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The map label for this gene is czcR [H]

Identifier: 119946605

GI number: 119946605

Start: 3679102

End: 3679989

Strand: Reverse

Name: czcR [H]

Synonym: Ping_2984

Alternate gene names: 119946605

Gene position: 3679989-3679102 (Counterclockwise)

Preceding gene: 119946606

Following gene: 119946604

Centisome position: 80.71

GC content: 42.23

Gene sequence:

>888_bases
ATGAAGCATAATAACAGTGATGTTGTTTTAGTGGTTGATGATTCCCCGGAATCTTTAGGCATGCTCAATGTTGCTCTTAA
TAGTCAGGGTTATACTGCGCTGGTTGCTCTGAATGGCTTACAGGCGTTAGCTATCGCCGAGAAAGTGCCACCTGATGTGG
TGTTATTGGATGCTATGATGCCGCAAATGGATGGTTTTGAAACCTGTCGGCGTCTTAAGCTTATTTTGCCTAATACCCCG
ATTATATTTATGACCGGATTAACCGATGTTGAAGATGTGGTGAAAGGTTTTGAAGCGGGAGGGGTCGATTATGTCACTAA
ACCTATTTCACCCGATGAAGTTATCGCGCGCATTAAAAGACATATTGAAACGGCGAAATTGGCATTAAGCGCGCAGGATG
CACTTGACCATGCGGGTAAAAATGTATTTTGTGTCAGTGAATTAGGTCGGCTTTCCTGGGCAACTCCTTATGTGCATGCT
TTAATAGAGCAGACATCTGGGGACAATCCAAGTCCGTGGGCGAGTATGGCGCTATTAATAGAAAACTGGTTAAAAACCGA
CAAATCGCAAAATCTGAAAATAAACTGTTTTTCGGATCAGATAGAAGTGTATTACGAGCGCCAGCAGGAAAATATGCATC
TTCTGCGCATTGTCCAAAAAGCACCGCAAAAAAATCCGCAGGATTTAAAAAATAAACTTCCCATCACCAAACGTGAATCG
GAAGTGCTGTATTGGGTTTCCTATGGTAAAACAAGCTGGGAAATTTCACTTATTTTAGAGATGAGTCCGCGCACTGTTAA
TAAACATTTAGAGCAGATTTATAAAAAACTGGGTGTCGATAATCGTACCTCCGCGGCGGCAATATCTATTCGCATACTGG
AAGCTTAA

Upstream 100 bases:

>100_bases
TCTCAATATTGCTATCCGCAAGCGAGTGCATCACAAATTAAGGAGTATGTTGAAGTGTGTGATTTTCCTAAGATCATTGA
ATATTTAAGTGAGTTAAATC

Downstream 100 bases:

>100_bases
TCTGTGGCAGCATTGGTTTATTTATAAAGGTTTGGGTTATGTCCCATCTTTCTCTTTGCGCAATATACTCAAATATTGTG
CTGTGGAGTAAAGTTAAACC

Product: two component transcriptional regulator, LuxR family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKHNNSDVVLVVDDSPESLGMLNVALNSQGYTALVALNGLQALAIAEKVPPDVVLLDAMMPQMDGFETCRRLKLILPNTP
IIFMTGLTDVEDVVKGFEAGGVDYVTKPISPDEVIARIKRHIETAKLALSAQDALDHAGKNVFCVSELGRLSWATPYVHA
LIEQTSGDNPSPWASMALLIENWLKTDKSQNLKINCFSDQIEVYYERQQENMHLLRIVQKAPQKNPQDLKNKLPITKRES
EVLYWVSYGKTSWEISLILEMSPRTVNKHLEQIYKKLGVDNRTSAAAISIRILEA

Sequences:

>Translated_295_residues
MKHNNSDVVLVVDDSPESLGMLNVALNSQGYTALVALNGLQALAIAEKVPPDVVLLDAMMPQMDGFETCRRLKLILPNTP
IIFMTGLTDVEDVVKGFEAGGVDYVTKPISPDEVIARIKRHIETAKLALSAQDALDHAGKNVFCVSELGRLSWATPYVHA
LIEQTSGDNPSPWASMALLIENWLKTDKSQNLKINCFSDQIEVYYERQQENMHLLRIVQKAPQKNPQDLKNKLPITKRES
EVLYWVSYGKTSWEISLILEMSPRTVNKHLEQIYKKLGVDNRTSAAAISIRILEA
>Mature_295_residues
MKHNNSDVVLVVDDSPESLGMLNVALNSQGYTALVALNGLQALAIAEKVPPDVVLLDAMMPQMDGFETCRRLKLILPNTP
IIFMTGLTDVEDVVKGFEAGGVDYVTKPISPDEVIARIKRHIETAKLALSAQDALDHAGKNVFCVSELGRLSWATPYVHA
LIEQTSGDNPSPWASMALLIENWLKTDKSQNLKINCFSDQIEVYYERQQENMHLLRIVQKAPQKNPQDLKNKLPITKRES
EVLYWVSYGKTSWEISLILEMSPRTVNKHLEQIYKKLGVDNRTSAAAISIRILEA

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=115, Percent_Identity=36.5217391304348, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788394, Length=133, Percent_Identity=34.5864661654135, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790860, Length=122, Percent_Identity=36.0655737704918, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790437, Length=120, Percent_Identity=35, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790299, Length=115, Percent_Identity=35.6521739130435, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786784, Length=111, Percent_Identity=32.4324324324324, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786599, Length=113, Percent_Identity=34.5132743362832, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789809, Length=111, Percent_Identity=34.2342342342342, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI87082012, Length=115, Percent_Identity=29.5652173913043, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787229, Length=124, Percent_Identity=32.258064516129, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788905, Length=115, Percent_Identity=29.5652173913043, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI145693157, Length=123, Percent_Identity=30.0813008130081, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 32966; Mature: 32966

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHNNSDVVLVVDDSPESLGMLNVALNSQGYTALVALNGLQALAIAEKVPPDVVLLDAMM
CCCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHCCCCEEEHHHHC
PQMDGFETCRRLKLILPNTPIIFMTGLTDVEDVVKGFEAGGVDYVTKPISPDEVIARIKR
CCCCCHHHHHHEEEEECCCCEEEEECCCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHH
HIETAKLALSAQDALDHAGKNVFCVSELGRLSWATPYVHALIEQTSGDNPSPWASMALLI
HHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHH
ENWLKTDKSQNLKINCFSDQIEVYYERQQENMHLLRIVQKAPQKNPQDLKNKLPITKRES
HHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHCCCCCCCCC
EVLYWVSYGKTSWEISLILEMSPRTVNKHLEQIYKKLGVDNRTSAAAISIRILEA
CEEEEEEECCCEEEEEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MKHNNSDVVLVVDDSPESLGMLNVALNSQGYTALVALNGLQALAIAEKVPPDVVLLDAMM
CCCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHCCCCEEEHHHHC
PQMDGFETCRRLKLILPNTPIIFMTGLTDVEDVVKGFEAGGVDYVTKPISPDEVIARIKR
CCCCCHHHHHHEEEEECCCCEEEEECCCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHH
HIETAKLALSAQDALDHAGKNVFCVSELGRLSWATPYVHALIEQTSGDNPSPWASMALLI
HHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHH
ENWLKTDKSQNLKINCFSDQIEVYYERQQENMHLLRIVQKAPQKNPQDLKNKLPITKRES
HHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHCCCCCCCCC
EVLYWVSYGKTSWEISLILEMSPRTVNKHLEQIYKKLGVDNRTSAAAISIRILEA
CEEEEEEECCCEEEEEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]