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The map label for this gene is deoA

Identifier: 120598013

GI number: 120598013

Start: 1340740

End: 1342071

Strand: Direct

Name: deoA

Synonym: Sputw3181_1190

Alternate gene names: 120598013

Gene position: 1340740-1342071 (Clockwise)

Preceding gene: 120598012

Following gene: 120598014

Centisome position: 28.48

GC content: 47.3

Gene sequence:

>1332_bases
ATGTTTCTAGCTCAAGAGATTATTCGTAAAAAACGTAATGGTTTAGCGCTAAGTCCTGCAGAAATACAGTTTTTTGTTCA
AGGTATCACTACTAACGCAGTATCCGAAGGCCAGATCGCTGCATTCGGTATGGCAGTGTACTTTAATGACATGAATATGG
ATGAAAGAATCGCTTTGACGACGGCAATGCGTGATTCTGGCACTGTACTTAATTGGCAATCATTGGGACTCAATGGCCCT
GTTATCGACAAACACAGCACTGGCGGTGTGGGCGATGTGATTAGCCTTATGCTTGGCCCTATGGCTGCGGCTTGTGGTGG
TTATGTGCCTATGATTTCTGGGCGTGGCCTAGGCCATACGGGCGGCACGCTCGATAAGTTTGATGCGATTCCAGGTTATC
AAACTGAGCCATCAAGCGAACTATTTCGCAAAGTCGTTAAAGAGGTCGGTGTCGCCATTATTGGTCAGACAGGTGATCTC
GTTCCTGCCGATAAACGCTTCTATTCTATCCGTGATAATACCGCTACCGTTGAATCTATTTCCCTCATCACAGCGTCGAT
TCTGTCTAAGAAATTAGCCTGCAATTTAGATGCACTCGCTATGGATGTAAAAGTCGGTAGTGGCGCTTTTATGCCTACCT
ATGAGGCTTCTGAAGAGTTAGCGCGCAGTATTACTGCTGTAGCCAATGGTGCGGGAACGAAGACCACAGCATTACTTACC
GACATGAACCAAGTGCTAGCCTCCTGTGCCGGTAACGCGGTTGAAGTGAAAGAAGCCATTGACTTCTTAACAGGTGCTTA
CCGTAACCCACGTCTATATGAAGTGACTATGGGCCTTTGTGCTGAGATGTTGCTCCTTGGCGGTCTTGCAAGCAATGAAA
CTGAGGCTCGCGCTAAACTCAATCGTGTGCTCGATAACGGCCGTGCCGCTGAAATTTTTGGCAAGATGGTCTCAGGGCTT
GGTGGGCCAGTCGATTTTGTTGAAAACTACAGTAAGTACCTACCGCAATCACAGATTATTCGCCCTGTATTTGCCGATGC
AAAGGGTTATGCCTATAGCATGGATACCCGAGAGCTTGGTTTAGCTGTGGTGACTCTCGGTGGTGGACGCAGAAAGCCTG
GCGATGCACTAGACTATAGTGTTGGTTTAACCCAAGTCTGTGCCCTTGGTGATAAAATTGATTCATCAACGCCTATTGCC
GTTATCCACGCACAGTCTGAAGCTGCCTTTACAGAAGCGGAAAATGCGGTGAAAAAAGCGATTCACATAGGTGAAACCGC
CCCAGAAAAAACACCTGAGATCTACGCTTACATTCGTGCAGCGGATCTTTAA

Upstream 100 bases:

>100_bases
TCGATAGTATGAACTTGTAATATTGCTACAGTTTTGATGTTTCATTGCAAAGGTAAGCACTAGCGACAGGGTTGTTAGTG
CCTATCTTGGAGGCAGTATC

Downstream 100 bases:

>100_bases
GGAAAAATGATGAAACGTACCATTATTATGATGTTGGACTCCTTTGGAGTCGGTGCTTCTGCTGATGCAGCAAGCTTTGG
TGATGTCGGTTCCGATACCT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MFLAQEIIRKKRNGLALSPAEIQFFVQGITTNAVSEGQIAAFGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLGLNGP
VIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKEVGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLACNLDALAMDVKVGSGAFMPTYEASEELARSITAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYEVTMGLCAEMLLLGGLASNETEARAKLNRVLDNGRAAEIFGKMVSGL
GGPVDFVENYSKYLPQSQIIRPVFADAKGYAYSMDTRELGLAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDSSTPIA
VIHAQSEAAFTEAENAVKKAIHIGETAPEKTPEIYAYIRAADL

Sequences:

>Translated_443_residues
MFLAQEIIRKKRNGLALSPAEIQFFVQGITTNAVSEGQIAAFGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLGLNGP
VIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKEVGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLACNLDALAMDVKVGSGAFMPTYEASEELARSITAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYEVTMGLCAEMLLLGGLASNETEARAKLNRVLDNGRAAEIFGKMVSGL
GGPVDFVENYSKYLPQSQIIRPVFADAKGYAYSMDTRELGLAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDSSTPIA
VIHAQSEAAFTEAENAVKKAIHIGETAPEKTPEIYAYIRAADL
>Mature_443_residues
MFLAQEIIRKKRNGLALSPAEIQFFVQGITTNAVSEGQIAAFGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLGLNGP
VIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKEVGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLACNLDALAMDVKVGSGAFMPTYEASEELARSITAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYEVTMGLCAEMLLLGGLASNETEARAKLNRVLDNGRAAEIFGKMVSGL
GGPVDFVENYSKYLPQSQIIRPVFADAKGYAYSMDTRELGLAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDSSTPIA
VIHAQSEAAFTEAENAVKKAIHIGETAPEKTPEIYAYIRAADL

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=443, Percent_Identity=37.6975169300226, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI4503445, Length=443, Percent_Identity=37.6975169300226, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI166158922, Length=443, Percent_Identity=37.6975169300226, Blast_Score=271, Evalue=1e-72,
Organism=Escherichia coli, GI1790842, Length=438, Percent_Identity=66.8949771689498, Blast_Score=607, Evalue=1e-175,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 46903; Mature: 46903

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLAQEIIRKKRNGLALSPAEIQFFVQGITTNAVSEGQIAAFGMAVYFNDMNMDERIALT
CCHHHHHHHHHHCCCCCCHHHHEEEEEEHHHCCCCCCCEEEEEEEEEEECCCCCCEEEEE
TAMRDSGTVLNWQSLGLNGPVIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHT
EEECCCCCEEEEHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
GGTLDKFDAIPGYQTEPSSELFRKVVKEVGVAIIGQTGDLVPADKRFYSIRDNTATVESI
CCCCHHHCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEECCCCCHHHHH
SLITASILSKKLACNLDALAMDVKVGSGAFMPTYEASEELARSITAVANGAGTKTTALLT
HHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYEVTMGLCAEMLLLGGLASNETEARAKL
HHHHHHHHHCCCCEEHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCCHHHHHHH
NRVLDNGRAAEIFGKMVSGLGGPVDFVENYSKYLPQSQIIRPVFADAKGYAYSMDTRELG
HHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCHHCC
LAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDSSTPIAVIHAQSEAAFTEAENAVKKA
EEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
IHIGETAPEKTPEIYAYIRAADL
HHCCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MFLAQEIIRKKRNGLALSPAEIQFFVQGITTNAVSEGQIAAFGMAVYFNDMNMDERIALT
CCHHHHHHHHHHCCCCCCHHHHEEEEEEHHHCCCCCCCEEEEEEEEEEECCCCCCEEEEE
TAMRDSGTVLNWQSLGLNGPVIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHT
EEECCCCCEEEEHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
GGTLDKFDAIPGYQTEPSSELFRKVVKEVGVAIIGQTGDLVPADKRFYSIRDNTATVESI
CCCCHHHCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEECCCCCHHHHH
SLITASILSKKLACNLDALAMDVKVGSGAFMPTYEASEELARSITAVANGAGTKTTALLT
HHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYEVTMGLCAEMLLLGGLASNETEARAKL
HHHHHHHHHCCCCEEHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCCHHHHHHH
NRVLDNGRAAEIFGKMVSGLGGPVDFVENYSKYLPQSQIIRPVFADAKGYAYSMDTRELG
HHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCHHCC
LAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDSSTPIAVIHAQSEAAFTEAENAVKKA
EEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
IHIGETAPEKTPEIYAYIRAADL
HHCCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA