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The map label for this gene is lpd [H]

Identifier: 119946405

GI number: 119946405

Start: 3419147

End: 3420538

Strand: Reverse

Name: lpd [H]

Synonym: Ping_2779

Alternate gene names: 119946405

Gene position: 3420538-3419147 (Counterclockwise)

Preceding gene: 119946406

Following gene: 119946404

Centisome position: 75.02

GC content: 34.05

Gene sequence:

>1392_bases
ATGAGTTCTGCAGATATTGAATATGATGTCATTATTATAGGGGGTGGCCCCGGAGGTTATGTTAGTGCAATTAAAGCTGC
TCAAAACAACCTGAAAGTCGCCTTGGTAGAGAAAGATAAGATGGGTGGTATATGTCTTAATTGGGGGTGTATACCCACTA
AAGCCTTGTTAAAATCAGGTGAATTCATTAATAAACTTCATAAAGCAAATGACTTTGGTGTTGTGGTTGATAAGTTTTCT
TTTGATTTGAAATCCATCGTTAATCGCTCTAGGGACATATCTAAAAATTTAAATAAAGGTGTTGATGCGTTAATGAAAAA
AAACGGCATAACCGTTTTTAATGATACCGCTAAAATCATAAGTAACCATAAAGTAGCGCTAAGTAATCAAACATTAAATA
CTAAAAATATAGTGATAGCGACAGGGAGTAAATCTAAAATAATTCCTGGTTTAGAGCCTGATGGTAATGTTGTTTGGAAT
TACAGGAATGCTATGACACCTAAAAAAGTACCAGAAAACCTCTTGATTATTGGTGCTGGGGCTATTGGTGTTGAATTTGC
TTGTTTTTATAATTCATTAGGCAGCAATGTCACTATTGTTGAAAATCAAGAAAATATATTGTCAACAGAAGATGATGATG
TGTCAGCGCTTGCAAAAAAACATTTTATTAAATTAGGCATTTCAATTTTAAATAGCACAAAAGTTAATTTTATTGAAAAA
TCAAAGGACAGCATTACTTTTGAACTAACCAGTGAGAATTTTAAAGAAACAAAAGTTTTTGACAACGTAATAATGGCTAT
AGGCGTTTCAGGCAGTTTTGATAATATTGGTCTGGAAACATTAGGTATTAAAACTAATCATGGTTTTATTGAAACGAATG
AGTTTATGCAAACTAATGTACCTAATATTTACGCCATTGGAGATGTGGCAGGTGCACCTTGTCTCGCTCATAAAGCCAGC
CATGAAGGTATTATTTGTATTGAAAAGATTTTAAATAAAAATAACATTAAAACGCTTAATAATAATTCTATCCCATCTTG
TATTTATAGTTACCCGCAAATTGCCAGTTTAGGATTAACTGAAAAAGCCGTTATTGCCTCGGGTGAAACCTACACAGTAG
GGAGATTTCCATTTAATGCTAATGGTAAGGCGATTGCTTCTGGTGAGACTGATGGTTTTATAAAAACGTTATTTTCAGCG
AATACGGGTGAGTTGTTAGGCGTGCATATGATTGGTGCCGAAGTCACTGAGATGATCCAAGGATATGCTATTGGAAAAGA
ATTGGAAACAACACAAGTTGAATTGGAACATGTGATATTTCCACATCCAACAATGTCTGAAGCGATGCATGAAGCTGTAT
TGGATGCTTCTGATAAAGCAATTCATATATAA

Upstream 100 bases:

>100_bases
CATCGTGTTATAGATGGTTCAGTTGCTGCTGAGTTTTTACAAACATTTAAATTTTATATTGAAAACCCTAAACACATGAT
GCTGTTTGGAGGCGAATAAG

Downstream 100 bases:

>100_bases
AAACAATTACTTCCACTTGATTGTGCGCGTTTAGCCGCTCGTTTAATTGATAGGAAATAAGCTTATTGAGATTAGATTAA
TCAGATCCTCTTTCTTTGCC

Product: dihydrolipoamide dehydrogenase E3 component of 3 enzyme complexes

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSSADIEYDVIIIGGGPGGYVSAIKAAQNNLKVALVEKDKMGGICLNWGCIPTKALLKSGEFINKLHKANDFGVVVDKFS
FDLKSIVNRSRDISKNLNKGVDALMKKNGITVFNDTAKIISNHKVALSNQTLNTKNIVIATGSKSKIIPGLEPDGNVVWN
YRNAMTPKKVPENLLIIGAGAIGVEFACFYNSLGSNVTIVENQENILSTEDDDVSALAKKHFIKLGISILNSTKVNFIEK
SKDSITFELTSENFKETKVFDNVIMAIGVSGSFDNIGLETLGIKTNHGFIETNEFMQTNVPNIYAIGDVAGAPCLAHKAS
HEGIICIEKILNKNNIKTLNNNSIPSCIYSYPQIASLGLTEKAVIASGETYTVGRFPFNANGKAIASGETDGFIKTLFSA
NTGELLGVHMIGAEVTEMIQGYAIGKELETTQVELEHVIFPHPTMSEAMHEAVLDASDKAIHI

Sequences:

>Translated_463_residues
MSSADIEYDVIIIGGGPGGYVSAIKAAQNNLKVALVEKDKMGGICLNWGCIPTKALLKSGEFINKLHKANDFGVVVDKFS
FDLKSIVNRSRDISKNLNKGVDALMKKNGITVFNDTAKIISNHKVALSNQTLNTKNIVIATGSKSKIIPGLEPDGNVVWN
YRNAMTPKKVPENLLIIGAGAIGVEFACFYNSLGSNVTIVENQENILSTEDDDVSALAKKHFIKLGISILNSTKVNFIEK
SKDSITFELTSENFKETKVFDNVIMAIGVSGSFDNIGLETLGIKTNHGFIETNEFMQTNVPNIYAIGDVAGAPCLAHKAS
HEGIICIEKILNKNNIKTLNNNSIPSCIYSYPQIASLGLTEKAVIASGETYTVGRFPFNANGKAIASGETDGFIKTLFSA
NTGELLGVHMIGAEVTEMIQGYAIGKELETTQVELEHVIFPHPTMSEAMHEAVLDASDKAIHI
>Mature_462_residues
SSADIEYDVIIIGGGPGGYVSAIKAAQNNLKVALVEKDKMGGICLNWGCIPTKALLKSGEFINKLHKANDFGVVVDKFSF
DLKSIVNRSRDISKNLNKGVDALMKKNGITVFNDTAKIISNHKVALSNQTLNTKNIVIATGSKSKIIPGLEPDGNVVWNY
RNAMTPKKVPENLLIIGAGAIGVEFACFYNSLGSNVTIVENQENILSTEDDDVSALAKKHFIKLGISILNSTKVNFIEKS
KDSITFELTSENFKETKVFDNVIMAIGVSGSFDNIGLETLGIKTNHGFIETNEFMQTNVPNIYAIGDVAGAPCLAHKASH
EGIICIEKILNKNNIKTLNNNSIPSCIYSYPQIASLGLTEKAVIASGETYTVGRFPFNANGKAIASGETDGFIKTLFSAN
TGELLGVHMIGAEVTEMIQGYAIGKELETTQVELEHVIFPHPTMSEAMHEAVLDASDKAIHI

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=466, Percent_Identity=37.3390557939914, Blast_Score=285, Evalue=8e-77,
Organism=Homo sapiens, GI50301238, Length=465, Percent_Identity=27.3118279569892, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI22035672, Length=456, Percent_Identity=24.1228070175439, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI33519430, Length=473, Percent_Identity=26.0042283298097, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI33519428, Length=473, Percent_Identity=26.0042283298097, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI33519426, Length=473, Percent_Identity=26.0042283298097, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI148277065, Length=473, Percent_Identity=26.0042283298097, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI148277071, Length=473, Percent_Identity=26.0042283298097, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI291045266, Length=429, Percent_Identity=23.0769230769231, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI291045268, Length=422, Percent_Identity=22.9857819905213, Blast_Score=96, Evalue=9e-20,
Organism=Escherichia coli, GI1786307, Length=454, Percent_Identity=30.6167400881057, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87082354, Length=464, Percent_Identity=28.6637931034483, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=27.3348519362187, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI87081717, Length=458, Percent_Identity=26.6375545851528, Blast_Score=135, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=463, Percent_Identity=35.85313174946, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=25.8872651356994, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI71983429, Length=459, Percent_Identity=27.4509803921569, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71983419, Length=459, Percent_Identity=27.4509803921569, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=24.375, Blast_Score=108, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6321091, Length=474, Percent_Identity=35.8649789029536, Blast_Score=268, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6325240, Length=468, Percent_Identity=29.9145299145299, Blast_Score=189, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6325166, Length=468, Percent_Identity=28.2051282051282, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21358499, Length=467, Percent_Identity=37.6873661670236, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI17737741, Length=480, Percent_Identity=24.7916666666667, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24640549, Length=478, Percent_Identity=26.3598326359833, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24640553, Length=478, Percent_Identity=26.3598326359833, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24640551, Length=478, Percent_Identity=26.3598326359833, Blast_Score=125, Evalue=8e-29,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49931; Mature: 49800

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSADIEYDVIIIGGGPGGYVSAIKAAQNNLKVALVEKDKMGGICLNWGCIPTKALLKSG
CCCCCEEEEEEEEECCCCHHHHHHHHHCCCEEEEEEECCCCCCEEEECCCCCHHHHHHCC
EFINKLHKANDFGVVVDKFSFDLKSIVNRSRDISKNLNKGVDALMKKNGITVFNDTAKII
HHHHHHHCCCCCEEEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHH
SNHKVALSNQTLNTKNIVIATGSKSKIIPGLEPDGNVVWNYRNAMTPKKVPENLLIIGAG
CCCEEEEECCEECCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEECC
AIGVEFACFYNSLGSNVTIVENQENILSTEDDDVSALAKKHFIKLGISILNSTKVNFIEK
HHHHHHEEEHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEC
SKDSITFELTSENFKETKVFDNVIMAIGVSGSFDNIGLETLGIKTNHGFIETNEFMQTNV
CCCCEEEEEECCCCHHHHHHHHEEEEEECCCCCCCCCEEEEEEECCCCEEECCHHHHCCC
PNIYAIGDVAGAPCLAHKASHEGIICIEKILNKNNIKTLNNNSIPSCIYSYPQIASLGLT
CCEEEECCCCCCCHHHHCCCCCCEEEHHHHCCCCCCEECCCCCCCHHHHCCCCHHHCCCC
EKAVIASGETYTVGRFPFNANGKAIASGETDGFIKTLFSANTGELLGVHMIGAEVTEMIQ
CEEEEECCCEEEEECCEECCCCCEEECCCCCHHHHHHHCCCCCCEEEEEEHHHHHHHHHH
GYAIGKELETTQVELEHVIFPHPTMSEAMHEAVLDASDKAIHI
HHCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCEEEC
>Mature Secondary Structure 
SSADIEYDVIIIGGGPGGYVSAIKAAQNNLKVALVEKDKMGGICLNWGCIPTKALLKSG
CCCCEEEEEEEEECCCCHHHHHHHHHCCCEEEEEEECCCCCCEEEECCCCCHHHHHHCC
EFINKLHKANDFGVVVDKFSFDLKSIVNRSRDISKNLNKGVDALMKKNGITVFNDTAKII
HHHHHHHCCCCCEEEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHH
SNHKVALSNQTLNTKNIVIATGSKSKIIPGLEPDGNVVWNYRNAMTPKKVPENLLIIGAG
CCCEEEEECCEECCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEECC
AIGVEFACFYNSLGSNVTIVENQENILSTEDDDVSALAKKHFIKLGISILNSTKVNFIEK
HHHHHHEEEHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEC
SKDSITFELTSENFKETKVFDNVIMAIGVSGSFDNIGLETLGIKTNHGFIETNEFMQTNV
CCCCEEEEEECCCCHHHHHHHHEEEEEECCCCCCCCCEEEEEEECCCCEEECCHHHHCCC
PNIYAIGDVAGAPCLAHKASHEGIICIEKILNKNNIKTLNNNSIPSCIYSYPQIASLGLT
CCEEEECCCCCCCHHHHCCCCCCEEEHHHHCCCCCCEECCCCCCCHHHHCCCCHHHCCCC
EKAVIASGETYTVGRFPFNANGKAIASGETDGFIKTLFSANTGELLGVHMIGAEVTEMIQ
CEEEEECCCEEEEECCEECCCCCEEECCCCCHHHHHHHCCCCCCEEEEEEHHHHHHHHHH
GYAIGKELETTQVELEHVIFPHPTMSEAMHEAVLDASDKAIHI
HHCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]