H]

Synonym: Sputw3181_2158

Alternate gene names: 120598966

Gene position: 2487294-2489198 (Clockwise)

Preceding gene: 120598964

Following gene: 120598967

Centisome position: 52.83

GC content: 41.05

Gene sequence:

>1905_bases
ATGACCATGTCAAAATCATATCCAGTCTTTTTATTACTGATCTTTTTAGCATTATTTGCTGGCGTTTTTCAAAATGAAAA
TAGCCAATTGCAAATCCAGCAGCAACAAGAGCTCGAACGCTTCAAAAGGGATTTAACGGCTTACTCCCAATGGCAAGGCA
GTGGTAAAGATCTTTTTAACGCCTTATCAATCAAGTATCCATTTCAATTTTTTCAGTATATTAATGATACTGATGGTGAG
CTAAATCATACCGAAGGTAGCCTTACATCTGACAATGCACATCCATTGGCTGGATTATTCTCCGTCGATTTATCCCATAC
CCAGAAATTAGCCACAGGCCGATTGCAGGTCAAACTCAGTGCGAACGCACAAATAGCTCAATCTATCTCAAATACAGAAA
AACTCGGGTTAATGTTGTTGCTGAGCTTCATCATTCTGCTGGCCATTTTTACGTTTTTAATGGCAAAACTCAAAACGTCG
ATTCAATATGCCGCCGATTATGTCTCACATATTTCCGATATGAGCTTTTCCGCACTCGCCGCCTCTAAACTCAATGGCGA
ATTAAATCCGCTTAAGCAGGCATTAGAAGATTGCCGTCATCAGCTTAAAGTACAGCTTGACACTCTCACACAAGAAAATG
AGAAACTGCATAAAGTCGCCTATCAGGATCCAATTACCGGCTTTGCTAGTCGACCACGCTTCACAAATAAACTTGAAACC
ATCAATAATCCTGATATCCCTCAATTTGGATTGATGGTCATGGTTAAAGCAACCGAACTTGCCAATATCAATCAACACCA
AGGACGTTCTGCGGGAGATGATTATTTAGCCCGAGTAGCCAACTGTATCCGTAAAACCTGTACTAAATACCCTGACGCAC
AATGTTACCGAGTGTCCAGCGCTGATTTTGCCGTATTTATACCAGATACAGTGCTTAAAGATGGGCCAAAATTTTTAGAT
GAGTTAAAAGTGTATCTTGATGAATATCAGCAAATGACCAAAACGGAATCTGTTGCTCATATAGGTTTAGTCCCCTATCA
ACAGGGTGTAGAGGCTATTCATTTACTGACCCTTGCCGATACGGCGGTCAGTATTGCACAAACATTGGGCCCTAATAGTT
ACCATATTCAAGAAAAACTCGATGGTAATGAGCAATTTGGTGATGATCGTTGGAAACTTGCCATCCATGACTTAATTAGT
CGTAAGGCTCTTAAATTCTATCAACAACCCATCCAACCCTGCCGCACTGAAGTCGAGGTTTACCGCGAACTGTTAGCCCG
TTTTTATAACAGTGAAGGTAAGTTTCTGCCGACAACCACTGTGATTGCTATGGCTGAGCGCCATGGAATGAGCACAGAGT
TAGATAAATTAGTGGTGATCAGTGCATTAAAGATGCTTAAGGAAAATCCAACCATCAATGGCAATTTTGGGGTAAACATT
AGTGCTTTTTCAGCCCACCAAGAACTCTTTGTCGGGTGGCTAAAAGATATTTTAGGCAAACAAAAATATATTGCTTCTCG
CTTAGTATTTGAGATTAACGAATCAGGTATGCAATCCAATTTAGGCGCAAGCCACAAGTTTGTGCGTGACGTGCATAGCG
TGGGTTCTCGAGTCTCTATTGAGCGTTTTGGCATGAGCTTCACTTCCTTTAAATTCTTCAGTGAGGTACGCCCCGACTAC
ATTAAGCTTGATGGTAGCTACACTTCAAATATCGATGAAGATAACAATAATAAATTTTTCGTTCGTATGATGGTCGACGT
GGCAAGGCGAATAGGTATCAGAGTGATTGCAACCAGTGTTGAGCGACAAGAAGAAAAACTGACCCTAGAAAAACTCTTAG
TCGATGGTCTTCAAGGCTATTATATTGCTCAGCCCCAAGCGATCACTAGCAGAGATCAAATTTAG

Upstream 100 bases:

>100_bases
TTAAATAAAATAATGAGCATCTTCACACAGAGTATGGTGTTGAACAAAAACTCACCCAATAGACTGTTGCAAGACTCGCC
TGAAGTGAGAGCGGATTTAT

Downstream 100 bases:

>100_bases
TTAAGATATCGGTGAATTCATCAGCATTCTTTACAGTAAAGATGCTTAACCCTGCATTCTATATGTTGTTTATGCAAACG
GAAAAGTCGATAATACGGCC

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MTMSKSYPVFLLLIFLALFAGVFQNENSQLQIQQQQELERFKRDLTAYSQWQGSGKDLFNALSIKYPFQFFQYINDTDGE
LNHTEGSLTSDNAHPLAGLFSVDLSHTQKLATGRLQVKLSANAQIAQSISNTEKLGLMLLLSFIILLAIFTFLMAKLKTS
IQYAADYVSHISDMSFSALAASKLNGELNPLKQALEDCRHQLKVQLDTLTQENEKLHKVAYQDPITGFASRPRFTNKLET
INNPDIPQFGLMVMVKATELANINQHQGRSAGDDYLARVANCIRKTCTKYPDAQCYRVSSADFAVFIPDTVLKDGPKFLD
ELKVYLDEYQQMTKTESVAHIGLVPYQQGVEAIHLLTLADTAVSIAQTLGPNSYHIQEKLDGNEQFGDDRWKLAIHDLIS
RKALKFYQQPIQPCRTEVEVYRELLARFYNSEGKFLPTTTVIAMAERHGMSTELDKLVVISALKMLKENPTINGNFGVNI
SAFSAHQELFVGWLKDILGKQKYIASRLVFEINESGMQSNLGASHKFVRDVHSVGSRVSIERFGMSFTSFKFFSEVRPDY
IKLDGSYTSNIDEDNNNKFFVRMMVDVARRIGIRVIATSVERQEEKLTLEKLLVDGLQGYYIAQPQAITSRDQI

Sequences:

>Translated_634_residues
MTMSKSYPVFLLLIFLALFAGVFQNENSQLQIQQQQELERFKRDLTAYSQWQGSGKDLFNALSIKYPFQFFQYINDTDGE
LNHTEGSLTSDNAHPLAGLFSVDLSHTQKLATGRLQVKLSANAQIAQSISNTEKLGLMLLLSFIILLAIFTFLMAKLKTS
IQYAADYVSHISDMSFSALAASKLNGELNPLKQALEDCRHQLKVQLDTLTQENEKLHKVAYQDPITGFASRPRFTNKLET
INNPDIPQFGLMVMVKATELANINQHQGRSAGDDYLARVANCIRKTCTKYPDAQCYRVSSADFAVFIPDTVLKDGPKFLD
ELKVYLDEYQQMTKTESVAHIGLVPYQQGVEAIHLLTLADTAVSIAQTLGPNSYHIQEKLDGNEQFGDDRWKLAIHDLIS
RKALKFYQQPIQPCRTEVEVYRELLARFYNSEGKFLPTTTVIAMAERHGMSTELDKLVVISALKMLKENPTINGNFGVNI
SAFSAHQELFVGWLKDILGKQKYIASRLVFEINESGMQSNLGASHKFVRDVHSVGSRVSIERFGMSFTSFKFFSEVRPDY
IKLDGSYTSNIDEDNNNKFFVRMMVDVARRIGIRVIATSVERQEEKLTLEKLLVDGLQGYYIAQPQAITSRDQI
>Mature_633_residues
TMSKSYPVFLLLIFLALFAGVFQNENSQLQIQQQQELERFKRDLTAYSQWQGSGKDLFNALSIKYPFQFFQYINDTDGEL
NHTEGSLTSDNAHPLAGLFSVDLSHTQKLATGRLQVKLSANAQIAQSISNTEKLGLMLLLSFIILLAIFTFLMAKLKTSI
QYAADYVSHISDMSFSALAASKLNGELNPLKQALEDCRHQLKVQLDTLTQENEKLHKVAYQDPITGFASRPRFTNKLETI
NNPDIPQFGLMVMVKATELANINQHQGRSAGDDYLARVANCIRKTCTKYPDAQCYRVSSADFAVFIPDTVLKDGPKFLDE
LKVYLDEYQQMTKTESVAHIGLVPYQQGVEAIHLLTLADTAVSIAQTLGPNSYHIQEKLDGNEQFGDDRWKLAIHDLISR
KALKFYQQPIQPCRTEVEVYRELLARFYNSEGKFLPTTTVIAMAERHGMSTELDKLVVISALKMLKENPTINGNFGVNIS
AFSAHQELFVGWLKDILGKQKYIASRLVFEINESGMQSNLGASHKFVRDVHSVGSRVSIERFGMSFTSFKFFSEVRPDYI
KLDGSYTSNIDEDNNNKFFVRMMVDVARRIGIRVIATSVERQEEKLTLEKLLVDGLQGYYIAQPQAITSRDQI

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=456, Percent_Identity=24.1228070175439, Blast_Score=147, Evalue=3e-36,
Organism=Escherichia coli, GI1788849, Length=224, Percent_Identity=27.6785714285714, Blast_Score=97, Evalue=5e-21,
Organism=Escherichia coli, GI87082096, Length=232, Percent_Identity=29.3103448275862, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1787541, Length=425, Percent_Identity=25.1764705882353, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI87081980, Length=234, Percent_Identity=25.6410256410256, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI87081921, Length=432, Percent_Identity=21.5277777777778, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1787055, Length=230, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788502, Length=231, Percent_Identity=24.6753246753247, Blast_Score=73, Evalue=7e-14,
Organism=Escherichia coli, GI1790496, Length=228, Percent_Identity=20.6140350877193, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87081845, Length=252, Percent_Identity=25, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786507, Length=245, Percent_Identity=23.6734693877551, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 71631; Mature: 71500

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMSKSYPVFLLLIFLALFAGVFQNENSQLQIQQQQELERFKRDLTAYSQWQGSGKDLFN
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ALSIKYPFQFFQYINDTDGELNHTEGSLTSDNAHPLAGLFSVDLSHTQKLATGRLQVKLS
HHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEC
ANAQIAQSISNTEKLGLMLLLSFIILLAIFTFLMAKLKTSIQYAADYVSHISDMSFSALA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ASKLNGELNPLKQALEDCRHQLKVQLDTLTQENEKLHKVAYQDPITGFASRPRFTNKLET
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHC
INNPDIPQFGLMVMVKATELANINQHQGRSAGDDYLARVANCIRKTCTKYPDAQCYRVSS
CCCCCCCCCCCEEEEEHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECC
ADFAVFIPDTVLKDGPKFLDELKVYLDEYQQMTKTESVAHIGLVPYQQGVEAIHLLTLAD
CCEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHCHHHHHHHHHHH
TAVSIAQTLGPNSYHIQEKLDGNEQFGDDRWKLAIHDLISRKALKFYQQPIQPCRTEVEV
HHHHHHHHCCCCCEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRELLARFYNSEGKFLPTTTVIAMAERHGMSTELDKLVVISALKMLKENPTINGNFGVNI
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
SAFSAHQELFVGWLKDILGKQKYIASRLVFEINESGMQSNLGASHKFVRDVHSVGSRVSI
EEHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEH
ERFGMSFTSFKFFSEVRPDYIKLDGSYTSNIDEDNNNKFFVRMMVDVARRIGIRVIATSV
HHHCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEEHHHHHHHHHCCCEEEEHHH
ERQEEKLTLEKLLVDGLQGYYIAQPQAITSRDQI
HHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
TMSKSYPVFLLLIFLALFAGVFQNENSQLQIQQQQELERFKRDLTAYSQWQGSGKDLFN
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ALSIKYPFQFFQYINDTDGELNHTEGSLTSDNAHPLAGLFSVDLSHTQKLATGRLQVKLS
HHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEC
ANAQIAQSISNTEKLGLMLLLSFIILLAIFTFLMAKLKTSIQYAADYVSHISDMSFSALA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ASKLNGELNPLKQALEDCRHQLKVQLDTLTQENEKLHKVAYQDPITGFASRPRFTNKLET
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHC
INNPDIPQFGLMVMVKATELANINQHQGRSAGDDYLARVANCIRKTCTKYPDAQCYRVSS
CCCCCCCCCCCEEEEEHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECC
ADFAVFIPDTVLKDGPKFLDELKVYLDEYQQMTKTESVAHIGLVPYQQGVEAIHLLTLAD
CCEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHCHHHHHHHHHHH
TAVSIAQTLGPNSYHIQEKLDGNEQFGDDRWKLAIHDLISRKALKFYQQPIQPCRTEVEV
HHHHHHHHCCCCCEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRELLARFYNSEGKFLPTTTVIAMAERHGMSTELDKLVVISALKMLKENPTINGNFGVNI
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
SAFSAHQELFVGWLKDILGKQKYIASRLVFEINESGMQSNLGASHKFVRDVHSVGSRVSI
EEHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEH
ERFGMSFTSFKFFSEVRPDYIKLDGSYTSNIDEDNNNKFFVRMMVDVARRIGIRVIATSV
HHHCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEEHHHHHHHHHCCCEEEEHHH
ERQEEKLTLEKLLVDGLQGYYIAQPQAITSRDQI
HHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]