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The map label for this gene is mutL

Identifier: 120597490

GI number: 120597490

Start: 726213

End: 728138

Strand: Direct

Name: mutL

Synonym: Sputw3181_0659

Alternate gene names: 120597490

Gene position: 726213-728138 (Clockwise)

Preceding gene: 120597489

Following gene: 120597491

Centisome position: 15.42

GC content: 44.96

Gene sequence:

>1926_bases
ATGGAAAAATCTATGGGTATTCAGATCTTACCGCCGCAATTAGCCAACCAGATCGCCGCGGGCGAAGTGGTTGAAAGGCC
CGCCTCAGTGGTTAAAGAGTTGGTTGAAAATAGCCTTGATGCGGGTGCGACTCGAATTGATATTGAAATCGATAAAGGCG
GCAGTAAGCTGATTAAAATTCGGGATAATGGCTCCGGAATTCCTAAGGAAGAACTGACCTTGGCCTTATCACGCCATGCG
ACGTCAAAGTTACATTCATTGGATGATCTTGAGGCCATACTCAGTTTTGGATTTCGCGGCGAAGCGCTCGCGAGTATAAG
CTCGGTTTCACGTTTGACTTTAACCTCTCGCACTGCTGAACAAACCGAAGCATGGCAAGCCTATGCGGAAGGTGTTGATA
TGGCAGTTAAAATTATGCCAGCAGCACATCCCGTAGGCTCCACAATTGAAGCCGTTGATTTATTTTTTAATACCCCAGCA
AGACGGCGCTTTTTAAAGAGTGATAAAACCGAATTTACTCACATTGACGAGTGGTTAAAGCGTATTGCTCTAGTGCGTGG
CGATATCCATTTTACGCTGACGCATAATGGTAAACTTGTGCGTAATTACCGCCCAGCGGTAAATGAAGCCCAATACTTAC
AGCGTTTAACGCAGGTGTCAGGGCGACAGTTTGCGGAACACGCTTTAAAAATTGAGTGCCAACACGATGATTTACGACTA
AGCGGTTATTTACAATCGCCTTGGTCGACCGTGTTAACGGACACTCACTATTTTTATGTAAATGGTCGTTTAATTCGCGA
CCGTTTAGTGAATCATGCAGTGCGCCAAGCTTTTGCACACAAAGCCGAAATTGAACAACCCGGTTATGTGTTGATGTTAG
AAATTGATCCCCATCAGGTGGATGTGAATGTGCATCCCGCTAAGCATGAAGTTCGATTTCATCAGAGTCGTTATGTCCAT
GATTATATTTTACAAGCATTACAATCGGCCCTCGAAGAGGCGGGGGAACTCTGCCTTACGGACAATGGTAATTTAACCGA
ACCTGAAGCTGCATGTATGGATACACAGTGCACTAAGGCGATTGAACCCTCAGGATTATTTGAACTTGCAAGTATCAGTG
ATCAAACTGACAAGATTGAACGTATTCGAGACGCAAGCCCTGTTACGGCTTCTCAGGAGCGATTCACTGAGTCTTCCCAA
GCGCAAGCCGTGACATCAGTTCGTTCAGGTTTTGGCATCCAGAAAAATGCTTTTGGCAGTATGGCACAGCCAAGAGATAG
CCATTACCGCAGTTTTTCAGGTGGTGAAGCTCGGCAGCGCGCTGAATTACCTTCAAAGTCGGCAATAGTGAGTTATGGTG
CTTTATTGCAAACACCATCTTATAACGTAAAAGATAAAGATTATCAGCCAGTAGCCCCTATGCCACCTATTTTAGATGGC
CAATATTGGGTCGTCGTCGAAGCAAATCATCTTCGTCTTTTACCCATAAAATCAGTCGCATTGGCAACTCGCGCCCAAGA
AATAGAAGCTAAGCTGGCAACGGGTCTCATTGGTCAACCATTGTTGATGCCGGTATCAGTTGTAGCCGATCCAGACTGGC
AATCATTGCTCGATGAAAATGAGCAATTAATACGTCAAATAGGCTTAGAACTTACAATTCGTTACCAGCAGTTGATAATT
AAAAAAGTGCCCCCATATCTGAGGGAAAGCCAATTAGCGAAGCTGATACCAGAGTGGTTACAATCGCTGCGTTTTGAAAC
GCCATCGCCCAATGCATTGGCTAAGTGGTTGGCAAAACAAAGTTTAAGTGGATTTGTGTCGGCACCAGAAATCTGGGCGG
CTTTTTCCTTGCTAACGGATGAAACAAGACAGCATATTGCCAATCAAGCGATATCTTTACCTTGGCAATCATGGCTAGAA
GAGTAA

Upstream 100 bases:

>100_bases
CAGCGTTATCAAGTCCCAATGTCGAGTATTAAACGTGCGAATGGGATGAAAACCGATGTAGTGCAACTAGGGCAAACGCT
CGTTATTCCTGAGAGTTAGA

Downstream 100 bases:

>100_bases
TAAGTGAATACAGAATTGCTGCCTAAAGTGTTATTTCTTATGGGGCCTACTGCCTCTGGAAAAACGGCTTTAGCACTAGA
ATTAGCCGAAAACCATAACT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 641; Mature: 641

Protein sequence:

>641_residues
MEKSMGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKIRDNGSGIPKEELTLALSRHA
TSKLHSLDDLEAILSFGFRGEALASISSVSRLTLTSRTAEQTEAWQAYAEGVDMAVKIMPAAHPVGSTIEAVDLFFNTPA
RRRFLKSDKTEFTHIDEWLKRIALVRGDIHFTLTHNGKLVRNYRPAVNEAQYLQRLTQVSGRQFAEHALKIECQHDDLRL
SGYLQSPWSTVLTDTHYFYVNGRLIRDRLVNHAVRQAFAHKAEIEQPGYVLMLEIDPHQVDVNVHPAKHEVRFHQSRYVH
DYILQALQSALEEAGELCLTDNGNLTEPEAACMDTQCTKAIEPSGLFELASISDQTDKIERIRDASPVTASQERFTESSQ
AQAVTSVRSGFGIQKNAFGSMAQPRDSHYRSFSGGEARQRAELPSKSAIVSYGALLQTPSYNVKDKDYQPVAPMPPILDG
QYWVVVEANHLRLLPIKSVALATRAQEIEAKLATGLIGQPLLMPVSVVADPDWQSLLDENEQLIRQIGLELTIRYQQLII
KKVPPYLRESQLAKLIPEWLQSLRFETPSPNALAKWLAKQSLSGFVSAPEIWAAFSLLTDETRQHIANQAISLPWQSWLE
E

Sequences:

>Translated_641_residues
MEKSMGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKIRDNGSGIPKEELTLALSRHA
TSKLHSLDDLEAILSFGFRGEALASISSVSRLTLTSRTAEQTEAWQAYAEGVDMAVKIMPAAHPVGSTIEAVDLFFNTPA
RRRFLKSDKTEFTHIDEWLKRIALVRGDIHFTLTHNGKLVRNYRPAVNEAQYLQRLTQVSGRQFAEHALKIECQHDDLRL
SGYLQSPWSTVLTDTHYFYVNGRLIRDRLVNHAVRQAFAHKAEIEQPGYVLMLEIDPHQVDVNVHPAKHEVRFHQSRYVH
DYILQALQSALEEAGELCLTDNGNLTEPEAACMDTQCTKAIEPSGLFELASISDQTDKIERIRDASPVTASQERFTESSQ
AQAVTSVRSGFGIQKNAFGSMAQPRDSHYRSFSGGEARQRAELPSKSAIVSYGALLQTPSYNVKDKDYQPVAPMPPILDG
QYWVVVEANHLRLLPIKSVALATRAQEIEAKLATGLIGQPLLMPVSVVADPDWQSLLDENEQLIRQIGLELTIRYQQLII
KKVPPYLRESQLAKLIPEWLQSLRFETPSPNALAKWLAKQSLSGFVSAPEIWAAFSLLTDETRQHIANQAISLPWQSWLE
E
>Mature_641_residues
MEKSMGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKIRDNGSGIPKEELTLALSRHA
TSKLHSLDDLEAILSFGFRGEALASISSVSRLTLTSRTAEQTEAWQAYAEGVDMAVKIMPAAHPVGSTIEAVDLFFNTPA
RRRFLKSDKTEFTHIDEWLKRIALVRGDIHFTLTHNGKLVRNYRPAVNEAQYLQRLTQVSGRQFAEHALKIECQHDDLRL
SGYLQSPWSTVLTDTHYFYVNGRLIRDRLVNHAVRQAFAHKAEIEQPGYVLMLEIDPHQVDVNVHPAKHEVRFHQSRYVH
DYILQALQSALEEAGELCLTDNGNLTEPEAACMDTQCTKAIEPSGLFELASISDQTDKIERIRDASPVTASQERFTESSQ
AQAVTSVRSGFGIQKNAFGSMAQPRDSHYRSFSGGEARQRAELPSKSAIVSYGALLQTPSYNVKDKDYQPVAPMPPILDG
QYWVVVEANHLRLLPIKSVALATRAQEIEAKLATGLIGQPLLMPVSVVADPDWQSLLDENEQLIRQIGLELTIRYQQLII
KKVPPYLRESQLAKLIPEWLQSLRFETPSPNALAKWLAKQSLSGFVSAPEIWAAFSLLTDETRQHIANQAISLPWQSWLE
E

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=329, Percent_Identity=36.4741641337386, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI4505911, Length=372, Percent_Identity=26.8817204301075, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI189458898, Length=372, Percent_Identity=26.8817204301075, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI189458896, Length=366, Percent_Identity=26.5027322404372, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI4505913, Length=354, Percent_Identity=26.8361581920904, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI310128478, Length=354, Percent_Identity=26.8361581920904, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=30.6382978723404, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI91992160, Length=336, Percent_Identity=23.5119047619048, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI91992162, Length=336, Percent_Identity=23.5119047619048, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI310128480, Length=302, Percent_Identity=23.841059602649, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790612, Length=640, Percent_Identity=46.09375, Blast_Score=485, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=35.4037267080745, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17562796, Length=345, Percent_Identity=25.5072463768116, Blast_Score=118, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323819, Length=336, Percent_Identity=36.9047619047619, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324247, Length=346, Percent_Identity=26.0115606936416, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6325093, Length=354, Percent_Identity=26.271186440678, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323063, Length=360, Percent_Identity=24.4444444444444, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17136968, Length=335, Percent_Identity=34.0298507462687, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI17136970, Length=356, Percent_Identity=26.123595505618, Blast_Score=109, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 71596; Mature: 71596

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKSMGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKI
CCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEE
RDNGSGIPKEELTLALSRHATSKLHSLDDLEAILSFGFRGEALASISSVSRLTLTSRTAE
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCHH
QTEAWQAYAEGVDMAVKIMPAAHPVGSTIEAVDLFFNTPARRRFLKSDKTEFTHIDEWLK
HHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHH
RIALVRGDIHFTLTHNGKLVRNYRPAVNEAQYLQRLTQVSGRQFAEHALKIECQHDDLRL
HHHHHCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHEEEEECCCCEEE
SGYLQSPWSTVLTDTHYFYVNGRLIRDRLVNHAVRQAFAHKAEIEQPGYVLMLEIDPHQV
ECEECCCHHHHHCCCEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEE
DVNVHPAKHEVRFHQSRYVHDYILQALQSALEEAGELCLTDNGNLTEPEAACMDTQCTKA
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHCCHHHHHC
IEPSGLFELASISDQTDKIERIRDASPVTASQERFTESSQAQAVTSVRSGFGIQKNAFGS
CCCCCCEEHHHCCCHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCC
MAQPRDSHYRSFSGGEARQRAELPSKSAIVSYGALLQTPSYNVKDKDYQPVAPMPPILDG
CCCCCHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
QYWVVVEANHLRLLPIKSVALATRAQEIEAKLATGLIGQPLLMPVSVVADPDWQSLLDEN
CEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEECCCCHHHHHHHH
EQLIRQIGLELTIRYQQLIIKKVPPYLRESQLAKLIPEWLQSLRFETPSPNALAKWLAKQ
HHHHHHHCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SLSGFVSAPEIWAAFSLLTDETRQHIANQAISLPWQSWLEE
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure
MEKSMGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKI
CCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEE
RDNGSGIPKEELTLALSRHATSKLHSLDDLEAILSFGFRGEALASISSVSRLTLTSRTAE
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCHH
QTEAWQAYAEGVDMAVKIMPAAHPVGSTIEAVDLFFNTPARRRFLKSDKTEFTHIDEWLK
HHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHH
RIALVRGDIHFTLTHNGKLVRNYRPAVNEAQYLQRLTQVSGRQFAEHALKIECQHDDLRL
HHHHHCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHEEEEECCCCEEE
SGYLQSPWSTVLTDTHYFYVNGRLIRDRLVNHAVRQAFAHKAEIEQPGYVLMLEIDPHQV
ECEECCCHHHHHCCCEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEE
DVNVHPAKHEVRFHQSRYVHDYILQALQSALEEAGELCLTDNGNLTEPEAACMDTQCTKA
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHCCHHHHHC
IEPSGLFELASISDQTDKIERIRDASPVTASQERFTESSQAQAVTSVRSGFGIQKNAFGS
CCCCCCEEHHHCCCHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCC
MAQPRDSHYRSFSGGEARQRAELPSKSAIVSYGALLQTPSYNVKDKDYQPVAPMPPILDG
CCCCCHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
QYWVVVEANHLRLLPIKSVALATRAQEIEAKLATGLIGQPLLMPVSVVADPDWQSLLDEN
CEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEECCCCHHHHHHHH
EQLIRQIGLELTIRYQQLIIKKVPPYLRESQLAKLIPEWLQSLRFETPSPNALAKWLAKQ
HHHHHHHCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SLSGFVSAPEIWAAFSLLTDETRQHIANQAISLPWQSWLEE
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA