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The map label for this gene is neuA [H]

Identifier: 120598203

GI number: 120598203

Start: 1570855

End: 1571559

Strand: Direct

Name: neuA [H]

Synonym: Sputw3181_1380

Alternate gene names: 120598203

Gene position: 1570855-1571559 (Clockwise)

Preceding gene: 120598202

Following gene: 120598204

Centisome position: 33.36

GC content: 40.99

Gene sequence:

>705_bases
ATGAGAGTGGCGATTATTCCCGCACGAGGAGGAAGCAAGCGTATTGCGCATAAAAATATTCGCAATTTTAATGGTAAGCC
AATGATTTCGTATCCTATCACTGCTGCTATACGTAGTGGGTGCTTTGATAAAGTGATTGTATCGACAGACTCGATGGAAA
TTGCCACTATTGCTAAGTCTTTTGGTGCTGAAATTCCTTTTATGCGTCCGACAGAACTAGCTGATGATTTTGTAGGGACA
ACTCCTGTTGTACGTCATGCACTTAATGAGTTAGTTTCTTTAGGCCATATGGTGGATATTTGTTGTTGTATTTACGCAAC
GACTCCTTTACTTCAATACTCGTTTTTACGAGAGGCTGGTGAGTTACTAGAATCGACACCCAATCTTGATTATGTGTTCT
CAGCTTGCCGTTTTTCATTCCCTATCCAAAGGGCTTTGCTGTTAGATGCTAATGGTGGAGTATTACCCTTTGATAACAAA
AGTATTAGTCAACGATCGCAAGATTTAGTTGAGACATATCATGATGCTGGTCAGTTCTACTGGGGGAGAGCTAGTGCTTT
TTTGAATGAGGAAACTCGAGTGTTTGGTGCTCGGTCTCGAATGAAACTCTTGCCCAATTATATGGTTGCAGATATTGATA
CCTTAGAGGATTGGGAACGCGCCGAGGTGTTATACGATGTATTGAAAAAGCAAGGAAAGTTATGA

Upstream 100 bases:

>100_bases
CTGAGCGTTTCTATCGGTCGATACTGACGTTGCCTTTATATCCTAATCTTACTGCTGAGCAGATTGGTTATATCTGTGAC
AACTTAAGGGAATTGTTGAT

Downstream 100 bases:

>100_bases
AATTGGCCATTCGTGTTGATGCTTCTATTAGAATCGGTATTGGCCATGTTACCCGTTGCTTAGCGTTCGCGAACGCGTTA
AAGAAAACCTTCCTTAATCT

Product: acylneuraminate cytidylyltransferase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase; CMP-sialic acid synthase [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MRVAIIPARGGSKRIAHKNIRNFNGKPMISYPITAAIRSGCFDKVIVSTDSMEIATIAKSFGAEIPFMRPTELADDFVGT
TPVVRHALNELVSLGHMVDICCCIYATTPLLQYSFLREAGELLESTPNLDYVFSACRFSFPIQRALLLDANGGVLPFDNK
SISQRSQDLVETYHDAGQFYWGRASAFLNEETRVFGARSRMKLLPNYMVADIDTLEDWERAEVLYDVLKKQGKL

Sequences:

>Translated_234_residues
MRVAIIPARGGSKRIAHKNIRNFNGKPMISYPITAAIRSGCFDKVIVSTDSMEIATIAKSFGAEIPFMRPTELADDFVGT
TPVVRHALNELVSLGHMVDICCCIYATTPLLQYSFLREAGELLESTPNLDYVFSACRFSFPIQRALLLDANGGVLPFDNK
SISQRSQDLVETYHDAGQFYWGRASAFLNEETRVFGARSRMKLLPNYMVADIDTLEDWERAEVLYDVLKKQGKL
>Mature_234_residues
MRVAIIPARGGSKRIAHKNIRNFNGKPMISYPITAAIRSGCFDKVIVSTDSMEIATIAKSFGAEIPFMRPTELADDFVGT
TPVVRHALNELVSLGHMVDICCCIYATTPLLQYSFLREAGELLESTPNLDYVFSACRFSFPIQRALLLDANGGVLPFDNK
SISQRSQDLVETYHDAGQFYWGRASAFLNEETRVFGARSRMKLLPNYMVADIDTLEDWERAEVLYDVLKKQGKL

Specific function: Activates Kdo (A Required 8-Carbon Sugar) For Incorporation Into Bacterial Lipopolysaccharide In Gram-Negative Bacteria (By Similarity). [C]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=224, Percent_Identity=33.0357142857143, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 26211; Mature: 26211

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVAIIPARGGSKRIAHKNIRNFNGKPMISYPITAAIRSGCFDKVIVSTDSMEIATIAKS
CEEEEEECCCCCCHHHHHHHHCCCCCEEEECCHHHHHHCCCHHHEEECCCCHHHHHHHHH
FGAEIPFMRPTELADDFVGTTPVVRHALNELVSLGHMVDICCCIYATTPLLQYSFLREAG
HCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLESTPNLDYVFSACRFSFPIQRALLLDANGGVLPFDNKSISQRSQDLVETYHDAGQFY
HHHHCCCCHHHHHHHHHHCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEE
WGRASAFLNEETRVFGARSRMKLLPNYMVADIDTLEDWERAEVLYDVLKKQGKL
HHHHHHHHCHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRVAIIPARGGSKRIAHKNIRNFNGKPMISYPITAAIRSGCFDKVIVSTDSMEIATIAKS
CEEEEEECCCCCCHHHHHHHHCCCCCEEEECCHHHHHHCCCHHHEEECCCCHHHHHHHHH
FGAEIPFMRPTELADDFVGTTPVVRHALNELVSLGHMVDICCCIYATTPLLQYSFLREAG
HCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLESTPNLDYVFSACRFSFPIQRALLLDANGGVLPFDNKSISQRSQDLVETYHDAGQFY
HHHHCCCCHHHHHHHHHHCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEE
WGRASAFLNEETRVFGARSRMKLLPNYMVADIDTLEDWERAEVLYDVLKKQGKL
HHHHHHHHCHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1398032; 7830552; 8113198; 8045888; 10710307 [H]