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The map label for this gene is fadI [H]

Identifier: 119946243

GI number: 119946243

Start: 3198440

End: 3199753

Strand: Reverse

Name: fadI [H]

Synonym: Ping_2605

Alternate gene names: 119946243

Gene position: 3199753-3198440 (Counterclockwise)

Preceding gene: 119946244

Following gene: 119946242

Centisome position: 70.18

GC content: 42.92

Gene sequence:

>1314_bases
ATGGTGATTCAGCAGGGGAATGATATGAAAGAGAGATTAGCAATTGTAGACGGTATTCGCAGTCCATTTTGTAAATCTGG
TACCAGTATGGCAAATATTCTAGCCGATGATTTAGGGGCTGTTATTGTCAAAGAATTAATTGCAAGAACCGAAATCGATC
TGAAGTTGATTGATGAACTAATATTTGGCAATGTTGGTCAACCTGCAAATGCGCCCAATATTGCCAGAGTTATCGCCCTA
AAAGCGGGGTTGCCGTTAGAGGTTATTGCACATACCGTGCACCGAAATTGTGCTTCAGGCATGGAGTCTGTCACCACCGG
ATACGATAAATTATTAGCGGGAAACGCCAATATATTGATCGCAGGAGGGACAGAAAGTATGAGTAATTTACCTTTCAATT
TTAGCAAAAAAATGACTCAGGTTTTTGAAAATGTAATGAAGGCTAAATCCATTGGACAAAAGTTATCAGCTATTTCAACA
TTGAGGCCCGCCGATTTAAAGCCCGTTATATCCATTGTAGAAGGGTTAACCGATCCGGTTTGTGGCTTAAGTATGGGGCA
AACGGCCGAAGTATTAGCCCGTGAATTTGCTATCACAAGAGCCGAGCAGGATCAGTTTGCCCTGCAATCGCACTTGAAGG
CTGCCAAAGCAAATGAAGCTGGTTTTTTTACCCAAGAAATCCATCCGATCATGTTACCGCCAGATTACAGTCACGTGCAA
TTTAATGATAATGCTATTCGGCATGATCAAAGTCTAGAAAAATTAGCTAAATTAAAACCCTTTTTTGATCGTGTTGCCGG
CACTGTCACAGCCGCTAATGCCTGTCCTATTACTGATGGTGCGGGTGCGGTGTTAATTATGTTGGAAAGTAAAGCAAAGG
AATTGGGTTATTCGCCCTTAGGTTATTTAAAAGCCTATAGCTATGCGGGATTGCAACCGGAAAGAATGGGGTTGGGCCCG
GTTTACGCAACCTCTAAACTTTTAGATAAAACCGGGATGGCGATCTCAGATTTTGATCTGGTGGAGTTAAACGAAGCCTT
TGCCGCTCAAGTTATTGCTAATCAAAAAGCGTTTGCATCGGCTGTTTTTGCGCAACGATATTTACACAAAGATAAAGCGC
TTGGTGTGCTGAACAGTGATTTATTAAACGTTAATGGCGGTGCTATTGCATTAGGACACCCCGTGGGAGCGACCGGTACC
AGATTGATCATTACCATGTTAAATGCCCTGCGCCGACGTAATAAAAACAGTGGATTGGTGACCTTGTGTATAGGTGGCGG
TCAAGGTGCTGCTATCGCATTGGAGGTAGAATAA

Upstream 100 bases:

>100_bases
ATTGAACAGGAATTCAGTGAAATTATTAATAATTTTTATAGGGATCAGGATCAAGAAGGCGAGTAATTGGTTATTTCATT
ATCGATAATAGTTTGCAGTA

Downstream 100 bases:

>100_bases
TGAATTTTACATTAGATATTTCACAATCAGGCCCAACTTCGGGGGTTGCAACATTGACCTTTGATTTTCCGGGGGCACGA
GTTAATAAATTAGATTCAGT

Product: acetyl-CoA acetyltransferases

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MVIQQGNDMKERLAIVDGIRSPFCKSGTSMANILADDLGAVIVKELIARTEIDLKLIDELIFGNVGQPANAPNIARVIAL
KAGLPLEVIAHTVHRNCASGMESVTTGYDKLLAGNANILIAGGTESMSNLPFNFSKKMTQVFENVMKAKSIGQKLSAIST
LRPADLKPVISIVEGLTDPVCGLSMGQTAEVLAREFAITRAEQDQFALQSHLKAAKANEAGFFTQEIHPIMLPPDYSHVQ
FNDNAIRHDQSLEKLAKLKPFFDRVAGTVTAANACPITDGAGAVLIMLESKAKELGYSPLGYLKAYSYAGLQPERMGLGP
VYATSKLLDKTGMAISDFDLVELNEAFAAQVIANQKAFASAVFAQRYLHKDKALGVLNSDLLNVNGGAIALGHPVGATGT
RLIITMLNALRRRNKNSGLVTLCIGGGQGAAIALEVE

Sequences:

>Translated_437_residues
MVIQQGNDMKERLAIVDGIRSPFCKSGTSMANILADDLGAVIVKELIARTEIDLKLIDELIFGNVGQPANAPNIARVIAL
KAGLPLEVIAHTVHRNCASGMESVTTGYDKLLAGNANILIAGGTESMSNLPFNFSKKMTQVFENVMKAKSIGQKLSAIST
LRPADLKPVISIVEGLTDPVCGLSMGQTAEVLAREFAITRAEQDQFALQSHLKAAKANEAGFFTQEIHPIMLPPDYSHVQ
FNDNAIRHDQSLEKLAKLKPFFDRVAGTVTAANACPITDGAGAVLIMLESKAKELGYSPLGYLKAYSYAGLQPERMGLGP
VYATSKLLDKTGMAISDFDLVELNEAFAAQVIANQKAFASAVFAQRYLHKDKALGVLNSDLLNVNGGAIALGHPVGATGT
RLIITMLNALRRRNKNSGLVTLCIGGGQGAAIALEVE
>Mature_437_residues
MVIQQGNDMKERLAIVDGIRSPFCKSGTSMANILADDLGAVIVKELIARTEIDLKLIDELIFGNVGQPANAPNIARVIAL
KAGLPLEVIAHTVHRNCASGMESVTTGYDKLLAGNANILIAGGTESMSNLPFNFSKKMTQVFENVMKAKSIGQKLSAIST
LRPADLKPVISIVEGLTDPVCGLSMGQTAEVLAREFAITRAEQDQFALQSHLKAAKANEAGFFTQEIHPIMLPPDYSHVQ
FNDNAIRHDQSLEKLAKLKPFFDRVAGTVTAANACPITDGAGAVLIMLESKAKELGYSPLGYLKAYSYAGLQPERMGLGP
VYATSKLLDKTGMAISDFDLVELNEAFAAQVIANQKAFASAVFAQRYLHKDKALGVLNSDLLNVNGGAIALGHPVGATGT
RLIITMLNALRRRNKNSGLVTLCIGGGQGAAIALEVE

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=40.8018867924528, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI167614485, Length=424, Percent_Identity=36.3207547169811, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI148539872, Length=433, Percent_Identity=33.0254041570439, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI4501853, Length=431, Percent_Identity=33.4106728538283, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI4557237, Length=429, Percent_Identity=31.9347319347319, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI194353979, Length=105, Percent_Identity=42.8571428571429, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1788683, Length=438, Percent_Identity=44.2922374429224, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1788554, Length=422, Percent_Identity=40.9952606635071, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI87082165, Length=430, Percent_Identity=39.0697674418605, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1787663, Length=433, Percent_Identity=37.6443418013857, Blast_Score=251, Evalue=8e-68,
Organism=Escherichia coli, GI48994986, Length=436, Percent_Identity=36.0091743119266, Blast_Score=230, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=37.7358490566038, Blast_Score=274, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI133906874, Length=422, Percent_Identity=36.0189573459716, Blast_Score=241, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI17535921, Length=426, Percent_Identity=30.9859154929577, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI25147385, Length=426, Percent_Identity=28.6384976525822, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=199, Percent_Identity=27.6381909547739, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6325229, Length=437, Percent_Identity=34.5537757437071, Blast_Score=223, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6322031, Length=381, Percent_Identity=35.6955380577428, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17137578, Length=429, Percent_Identity=39.1608391608392, Blast_Score=297, Evalue=9e-81,
Organism=Drosophila melanogaster, GI24655093, Length=422, Percent_Identity=35.5450236966825, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI17648125, Length=424, Percent_Identity=36.0849056603774, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24640423, Length=424, Percent_Identity=30.6603773584906, Blast_Score=189, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 46558; Mature: 46558

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIQQGNDMKERLAIVDGIRSPFCKSGTSMANILADDLGAVIVKELIARTEIDLKLIDEL
CCCCCCCCHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
IFGNVGQPANAPNIARVIALKAGLPLEVIAHTVHRNCASGMESVTTGYDKLLAGNANILI
HHCCCCCCCCCCCHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
AGGTESMSNLPFNFSKKMTQVFENVMKAKSIGQKLSAISTLRPADLKPVISIVEGLTDPV
ECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
CGLSMGQTAEVLAREFAITRAEQDQFALQSHLKAAKANEAGFFTQEIHPIMLPPDYSHVQ
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHCCCEEECCCCCCEEE
FNDNAIRHDQSLEKLAKLKPFFDRVAGTVTAANACPITDGAGAVLIMLESKAKELGYSPL
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEEEEEECHHHHCCCCCH
GYLKAYSYAGLQPERMGLGPVYATSKLLDKTGMAISDFDLVELNEAFAAQVIANQKAFAS
HHHHHHHHCCCCHHHCCCCCHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHH
AVFAQRYLHKDKALGVLNSDLLNVNGGAIALGHPVGATGTRLIITMLNALRRRNKNSGLV
HHHHHHHHHHHHHCCHHCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEE
TLCIGGGQGAAIALEVE
EEEEECCCCCEEEEEEC
>Mature Secondary Structure
MVIQQGNDMKERLAIVDGIRSPFCKSGTSMANILADDLGAVIVKELIARTEIDLKLIDEL
CCCCCCCCHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
IFGNVGQPANAPNIARVIALKAGLPLEVIAHTVHRNCASGMESVTTGYDKLLAGNANILI
HHCCCCCCCCCCCHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
AGGTESMSNLPFNFSKKMTQVFENVMKAKSIGQKLSAISTLRPADLKPVISIVEGLTDPV
ECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
CGLSMGQTAEVLAREFAITRAEQDQFALQSHLKAAKANEAGFFTQEIHPIMLPPDYSHVQ
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHCCCEEECCCCCCEEE
FNDNAIRHDQSLEKLAKLKPFFDRVAGTVTAANACPITDGAGAVLIMLESKAKELGYSPL
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEEEEEECHHHHCCCCCH
GYLKAYSYAGLQPERMGLGPVYATSKLLDKTGMAISDFDLVELNEAFAAQVIANQKAFAS
HHHHHHHHCCCCHHHCCCCCHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHH
AVFAQRYLHKDKALGVLNSDLLNVNGGAIALGHPVGATGTRLIITMLNALRRRNKNSGLV
HHHHHHHHHHHHHCCHHCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEE
TLCIGGGQGAAIALEVE
EEEEECCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA