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The map label for this gene is copA [H]

Identifier: 120598860

GI number: 120598860

Start: 2360597

End: 2362996

Strand: Direct

Name: copA [H]

Synonym: Sputw3181_2051

Alternate gene names: 120598860

Gene position: 2360597-2362996 (Clockwise)

Preceding gene: 120598859

Following gene: 120598861

Centisome position: 50.14

GC content: 44.12

Gene sequence:

>2400_bases
ATGACACATCCAAGTTGTTTCCATTGTAATGAGCCCGTACTCACGGGCCAGCAGTTTATTACCCGTATAAATGATCGCGA
TGAGCTAATGTGCTGTCCCGGTTGTCAAGCGGTGTCACAGGCGATTGTTGATGCAGGATTGCTCAGTTATTACAAGTTTC
GAACTGAACCTGGAAATAAGCAAACAGCCCTTGTTCCTGATGCATTAAACCAATTTAGTGCTTACGATTTACCTGAAGTA
CAGCAAGATTTTGTGCATTCTGAAGAGAATATTGAATCAGTATCGCTGTCAATTGATGGTATCACCTGCGCGGCTTGTGC
TTGGTTAATAGAACACAAAGTCAAACAACTGTCTGGTATAACACAAGTACTTGTCAATTCGACAACTCAAAGAGCCATGA
TCAGTTGGGATAAACATAAAATAAAACTCAGCGATATCCTCGCCCAAATTAGTCGCATTGGCTATCAAGCAGCTCCTTAT
CAAGTTGATGAACAAGAACGCAGCAGCCAACAAAATAGCCGTAAATTTTTACTGCGTTTAGGGTTAGCCGGTTTTGCTAC
AATGCAAGTCATGATGTTTGCTCTTGCCTTGTATACGGGCTATTTCACTGACTTAGATGTGCAATATCGCGATTATTTCC
GCTGGGTTAGTATGATTTTTGCGACCCCAGTTGTGCTCTATTCTGCTCAACCTTTTTATTTTAGCGCCATTCGTACCCTA
CTTAGTGGCAAGCTCAATATGGATGTATCTGTCTCCATCGCCATTGGTGGTGCCTATACTGCAAGCTGTTTTGCCACAGT
GAATGGCACCGGCGAAGTGTATTTTGAATCCGTATCTATGTTTACCTTCTTCTTATTGTTGGGGCGTTATTTTGAGCAGA
AAGCTAGACAAAAGGCTTCAGTTAGTTCCAGTAACTTACACAAACTAGTCCCACTGACAGCACATCTTGTTACAGAGCAA
GGCCAAGAAGAAATCCCCGCCAAAAAGTTACGCCTCAATGATGTGATCCTTGTGAAACCGGGGGAAATGGTCGCTGCCGA
TGGTGTGGTGGTTGGCGGCCACACGAGTATCAATGAGGCCATGCTTACTGGTGAGCAAATGCCAATTGAAAAAAATATTG
ATAATCAAGTCTATGCGGGAACGATTAATATCGACCAACCCATCACAGTGAAGGTGTCTGCACTTGGACAAGATCAATTG
GTTGCTGAGATTATTCGCCTACAAGAGCTTGCTTCTAATACTAAGCCGGCGGTTGCATTACTTGCTGATAAGTTATCACG
TTACTTTTCTGGCACCATTCTTTCTATCGCCACTATTACCTACTTAGTGTGGCATCAGATCTCCCCTGATGATGCCTTTT
GGGTCACGCTGTCTGTGCTCGTTGCGACTTGTCCGTGCGCTTTGGCCCTGGCAACCCCTACAGCCGTTACCTGTGCTACC
GCTATTTTTACCCGTCTTGGGATCATTACCCGCAAAGCCGGAGTATTCGAAAAACTCCCACTGATTAAGCATGTTGTTTT
CGATAAAACAGGCACCCTCACCTGTGGCACGTTATCTATTGGTCAAGTTGAATGTCTTGCAGATAGTGATCAGAACCGCG
TTCTTGCTATCGCCGCAGCATTAGAAGCTGGTTCTCGTCACCCAATTGCTGCCGCGTTTGCCGTATTTGCTGAGCCTACT
CTCACAGCAGAACAAGTACACCACACTGTGGGGTTTGGTATACAAGGTTCGATTGATGGTATTGAGTATCGTATTGGCAA
CGCATTGTTTACCGATGCTCATATCAGCAGCACTAACCCGATACAACAAATTTGGTTAGCGCGATTGAACGATGGAAAAT
ATGACTTAATTGCCAGTTTTGAAATTAAAGACAATATCCGCGTTGACAGTAAAACAACGGTTGAACAGTTAAAGAGACAG
GGTTGCAGTGTTAGCATTGCCAGTGGTGATCATTCTGGTCACGTATATCAACTGGCAAAAGAGTTAGGGATTGAAGACGT
TCATAGTGGTTTAACACCAGCAGATAAGCTTGCTTTAGTAACTGAACTCCAAAAAACCTCAACAGTTGCCATGTTTGGGG
ATGGCATTAACGATGCTCCAGTACTTGCTGGTGCTGATCTATCTGTTGCTATGGGCAGTGGCAGTGCGATTGCTAAAAAC
AGTGCAGATTTGATCCTACTTGGGGATCACCTTTCTCGCTTCACCCAAGCTGTCTCGGTCGCCAAACTGACCACGCAAAT
CATTAAACAAAATCTCGCTTGGGCTTTAGGATATAACGCACTTATTTTGCCGTTAGCTGTTACAGGCCATGTGGCACCTT
ATATTGCCGCAATAGGCATGTCAGCAAGTTCTTTAATTGTTGTTGGTAATAGTTTGAGATTATTACGCGTAAAAGTGTGA

Upstream 100 bases:

>100_bases
CTCGAGGGCTACGATGGCAAATGGCGAATTCACCAACGTGTTGAATTAAAAGATAGTATCCAGTTGTGGTTGAATTAGTT
GTAGTTGAATAAGAATTGTT

Downstream 100 bases:

>100_bases
TCATCATAGACAGTTTAATCGGAATAGTAAGAGGTCATTATGGAAATTATTTATGTGCTTATCCCCATTGCCATGATCTT
TGTCGCCATCGCTGTAATGG

Product: heavy metal translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 799; Mature: 798

Protein sequence:

>799_residues
MTHPSCFHCNEPVLTGQQFITRINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTEPGNKQTALVPDALNQFSAYDLPEV
QQDFVHSEENIESVSLSIDGITCAACAWLIEHKVKQLSGITQVLVNSTTQRAMISWDKHKIKLSDILAQISRIGYQAAPY
QVDEQERSSQQNSRKFLLRLGLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMIFATPVVLYSAQPFYFSAIRTL
LSGKLNMDVSVSIAIGGAYTASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKARQKASVSSSNLHKLVPLTAHLVTEQ
GQEEIPAKKLRLNDVILVKPGEMVAADGVVVGGHTSINEAMLTGEQMPIEKNIDNQVYAGTINIDQPITVKVSALGQDQL
VAEIIRLQELASNTKPAVALLADKLSRYFSGTILSIATITYLVWHQISPDDAFWVTLSVLVATCPCALALATPTAVTCAT
AIFTRLGIITRKAGVFEKLPLIKHVVFDKTGTLTCGTLSIGQVECLADSDQNRVLAIAAALEAGSRHPIAAAFAVFAEPT
LTAEQVHHTVGFGIQGSIDGIEYRIGNALFTDAHISSTNPIQQIWLARLNDGKYDLIASFEIKDNIRVDSKTTVEQLKRQ
GCSVSIASGDHSGHVYQLAKELGIEDVHSGLTPADKLALVTELQKTSTVAMFGDGINDAPVLAGADLSVAMGSGSAIAKN
SADLILLGDHLSRFTQAVSVAKLTTQIIKQNLAWALGYNALILPLAVTGHVAPYIAAIGMSASSLIVVGNSLRLLRVKV

Sequences:

>Translated_799_residues
MTHPSCFHCNEPVLTGQQFITRINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTEPGNKQTALVPDALNQFSAYDLPEV
QQDFVHSEENIESVSLSIDGITCAACAWLIEHKVKQLSGITQVLVNSTTQRAMISWDKHKIKLSDILAQISRIGYQAAPY
QVDEQERSSQQNSRKFLLRLGLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMIFATPVVLYSAQPFYFSAIRTL
LSGKLNMDVSVSIAIGGAYTASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKARQKASVSSSNLHKLVPLTAHLVTEQ
GQEEIPAKKLRLNDVILVKPGEMVAADGVVVGGHTSINEAMLTGEQMPIEKNIDNQVYAGTINIDQPITVKVSALGQDQL
VAEIIRLQELASNTKPAVALLADKLSRYFSGTILSIATITYLVWHQISPDDAFWVTLSVLVATCPCALALATPTAVTCAT
AIFTRLGIITRKAGVFEKLPLIKHVVFDKTGTLTCGTLSIGQVECLADSDQNRVLAIAAALEAGSRHPIAAAFAVFAEPT
LTAEQVHHTVGFGIQGSIDGIEYRIGNALFTDAHISSTNPIQQIWLARLNDGKYDLIASFEIKDNIRVDSKTTVEQLKRQ
GCSVSIASGDHSGHVYQLAKELGIEDVHSGLTPADKLALVTELQKTSTVAMFGDGINDAPVLAGADLSVAMGSGSAIAKN
SADLILLGDHLSRFTQAVSVAKLTTQIIKQNLAWALGYNALILPLAVTGHVAPYIAAIGMSASSLIVVGNSLRLLRVKV
>Mature_798_residues
THPSCFHCNEPVLTGQQFITRINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTEPGNKQTALVPDALNQFSAYDLPEVQ
QDFVHSEENIESVSLSIDGITCAACAWLIEHKVKQLSGITQVLVNSTTQRAMISWDKHKIKLSDILAQISRIGYQAAPYQ
VDEQERSSQQNSRKFLLRLGLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMIFATPVVLYSAQPFYFSAIRTLL
SGKLNMDVSVSIAIGGAYTASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKARQKASVSSSNLHKLVPLTAHLVTEQG
QEEIPAKKLRLNDVILVKPGEMVAADGVVVGGHTSINEAMLTGEQMPIEKNIDNQVYAGTINIDQPITVKVSALGQDQLV
AEIIRLQELASNTKPAVALLADKLSRYFSGTILSIATITYLVWHQISPDDAFWVTLSVLVATCPCALALATPTAVTCATA
IFTRLGIITRKAGVFEKLPLIKHVVFDKTGTLTCGTLSIGQVECLADSDQNRVLAIAAALEAGSRHPIAAAFAVFAEPTL
TAEQVHHTVGFGIQGSIDGIEYRIGNALFTDAHISSTNPIQQIWLARLNDGKYDLIASFEIKDNIRVDSKTTVEQLKRQG
CSVSIASGDHSGHVYQLAKELGIEDVHSGLTPADKLALVTELQKTSTVAMFGDGINDAPVLAGADLSVAMGSGSAIAKNS
ADLILLGDHLSRFTQAVSVAKLTTQIIKQNLAWALGYNALILPLAVTGHVAPYIAAIGMSASSLIVVGNSLRLLRVKV

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=793, Percent_Identity=29.0037831021438, Blast_Score=291, Evalue=2e-78,
Organism=Homo sapiens, GI115529486, Length=810, Percent_Identity=27.5308641975309, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI55743073, Length=595, Percent_Identity=28.0672268907563, Blast_Score=196, Evalue=1e-49,
Organism=Homo sapiens, GI51944966, Length=169, Percent_Identity=31.9526627218935, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI83700225, Length=134, Percent_Identity=34.3283582089552, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI297374799, Length=134, Percent_Identity=34.3283582089552, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1786691, Length=747, Percent_Identity=30.5220883534137, Blast_Score=313, Evalue=4e-86,
Organism=Escherichia coli, GI1789879, Length=734, Percent_Identity=31.3351498637602, Blast_Score=282, Evalue=8e-77,
Organism=Escherichia coli, GI1786914, Length=464, Percent_Identity=26.0775862068966, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17556548, Length=813, Percent_Identity=26.9372693726937, Blast_Score=220, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17557770, Length=194, Percent_Identity=26.8041237113402, Blast_Score=74, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17557486, Length=194, Percent_Identity=26.8041237113402, Blast_Score=74, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32566766, Length=194, Percent_Identity=26.8041237113402, Blast_Score=74, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320475, Length=741, Percent_Identity=27.5303643724696, Blast_Score=262, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6319772, Length=664, Percent_Identity=29.5180722891566, Blast_Score=254, Evalue=3e-68,
Organism=Drosophila melanogaster, GI221329854, Length=541, Percent_Identity=29.0203327171904, Blast_Score=200, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR001366
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 86523; Mature: 86392

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPSCFHCNEPVLTGQQFITRINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTEPGNK
CCCCCCCCCCCCCCCHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHEECCCCCC
QTALVPDALNQFSAYDLPEVQQDFVHSEENIESVSLSIDGITCAACAWLIEHKVKQLSGI
CEEECHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
TQVLVNSTTQRAMISWDKHKIKLSDILAQISRIGYQAAPYQVDEQERSSQQNSRKFLLRL
HHHHHCCCCHHHHEECCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMIFATPVVLYSAQPFYFSAIRTL
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHH
LSGKLNMDVSVSIAIGGAYTASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKARQKAS
HCCCCCCCEEEEEEECCCEEEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHC
VSSSNLHKLVPLTAHLVTEQGQEEIPAKKLRLNDVILVKPGEMVAADGVVVGGHTSINEA
CCCCCCHHHHHHHHHHHHCCCCHHCCHHHEEECCEEEECCCCEEEECCEEECCCCCCCHH
MLTGEQMPIEKNIDNQVYAGTINIDQPITVKVSALGQDQLVAEIIRLQELASNTKPAVAL
HHCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCHHHH
LADKLSRYFSGTILSIATITYLVWHQISPDDAFWVTLSVLVATCPCALALATPTAVTCAT
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHCCCHHHHHHH
AIFTRLGIITRKAGVFEKLPLIKHVVFDKTGTLTCGTLSIGQVECLADSDQNRVLAIAAA
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCEEEEEEE
LEAGSRHPIAAAFAVFAEPTLTAEQVHHTVGFGIQGSIDGIEYRIGNALFTDAHISSTNP
HHCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCEEEECCCCCCCCH
IQQIWLARLNDGKYDLIASFEIKDNIRVDSKTTVEQLKRQGCSVSIASGDHSGHVYQLAK
HHHHHHHHCCCCCEEEEEEEEECCCCEECCHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
ELGIEDVHSGLTPADKLALVTELQKTSTVAMFGDGINDAPVLAGADLSVAMGSGSAIAKN
HCCHHHHHCCCCCHHHHHHHHHHHHHCEEEEECCCCCCCCEEECCCCEEEECCCCEEECC
SADLILLGDHLSRFTQAVSVAKLTTQIIKQNLAWALGYNALILPLAVTGHVAPYIAAIGM
CCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCC
SASSLIVVGNSLRLLRVKV
CCCEEEEECCCEEEEEEEC
>Mature Secondary Structure 
THPSCFHCNEPVLTGQQFITRINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTEPGNK
CCCCCCCCCCCCCCHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHEECCCCCC
QTALVPDALNQFSAYDLPEVQQDFVHSEENIESVSLSIDGITCAACAWLIEHKVKQLSGI
CEEECHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
TQVLVNSTTQRAMISWDKHKIKLSDILAQISRIGYQAAPYQVDEQERSSQQNSRKFLLRL
HHHHHCCCCHHHHEECCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMIFATPVVLYSAQPFYFSAIRTL
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHH
LSGKLNMDVSVSIAIGGAYTASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKARQKAS
HCCCCCCCEEEEEEECCCEEEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHC
VSSSNLHKLVPLTAHLVTEQGQEEIPAKKLRLNDVILVKPGEMVAADGVVVGGHTSINEA
CCCCCCHHHHHHHHHHHHCCCCHHCCHHHEEECCEEEECCCCEEEECCEEECCCCCCCHH
MLTGEQMPIEKNIDNQVYAGTINIDQPITVKVSALGQDQLVAEIIRLQELASNTKPAVAL
HHCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCHHHH
LADKLSRYFSGTILSIATITYLVWHQISPDDAFWVTLSVLVATCPCALALATPTAVTCAT
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHCCCHHHHHHH
AIFTRLGIITRKAGVFEKLPLIKHVVFDKTGTLTCGTLSIGQVECLADSDQNRVLAIAAA
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCEEEEEEE
LEAGSRHPIAAAFAVFAEPTLTAEQVHHTVGFGIQGSIDGIEYRIGNALFTDAHISSTNP
HHCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCEEEECCCCCCCCH
IQQIWLARLNDGKYDLIASFEIKDNIRVDSKTTVEQLKRQGCSVSIASGDHSGHVYQLAK
HHHHHHHHCCCCCEEEEEEEEECCCCEECCHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
ELGIEDVHSGLTPADKLALVTELQKTSTVAMFGDGINDAPVLAGADLSVAMGSGSAIAKN
HCCHHHHHCCCCCHHHHHHHHHHHHHCEEEEECCCCCCCCEEECCCCEEEECCCCEEECC
SADLILLGDHLSRFTQAVSVAKLTTQIIKQNLAWALGYNALILPLAVTGHVAPYIAAIGM
CCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCC
SASSLIVVGNSLRLLRVKV
CCCEEEEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA