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The map label for this gene is hutH [H]

Identifier: 120598394

GI number: 120598394

Start: 1799784

End: 1801421

Strand: Direct

Name: hutH [H]

Synonym: Sputw3181_1577

Alternate gene names: 120598394

Gene position: 1799784-1801421 (Clockwise)

Preceding gene: 120598393

Following gene: 120598395

Centisome position: 38.23

GC content: 43.65

Gene sequence:

>1638_bases
ATGAATAAATCAGTGTTGATGGCATCGCTTACTTTAAGTCTACTCTCTGGGAGTGCTTTAGCGATGGAGCACGTTGTCCT
CGATGGTAAACATTTAACGCAAGAACAAGCATGGGCAATCGCCGATGGCGCTAAAGTCAAGATTGCATCTCAAGCGAAAA
CTCAACTCGTTAAAGCTAATAGTTTGTTGATGGAAGCTGCTCGTTTAGGTAAGCCTGTTTATGGTCTTACTGTTGGCGTT
GGTTTGAACAAAGATCACAAGTTATTTGATGCCAATGGCAAGTTAAGTGATGAAGTGCTTGAGGCATCACGTAACTTTAA
CTACAGCACTTTTCGAGCCCATAGTGCTGGTGTTGGTGACGCTGCACCGATTCGGTTAACTCGATTAGCCTTGGCGGTAC
GCTTAAATACTATGCTCGCGGGACAAACAGGGGTGCAACCTGTTGTGGCTGAACTCTATGAGGCATACCTTAACAAAGGG
TTAACGCCAGTCATCCCCGCTCACGGTACTGTAGGTGAAGCGGATATTTTGCTCTCATCCCATGTCGGGTTGGCGATGGT
GGGTGAGTGGGAAGTATTCTACAAAGGACAACGTGTTAGCAGTAAAGATGCTATGGCGGATGCCGGAATTACACCACTTG
TGCCTATGGGTAAAGATGCACTATCAATTCTGTCTAACAATTCGTTTTCAGTCGCTTATGCGATGCAAGGTTACCGTGAG
GCCAAGCAATTACTCTCTATCTCGCCAACGCTATTTGGTTTAAGCCTTGAGGGATTAAATGGTAACGTGGCACCATTTTT
ACCACAAACCAATGATATTCGTCCTTTCCCTTATATTAAAGCCAGCACAAATGACATTCTAAAACAGTTAGATGGCAGTT
ATTTATGGCAACTCAATGATGAACGTCCTTTGCAGGATCCACTCAGTTACAGAACAACGGCATACACGTTAGCCAGTGCT
GAACAAGCGTTAGCAGAATTGAATGATGTGGTAAATATTCAAATCAATCATTCGGATGATAACCCTGCAGTTATTGTTGG
CGCATCAAATGAGTATGCGAAGTTTCCACAGGTTGCTAAGTATATCGTCGAAGGGCAAGGTGGTGTGTTTCCAACCACGA
ACTTTGAACCTTTGCCTGTTGCATTGGCAGTACAAAACTTGAGTGTCGCTCTGACACATGTATCCCATAACAGTGTTATG
CGCACCATCCATTTATCTGATGACCATTTTACTAAGTTACCCCGTTTTTTAAGTGCTCCAGGTAATAATGGTCATGCTTT
TGGCGCGATTCAAAAAGTGTTTGTAGATATGCAAGTTCGTAATAAACAGTTGGCGACCCCAGTGTCATTTGATGGGATCT
CAATTGCGGGGGGAATTGAAGATACTTTCACTAACCTCAAGCTTGCTGCGGACAATTTGATCCAGATTGTTGACAACACA
CGTGTGATCTACGGTCTAGAGCTGCTGCATTCAAGTCAAGCGATTGATTTACGTAAGTTGGCTACTCCAGATCTTCATTT
AGGTAAAGCGACCGAAGCCATGTACAAGGCGTACCGTGAAAAAGTACCTTTTGTAGCTCAAGATCGCCCATTTACGCCTG
ATATCCAAACTTCAACTGAATTTATCGCAAACTATTAA

Upstream 100 bases:

>100_bases
GGTCGCAACGCAGGCCGAAATTGTGCAGCGGCAAAGGCGGCGGTGCTTAAGCAAGCATAATTAGATTTTATTAAAAATTA
CAATGTATTGGAGAATGGTA

Downstream 100 bases:

>100_bases
TATGTTATGCGGGGCAGCATGCCCCGCTATAGGAAGAGTCTGATGTTAAAACCCTTATATACACTTTTACTTGGTTGTAT
ATTCATGCTGCCAATAACAA

Product: phenylalanine/histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MNKSVLMASLTLSLLSGSALAMEHVVLDGKHLTQEQAWAIADGAKVKIASQAKTQLVKANSLLMEAARLGKPVYGLTVGV
GLNKDHKLFDANGKLSDEVLEASRNFNYSTFRAHSAGVGDAAPIRLTRLALAVRLNTMLAGQTGVQPVVAELYEAYLNKG
LTPVIPAHGTVGEADILLSSHVGLAMVGEWEVFYKGQRVSSKDAMADAGITPLVPMGKDALSILSNNSFSVAYAMQGYRE
AKQLLSISPTLFGLSLEGLNGNVAPFLPQTNDIRPFPYIKASTNDILKQLDGSYLWQLNDERPLQDPLSYRTTAYTLASA
EQALAELNDVVNIQINHSDDNPAVIVGASNEYAKFPQVAKYIVEGQGGVFPTTNFEPLPVALAVQNLSVALTHVSHNSVM
RTIHLSDDHFTKLPRFLSAPGNNGHAFGAIQKVFVDMQVRNKQLATPVSFDGISIAGGIEDTFTNLKLAADNLIQIVDNT
RVIYGLELLHSSQAIDLRKLATPDLHLGKATEAMYKAYREKVPFVAQDRPFTPDIQTSTEFIANY

Sequences:

>Translated_545_residues
MNKSVLMASLTLSLLSGSALAMEHVVLDGKHLTQEQAWAIADGAKVKIASQAKTQLVKANSLLMEAARLGKPVYGLTVGV
GLNKDHKLFDANGKLSDEVLEASRNFNYSTFRAHSAGVGDAAPIRLTRLALAVRLNTMLAGQTGVQPVVAELYEAYLNKG
LTPVIPAHGTVGEADILLSSHVGLAMVGEWEVFYKGQRVSSKDAMADAGITPLVPMGKDALSILSNNSFSVAYAMQGYRE
AKQLLSISPTLFGLSLEGLNGNVAPFLPQTNDIRPFPYIKASTNDILKQLDGSYLWQLNDERPLQDPLSYRTTAYTLASA
EQALAELNDVVNIQINHSDDNPAVIVGASNEYAKFPQVAKYIVEGQGGVFPTTNFEPLPVALAVQNLSVALTHVSHNSVM
RTIHLSDDHFTKLPRFLSAPGNNGHAFGAIQKVFVDMQVRNKQLATPVSFDGISIAGGIEDTFTNLKLAADNLIQIVDNT
RVIYGLELLHSSQAIDLRKLATPDLHLGKATEAMYKAYREKVPFVAQDRPFTPDIQTSTEFIANY
>Mature_545_residues
MNKSVLMASLTLSLLSGSALAMEHVVLDGKHLTQEQAWAIADGAKVKIASQAKTQLVKANSLLMEAARLGKPVYGLTVGV
GLNKDHKLFDANGKLSDEVLEASRNFNYSTFRAHSAGVGDAAPIRLTRLALAVRLNTMLAGQTGVQPVVAELYEAYLNKG
LTPVIPAHGTVGEADILLSSHVGLAMVGEWEVFYKGQRVSSKDAMADAGITPLVPMGKDALSILSNNSFSVAYAMQGYRE
AKQLLSISPTLFGLSLEGLNGNVAPFLPQTNDIRPFPYIKASTNDILKQLDGSYLWQLNDERPLQDPLSYRTTAYTLASA
EQALAELNDVVNIQINHSDDNPAVIVGASNEYAKFPQVAKYIVEGQGGVFPTTNFEPLPVALAVQNLSVALTHVSHNSVM
RTIHLSDDHFTKLPRFLSAPGNNGHAFGAIQKVFVDMQVRNKQLATPVSFDGISIAGGIEDTFTNLKLAADNLIQIVDNT
RVIYGLELLHSSQAIDLRKLATPDLHLGKATEAMYKAYREKVPFVAQDRPFTPDIQTSTEFIANY

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=547, Percent_Identity=23.217550274223, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17567831, Length=541, Percent_Identity=22.735674676525, Blast_Score=101, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 58970; Mature: 58970

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSVLMASLTLSLLSGSALAMEHVVLDGKHLTQEQAWAIADGAKVKIASQAKTQLVKAN
CCCCEEHHHHHHHHHCCCHHEEHHEEECCCCCCHHHHEEEECCCEEEEECHHHHHHHHHH
SLLMEAARLGKPVYGLTVGVGLNKDHKLFDANGKLSDEVLEASRNFNYSTFRAHSAGVGD
HHHHHHHHHCCCEEEEEEEECCCCCCEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCC
AAPIRLTRLALAVRLNTMLAGQTGVQPVVAELYEAYLNKGLTPVIPAHGTVGEADILLSS
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCHHEEEEC
HVGLAMVGEWEVFYKGQRVSSKDAMADAGITPLVPMGKDALSILSNNSFSVAYAMQGYRE
CCCEEEEECEEEEEECCCCCCCHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEHHHHHHHH
AKQLLSISPTLFGLSLEGLNGNVAPFLPQTNDIRPFPYIKASTNDILKQLDGSYLWQLND
HHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEECC
ERPLQDPLSYRTTAYTLASAEQALAELNDVVNIQINHSDDNPAVIVGASNEYAKFPQVAK
CCCCCCCHHHCHHHEEHHHHHHHHHHHCCEEEEEEEECCCCCEEEEECCCCCHHHHHHHH
YIVEGQGGVFPTTNFEPLPVALAVQNLSVALTHVSHNSVMRTIHLSDDHFTKLPRFLSAP
HHHCCCCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHCCC
GNNGHAFGAIQKVFVDMQVRNKQLATPVSFDGISIAGGIEDTFTNLKLAADNLIQIVDNT
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHEEHHHHHHHHHCCC
RVIYGLELLHSSQAIDLRKLATPDLHLGKATEAMYKAYREKVPFVAQDRPFTPDIQTSTE
EEEEEEEHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHH
FIANY
HHHCC
>Mature Secondary Structure
MNKSVLMASLTLSLLSGSALAMEHVVLDGKHLTQEQAWAIADGAKVKIASQAKTQLVKAN
CCCCEEHHHHHHHHHCCCHHEEHHEEECCCCCCHHHHEEEECCCEEEEECHHHHHHHHHH
SLLMEAARLGKPVYGLTVGVGLNKDHKLFDANGKLSDEVLEASRNFNYSTFRAHSAGVGD
HHHHHHHHHCCCEEEEEEEECCCCCCEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCC
AAPIRLTRLALAVRLNTMLAGQTGVQPVVAELYEAYLNKGLTPVIPAHGTVGEADILLSS
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCHHEEEEC
HVGLAMVGEWEVFYKGQRVSSKDAMADAGITPLVPMGKDALSILSNNSFSVAYAMQGYRE
CCCEEEEECEEEEEECCCCCCCHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEHHHHHHHH
AKQLLSISPTLFGLSLEGLNGNVAPFLPQTNDIRPFPYIKASTNDILKQLDGSYLWQLND
HHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEECC
ERPLQDPLSYRTTAYTLASAEQALAELNDVVNIQINHSDDNPAVIVGASNEYAKFPQVAK
CCCCCCCHHHCHHHEEHHHHHHHHHHHCCEEEEEEEECCCCCEEEEECCCCCHHHHHHHH
YIVEGQGGVFPTTNFEPLPVALAVQNLSVALTHVSHNSVMRTIHLSDDHFTKLPRFLSAP
HHHCCCCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHCCC
GNNGHAFGAIQKVFVDMQVRNKQLATPVSFDGISIAGGIEDTFTNLKLAADNLIQIVDNT
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHEEHHHHHHHHHCCC
RVIYGLELLHSSQAIDLRKLATPDLHLGKATEAMYKAYREKVPFVAQDRPFTPDIQTSTE
EEEEEEEHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHH
FIANY
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]