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The map label for this gene is thrC [H]

Identifier: 120598102

GI number: 120598102

Start: 1458543

End: 1459826

Strand: Direct

Name: thrC [H]

Synonym: Sputw3181_1279

Alternate gene names: 120598102

Gene position: 1458543-1459826 (Clockwise)

Preceding gene: 120598101

Following gene: 120598103

Centisome position: 30.98

GC content: 47.98

Gene sequence:

>1284_bases
ATGGAACTATATAATTTAAAACACCCTTCGCAGAAAGTGAGCTTTAAAGAAGCGGTACAACTGGGGTTAGGCAAAGACAG
AGGTTTGTTCTTTCCTAGTCAGATACCCGTACTAGACGATATTGAAGGGCTGCTGGCGTTGCCATTTGTTGAGCGCAGTA
AAAAAGTGCTCGGTGCATGGCTTGCTTCTGAATTAGGCCAAGATGCGGTTGATAAATTAGTTGAGCGTGCCTTTAACTTC
GATTTACCTTTGGTTGCCGTCGATGAGCAGCGCGCCTGCCTTGAATTATTCCACGGTCCAACACTGGCGTTTAAAGATTT
TGGGGCGCGTTTTATGGCGCAATGTGTCAATGCCTTTGTGGGTGACACGCGTTTAACTATTTTGACTGCGACCTCGGGCG
ACACTGGCGCAGCGGTTGCCGATGCCTTCTATGGGCTTGAGAAAGTCAATGTGGTGGTGCTCTATCCTAAGGGCAAGATC
AGTGAGCTGCAGGAAAAGATGTTCACGACGTTGGGCAAGAATATCCATACAGTCGCTGTCTCGTCCGATTTCGATGCCTG
CCAAGATCTCGTTAAGCGCGCCTTTGATGATCCCGAAGTCCGTGATGGTCTGAGCCTGAATTCGGCTAACTCTATCAATA
TCAGCCGCTTACTCGCGCAAATTTGTTATTACTTTGAAGCCGTTGCCCAGTCTAAACAACGCCATGAAGCCGATCCTGTG
ATTTCTGTGCCAAGTGGTAACTTTGGTAACTTGACCGCAGGTTTATTCGCTAAAGCCATGGGATTACCGGTTAAACGCTT
TATTGCCGCGACCAATGCCAACGATACAGTGCCGCGTTATTTAGACAATGGCCAATGGCAGCCCAATCCGACTCAAGCGA
CTATGTCCAATGCCATGGATGTGAGTGAGCCAAGTAACTGGCCGCGAGTGGAAGCCATTTGTGAGAAATTAGGCTGGCCA
CTGAGTAATTTGGTTGGGATCCGTTTATCGGAGGAACAAACGTCACAGGCGCTGGTCGAGTTACACGCTCAAGGTTATGT
GTCTGAGCCCCATGCGGCGATTGCGGCTAAGGCCTTATCTTTAACTTTAGTGCCCGATGAAGTGGGCATATTTTTGGGGA
CGGCGCATCCCGCTAAGTTTAAGGATGTTGTGGATAGGGAGTTAACGCTTAACTTACCCTTGCCGCCCGAGCTTGAAGCT
GTTGCGAGTAAGCCTATCTTATCGGCGGAATTAGCACCTGATTTTATCAAATTAAAAGCACATCTATTTAAAGTATTGGT
TTAA

Upstream 100 bases:

>100_bases
GATGAGCAGGGCACGCGTAGGGTCGATTAATTGTCAATTTAGCTAAGACTAAGCACCCAAAATTAGCATTTAAGGTTTAG
CATCAAAAGGTTGAGTGAGC

Downstream 100 bases:

>100_bases
TGTTTTATTGCTTTTAGTCAAGCGGTCATATTTTAAATTGTAAAAGGGAGCTGGGCTCCCTTTTTACATGTCTCGAATTT
GAAGATGACGTAATGAATCT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MELYNLKHPSQKVSFKEAVQLGLGKDRGLFFPSQIPVLDDIEGLLALPFVERSKKVLGAWLASELGQDAVDKLVERAFNF
DLPLVAVDEQRACLELFHGPTLAFKDFGARFMAQCVNAFVGDTRLTILTATSGDTGAAVADAFYGLEKVNVVVLYPKGKI
SELQEKMFTTLGKNIHTVAVSSDFDACQDLVKRAFDDPEVRDGLSLNSANSINISRLLAQICYYFEAVAQSKQRHEADPV
ISVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLDNGQWQPNPTQATMSNAMDVSEPSNWPRVEAICEKLGWP
LSNLVGIRLSEEQTSQALVELHAQGYVSEPHAAIAAKALSLTLVPDEVGIFLGTAHPAKFKDVVDRELTLNLPLPPELEA
VASKPILSAELAPDFIKLKAHLFKVLV

Sequences:

>Translated_427_residues
MELYNLKHPSQKVSFKEAVQLGLGKDRGLFFPSQIPVLDDIEGLLALPFVERSKKVLGAWLASELGQDAVDKLVERAFNF
DLPLVAVDEQRACLELFHGPTLAFKDFGARFMAQCVNAFVGDTRLTILTATSGDTGAAVADAFYGLEKVNVVVLYPKGKI
SELQEKMFTTLGKNIHTVAVSSDFDACQDLVKRAFDDPEVRDGLSLNSANSINISRLLAQICYYFEAVAQSKQRHEADPV
ISVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLDNGQWQPNPTQATMSNAMDVSEPSNWPRVEAICEKLGWP
LSNLVGIRLSEEQTSQALVELHAQGYVSEPHAAIAAKALSLTLVPDEVGIFLGTAHPAKFKDVVDRELTLNLPLPPELEA
VASKPILSAELAPDFIKLKAHLFKVLV
>Mature_427_residues
MELYNLKHPSQKVSFKEAVQLGLGKDRGLFFPSQIPVLDDIEGLLALPFVERSKKVLGAWLASELGQDAVDKLVERAFNF
DLPLVAVDEQRACLELFHGPTLAFKDFGARFMAQCVNAFVGDTRLTILTATSGDTGAAVADAFYGLEKVNVVVLYPKGKI
SELQEKMFTTLGKNIHTVAVSSDFDACQDLVKRAFDDPEVRDGLSLNSANSINISRLLAQICYYFEAVAQSKQRHEADPV
ISVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLDNGQWQPNPTQATMSNAMDVSEPSNWPRVEAICEKLGWP
LSNLVGIRLSEEQTSQALVELHAQGYVSEPHAAIAAKALSLTLVPDEVGIFLGTAHPAKFKDVVDRELTLNLPLPPELEA
VASKPILSAELAPDFIKLKAHLFKVLV

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=453, Percent_Identity=31.5673289183223, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI149193323, Length=347, Percent_Identity=32.2766570605187, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1786185, Length=421, Percent_Identity=60.0950118764846, Blast_Score=486, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6319901, Length=448, Percent_Identity=33.7053571428571, Blast_Score=214, Evalue=2e-56,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46530; Mature: 46530

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELYNLKHPSQKVSFKEAVQLGLGKDRGLFFPSQIPVLDDIEGLLALPFVERSKKVLGAW
CCCCCCCCCCHHCCHHHHHHHCCCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHH
LASELGQDAVDKLVERAFNFDLPLVAVDEQRACLELFHGPTLAFKDFGARFMAQCVNAFV
HHHHHCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GDTRLTILTATSGDTGAAVADAFYGLEKVNVVVLYPKGKISELQEKMFTTLGKNIHTVAV
CCCEEEEEEECCCCCCHHHHHHHHCHHHEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
SSDFDACQDLVKRAFDDPEVRDGLSLNSANSINISRLLAQICYYFEAVAQSKQRHEADPV
CCCHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
ISVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLDNGQWQPNPTQATMSNAMD
EECCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHCCC
VSEPSNWPRVEAICEKLGWPLSNLVGIRLSEEQTSQALVELHAQGYVSEPHAAIAAKALS
CCCCCCCCHHHHHHHHHCCCHHHHEECEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHE
LTLVPDEVGIFLGTAHPAKFKDVVDRELTLNLPLPPELEAVASKPILSAELAPDFIKLKA
EEECCCCCCEEEECCCCHHHHHHHCCCEEEECCCCCCHHHHHCCCCHHHHCCHHHHHHHH
HLFKVLV
HHHHHCC
>Mature Secondary Structure
MELYNLKHPSQKVSFKEAVQLGLGKDRGLFFPSQIPVLDDIEGLLALPFVERSKKVLGAW
CCCCCCCCCCHHCCHHHHHHHCCCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHH
LASELGQDAVDKLVERAFNFDLPLVAVDEQRACLELFHGPTLAFKDFGARFMAQCVNAFV
HHHHHCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GDTRLTILTATSGDTGAAVADAFYGLEKVNVVVLYPKGKISELQEKMFTTLGKNIHTVAV
CCCEEEEEEECCCCCCHHHHHHHHCHHHEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
SSDFDACQDLVKRAFDDPEVRDGLSLNSANSINISRLLAQICYYFEAVAQSKQRHEADPV
CCCHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
ISVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLDNGQWQPNPTQATMSNAMD
EECCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHCCC
VSEPSNWPRVEAICEKLGWPLSNLVGIRLSEEQTSQALVELHAQGYVSEPHAAIAAKALS
CCCCCCCCHHHHHHHHHCCCHHHHEECEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHE
LTLVPDEVGIFLGTAHPAKFKDVVDRELTLNLPLPPELEAVASKPILSAELAPDFIKLKA
EEECCCCCCEEEECCCCHHHHHHHCCCEEEECCCCCCHHHHHCCCCHHHHCCHHHHHHHH
HLFKVLV
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]