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The map label for this gene is groL1 [H]

Identifier: 119946138

GI number: 119946138

Start: 3050162

End: 3051796

Strand: Reverse

Name: groL1 [H]

Synonym: Ping_2493

Alternate gene names: 119946138

Gene position: 3051796-3050162 (Counterclockwise)

Preceding gene: 119946139

Following gene: 119946137

Centisome position: 66.93

GC content: 43.18

Gene sequence:

>1635_bases
ATGTCTAAAGAAATTAAATTCGGAAATGATTCTCGTAGCAAAATGTTAAACGGCGTTAATATCTTAGCCGATGCAGTTAA
AATTACTTTAGGACCAAAGGGTCGTAATGTTGTCATCGATAAAAGTTACGGTGCGCCACAAATTACTAAAGACGGTGTCA
CGGTTGCTAAAGAAATTGAACTGGAAGATAAGTTTGAAAACATGGGCGCACAGATGGTAAAAGATGTTGCGTCACAAACT
AATGATGCTGCCGGTGACGGAACAACAACGGCAACCGTATTGGCGCAGGCTATTATTGCTGATGGTTTAAAAGCCGTTGC
TGCTGGTATGAATCCGATGGATTTAAAACGCGGTATTGATCAAACTGTAAAAGCGGCTGTTGCCGAGTTAAAAAAATTAT
CTACACCTTGTTCAGATTCAAAAGCCATCACACAGGTAGGCACTATCTCTGCCAACTCGGATCATGAAATTGGTGAAATC
ATTGCGCGAGCGATGCAAAAAGTCGGTAACCAGGGTGTTATCACGGTAGAAGAAGGTCAGGGTCTAGAAACTGAATTAGA
CGTGGTTGAAGGTATGCAGTTTGATCGTGGTTACCTGTCTCCTTACTTTATGACAAATCATGAATCTGGCACGGTTGAAC
TTGAAAACCCGTATATCTTATTAGTTGATAAAAAAATAGGCAATATTCGTGAATTATTACCTACATTAGAAGCCGTTGCA
AAAGCCTCTAAGCCATTACTGATTATTGCAGAAGATGTAGAAGGTGAAGCATTAGCAACATTAGTAGTCAACAATATGCG
TGGTATCGTTAAAGTCTGCGCCGTTAAAGCACCTGGTTTTGGTGATCGCCGTAAAGCAATGTTACAAGATATTGCCACAT
TAACGGGCGGTACGGTTATCTCTGAAGAGATTGGTTTAGATATGGAAAAAGTCCAACTTGAAGATTTAGGTCAGGCTAAA
CGTATTGTGATCAACAAAGATGAAACCACTATTATTGATGGTATTGGTGACGAGTCCGTTATCAATGCACGGGTAAGCCA
AATTAAACAACAAATTGAAGCTTCCACGTCTGACTACGATAAAGAAAAACTGCAGGAACGTTCAGCTAAATTAGCCGGTG
GCGTTGCGGTTATTAAAGTTGGCGCATCCACTGAAGTTGAAATGAAAGAGAAAAAAGATCGCGTAGATGATGCATTGCAT
GCAACACGTGCCGCGGTTGAAGAAGGTGTTGTTGCCGGTGGTGGTGTTGCCCTGGTACGTGTCGCTGCTATATTAAAAGG
CTTAACGGGTGAGAACGAAGATCAGAATGTGGGTATTCGTGTTGCACTGCGCGCCATGGAAGCACCATTGCGTCAAATCG
TAGAAAACTGCGGTGAAGAAGCTTCTGTTGTAGCAAACAATGTACGCCAGGGTGAAGGAAACTACGGTTACAATGCAACT
ACAGGTGAATACGGTGATATGTTAGAGATGGGTATCATTGACCCGACTAAAGTAGCCCGTAGCGCACTGCAGTTTGCTGC
ATCGGTAGCTGCTCTTATGATCACGACTGAATGTATGATCACCGATCGCCCTGTTGCGGCTTCAGCAGCAGCGCCTGATA
TGGGCGGCATGGGTGGAATGGGCGGAATGATGTAA

Upstream 100 bases:

>100_bases
GTGAAAACGATATTCTTGCCGTCGTTGAATAACGCCTATCTGCTTTTTTAAAGATCGAAAAGCAAGACTCTCAATATTAA
AGATTTAAAGGAATATAATA

Downstream 100 bases:

>100_bases
AAAATCATCCTTTGATTATTTCATAGGAACTCATCACGTTTCACTAAGCCCGTAAAGCTATGCTTTACGGGCTTTTTTTG
TTTTAGGTTAGTGCAATTCA

Product: chaperonin Cpn60, GroEL, large subunit of GroESL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MSKEIKFGNDSRSKMLNGVNILADAVKITLGPKGRNVVIDKSYGAPQITKDGVTVAKEIELEDKFENMGAQMVKDVASQT
NDAAGDGTTTATVLAQAIIADGLKAVAAGMNPMDLKRGIDQTVKAAVAELKKLSTPCSDSKAITQVGTISANSDHEIGEI
IARAMQKVGNQGVITVEEGQGLETELDVVEGMQFDRGYLSPYFMTNHESGTVELENPYILLVDKKIGNIRELLPTLEAVA
KASKPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGLDMEKVQLEDLGQAK
RIVINKDETTIIDGIGDESVINARVSQIKQQIEASTSDYDKEKLQERSAKLAGGVAVIKVGASTEVEMKEKKDRVDDALH
ATRAAVEEGVVAGGGVALVRVAAILKGLTGENEDQNVGIRVALRAMEAPLRQIVENCGEEASVVANNVRQGEGNYGYNAT
TGEYGDMLEMGIIDPTKVARSALQFAASVAALMITTECMITDRPVAASAAAPDMGGMGGMGGMM

Sequences:

>Translated_544_residues
MSKEIKFGNDSRSKMLNGVNILADAVKITLGPKGRNVVIDKSYGAPQITKDGVTVAKEIELEDKFENMGAQMVKDVASQT
NDAAGDGTTTATVLAQAIIADGLKAVAAGMNPMDLKRGIDQTVKAAVAELKKLSTPCSDSKAITQVGTISANSDHEIGEI
IARAMQKVGNQGVITVEEGQGLETELDVVEGMQFDRGYLSPYFMTNHESGTVELENPYILLVDKKIGNIRELLPTLEAVA
KASKPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGLDMEKVQLEDLGQAK
RIVINKDETTIIDGIGDESVINARVSQIKQQIEASTSDYDKEKLQERSAKLAGGVAVIKVGASTEVEMKEKKDRVDDALH
ATRAAVEEGVVAGGGVALVRVAAILKGLTGENEDQNVGIRVALRAMEAPLRQIVENCGEEASVVANNVRQGEGNYGYNAT
TGEYGDMLEMGIIDPTKVARSALQFAASVAALMITTECMITDRPVAASAAAPDMGGMGGMGGMM
>Mature_543_residues
SKEIKFGNDSRSKMLNGVNILADAVKITLGPKGRNVVIDKSYGAPQITKDGVTVAKEIELEDKFENMGAQMVKDVASQTN
DAAGDGTTTATVLAQAIIADGLKAVAAGMNPMDLKRGIDQTVKAAVAELKKLSTPCSDSKAITQVGTISANSDHEIGEII
ARAMQKVGNQGVITVEEGQGLETELDVVEGMQFDRGYLSPYFMTNHESGTVELENPYILLVDKKIGNIRELLPTLEAVAK
ASKPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGLDMEKVQLEDLGQAKR
IVINKDETTIIDGIGDESVINARVSQIKQQIEASTSDYDKEKLQERSAKLAGGVAVIKVGASTEVEMKEKKDRVDDALHA
TRAAVEEGVVAGGGVALVRVAAILKGLTGENEDQNVGIRVALRAMEAPLRQIVENCGEEASVVANNVRQGEGNYGYNATT
GEYGDMLEMGIIDPTKVARSALQFAASVAALMITTECMITDRPVAASAAAPDMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=524, Percent_Identity=51.5267175572519, Blast_Score=550, Evalue=1e-156,
Organism=Homo sapiens, GI31542947, Length=524, Percent_Identity=51.5267175572519, Blast_Score=550, Evalue=1e-156,
Organism=Escherichia coli, GI1790586, Length=523, Percent_Identity=80.8795411089866, Blast_Score=860, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=526, Percent_Identity=51.3307984790874, Blast_Score=539, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI193210679, Length=208, Percent_Identity=52.8846153846154, Blast_Score=211, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=54.0076335877863, Blast_Score=556, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6322524, Length=163, Percent_Identity=28.8343558282209, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641193, Length=524, Percent_Identity=51.7175572519084, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24641191, Length=524, Percent_Identity=51.7175572519084, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=49.7142857142857, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=49.7142857142857, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=49.7142857142857, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI17864606, Length=523, Percent_Identity=43.7858508604207, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24584129, Length=548, Percent_Identity=37.2262773722628, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI19921262, Length=548, Percent_Identity=37.2262773722628, Blast_Score=348, Evalue=5e-96,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57467; Mature: 57335

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEIKFGNDSRSKMLNGVNILADAVKITLGPKGRNVVIDKSYGAPQITKDGVTVAKEIE
CCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCCEEEHHCC
LEDKFENMGAQMVKDVASQTNDAAGDGTTTATVLAQAIIADGLKAVAAGMNPMDLKRGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QTVKAAVAELKKLSTPCSDSKAITQVGTISANSDHEIGEIIARAMQKVGNQGVITVEEGQ
HHHHHHHHHHHHHCCCCCCCCHHHHEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
GLETELDVVEGMQFDRGYLSPYFMTNHESGTVELENPYILLVDKKIGNIRELLPTLEAVA
CCCHHHHHHHCCCCCCCCCCCEEEECCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHH
KASKPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIATLTGGTVI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
SEEIGLDMEKVQLEDLGQAKRIVINKDETTIIDGIGDESVINARVSQIKQQIEASTSDYD
HHHHCCCHHHHHHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCH
KEKLQERSAKLAGGVAVIKVGASTEVEMKEKKDRVDDALHATRAAVEEGVVAGGGVALVR
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
VAAILKGLTGENEDQNVGIRVALRAMEAPLRQIVENCGEEASVVANNVRQGEGNYGYNAT
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCC
TGEYGDMLEMGIIDPTKVARSALQFAASVAALMITTECMITDRPVAASAAAPDMGGMGGM
CCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCC
GGMM
CCCC
>Mature Secondary Structure 
SKEIKFGNDSRSKMLNGVNILADAVKITLGPKGRNVVIDKSYGAPQITKDGVTVAKEIE
CCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCCEEEHHCC
LEDKFENMGAQMVKDVASQTNDAAGDGTTTATVLAQAIIADGLKAVAAGMNPMDLKRGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QTVKAAVAELKKLSTPCSDSKAITQVGTISANSDHEIGEIIARAMQKVGNQGVITVEEGQ
HHHHHHHHHHHHHCCCCCCCCHHHHEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
GLETELDVVEGMQFDRGYLSPYFMTNHESGTVELENPYILLVDKKIGNIRELLPTLEAVA
CCCHHHHHHHCCCCCCCCCCCEEEECCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHH
KASKPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIATLTGGTVI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
SEEIGLDMEKVQLEDLGQAKRIVINKDETTIIDGIGDESVINARVSQIKQQIEASTSDYD
HHHHCCCHHHHHHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCH
KEKLQERSAKLAGGVAVIKVGASTEVEMKEKKDRVDDALHATRAAVEEGVVAGGGVALVR
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
VAAILKGLTGENEDQNVGIRVALRAMEAPLRQIVENCGEEASVVANNVRQGEGNYGYNAT
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCC
TGEYGDMLEMGIIDPTKVARSALQFAASVAALMITTECMITDRPVAASAAAPDMGGMGGM
CCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCC
GGMM
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA