Click here to switch to the map view.

The map label for this gene is cysG1 [H]

Identifier: 120597731

GI number: 120597731

Start: 1028422

End: 1029255

Strand: Direct

Name: cysG1 [H]

Synonym: Sputw3181_0901

Alternate gene names: 120597731

Gene position: 1028422-1029255 (Clockwise)

Preceding gene: 120597728

Following gene: 120597732

Centisome position: 21.84

GC content: 50.24

Gene sequence:

>834_bases
ATGGAAATTTTCTCTTTACCGGGCCAAGCGGCCAAAGGCAAAGTCTGGCTGGTGGGGGCTGGTCCCGGTGACGTTGAGTT
ATTGACGTTAAAGGCATGGCGTATCCTTAAAACCGCCGATGCAGTGCTATACGACGCTTTAGTCAGCCAAGATATCCTCG
ATCTTATTCCCAAAGACGCTGAGAAGATTGCTGTAGGTAAGCGTGCGGGCAAGCATAGCGCCGCACAGGACGAGATTAAT
CAGTTACTCGTCACTAAAGCCTACACCCGTAAAAATGTGGTTCGCCTTAAAGGTGGCGATCCTTTTATTTTCGGCCGCGG
GGGGGAAGAGTTACAAACTTTAGTTGAAGCTGGGGTGGAGTTTGAAGTCATCCCCGGCATTACCGCCGCCAGCGGCACGT
CAGCCTATGCGGGAATTCCCCTAACCCACAGAGACCACGCCCAAGGCGTCACTTTTATCACTGGCCATTGTCAGTTAGAG
AGTCGCCCTATGGACTGGCAAGGTTATGCTAATCCCAACAATACCTTAGTCGTGTATATGGGGATTCTGAACGCCAGCAT
TATTCGCCAAGGTTTAGTCGATGCGGGCCGAAGCCCAGAAACACCTGTGGCGATAGTGTCAAAGGCCACAACGAATGAAC
AACGTCGTTTTATCGGCAGTTTAGGTGAGCTTGAACAGCTTGCCGCCGATCCAGAATTACACATGCCAGCCTTGATGATC
ATAGGTGAAGTGGTCGCGCTTTCTGAGACGCTCAATTGGTTCACACCAGAATCCATCGACAACGCACAATACCAACATGA
ACTGACTCAGACTGCAAAAGTATCGATAAATTAG

Upstream 100 bases:

>100_bases
GTTATATTCCTAAATGATATAAAAACTAATAATTATCTATTTATTATGGAATATAAGACGCGCTATATTTCTACAGACTA
AAGTGATCTTGGGGATTCTG

Downstream 100 bases:

>100_bases
CAAATTATAAAATTAAGTAATCATGCTGTATCAATGCAGCAAATTTTAGGTAAACGGAGAATAGTATGGCCGGGCGTGAA
CTAAGCCACTTACAACAACT

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MEIFSLPGQAAKGKVWLVGAGPGDVELLTLKAWRILKTADAVLYDALVSQDILDLIPKDAEKIAVGKRAGKHSAAQDEIN
QLLVTKAYTRKNVVRLKGGDPFIFGRGGEELQTLVEAGVEFEVIPGITAASGTSAYAGIPLTHRDHAQGVTFITGHCQLE
SRPMDWQGYANPNNTLVVYMGILNASIIRQGLVDAGRSPETPVAIVSKATTNEQRRFIGSLGELEQLAADPELHMPALMI
IGEVVALSETLNWFTPESIDNAQYQHELTQTAKVSIN

Sequences:

>Translated_277_residues
MEIFSLPGQAAKGKVWLVGAGPGDVELLTLKAWRILKTADAVLYDALVSQDILDLIPKDAEKIAVGKRAGKHSAAQDEIN
QLLVTKAYTRKNVVRLKGGDPFIFGRGGEELQTLVEAGVEFEVIPGITAASGTSAYAGIPLTHRDHAQGVTFITGHCQLE
SRPMDWQGYANPNNTLVVYMGILNASIIRQGLVDAGRSPETPVAIVSKATTNEQRRFIGSLGELEQLAADPELHMPALMI
IGEVVALSETLNWFTPESIDNAQYQHELTQTAKVSIN
>Mature_277_residues
MEIFSLPGQAAKGKVWLVGAGPGDVELLTLKAWRILKTADAVLYDALVSQDILDLIPKDAEKIAVGKRAGKHSAAQDEIN
QLLVTKAYTRKNVVRLKGGDPFIFGRGGEELQTLVEAGVEFEVIPGITAASGTSAYAGIPLTHRDHAQGVTFITGHCQLE
SRPMDWQGYANPNNTLVVYMGILNASIIRQGLVDAGRSPETPVAIVSKATTNEQRRFIGSLGELEQLAADPELHMPALMI
IGEVVALSETLNWFTPESIDNAQYQHELTQTAKVSIN

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=244, Percent_Identity=54.9180327868852, Blast_Score=264, Evalue=6e-72,
Organism=Saccharomyces cerevisiae, GI6322922, Length=238, Percent_Identity=34.453781512605, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 29910; Mature: 29910

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFSLPGQAAKGKVWLVGAGPGDVELLTLKAWRILKTADAVLYDALVSQDILDLIPKDA
CCEECCCCCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EKIAVGKRAGKHSAAQDEINQLLVTKAYTRKNVVRLKGGDPFIFGRGGEELQTLVEAGVE
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHCCCC
FEVIPGITAASGTSAYAGIPLTHRDHAQGVTFITGHCQLESRPMDWQGYANPNNTLVVYM
EEEECCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEEE
GILNASIIRQGLVDAGRSPETPVAIVSKATTNEQRRFIGSLGELEQLAADPELHMPALMI
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
IGEVVALSETLNWFTPESIDNAQYQHELTQTAKVSIN
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECC
>Mature Secondary Structure
MEIFSLPGQAAKGKVWLVGAGPGDVELLTLKAWRILKTADAVLYDALVSQDILDLIPKDA
CCEECCCCCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EKIAVGKRAGKHSAAQDEINQLLVTKAYTRKNVVRLKGGDPFIFGRGGEELQTLVEAGVE
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHCCCC
FEVIPGITAASGTSAYAGIPLTHRDHAQGVTFITGHCQLESRPMDWQGYANPNNTLVVYM
EEEECCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEEE
GILNASIIRQGLVDAGRSPETPVAIVSKATTNEQRRFIGSLGELEQLAADPELHMPALMI
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
IGEVVALSETLNWFTPESIDNAQYQHELTQTAKVSIN
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA