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The map label for this gene is pdhB [H]

Identifier: 119946408

GI number: 119946408

Start: 3422386

End: 3424569

Strand: Reverse

Name: pdhB [H]

Synonym: Ping_2782

Alternate gene names: 119946408

Gene position: 3424569-3422386 (Counterclockwise)

Preceding gene: 119946409

Following gene: 119946407

Centisome position: 75.11

GC content: 39.79

Gene sequence:

>2184_bases
ATGCCTAAAACGGAAAAATTATTAACAAATGTTGAGTGGCTTAAAATCGAAGCCGATAGCAAAGATATAAATAAGATCGG
TGCTAAAGAAAGCATAAAAATATTCACTCAAACTCAGATTATTAGAACCTTTGAAGAAGAAATGATTAAGCTGGATAAGC
TTGGTTTAGTACATGGTCCTTTACATACCAGTGTTGGTCAGGAGGGGGCGATGGTCGCTGCATTATCCGTTATGCGGGAT
AGTGATATTGCCAACGGTTCACATCGAGGACATCATTTATTTTTAGGGAAATCATTAAACTATGTTCTTCCTGACGATTT
TGACCCAAAAAATGATGACTATGACGTAAATATGGATGAGCTCATTTATAAAACCATGTCTGAAATTTTAGGGCTGAGTG
ATGGCTTTTCCGGTGGTCGTGGGGGGTCAATGCACTTGCGTTGGGAAGAGTCTGGTGTCATTGGCACCAATGCGATCGTT
GGTGGTGGTGTACCTACTGCATTAGGCGCTGCATGGTCTAAGAAACGTTCAGGAAATCAAGATATTGTATTTACATCATT
TGGTGATGGCTCTTGTCATATTGGTAACGTTTTAGAGTCATTTAACTTAGCCTCTTTATATGAATTACCGCTTTGTTTTT
ATATCGAAAATAATGGTTATGCGGTTTCGACAACATTAGAAGAACAATCTAAAGATATTCGAATGTCGTCTAGAGGACAA
GGTTTTTCAATCCCAGCCTATAAAGTGGATGGGCAGGATCCCTTCAGCGTGCGTACTGCTATGGAAATGGCAGAAAAACA
CATGCGCGCAGGTAAGGGGCCATTTATTCTTGAAGTCGATGTCTATCGTCACTTTCATCATAGTGGTGGCATTAAAGGCA
GTGCTTTTGGCTATCGTTCCAAAGATGAAGAAAAAAAAGAAACGGAGAGAGATGCATTAAATTTCATACAAAAAATATTG
ATTGAAAAATCATGGATCACGCAAAATGAAATTGATGTTATAAAAAATAGAATTGAAGTGATGGTTCAGAAATCGGTCAA
ACGCATTCTGATAAAAGACAATGATAAAAATATAATCAACCCCGTGTTGTGGCCTAGTACGACTACACGTGATGATGGTT
TAAGAAGTGATAAAAGTGAATTCGAGGGTGTTAAATACACTGAATTTAATGACTTCAATGGTGGGTTAGAAAATAAGAGA
TTCGTGGACGTCATTGCACAAAACATGGTCAGACGTTTTGAGGATGATGATCGCTACTTTGTTATTGGTGAAGATGTTCA
TAAATTAAAAGGCGGCACTAACGGCGCAACAAAAGGAATTCCTGAACGTTGGCCTGACCGTTGTGTACCAACACCCATTG
CTGAGCATGCTTTTGTCGGTTTGAGTGGTGGTGTGGCTATGCTTGGAGAGTATCGTCCGATCGTAGAATTAATGTATCCT
GATTTTGGACTTGTTGCGGCAGATCAGCTTTTTAATCAAATTGCAAAAGCCCGCCATATGTTTGGTAATACGGTGAAAGT
ACCCTTGGTATTGCGCACTAAAATAGCAATAGGAAGCGGCTATGGTTCTCAACATTCAATGGATCCTGCCGGTTTATTTG
CGATGTGGCCAGGTTGGAGAATCGTTGTCCCTTCAACACCTTATGATTATGTTGGATTAATGAACTCGGCATTAAAATGT
GAAGATCCCGTTCTGGTGATTGAAACCGTGGAGCTTTATTCTAAAACCGGGTTGGCACCCACTGACAACTTCGATTACTT
TATTGAGTTAGGCAAAGCTAAAGTGGTGAGAGAAGGTCAGAAATTCACCGTGCTGACTTATTTAAATATGATTTCACTGG
CTGAAAAAGCCTGCGAAAATTTAGGCATTGATGCTGAAGTTATTGATTTACGCAGCCTGGATAGAGCGAGTTTGGACTGG
GATACGATTGGAGAGAGTATCAAGAAAACCAATCATGTGATCGTTCTTGAGCAAGGTAGTCTGACCAATTCTTACGGGGC
TATGTTATCCGATGAAATTCAGAAGCGCTATTTTGATTATTTAGATCACCCTGTTAAACGTGTCTATGGTGGTGAGTCTT
CACCTAATGTATCTAAAGTCTTGGAACGTTCAGCCTATGTTGGTTTGGAAGAGATTGAAAAGGCTTTTACTGAATCAATG
AACGATAAGGGTATTAGGGGTTAA

Upstream 100 bases:

>100_bases
ATTTGGGAATTTATTGAAAAAAAATATATAGCAGTCGATTGGTAGGGCTATTTAAAATAGATCACCCTTTACATTATCTC
ATTTAGTAAGGATATAGCAG

Downstream 100 bases:

>100_bases
TAAGATGAGTCATAAAATACCAGGTCTTCGAGGCATTGATCATATTGGATTAACAGTACCCAATTTAGAAGAAGCGGTAG
ACTTTTTTGTCAATGTCGTG

Product: pyruvate dehydrogenase complex, E1 beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 727; Mature: 726

Protein sequence:

>727_residues
MPKTEKLLTNVEWLKIEADSKDINKIGAKESIKIFTQTQIIRTFEEEMIKLDKLGLVHGPLHTSVGQEGAMVAALSVMRD
SDIANGSHRGHHLFLGKSLNYVLPDDFDPKNDDYDVNMDELIYKTMSEILGLSDGFSGGRGGSMHLRWEESGVIGTNAIV
GGGVPTALGAAWSKKRSGNQDIVFTSFGDGSCHIGNVLESFNLASLYELPLCFYIENNGYAVSTTLEEQSKDIRMSSRGQ
GFSIPAYKVDGQDPFSVRTAMEMAEKHMRAGKGPFILEVDVYRHFHHSGGIKGSAFGYRSKDEEKKETERDALNFIQKIL
IEKSWITQNEIDVIKNRIEVMVQKSVKRILIKDNDKNIINPVLWPSTTTRDDGLRSDKSEFEGVKYTEFNDFNGGLENKR
FVDVIAQNMVRRFEDDDRYFVIGEDVHKLKGGTNGATKGIPERWPDRCVPTPIAEHAFVGLSGGVAMLGEYRPIVELMYP
DFGLVAADQLFNQIAKARHMFGNTVKVPLVLRTKIAIGSGYGSQHSMDPAGLFAMWPGWRIVVPSTPYDYVGLMNSALKC
EDPVLVIETVELYSKTGLAPTDNFDYFIELGKAKVVREGQKFTVLTYLNMISLAEKACENLGIDAEVIDLRSLDRASLDW
DTIGESIKKTNHVIVLEQGSLTNSYGAMLSDEIQKRYFDYLDHPVKRVYGGESSPNVSKVLERSAYVGLEEIEKAFTESM
NDKGIRG

Sequences:

>Translated_727_residues
MPKTEKLLTNVEWLKIEADSKDINKIGAKESIKIFTQTQIIRTFEEEMIKLDKLGLVHGPLHTSVGQEGAMVAALSVMRD
SDIANGSHRGHHLFLGKSLNYVLPDDFDPKNDDYDVNMDELIYKTMSEILGLSDGFSGGRGGSMHLRWEESGVIGTNAIV
GGGVPTALGAAWSKKRSGNQDIVFTSFGDGSCHIGNVLESFNLASLYELPLCFYIENNGYAVSTTLEEQSKDIRMSSRGQ
GFSIPAYKVDGQDPFSVRTAMEMAEKHMRAGKGPFILEVDVYRHFHHSGGIKGSAFGYRSKDEEKKETERDALNFIQKIL
IEKSWITQNEIDVIKNRIEVMVQKSVKRILIKDNDKNIINPVLWPSTTTRDDGLRSDKSEFEGVKYTEFNDFNGGLENKR
FVDVIAQNMVRRFEDDDRYFVIGEDVHKLKGGTNGATKGIPERWPDRCVPTPIAEHAFVGLSGGVAMLGEYRPIVELMYP
DFGLVAADQLFNQIAKARHMFGNTVKVPLVLRTKIAIGSGYGSQHSMDPAGLFAMWPGWRIVVPSTPYDYVGLMNSALKC
EDPVLVIETVELYSKTGLAPTDNFDYFIELGKAKVVREGQKFTVLTYLNMISLAEKACENLGIDAEVIDLRSLDRASLDW
DTIGESIKKTNHVIVLEQGSLTNSYGAMLSDEIQKRYFDYLDHPVKRVYGGESSPNVSKVLERSAYVGLEEIEKAFTESM
NDKGIRG
>Mature_726_residues
PKTEKLLTNVEWLKIEADSKDINKIGAKESIKIFTQTQIIRTFEEEMIKLDKLGLVHGPLHTSVGQEGAMVAALSVMRDS
DIANGSHRGHHLFLGKSLNYVLPDDFDPKNDDYDVNMDELIYKTMSEILGLSDGFSGGRGGSMHLRWEESGVIGTNAIVG
GGVPTALGAAWSKKRSGNQDIVFTSFGDGSCHIGNVLESFNLASLYELPLCFYIENNGYAVSTTLEEQSKDIRMSSRGQG
FSIPAYKVDGQDPFSVRTAMEMAEKHMRAGKGPFILEVDVYRHFHHSGGIKGSAFGYRSKDEEKKETERDALNFIQKILI
EKSWITQNEIDVIKNRIEVMVQKSVKRILIKDNDKNIINPVLWPSTTTRDDGLRSDKSEFEGVKYTEFNDFNGGLENKRF
VDVIAQNMVRRFEDDDRYFVIGEDVHKLKGGTNGATKGIPERWPDRCVPTPIAEHAFVGLSGGVAMLGEYRPIVELMYPD
FGLVAADQLFNQIAKARHMFGNTVKVPLVLRTKIAIGSGYGSQHSMDPAGLFAMWPGWRIVVPSTPYDYVGLMNSALKCE
DPVLVIETVELYSKTGLAPTDNFDYFIELGKAKVVREGQKFTVLTYLNMISLAEKACENLGIDAEVIDLRSLDRASLDWD
TIGESIKKTNHVIVLEQGSLTNSYGAMLSDEIQKRYFDYLDHPVKRVYGGESSPNVSKVLERSAYVGLEEIEKAFTESMN
DKGIRG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=326, Percent_Identity=32.2085889570552, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI291084858, Length=326, Percent_Identity=30.9815950920245, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI4885543, Length=306, Percent_Identity=29.4117647058824, Blast_Score=141, Evalue=3e-33,
Organism=Homo sapiens, GI4557353, Length=336, Percent_Identity=28.2738095238095, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI34101272, Length=336, Percent_Identity=28.2738095238095, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI4505685, Length=320, Percent_Identity=26.5625, Blast_Score=123, Evalue=8e-28,
Organism=Homo sapiens, GI291084742, Length=320, Percent_Identity=26.5625, Blast_Score=122, Evalue=2e-27,
Organism=Homo sapiens, GI291084744, Length=327, Percent_Identity=26.2996941896024, Blast_Score=116, Evalue=9e-26,
Organism=Homo sapiens, GI11386135, Length=295, Percent_Identity=26.1016949152542, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI258645172, Length=295, Percent_Identity=26.1016949152542, Blast_Score=103, Evalue=8e-22,
Organism=Homo sapiens, GI291084757, Length=320, Percent_Identity=23.75, Blast_Score=87, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17538422, Length=326, Percent_Identity=33.1288343558282, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17536047, Length=321, Percent_Identity=28.6604361370716, Blast_Score=139, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI32564172, Length=321, Percent_Identity=28.6604361370716, Blast_Score=139, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17506935, Length=311, Percent_Identity=31.5112540192926, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI86563355, Length=293, Percent_Identity=25.938566552901, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI86563357, Length=293, Percent_Identity=25.938566552901, Blast_Score=103, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6319698, Length=325, Percent_Identity=34.4615384615385, Blast_Score=170, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6321026, Length=319, Percent_Identity=31.0344827586207, Blast_Score=134, Evalue=5e-32,
Organism=Drosophila melanogaster, GI21358145, Length=316, Percent_Identity=33.8607594936709, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24650940, Length=316, Percent_Identity=33.8607594936709, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24639744, Length=320, Percent_Identity=30.9375, Blast_Score=146, Evalue=6e-35,
Organism=Drosophila melanogaster, GI28571106, Length=320, Percent_Identity=30.9375, Blast_Score=146, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24639740, Length=320, Percent_Identity=30.9375, Blast_Score=145, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24639746, Length=310, Percent_Identity=29.6774193548387, Blast_Score=136, Evalue=7e-32,
Organism=Drosophila melanogaster, GI160714832, Length=300, Percent_Identity=32, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI160714828, Length=305, Percent_Identity=32.1311475409836, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24639748, Length=325, Percent_Identity=27.6923076923077, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21355903, Length=370, Percent_Identity=23.5135135135135, Blast_Score=99, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 81082; Mature: 80951

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKTEKLLTNVEWLKIEADSKDINKIGAKESIKIFTQTQIIRTFEEEMIKLDKLGLVHGP
CCCHHHHHCCCEEEEEECCCCHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCEECC
LHTSVGQEGAMVAALSVMRDSDIANGSHRGHHLFLGKSLNYVLPDDFDPKNDDYDVNMDE
HHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHH
LIYKTMSEILGLSDGFSGGRGGSMHLRWEESGVIGTNAIVGGGVPTALGAAWSKKRSGNQ
HHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEECCCEECCCCHHHHHHHHHHCCCCCC
DIVFTSFGDGSCHIGNVLESFNLASLYELPLCFYIENNGYAVSTTLEEQSKDIRMSSRGQ
CEEEEECCCCCCHHHHHHHHCCHHHHCCCCEEEEEECCCEEEEEEHHHCCCCCEECCCCC
GFSIPAYKVDGQDPFSVRTAMEMAEKHMRAGKGPFILEVDVYRHFHHSGGIKGSAFGYRS
CCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCC
KDEEKKETERDALNFIQKILIEKSWITQNEIDVIKNRIEVMVQKSVKRILIKDNDKNIIN
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC
PVLWPSTTTRDDGLRSDKSEFEGVKYTEFNDFNGGLENKRFVDVIAQNMVRRFEDDDRYF
CEECCCCCCCCCCCCCCHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEE
VIGEDVHKLKGGTNGATKGIPERWPDRCVPTPIAEHAFVGLSGGVAMLGEYRPIVELMYP
EECCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEECCCCHHHHCCCCCHHHHHCC
DFGLVAADQLFNQIAKARHMFGNTVKVPLVLRTKIAIGSGYGSQHSMDPAGLFAMWPGWR
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCEEEECCCCE
IVVPSTPYDYVGLMNSALKCEDPVLVIETVELYSKTGLAPTDNFDYFIELGKAKVVREGQ
EEECCCCHHHHHHHHCCCCCCCCEEEEEEHHHHHHCCCCCCCCCCEEEEECCHHHHHCCC
KFTVLTYLNMISLAEKACENLGIDAEVIDLRSLDRASLDWDTIGESIKKTNHVIVLEQGS
CEEEHHHHHHHHHHHHHHHHCCCCCEEEEHHCCCCCCCCHHHHHHHHHHCCCEEEEECCC
LTNSYGAMLSDEIQKRYFDYLDHPVKRVYGGESSPNVSKVLERSAYVGLEEIEKAFTESM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCC
NDKGIRG
CCCCCCC
>Mature Secondary Structure 
PKTEKLLTNVEWLKIEADSKDINKIGAKESIKIFTQTQIIRTFEEEMIKLDKLGLVHGP
CCHHHHHCCCEEEEEECCCCHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCEECC
LHTSVGQEGAMVAALSVMRDSDIANGSHRGHHLFLGKSLNYVLPDDFDPKNDDYDVNMDE
HHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHH
LIYKTMSEILGLSDGFSGGRGGSMHLRWEESGVIGTNAIVGGGVPTALGAAWSKKRSGNQ
HHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEECCCEECCCCHHHHHHHHHHCCCCCC
DIVFTSFGDGSCHIGNVLESFNLASLYELPLCFYIENNGYAVSTTLEEQSKDIRMSSRGQ
CEEEEECCCCCCHHHHHHHHCCHHHHCCCCEEEEEECCCEEEEEEHHHCCCCCEECCCCC
GFSIPAYKVDGQDPFSVRTAMEMAEKHMRAGKGPFILEVDVYRHFHHSGGIKGSAFGYRS
CCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCC
KDEEKKETERDALNFIQKILIEKSWITQNEIDVIKNRIEVMVQKSVKRILIKDNDKNIIN
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC
PVLWPSTTTRDDGLRSDKSEFEGVKYTEFNDFNGGLENKRFVDVIAQNMVRRFEDDDRYF
CEECCCCCCCCCCCCCCHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEE
VIGEDVHKLKGGTNGATKGIPERWPDRCVPTPIAEHAFVGLSGGVAMLGEYRPIVELMYP
EECCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEECCCCHHHHCCCCCHHHHHCC
DFGLVAADQLFNQIAKARHMFGNTVKVPLVLRTKIAIGSGYGSQHSMDPAGLFAMWPGWR
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCEEEECCCCE
IVVPSTPYDYVGLMNSALKCEDPVLVIETVELYSKTGLAPTDNFDYFIELGKAKVVREGQ
EEECCCCHHHHHHHHCCCCCCCCEEEEEEHHHHHHCCCCCCCCCCEEEEECCHHHHHCCC
KFTVLTYLNMISLAEKACENLGIDAEVIDLRSLDRASLDWDTIGESIKKTNHVIVLEQGS
CEEEHHHHHHHHHHHHHHHHCCCCCEEEEHHCCCCCCCCHHHHHHHHHHCCCEEEEECCC
LTNSYGAMLSDEIQKRYFDYLDHPVKRVYGGESSPNVSKVLERSAYVGLEEIEKAFTESM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCC
NDKGIRG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]