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The map label for this gene is hetI [H]

Identifier: 119946351

GI number: 119946351

Start: 3336940

End: 3337740

Strand: Direct

Name: hetI [H]

Synonym: Ping_2722

Alternate gene names: 119946351

Gene position: 3336940-3337740 (Clockwise)

Preceding gene: 119946350

Following gene: 119946352

Centisome position: 73.18

GC content: 40.95

Gene sequence:

>801_bases
GTGTTTGTCCACCATACTGCTTCAAAATTAACACTCAATAATAATGATCTGCATGTCTGGTTAATTGAGCCCGCTAAAGT
AAGCGACAGCAAACTGCTTAATGCCTTAAAAAGCTTACTCAGCCAGACTGAAATTGAAAAAACACAGCGTTACCGTCTGG
CAAAAGCCAAACACACCGCCCTCATCACAAGAGCCTTTGCCCGAACCGTTTTATCGCAATATGCTGACGTACCCGCTCAA
AAATGGTTATTTAATATTGGTGCTCATGGAAAACCCGAGATAGACAGCCCCCCTCTTCCGCTCTCTTTTAACCTTAGCCA
CAATGATGATTTGATCATTTGTGCGGTCTGTCTGGACAAAAATATTGGCTGCGATATCGAAAGTTTATCCCGAAAAATCA
GTATTAAAGCAATTGCACAACGTTACTTTTCGGCAATAGAATTTGACGCATTAATGGCACTTCCCCCCGCACAACAAAGG
CGGCGTTTTTTTGAGTATTGGACACTAAAAGAAGCATTTGTAAAAGCCACTGGAATGGGCATCAGTCAAGGCCTGGAATC
ATTTAACTTTACAATAGGCAAGGCAAAAAAAGATCAATTTAACGATAATATCCAGCTCAACTTCTCTCTATCCTGCTCCG
AGCAGGATAGCCAGGATTGGGTCAGCTATTTAGTTTATCCTGATCAACAGCACTGTATTGCTTTATGTGTAAAGGCAAAT
AATATTAATAAGCCACTGCCTAATAAAGCGGTTTTAAACGTCCAACTTTTTGACGGGCTAGATTTACTCAGCTGCTATTA
A

Upstream 100 bases:

>100_bases
AAATAATTATTTGAGTTAAATGAATAAAAAGGGATAGCTGAGCTATCCCTTTTTATTGTTTTGTTGATAGTTGTCTTTTT
TCTGAATTATCGGGTGAATC

Downstream 100 bases:

>100_bases
CCAGATTATATTCTCTCCCTCCTGCATTGAGCAGCTCGTAGGGTGCGCACCTATTGCCGCTGCTTGCGGTATAAAATGCA
CACTACCGATAATATATACC

Product: 4'-phosphopantetheinyl transferase

Products: adenosine 3',5'-bisphosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MFVHHTASKLTLNNNDLHVWLIEPAKVSDSKLLNALKSLLSQTEIEKTQRYRLAKAKHTALITRAFARTVLSQYADVPAQ
KWLFNIGAHGKPEIDSPPLPLSFNLSHNDDLIICAVCLDKNIGCDIESLSRKISIKAIAQRYFSAIEFDALMALPPAQQR
RRFFEYWTLKEAFVKATGMGISQGLESFNFTIGKAKKDQFNDNIQLNFSLSCSEQDSQDWVSYLVYPDQQHCIALCVKAN
NINKPLPNKAVLNVQLFDGLDLLSCY

Sequences:

>Translated_266_residues
MFVHHTASKLTLNNNDLHVWLIEPAKVSDSKLLNALKSLLSQTEIEKTQRYRLAKAKHTALITRAFARTVLSQYADVPAQ
KWLFNIGAHGKPEIDSPPLPLSFNLSHNDDLIICAVCLDKNIGCDIESLSRKISIKAIAQRYFSAIEFDALMALPPAQQR
RRFFEYWTLKEAFVKATGMGISQGLESFNFTIGKAKKDQFNDNIQLNFSLSCSEQDSQDWVSYLVYPDQQHCIALCVKAN
NINKPLPNKAVLNVQLFDGLDLLSCY
>Mature_266_residues
MFVHHTASKLTLNNNDLHVWLIEPAKVSDSKLLNALKSLLSQTEIEKTQRYRLAKAKHTALITRAFARTVLSQYADVPAQ
KWLFNIGAHGKPEIDSPPLPLSFNLSHNDDLIICAVCLDKNIGCDIESLSRKISIKAIAQRYFSAIEFDALMALPPAQQR
RRFFEYWTLKEAFVKATGMGISQGLESFNFTIGKAKKDQFNDNIQLNFSLSCSEQDSQDWVSYLVYPDQQHCIALCVKAN
NINKPLPNKAVLNVQLFDGLDLLSCY

Specific function: Probably activates the acyl carrier protein (ACP) domain of hetM, by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. May be required for maintaining vegetative growth and probably acts via hetN to inhibit differenti

COG id: COG2091

COG function: function code H; Phosphopantetheinyl transferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the P-Pant transferase superfamily. Gsp/sfp/hetI/acpT family [H]

Homologues:

Organism=Escherichia coli, GI1789886, Length=92, Percent_Identity=39.1304347826087, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17569611, Length=232, Percent_Identity=23.7068965517241, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24663173, Length=201, Percent_Identity=27.8606965174129, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008278 [H]

Pfam domain/function: PF01648 ACPS [H]

EC number: NA

Molecular weight: Translated: 30036; Mature: 30036

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVHHTASKLTLNNNDLHVWLIEPAKVSDSKLLNALKSLLSQTEIEKTQRYRLAKAKHTA
CCEEECCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LITRAFARTVLSQYADVPAQKWLFNIGAHGKPEIDSPPLPLSFNLSHNDDLIICAVCLDK
HHHHHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECC
NIGCDIESLSRKISIKAIAQRYFSAIEFDALMALPPAQQRRRFFEYWTLKEAFVKATGMG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
ISQGLESFNFTIGKAKKDQFNDNIQLNFSLSCSEQDSQDWVSYLVYPDQQHCIALCVKAN
HHHHHHHHCEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHHEEECCCCCCEEEEEEECC
NINKPLPNKAVLNVQLFDGLDLLSCY
CCCCCCCCCEEEEEEEECCCHHHHCC
>Mature Secondary Structure
MFVHHTASKLTLNNNDLHVWLIEPAKVSDSKLLNALKSLLSQTEIEKTQRYRLAKAKHTA
CCEEECCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LITRAFARTVLSQYADVPAQKWLFNIGAHGKPEIDSPPLPLSFNLSHNDDLIICAVCLDK
HHHHHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECC
NIGCDIESLSRKISIKAIAQRYFSAIEFDALMALPPAQQRRRFFEYWTLKEAFVKATGMG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
ISQGLESFNFTIGKAKKDQFNDNIQLNFSLSCSEQDSQDWVSYLVYPDQQHCIALCVKAN
HHHHHHHHCEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHHEEECCCCCCEEEEEEECC
NINKPLPNKAVLNVQLFDGLDLLSCY
CCCCCCCCCEEEEEEEECCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; apo-[acyl carrier protein] [C]

Specific reaction: Coenzyme A + apo-[acyl carrier protein] = adenosine 3',5'-bisphosphate + [acyl carrier protein] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8157596; 11759840; 8939709 [H]