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The map label for this gene is cysK [H]

Identifier: 119946088

GI number: 119946088

Start: 2986470

End: 2987441

Strand: Direct

Name: cysK [H]

Synonym: Ping_2438

Alternate gene names: 119946088

Gene position: 2986470-2987441 (Clockwise)

Preceding gene: 119946087

Following gene: 119946089

Centisome position: 65.5

GC content: 40.74

Gene sequence:

>972_bases
ATGTCAAACATATTTAGTGACCATTCACAAGCTATCGGCAAAACACCTCTGGTCCGCTTAAATAACGTTACATCTGGTAA
TGTTTTTGCAAAAATAGAAAGCCGTAACCCAAGCTTCAGTGTTAAATGCCGTATTGGTGCAAACATGATTTGGGACGCAG
AGAAGAAAGGCACGTTAACTAAAGATGTTGAACTTGTTGAGCCTACAAGTGGAAATACCGGTATTGCGCTGGCGTTTGTT
GCCGCTGCACGTGGTTATAAAATCACCTTAACGATGCCAAATACAATGAGTATTGAGCGTCGTAAGTTATTAAAAGCATT
AGGGGCTAATTTAGTATTAACCGATGGCGCAAAAGGTATGAAAGGTGCGATTGCTGAAGCTGAAGCTATTGTGAGTACAG
ATCCTTCTAAATACTTGTTATTACAACAATTCGATAACCCAGCTAACCCTGAAATTCATGAAAAAACAACAGGTCCTGAA
ATTTGGAATGATACCGATGGCGAAATCGATGTATTTGTTGCTGGAGTGGGTACTGGTGGGACAATCACAGGTGTCAGTCG
TTATATTAAGCAGACTCAAGGTAAAGCAATTATTAGTGTTGCTGTTGAGCCAACAAACTCTCAGGTGATTGCACAAACGC
TCGCCGGTGAAGAAGTCAAACCTGGCCCGCATAAAATTCAAGGTATTGGCGCTGGTTTTATTCCAAAGAATTTAGATCTT
TCTTTAATTGATCGTGTTGAAGCGGTCAGTAATGAAGATTCAATCGCAATGGCGCGTCGTTTAATGGAAGAAGAAGGTAT
TCTAGCAGGAATTTCATCGGGCGCTGCCGTTGTTGCTGCTGCTCGTTTAGCCGAGCTAGATGAATTTAAAGACAAAAACA
TTGTTGTTATTTTAGCAAGTGCAGCTGAACGTTATTTATCAAGCGCACTTTTTGCAGGTGCTTTTGAAGGTGAAAATTTC
CCTTCAATATAG

Upstream 100 bases:

>100_bases
ATTTCATCACAATCAATAGATCCGTTATATTCGAGATGCTACTATATTGTCGCAATATTGCTGCAATATTAATAAATATT
CAATAAAAAAAGGGAATGAC

Downstream 100 bases:

>100_bases
ACTGTGTTGAAATAACAGCGTTGTGAGTGAAGCATTTCCTCGCGACTTTTGAGCGAGTCTAGAGACAACTGAAGCAACTG
CTTCTGGTATACCTTTAGAT

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine sulfhydrylase A; Sulfate starvation-induced protein 5; SSI5 [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSNIFSDHSQAIGKTPLVRLNNVTSGNVFAKIESRNPSFSVKCRIGANMIWDAEKKGTLTKDVELVEPTSGNTGIALAFV
AAARGYKITLTMPNTMSIERRKLLKALGANLVLTDGAKGMKGAIAEAEAIVSTDPSKYLLLQQFDNPANPEIHEKTTGPE
IWNDTDGEIDVFVAGVGTGGTITGVSRYIKQTQGKAIISVAVEPTNSQVIAQTLAGEEVKPGPHKIQGIGAGFIPKNLDL
SLIDRVEAVSNEDSIAMARRLMEEEGILAGISSGAAVVAAARLAELDEFKDKNIVVILASAAERYLSSALFAGAFEGENF
PSI

Sequences:

