Click here to switch to the map view.

The map label for this gene is pdhR

Identifier: 120597356

GI number: 120597356

Start: 563987

End: 564739

Strand: Direct

Name: pdhR

Synonym: Sputw3181_0525

Alternate gene names: 120597356

Gene position: 563987-564739 (Clockwise)

Preceding gene: 120597355

Following gene: 120597357

Centisome position: 11.98

GC content: 47.54

Gene sequence:

>753_bases
ATGGCCTATAGTAAAATTAATCAGCCAAAAATTTCTGATGTGATCATGGCGCAATTAGAGCAAATGATCCTAGAGGGCAG
TTTAAAGCCCGGTCAGAAATTACCGCCCGAACGCGAACTGGCGATCCAGTTTGAAGTGTCTCGACCTTCTTTGCGTGAAG
CGATTCAAAAGCTTGAGGCAAAAGGACTGTTAATGCGCCGTCAAGGTGGCGGTACTTATGTCAAAGAACAACTCTGGCAG
ACTCTTGCCGATCCTATTGTTGAACTGATGAATTCCGATCCAGAAAGTCAATATGACTTACTGGAGTTCCGTCATGCGAC
TGAAGGCATGATGGCTTATTTTGCCGCGTTGCGTGGTACCGACGCCGATATGCAAAATATCAAACGTATGATCCTCGAAG
TTGAAGCCGCAAGTATTATCGAACAAAAAGCCGCCGCGATTGTACATTTTTATCGTGCTGTGGCCGAAGCGTCACATAAT
GTGGCCATGTTACATCTCGTACTCAGTTTAACCCCTGTGCTGCATAAAAATGTGGCGCAAAATTTGGAGCTTTTAAGCCG
CCGCGAAGAAGCTTCTACCATGGCAAACGATCATAGACGGGCTTTGCTCGCTGCTATCGTTCGCCGCGATCCCGACGCCG
CCAGAGAAGCCTCGAATGAACATTTAAGTTACATCGAAGAGGTGATGTTATCTGTGCGGGAAGAAGATAGCCGGTTGCAG
CGAAGCTTGCGCCGCTTAAAGAGTGGCGCTTAA

Upstream 100 bases:

>100_bases
TTAGGTTGATTTTCAATCTGGACATCAAAAGTCTGATTTGATAAAGTGCGCTCACTCAAAAAAATTGGTAAGACCAATTT
ACAACGGAGCTGAGTGCCAA

Downstream 100 bases:

>100_bases
TTTCCTGAGATTTAGCACTGAGCTAAATCGGAATATGCCGCAAACACCATTCATTATCATGTATATAGAGAAGGACAGTG
TCATGTCTGAAGATATGCTA

Product: transcriptional regulator PdhR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MAYSKINQPKISDVIMAQLEQMILEGSLKPGQKLPPERELAIQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQ
TLADPIVELMNSDPESQYDLLEFRHATEGMMAYFAALRGTDADMQNIKRMILEVEAASIIEQKAAAIVHFYRAVAEASHN
VAMLHLVLSLTPVLHKNVAQNLELLSRREEASTMANDHRRALLAAIVRRDPDAAREASNEHLSYIEEVMLSVREEDSRLQ
RSLRRLKSGA

Sequences:

>Translated_250_residues
MAYSKINQPKISDVIMAQLEQMILEGSLKPGQKLPPERELAIQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQ
TLADPIVELMNSDPESQYDLLEFRHATEGMMAYFAALRGTDADMQNIKRMILEVEAASIIEQKAAAIVHFYRAVAEASHN
VAMLHLVLSLTPVLHKNVAQNLELLSRREEASTMANDHRRALLAAIVRRDPDAAREASNEHLSYIEEVMLSVREEDSRLQ
RSLRRLKSGA
>Mature_249_residues
AYSKINQPKISDVIMAQLEQMILEGSLKPGQKLPPERELAIQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQT
LADPIVELMNSDPESQYDLLEFRHATEGMMAYFAALRGTDADMQNIKRMILEVEAASIIEQKAAAIVHFYRAVAEASHNV
AMLHLVLSLTPVLHKNVAQNLELLSRREEASTMANDHRRALLAAIVRRDPDAAREASNEHLSYIEEVMLSVREEDSRLQR
SLRRLKSGA

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=233, Percent_Identity=56.6523605150215, Blast_Score=269, Evalue=1e-73,
Organism=Escherichia coli, GI1790032, Length=239, Percent_Identity=34.3096234309623, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1789353, Length=238, Percent_Identity=29.4117647058824, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI1790780, Length=230, Percent_Identity=30.4347826086957, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082208, Length=237, Percent_Identity=29.1139240506329, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1789621, Length=229, Percent_Identity=28.3842794759825, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI48994955, Length=212, Percent_Identity=27.8301886792453, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28256; Mature: 28125

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSKINQPKISDVIMAQLEQMILEGSLKPGQKLPPERELAIQFEVSRPSLREAIQKLEA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
KGLLMRRQGGGTYVKEQLWQTLADPIVELMNSDPESQYDLLEFRHATEGMMAYFAALRGT
HHHHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DADMQNIKRMILEVEAASIIEQKAAAIVHFYRAVAEASHNVAMLHLVLSLTPVLHKNVAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
NLELLSRREEASTMANDHRRALLAAIVRRDPDAAREASNEHLSYIEEVMLSVREEDSRLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RSLRRLKSGA
HHHHHHHCCC
>Mature Secondary Structure 
AYSKINQPKISDVIMAQLEQMILEGSLKPGQKLPPERELAIQFEVSRPSLREAIQKLEA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
KGLLMRRQGGGTYVKEQLWQTLADPIVELMNSDPESQYDLLEFRHATEGMMAYFAALRGT
HHHHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DADMQNIKRMILEVEAASIIEQKAAAIVHFYRAVAEASHNVAMLHLVLSLTPVLHKNVAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
NLELLSRREEASTMANDHRRALLAAIVRRDPDAAREASNEHLSYIEEVMLSVREEDSRLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RSLRRLKSGA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]