Click here to switch to the map view.

The map label for this gene is pyrD [H]

Identifier: 120598631

GI number: 120598631

Start: 2094956

End: 2095975

Strand: Direct

Name: pyrD [H]

Synonym: Sputw3181_1815

Alternate gene names: 120598631

Gene position: 2094956-2095975 (Clockwise)

Preceding gene: 120598630

Following gene: 120598632

Centisome position: 44.49

GC content: 41.08

Gene sequence:

>1020_bases
ATGTTCTATAAAATCGCACAGAAAGTCATGTTTCAGATGGATCCTGAGCGAGCGCATAATCTGGCTATTGGCAGCTTAAA
AATGACAGGAAACAGTCCGTTAAACTGCTTTTATCGCCAAACGATTGCGCCAGCTCCAGTCACATTTATGGGGCTGACTT
TTCCAAATCCGGTAGGTCTCGCTGCGGGAATGGATAAAGACGGCGAATCAATTGATGCCTTTCATGCGATGGGATTTGGG
CACATTGAGGTGGGCACCGTTACCCCAAGACCACAACCAGGTAATGATTTACCCCGTTTATTTAGATTAAAACCTGCCAA
AGGCATCATTAATCGAATGGGGTTTAATAACAAAGGGGTTGATAATTTAGTTAGAAATTTGATCGCGAAAAAGTCCGATA
TCATGGTGGGTGTTAATATTGGTAAAAATAAAGACACACCAGTGGAGCAGGGCAAAGATGATTATTTGATCTGCATGGAT
AAAGTTTATCCCTATGCCGCTTATATTGCGGTGAATATTTCATCTCCCAATACCCCCGGATTACGATCGCTACAATATGG
CGATCTATTAGATGAATTATTAAGCGCCATTAAAACAAAGCAACTTGAACTGGCTGAGAAGCATAAAAAATACGTGCCTA
TCGCACTTAAAATTGCACCAGATTTAACCATTGAAGAAATTGAAAATATCGCCGACGCGCTGATTAAAAATAAATTTGAT
GGTGCTATTGCAACGAATACCACGTTAACGCGCGATGGCGTTAGTGGCCTTGCTAATGCTAATGAAAGCGGTGGTTTAAG
CGGCAAACCTTTAACAGAGCTGTCAACAAAAGTGATAAGGCAATTGGCAGCATGTTTGAAAGGACAGATCCCAATCATAG
GCGTAGGTGGGATTAATAGTGCTGAAGATGCCCTAGCAAAATTTGATGCGGGCGCCACTATGGTACAGATTTATTCTGGT
TTTATTTACCAAGGTCCGAAGTTAATTAAAGAGATAGTAGAAGCTTATCGCTTAAAATAA

Upstream 100 bases:

>100_bases
TTAATCTTCTGATCCTTCATTGCGAAGGCCAAAAGTAAACTTTTATAATAATCAGAAGCCCTGGCGATCGCCGGGGCTTT
TTTTAGGTCGAGGAAAGTAC

Downstream 100 bases:

>100_bases
TGATCTTAAGATCAATAAAGAGATCGAAAATAAGATCTTTTTGAATAACTGCGATCTAAAAAGATCATTGGATCGCAGTT
AAGATCCGATAATAGATCGA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MFYKIAQKVMFQMDPERAHNLAIGSLKMTGNSPLNCFYRQTIAPAPVTFMGLTFPNPVGLAAGMDKDGESIDAFHAMGFG
HIEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGVDNLVRNLIAKKSDIMVGVNIGKNKDTPVEQGKDDYLICMD
KVYPYAAYIAVNISSPNTPGLRSLQYGDLLDELLSAIKTKQLELAEKHKKYVPIALKIAPDLTIEEIENIADALIKNKFD
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIRQLAACLKGQIPIIGVGGINSAEDALAKFDAGATMVQIYSG
FIYQGPKLIKEIVEAYRLK

Sequences:

>Translated_339_residues
MFYKIAQKVMFQMDPERAHNLAIGSLKMTGNSPLNCFYRQTIAPAPVTFMGLTFPNPVGLAAGMDKDGESIDAFHAMGFG
HIEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGVDNLVRNLIAKKSDIMVGVNIGKNKDTPVEQGKDDYLICMD
KVYPYAAYIAVNISSPNTPGLRSLQYGDLLDELLSAIKTKQLELAEKHKKYVPIALKIAPDLTIEEIENIADALIKNKFD
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIRQLAACLKGQIPIIGVGGINSAEDALAKFDAGATMVQIYSG
FIYQGPKLIKEIVEAYRLK
>Mature_339_residues
MFYKIAQKVMFQMDPERAHNLAIGSLKMTGNSPLNCFYRQTIAPAPVTFMGLTFPNPVGLAAGMDKDGESIDAFHAMGFG
HIEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGVDNLVRNLIAKKSDIMVGVNIGKNKDTPVEQGKDDYLICMD
KVYPYAAYIAVNISSPNTPGLRSLQYGDLLDELLSAIKTKQLELAEKHKKYVPIALKIAPDLTIEEIENIADALIKNKFD
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIRQLAACLKGQIPIIGVGGINSAEDALAKFDAGATMVQIYSG
FIYQGPKLIKEIVEAYRLK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=330, Percent_Identity=43.3333333333333, Blast_Score=247, Evalue=1e-65,
Organism=Escherichia coli, GI1787177, Length=333, Percent_Identity=62.7627627627628, Blast_Score=435, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17509475, Length=351, Percent_Identity=42.4501424501425, Blast_Score=244, Evalue=4e-65,
Organism=Drosophila melanogaster, GI281361352, Length=334, Percent_Identity=41.0179640718563, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI17137316, Length=334, Percent_Identity=41.0179640718563, Blast_Score=234, Evalue=6e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36726; Mature: 36726

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYKIAQKVMFQMDPERAHNLAIGSLKMTGNSPLNCFYRQTIAPAPVTFMGLTFPNPVGL
CHHHHHHHHHHHCCHHHHHCEEEEEEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCCCC
AAGMDKDGESIDAFHAMGFGHIEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGV
CCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHCCCCHHHHHHHCCCCCCCH
DNLVRNLIAKKSDIMVGVNIGKNKDTPVEQGKDDYLICMDKVYPYAAYIAVNISSPNTPG
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCC
LRSLQYGDLLDELLSAIKTKQLELAEKHKKYVPIALKIAPDLTIEEIENIADALIKNKFD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCC
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIRQLAACLKGQIPIIGVGGINS
CCEECCCEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
AEDALAKFDAGATMVQIYSGFIYQGPKLIKEIVEAYRLK
HHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MFYKIAQKVMFQMDPERAHNLAIGSLKMTGNSPLNCFYRQTIAPAPVTFMGLTFPNPVGL
CHHHHHHHHHHHCCHHHHHCEEEEEEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCCCC
AAGMDKDGESIDAFHAMGFGHIEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGV
CCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHCCCCHHHHHHHCCCCCCCH
DNLVRNLIAKKSDIMVGVNIGKNKDTPVEQGKDDYLICMDKVYPYAAYIAVNISSPNTPG
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCC
LRSLQYGDLLDELLSAIKTKQLELAEKHKKYVPIALKIAPDLTIEEIENIADALIKNKFD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCC
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIRQLAACLKGQIPIIGVGGINS
CCEECCCEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
AEDALAKFDAGATMVQIYSGFIYQGPKLIKEIVEAYRLK
HHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA