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The map label for this gene is macA [H]

Identifier: 119947305

GI number: 119947305

Start: 4518068

End: 4519219

Strand: Reverse

Name: macA [H]

Synonym: Ping_3711

Alternate gene names: 119947305

Gene position: 4519219-4518068 (Counterclockwise)

Preceding gene: 119947316

Following gene: 119947304

Centisome position: 99.11

GC content: 47.74

Gene sequence:

>1152_bases
ATGCTAAAAAAACATCGCCTGCTTATTATCACTATGCTGATTATTGTTGCCATTGCAGTGCTTATTGTTTATCTCAAACG
TTCTCGCCCGATAGCGGTTGTGGTGCAGGAAGTAACAAAGGGTGAAGTGCTGGCAACTATTACTAATACTCGGGCGGGAA
CGCTCAAAGCCTGCCAGCGAGCACGTCTTTCACCTTCTATTGGTGGCCAGATTGAAAGTCTGCTGGTTAAAGAGGGGGAT
CTAGTCAAATCCGGGCAACTGCTGCTGGAAATATGGAATGATGATCTACAGGCACAGGTCACACTGGCTGAGTATGAAAG
TGAAATCTCTGCAGCTCTAGTGCGCGAGGCTTGTATTATTGGCGATCTTGCTAAACGAGAAGCTTATCGCCTGCGCACTT
TGTTCAAAAAAAACATGGTCTCTGCAGAGAGTGTTGATCAGGCCGAAAGTGCAGCGAACGCTAAGCTTGCAGCATGCGAA
GCTGCCCATACATCGGTCAAGGTGAGCCAGTCAAAAATTGATGCAACCCGCGCCGCTTTGGCACGCACCCGTTTAAATGC
CCCTTTTAACGGCCGCGTTGCCGAAGTGAATGGTGAAGTGGGGGAGTATCTAACCCCTTCGCCCATTGGTGTCGCTACTT
TGCCGGCGATTGACTTGATTGATTACAGCTGTCTGTATGTCTCTGCACCCATTGATGAAGTCGATGCACCGCAGATTCGC
CCGAAAATGCCCGCCCGTGTTTCACTGGATGCTTTTGCGGGGAAAACATTTGCCGGGAGAGTACGCCGGGTTGCTGACTA
TGTATTGGATCTGGAAAAACAGTCACGCACGGTTGAAATAGAAGTTGAATTTATCAATCTCGACAATATCGGTAATATGT
TGCCCGGTTACAGTGCCGATGCCGAAGTTATTCTTGATCAACGTGATAACGTTTTGCGTATTCCTACTGCGGCACTGTTC
GATCGTAACCAGGTATTGATTTTAAAAGAAGATGGTCTGCTTGAACAACGAAAGATCAAAATTGGCATAAGCAATTGGCA
TTATACAGAAGTGCTTGACGGTCTTGCTGCGGGTGAACTGCTGGTAACTTCAATCGAACGGGAAGGGGTCGAAGAAGGTG
CCCGTGCTGTTGTTGACAATAAAGATGACTGA

Upstream 100 bases:

>100_bases
TGATTGATCACATTGTTATTTTTCGCTGATCATAAATTAATCCAGTCTGGATTAATAACACAACAAATTATTTTCCTGTC
AAAATAACCGGGATCTTTTT

Downstream 100 bases:

>100_bases
ATTAACTATGATCGAATTAAAGAATATTCATCGTGACTTTCTGGTTGGAGAGCAAAAGGTACATGCCCTCGATAATATTA
ATCTGTCCATTGTGGCGGGT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MLKKHRLLIITMLIIVAIAVLIVYLKRSRPIAVVVQEVTKGEVLATITNTRAGTLKACQRARLSPSIGGQIESLLVKEGD
LVKSGQLLLEIWNDDLQAQVTLAEYESEISAALVREACIIGDLAKREAYRLRTLFKKNMVSAESVDQAESAANAKLAACE
AAHTSVKVSQSKIDATRAALARTRLNAPFNGRVAEVNGEVGEYLTPSPIGVATLPAIDLIDYSCLYVSAPIDEVDAPQIR
PKMPARVSLDAFAGKTFAGRVRRVADYVLDLEKQSRTVEIEVEFINLDNIGNMLPGYSADAEVILDQRDNVLRIPTAALF
DRNQVLILKEDGLLEQRKIKIGISNWHYTEVLDGLAAGELLVTSIEREGVEEGARAVVDNKDD

Sequences:

>Translated_383_residues
MLKKHRLLIITMLIIVAIAVLIVYLKRSRPIAVVVQEVTKGEVLATITNTRAGTLKACQRARLSPSIGGQIESLLVKEGD
LVKSGQLLLEIWNDDLQAQVTLAEYESEISAALVREACIIGDLAKREAYRLRTLFKKNMVSAESVDQAESAANAKLAACE
AAHTSVKVSQSKIDATRAALARTRLNAPFNGRVAEVNGEVGEYLTPSPIGVATLPAIDLIDYSCLYVSAPIDEVDAPQIR
PKMPARVSLDAFAGKTFAGRVRRVADYVLDLEKQSRTVEIEVEFINLDNIGNMLPGYSADAEVILDQRDNVLRIPTAALF
DRNQVLILKEDGLLEQRKIKIGISNWHYTEVLDGLAAGELLVTSIEREGVEEGARAVVDNKDD
>Mature_383_residues
MLKKHRLLIITMLIIVAIAVLIVYLKRSRPIAVVVQEVTKGEVLATITNTRAGTLKACQRARLSPSIGGQIESLLVKEGD
LVKSGQLLLEIWNDDLQAQVTLAEYESEISAALVREACIIGDLAKREAYRLRTLFKKNMVSAESVDQAESAANAKLAACE
AAHTSVKVSQSKIDATRAALARTRLNAPFNGRVAEVNGEVGEYLTPSPIGVATLPAIDLIDYSCLYVSAPIDEVDAPQIR
PKMPARVSLDAFAGKTFAGRVRRVADYVLDLEKQSRTVEIEVEFINLDNIGNMLPGYSADAEVILDQRDNVLRIPTAALF
DRNQVLILKEDGLLEQRKIKIGISNWHYTEVLDGLAAGELLVTSIEREGVEEGARAVVDNKDD

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081951, Length=233, Percent_Identity=29.1845493562232, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87082036, Length=358, Percent_Identity=25.6983240223464, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081796, Length=325, Percent_Identity=26.4615384615385, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790519, Length=245, Percent_Identity=31.0204081632653, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41855; Mature: 41855

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKHRLLIITMLIIVAIAVLIVYLKRSRPIAVVVQEVTKGEVLATITNTRAGTLKACQR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCEEEEEECCCCHHHHHHHH
ARLSPSIGGQIESLLVKEGDLVKSGQLLLEIWNDDLQAQVTLAEYESEISAALVREACII
HCCCCCCCCHHHHHHHCCCCCEECCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHH
GDLAKREAYRLRTLFKKNMVSAESVDQAESAANAKLAACEAAHTSVKVSQSKIDATRAAL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCEEEEHHHHHHHHHHHH
ARTRLNAPFNGRVAEVNGEVGEYLTPSPIGVATLPAIDLIDYSCLYVSAPIDEVDAPQIR
HHHHCCCCCCCEEEEECCCCCCCCCCCCCCEECCCHHHHHCCEEEEEECCCCCCCCCCCC
PKMPARVSLDAFAGKTFAGRVRRVADYVLDLEKQSRTVEIEVEFINLDNIGNMLPGYSAD
CCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCC
AEVILDQRDNVLRIPTAALFDRNQVLILKEDGLLEQRKIKIGISNWHYTEVLDGLAAGEL
CEEEECCCCCEEECCHHHHCCCCCEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHCHH
LVTSIEREGVEEGARAVVDNKDD
HHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLKKHRLLIITMLIIVAIAVLIVYLKRSRPIAVVVQEVTKGEVLATITNTRAGTLKACQR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCEEEEEECCCCHHHHHHHH
ARLSPSIGGQIESLLVKEGDLVKSGQLLLEIWNDDLQAQVTLAEYESEISAALVREACII
HCCCCCCCCHHHHHHHCCCCCEECCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHH
GDLAKREAYRLRTLFKKNMVSAESVDQAESAANAKLAACEAAHTSVKVSQSKIDATRAAL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCEEEEHHHHHHHHHHHH
ARTRLNAPFNGRVAEVNGEVGEYLTPSPIGVATLPAIDLIDYSCLYVSAPIDEVDAPQIR
HHHHCCCCCCCEEEEECCCCCCCCCCCCCCEECCCHHHHHCCEEEEEECCCCCCCCCCCC
PKMPARVSLDAFAGKTFAGRVRRVADYVLDLEKQSRTVEIEVEFINLDNIGNMLPGYSAD
CCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCC
AEVILDQRDNVLRIPTAALFDRNQVLILKEDGLLEQRKIKIGISNWHYTEVLDGLAAGEL
CEEEECCCCCEEECCHHHHCCCCCEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHCHH
LVTSIEREGVEEGARAVVDNKDD
HHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]