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The map label for this gene is lysC [H]

Identifier: 120598091

GI number: 120598091

Start: 1443490

End: 1444746

Strand: Direct

Name: lysC [H]

Synonym: Sputw3181_1268

Alternate gene names: 120598091

Gene position: 1443490-1444746 (Clockwise)

Preceding gene: 120598090

Following gene: 120598092

Centisome position: 30.66

GC content: 45.51

Gene sequence:

>1257_bases
GTGCCTGAAAAACGAAAGCTTAGTCGTAGCAAGCTTTTTGTGAAAAAGTTTGGTGGCACTTCGGTGGGTTCTATAGAACG
TATTGAAGTGGTCGCCGAACAGATTGCAAAGTCCGCTCGCAGTGGTGAACAACAGGTACTCGTGCTCTCTGCTATGGCAG
GGGAGACAAATAGACTTTTCGCACTTGCCGCGCAAGTTGACCCCCGTGCCTCGGCGCGGGAACTCGATATGCTTGTCTCA
ACAGGCGAACAAGTGAGTATCGCATTGATGGCGATAGCTTTGCAGCGACGTGGTATTAAGGCTAAGTCGCTCACGGGAGA
TCAAGTTCAAATCCATACCAATAGTCATTTTGGTCGCGCAAGTATTGAGAATGTCGATACTGGCTATCTAGAGTCACTGC
TTGATGATGGAATTGTGCCGATAGTCGCAGGGTTTCAAGGGATTGATCCTAACGGAGATGTAACGACTTTGGGGCGTGGA
GGGTCTGATACCACTGCGGTTGCGTTAGCTGCTGCACTTAACGCTGATGAGTGCCAAATTTTCACTGATGTTGCTGGTGT
CTTCACAACCGATCCAAATATTGATAGTAATGCACGTTGCCTTGATGTGATTGGCTTTGATGTTATGCTCGAAATGGCCA
AACTGGGAGCTAAGGTGCTACATCCTGACTCGGTTGAATATGCCGAACGTTTTCGAGTGCCTTTGCGAGTGTTATCTAGT
TTTGAAGTTGGTCAAGGTACCCTAATTCAATTTGGTACCGAATCTGACGTGATAAGTGCTTCCTTGGTGCAGGGGATTGC
GATCAATAAAGCGTTAGCAACATTAACGATTGATGGCTTATTAACGACGAGTGAACATTACCAAGCCTTGTTAGCTTGTT
TGTCTCGCCTTGAAATCGATGTGGAGTTTATCACCCCGCTCAGATTAAATGAGGATGCTCCCGCAGGGTGTGTGAGTTTT
ATGCTTGCAGAAGCAAAAGTGGATATTTTATTGCACGAGCTTGAAGCATTGAGTACAAGTCTTGAGCTTGGTCAATTGAT
TGTTGAGCGTCAACGTGCAAAAGTATCTTTAGTTGGCAAAGGTTTACAGGCAAAAATGGGATTATTGACTAAGATGTTAG
ATGTCTTGGGTAATGAAACAATCCATGCTAAGTTACTCTCGACGTCGGAGAGTAAATTATCAACCGTTATCGATGAAAGG
GACTTGCACAAAGCGGTTCGGGCGTTACATCACGCTTTCGAGCTAAATAAGGTGTAA

Upstream 100 bases:

>100_bases
AGATATGGCGCAAGCGGGTGGTAGCCAACCAGAAAATCTGGATGCGGCCTTAGCTCAAGTATTACCTTGGATTACTGAGC
GTTTAGCTTAAGAGGTTGTT

Downstream 100 bases:

>100_bases
TTAAATAACCGTTTGAGTATTGAATACTATTAATTTGTACTAAGCTGACCTTATAATAAGCCCATCTACCGGATGAGTGC
CGTGTGTAAGCTGAATTAAG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MPEKRKLSRSKLFVKKFGGTSVGSIERIEVVAEQIAKSARSGEQQVLVLSAMAGETNRLFALAAQVDPRASARELDMLVS
TGEQVSIALMAIALQRRGIKAKSLTGDQVQIHTNSHFGRASIENVDTGYLESLLDDGIVPIVAGFQGIDPNGDVTTLGRG
GSDTTAVALAAALNADECQIFTDVAGVFTTDPNIDSNARCLDVIGFDVMLEMAKLGAKVLHPDSVEYAERFRVPLRVLSS
FEVGQGTLIQFGTESDVISASLVQGIAINKALATLTIDGLLTTSEHYQALLACLSRLEIDVEFITPLRLNEDAPAGCVSF
MLAEAKVDILLHELEALSTSLELGQLIVERQRAKVSLVGKGLQAKMGLLTKMLDVLGNETIHAKLLSTSESKLSTVIDER
DLHKAVRALHHAFELNKV

Sequences:

>Translated_418_residues
MPEKRKLSRSKLFVKKFGGTSVGSIERIEVVAEQIAKSARSGEQQVLVLSAMAGETNRLFALAAQVDPRASARELDMLVS
TGEQVSIALMAIALQRRGIKAKSLTGDQVQIHTNSHFGRASIENVDTGYLESLLDDGIVPIVAGFQGIDPNGDVTTLGRG
GSDTTAVALAAALNADECQIFTDVAGVFTTDPNIDSNARCLDVIGFDVMLEMAKLGAKVLHPDSVEYAERFRVPLRVLSS
FEVGQGTLIQFGTESDVISASLVQGIAINKALATLTIDGLLTTSEHYQALLACLSRLEIDVEFITPLRLNEDAPAGCVSF
MLAEAKVDILLHELEALSTSLELGQLIVERQRAKVSLVGKGLQAKMGLLTKMLDVLGNETIHAKLLSTSESKLSTVIDER
DLHKAVRALHHAFELNKV
>Mature_417_residues
PEKRKLSRSKLFVKKFGGTSVGSIERIEVVAEQIAKSARSGEQQVLVLSAMAGETNRLFALAAQVDPRASARELDMLVST
GEQVSIALMAIALQRRGIKAKSLTGDQVQIHTNSHFGRASIENVDTGYLESLLDDGIVPIVAGFQGIDPNGDVTTLGRGG
SDTTAVALAAALNADECQIFTDVAGVFTTDPNIDSNARCLDVIGFDVMLEMAKLGAKVLHPDSVEYAERFRVPLRVLSSF
EVGQGTLIQFGTESDVISASLVQGIAINKALATLTIDGLLTTSEHYQALLACLSRLEIDVEFITPLRLNEDAPAGCVSFM
LAEAKVDILLHELEALSTSLELGQLIVERQRAKVSLVGKGLQAKMGLLTKMLDVLGNETIHAKLLSTSESKLSTVIDERD
LHKAVRALHHAFELNKV

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=462, Percent_Identity=30.7359307359307, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1786183, Length=349, Percent_Identity=28.6532951289398, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790376, Length=176, Percent_Identity=29.5454545454545, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320893, Length=391, Percent_Identity=26.8542199488491, Blast_Score=119, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44885; Mature: 44754

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEKRKLSRSKLFVKKFGGTSVGSIERIEVVAEQIAKSARSGEQQVLVLSAMAGETNRLF
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEE
ALAAQVDPRASARELDMLVSTGEQVSIALMAIALQRRGIKAKSLTGDQVQIHTNSHFGRA
EEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCC
SIENVDTGYLESLLDDGIVPIVAGFQGIDPNGDVTTLGRGGSDTTAVALAAALNADECQI
CCCCCCHHHHHHHHHCCCEEEHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCHHEE
FTDVAGVFTTDPNIDSNARCLDVIGFDVMLEMAKLGAKVLHPDSVEYAERFRVPLRVLSS
HHHHHHHEECCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
FEVGQGTLIQFGTESDVISASLVQGIAINKALATLTIDGLLTTSEHYQALLACLSRLEID
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCEEECHHHHHHHHHHHHHCEEE
VEFITPLRLNEDAPAGCVSFMLAEAKVDILLHELEALSTSLELGQLIVERQRAKVSLVGK
EEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCC
GLQAKMGLLTKMLDVLGNETIHAKLLSTSESKLSTVIDERDLHKAVRALHHAFELNKV
CHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PEKRKLSRSKLFVKKFGGTSVGSIERIEVVAEQIAKSARSGEQQVLVLSAMAGETNRLF
CCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEE
ALAAQVDPRASARELDMLVSTGEQVSIALMAIALQRRGIKAKSLTGDQVQIHTNSHFGRA
EEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCC
SIENVDTGYLESLLDDGIVPIVAGFQGIDPNGDVTTLGRGGSDTTAVALAAALNADECQI
CCCCCCHHHHHHHHHCCCEEEHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCHHEE
FTDVAGVFTTDPNIDSNARCLDVIGFDVMLEMAKLGAKVLHPDSVEYAERFRVPLRVLSS
HHHHHHHEECCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
FEVGQGTLIQFGTESDVISASLVQGIAINKALATLTIDGLLTTSEHYQALLACLSRLEID
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCEEECHHHHHHHHHHHHHCEEE
VEFITPLRLNEDAPAGCVSFMLAEAKVDILLHELEALSTSLELGQLIVERQRAKVSLVGK
EEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCC
GLQAKMGLLTKMLDVLGNETIHAKLLSTSESKLSTVIDERDLHKAVRALHHAFELNKV
CHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]