>Translated_323_residues
MSNIFSDHSQAIGKTPLVRLNNVTSGNVFAKIESRNPSFSVKCRIGANMIWDAEKKGTLTKDVELVEPTSGNTGIALAFV
AAARGYKITLTMPNTMSIERRKLLKALGANLVLTDGAKGMKGAIAEAEAIVSTDPSKYLLLQQFDNPANPEIHEKTTGPE
IWNDTDGEIDVFVAGVGTGGTITGVSRYIKQTQGKAIISVAVEPTNSQVIAQTLAGEEVKPGPHKIQGIGAGFIPKNLDL
SLIDRVEAVSNEDSIAMARRLMEEEGILAGISSGAAVVAAARLAELDEFKDKNIVVILASAAERYLSSALFAGAFEGENF
PSI
>Mature_322_residues
SNIFSDHSQAIGKTPLVRLNNVTSGNVFAKIESRNPSFSVKCRIGANMIWDAEKKGTLTKDVELVEPTSGNTGIALAFVA
AARGYKITLTMPNTMSIERRKLLKALGANLVLTDGAKGMKGAIAEAEAIVSTDPSKYLLLQQFDNPANPEIHEKTTGPEI
WNDTDGEIDVFVAGVGTGGTITGVSRYIKQTQGKAIISVAVEPTNSQVIAQTLAGEEVKPGPHKIQGIGAGFIPKNLDLS
LIDRVEAVSNEDSIAMARRLMEEEGILAGISSGAAVVAAARLAELDEFKDKNIVVILASAAERYLSSALFAGAFEGENFP
SI

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=320, Percent_Identity=37.5, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI295821200, Length=320, Percent_Identity=37.5, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI4557415, Length=320, Percent_Identity=37.5, Blast_Score=184, Evalue=7e-47,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=77.2151898734177, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI2367138, Length=311, Percent_Identity=40.8360128617363, Blast_Score=207, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17535051, Length=307, Percent_Identity=50.4885993485342, Blast_Score=280, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI17562970, Length=313, Percent_Identity=47.6038338658147, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI32566674, Length=307, Percent_Identity=48.5342019543974, Blast_Score=269, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI115535073, Length=304, Percent_Identity=53.6184210526316, Blast_Score=262, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17561720, Length=313, Percent_Identity=48.8817891373802, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI32566672, Length=221, Percent_Identity=47.9638009049774, Blast_Score=202, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17534315, Length=316, Percent_Identity=40.8227848101266, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI25147552, Length=313, Percent_Identity=37.6996805111821, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17561716, Length=126, Percent_Identity=47.6190476190476, Blast_Score=94, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=36.1904761904762, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321449, Length=323, Percent_Identity=33.4365325077399, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24643623, Length=319, Percent_Identity=36.0501567398119, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20129101, Length=319, Percent_Identity=36.0501567398119, Blast_Score=163, Evalue=1e-40,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34199; Mature: 34068

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIFSDHSQAIGKTPLVRLNNVTSGNVFAKIESRNPSFSVKCRIGANMIWDAEKKGTLT
CCCCCCCHHHHCCCCCEEEECCCCCCCEEEEEECCCCCEEEEEEECCCEEECCCCCCCCC
KDVELVEPTSGNTGIALAFVAAARGYKITLTMPNTMSIERRKLLKALGANLVLTDGAKGM
CCEEEECCCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCC
KGAIAEAEAIVSTDPSKYLLLQQFDNPANPEIHEKTTGPEIWNDTDGEIDVFVAGVGTGG
CCHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCC
TITGVSRYIKQTQGKAIISVAVEPTNSQVIAQTLAGEEVKPGPHKIQGIGAGFIPKNLDL
HHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCH
SLIDRVEAVSNEDSIAMARRLMEEEGILAGISSGAAVVAAARLAELDEFKDKNIVVILAS
HHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEH
AAERYLSSALFAGAFEGENFPSI
HHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SNIFSDHSQAIGKTPLVRLNNVTSGNVFAKIESRNPSFSVKCRIGANMIWDAEKKGTLT
CCCCCCHHHHCCCCCEEEECCCCCCCEEEEEECCCCCEEEEEEECCCEEECCCCCCCCC
KDVELVEPTSGNTGIALAFVAAARGYKITLTMPNTMSIERRKLLKALGANLVLTDGAKGM
CCEEEECCCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCC
KGAIAEAEAIVSTDPSKYLLLQQFDNPANPEIHEKTTGPEIWNDTDGEIDVFVAGVGTGG
CCHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCC
TITGVSRYIKQTQGKAIISVAVEPTNSQVIAQTLAGEEVKPGPHKIQGIGAGFIPKNLDL
HHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCH
SLIDRVEAVSNEDSIAMARRLMEEEGILAGISSGAAVVAAARLAELDEFKDKNIVVILAS
HHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEH
AAERYLSSALFAGAFEGENFPSI
HHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]