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The map label for this gene is folP [H]

Identifier: 120597894

GI number: 120597894

Start: 1209364

End: 1210197

Strand: Direct

Name: folP [H]

Synonym: Sputw3181_1064

Alternate gene names: 120597894

Gene position: 1209364-1210197 (Clockwise)

Preceding gene: 120597893

Following gene: 120597895

Centisome position: 25.69

GC content: 47.48

Gene sequence:

>834_bases
GTGTTTGAACTGATTGCTGGCACTAAACGCCTCGCATTATCTTCGCCCATTGTGATGGGTATTCTTAATGTCACTCCCGA
TTCTTTTTCCGACGGTGGTCAATATTCTTCCTATGAATTAGCCTGCCAACATGCCGATGATATGGTGGCTCAAGGCGCGG
GAATGATTGATATTGGCGGTGAGTCGACAAGACCGGGTGCCGCCGAGGTGAGCTTAGCCGATGAGCTTGCGCGGGTGATC
CCGTTAGTGAAATATGTTGCGGCGCACCACGATGTGTGGATTTCGGTCGATACCAGTAAAGCTGAAGTGATGCGTCAAGC
TGTTGCTGCAGGCGCACATTTGATTAACGATGTGCGCGCCCTGATGGAACCTGGAGCGCTTGAAGCCGCCGCAGAGTTGC
AAGTCCCCATATGTCTGATGCATATGCAAGGTGACCCCCAAAGCATGCAGTTTTCTCCGACTTACCATAATGTTATTGAA
GACGTTTCTGCCTTTTTAACTGAACGGATTGAGACTTGTTTGCGAGCGGGGATCTCCCGTGAGTTATTAATACTCGATCC
GGGATTCGGTTTTGGCAAAAGTTTAGAACATAACTATGAATTACTGGCAAAACTAGACCATTTTTCCAAGTTTGATTTAC
CGATATTAATAGGATTATCTCGTAAGAGCATGATAGGAAATCTCTTAGCAAAACCGACCTCAGAACGTCTTGCTGGGAGC
CTTGCTGGCGCTTTGATAGCGGCCCAAAAAGGCGCTCATATCATTCGCGTGCATGATGTTGCGCAAACTGTGGATATGCT
CAAGGTGTTACAAGCGACACAAGCGTATTTTTAA

Upstream 100 bases:

>100_bases
GACATTAGTTAGTTCGAATAGAAAGTGATAGCTTAAAAGTAATGACGCAAGTGATGCCAGCGAGTAAAATCGTACGTGTT
CGTATTACAGGAGTAAATGC

Downstream 100 bases:

>100_bases
GCATCGTTATGCTCTCGTTAAGCATTTAATTAATATTATGATCCCAAATCATTGGGACACATTTGAGTTTGTGGAGCGAT
ATGAAAGAACGTAAATTTTT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MFELIAGTKRLALSSPIVMGILNVTPDSFSDGGQYSSYELACQHADDMVAQGAGMIDIGGESTRPGAAEVSLADELARVI
PLVKYVAAHHDVWISVDTSKAEVMRQAVAAGAHLINDVRALMEPGALEAAAELQVPICLMHMQGDPQSMQFSPTYHNVIE
DVSAFLTERIETCLRAGISRELLILDPGFGFGKSLEHNYELLAKLDHFSKFDLPILIGLSRKSMIGNLLAKPTSERLAGS
LAGALIAAQKGAHIIRVHDVAQTVDMLKVLQATQAYF

Sequences:

>Translated_277_residues
MFELIAGTKRLALSSPIVMGILNVTPDSFSDGGQYSSYELACQHADDMVAQGAGMIDIGGESTRPGAAEVSLADELARVI
PLVKYVAAHHDVWISVDTSKAEVMRQAVAAGAHLINDVRALMEPGALEAAAELQVPICLMHMQGDPQSMQFSPTYHNVIE
DVSAFLTERIETCLRAGISRELLILDPGFGFGKSLEHNYELLAKLDHFSKFDLPILIGLSRKSMIGNLLAKPTSERLAGS
LAGALIAAQKGAHIIRVHDVAQTVDMLKVLQATQAYF
>Mature_277_residues
MFELIAGTKRLALSSPIVMGILNVTPDSFSDGGQYSSYELACQHADDMVAQGAGMIDIGGESTRPGAAEVSLADELARVI
PLVKYVAAHHDVWISVDTSKAEVMRQAVAAGAHLINDVRALMEPGALEAAAELQVPICLMHMQGDPQSMQFSPTYHNVIE
DVSAFLTERIETCLRAGISRELLILDPGFGFGKSLEHNYELLAKLDHFSKFDLPILIGLSRKSMIGNLLAKPTSERLAGS
LAGALIAAQKGAHIIRVHDVAQTVDMLKVLQATQAYF

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=272, Percent_Identity=60.2941176470588, Blast_Score=342, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6324073, Length=329, Percent_Identity=25.8358662613982, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29809; Mature: 29809

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFELIAGTKRLALSSPIVMGILNVTPDSFSDGGQYSSYELACQHADDMVAQGAGMIDIGG
CCCCCCCCHHHHHCCCHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECC
ESTRPGAAEVSLADELARVIPLVKYVAAHHDVWISVDTSKAEVMRQAVAAGAHLINDVRA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
LMEPGALEAAAELQVPICLMHMQGDPQSMQFSPTYHNVIEDVSAFLTERIETCLRAGISR
HHCCCCHHHHHHCCCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
ELLILDPGFGFGKSLEHNYELLAKLDHFSKFDLPILIGLSRKSMIGNLLAKPTSERLAGS
EEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCHHHHHHH
LAGALIAAQKGAHIIRVHDVAQTVDMLKVLQATQAYF
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFELIAGTKRLALSSPIVMGILNVTPDSFSDGGQYSSYELACQHADDMVAQGAGMIDIGG
CCCCCCCCHHHHHCCCHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECC
ESTRPGAAEVSLADELARVIPLVKYVAAHHDVWISVDTSKAEVMRQAVAAGAHLINDVRA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
LMEPGALEAAAELQVPICLMHMQGDPQSMQFSPTYHNVIEDVSAFLTERIETCLRAGISR
HHCCCCHHHHHHCCCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
ELLILDPGFGFGKSLEHNYELLAKLDHFSKFDLPILIGLSRKSMIGNLLAKPTSERLAGS
EEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCHHHHHHH
LAGALIAAQKGAHIIRVHDVAQTVDMLKVLQATQAYF
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]