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The map label for this gene is pykA [H]

Identifier: 119946017

GI number: 119946017

Start: 2872575

End: 2874005

Strand: Direct

Name: pykA [H]

Synonym: Ping_2361

Alternate gene names: 119946017

Gene position: 2872575-2874005 (Clockwise)

Preceding gene: 119946016

Following gene: 119946022

Centisome position: 63.0

GC content: 43.82

Gene sequence:

>1431_bases
ATGTTGAGACGCACAAAAATTGTGACAACCTTAGGTCCCGCGACGGATCGTGATAATAATTTGGAAAAAATCATCGCAGC
CGGCGCGAATATGGTGCGCATGAACTTCTCACACGGCGAAGCGATTGATCATGTAAGACGTGCCAATGAAGTGCGAGAAA
TAGCAGCCCGTTTAGGTAAAGATGTGGCCATTATGGGCGATTTACAGGGGCCTAAAATCCGCGTTTCTACTTTTAAAGAC
AATAAAATCATCTTAGTGGTAGGTGATAAATTTACCCTGGACAGTGATATCGAAAAAGGTCAGGGGGATCAACAAGCGGT
TGGCCTTGATTACAAAACGCTGCCACAGGAAGTCGTTGCTGGTGATCTGTTATTACTTGACGATGGTCGTGTGCAACTGC
AGGTAGAAAATGTGCTTGGCAATAAAGTTAATACGGTTGTTACTATTGGTGGTCCTTTGTCCAACAATAAAGGTATTAAC
AAAAAAGGCGGTGGTTTATCGGCTGCAGCGTTAACACCTAAAGATAAAAAAGACATTATTACGGCAGCTGAAATTGGTTG
CGATTACTTAGCAGTTTCTTTTCCCCGTAATGGTGCAGATCTTCATTATGCACGTCGTTTAGCAATTGAGGCGGGTTGTA
ATGCTAAAATAGTGGCCAAAGTAGAACGTGCCGAAGCCGTTGAAACCCAAGAAGCATTAGAAGAAATTATTCTTGCTTCT
GATGTCGTGATGGTTGCCCGTGGTGACTTAGGGGTGGAAATTGGTGATGCACGTTTAGTGGGTGTGCAGAAAAACATGAT
CCGCACGGCACGGCGTTTAAATCGTGTTGTTATCACAGCAACACAAATGATGGAGTCAATGGTAAGTTCACCCATGCCGA
CACGCGCCGAGGTAATGGATGTGGCCAATGCGGTATTAGATGGTACCGATGCGGTGATGCTCTCAGGCGAAACGGCTGCA
GGTGATTATCCAGTAGAAACTGTGAAAGCAATGAGTGAAGTTTGCCTTGGCGCTGAAAAGCATCCAAGCATTAATATCTC
CAAAAACCGCATGGAATGTACCTTTGATGATCCTACTGAAGCATTAGCGATAACCGCCATGTTTGCAGCTAATCACACTA
ATGGTATTAAAGCGATTGTCGCCCTAACAGCGACAGGGACCACCGCTTTATTAATGTCACGGCTAAGCTCTGGTTTGCCT
ATATTTGCACTTTCAAGTAACCCGCAAACATTAAGTTATTGTGCATTATACCGTGGTGTAACGCCCATTAAATTTAACTC
AAACGCATCCAATAATTTAGTCTTTACAGGTGCCGCGATTGAGACATTAAAAGAGGCCGGTTACTTACAGAAGGGAGATC
TAATCATCATCACCCACGGTGATAATCATTACGCAGGATCAACCAATACTTGTAAAATCGTTACCGTTTAA

Upstream 100 bases:

>100_bases
ATAAAGTTGATCTAAACGAAGACTGAAAGTTTTACCCCTTTATACTTTTCAATAGATTAAAAACCTAACAGCAAAATAAC
TTTAATGACTGGAGTAGATA

Downstream 100 bases:

>100_bases
ATCAATCTGGGATTGAAGGGTATCAATCAAAAAGCTTCTCATGAGAAGCTTTTTTTATCAATATTATATGTATCATCCTG
GGACTTGTAATAGTTATAAC

Product: pyruvate kinase

Products: NA

Alternate protein names: PK-2 [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MLRRTKIVTTLGPATDRDNNLEKIIAAGANMVRMNFSHGEAIDHVRRANEVREIAARLGKDVAIMGDLQGPKIRVSTFKD
NKIILVVGDKFTLDSDIEKGQGDQQAVGLDYKTLPQEVVAGDLLLLDDGRVQLQVENVLGNKVNTVVTIGGPLSNNKGIN
KKGGGLSAAALTPKDKKDIITAAEIGCDYLAVSFPRNGADLHYARRLAIEAGCNAKIVAKVERAEAVETQEALEEIILAS
DVVMVARGDLGVEIGDARLVGVQKNMIRTARRLNRVVITATQMMESMVSSPMPTRAEVMDVANAVLDGTDAVMLSGETAA
GDYPVETVKAMSEVCLGAEKHPSINISKNRMECTFDDPTEALAITAMFAANHTNGIKAIVALTATGTTALLMSRLSSGLP
IFALSSNPQTLSYCALYRGVTPIKFNSNASNNLVFTGAAIETLKEAGYLQKGDLIIITHGDNHYAGSTNTCKIVTV

Sequences:

>Translated_476_residues
MLRRTKIVTTLGPATDRDNNLEKIIAAGANMVRMNFSHGEAIDHVRRANEVREIAARLGKDVAIMGDLQGPKIRVSTFKD
NKIILVVGDKFTLDSDIEKGQGDQQAVGLDYKTLPQEVVAGDLLLLDDGRVQLQVENVLGNKVNTVVTIGGPLSNNKGIN
KKGGGLSAAALTPKDKKDIITAAEIGCDYLAVSFPRNGADLHYARRLAIEAGCNAKIVAKVERAEAVETQEALEEIILAS
DVVMVARGDLGVEIGDARLVGVQKNMIRTARRLNRVVITATQMMESMVSSPMPTRAEVMDVANAVLDGTDAVMLSGETAA
GDYPVETVKAMSEVCLGAEKHPSINISKNRMECTFDDPTEALAITAMFAANHTNGIKAIVALTATGTTALLMSRLSSGLP
IFALSSNPQTLSYCALYRGVTPIKFNSNASNNLVFTGAAIETLKEAGYLQKGDLIIITHGDNHYAGSTNTCKIVTV
>Mature_476_residues
MLRRTKIVTTLGPATDRDNNLEKIIAAGANMVRMNFSHGEAIDHVRRANEVREIAARLGKDVAIMGDLQGPKIRVSTFKD
NKIILVVGDKFTLDSDIEKGQGDQQAVGLDYKTLPQEVVAGDLLLLDDGRVQLQVENVLGNKVNTVVTIGGPLSNNKGIN
KKGGGLSAAALTPKDKKDIITAAEIGCDYLAVSFPRNGADLHYARRLAIEAGCNAKIVAKVERAEAVETQEALEEIILAS
DVVMVARGDLGVEIGDARLVGVQKNMIRTARRLNRVVITATQMMESMVSSPMPTRAEVMDVANAVLDGTDAVMLSGETAA
GDYPVETVKAMSEVCLGAEKHPSINISKNRMECTFDDPTEALAITAMFAANHTNGIKAIVALTATGTTALLMSRLSSGLP
IFALSSNPQTLSYCALYRGVTPIKFNSNASNNLVFTGAAIETLKEAGYLQKGDLIIITHGDNHYAGSTNTCKIVTV

Specific function: Glycolysis; final step. [C]

COG id: COG0469

COG function: function code G; Pyruvate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyruvate kinase family [H]

Homologues:

Organism=Homo sapiens, GI33286418, Length=493, Percent_Identity=37.525354969574, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI33286422, Length=493, Percent_Identity=36.7139959432049, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI33286420, Length=493, Percent_Identity=36.7139959432049, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI32967597, Length=495, Percent_Identity=34.9494949494949, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI10835121, Length=495, Percent_Identity=34.9494949494949, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI310128732, Length=290, Percent_Identity=36.551724137931, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI310128730, Length=290, Percent_Identity=36.551724137931, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI310128736, Length=239, Percent_Identity=34.3096234309623, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI310128734, Length=239, Percent_Identity=34.3096234309623, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI310128738, Length=215, Percent_Identity=33.953488372093, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1788160, Length=476, Percent_Identity=69.5378151260504, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI1787965, Length=478, Percent_Identity=36.8200836820084, Blast_Score=281, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI17544584, Length=484, Percent_Identity=36.3636363636364, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI71984413, Length=495, Percent_Identity=35.959595959596, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17506829, Length=495, Percent_Identity=35.959595959596, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI71984406, Length=495, Percent_Identity=35.959595959596, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17506831, Length=495, Percent_Identity=35.959595959596, Blast_Score=238, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6319279, Length=492, Percent_Identity=35.5691056910569, Blast_Score=260, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6324923, Length=497, Percent_Identity=32.3943661971831, Blast_Score=224, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24648964, Length=495, Percent_Identity=36.969696969697, Blast_Score=264, Evalue=8e-71,
Organism=Drosophila melanogaster, GI28571814, Length=495, Percent_Identity=36.969696969697, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24648966, Length=448, Percent_Identity=34.375, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24581235, Length=491, Percent_Identity=30.3462321792261, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24646914, Length=271, Percent_Identity=34.6863468634686, Blast_Score=138, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001697
- InterPro:   IPR015813
- InterPro:   IPR011037
- InterPro:   IPR015794
- InterPro:   IPR018209
- InterPro:   IPR015793
- InterPro:   IPR015795
- InterPro:   IPR015806 [H]

Pfam domain/function: PF00224 PK; PF02887 PK_C [H]

EC number: =2.7.1.40 [H]

Molecular weight: Translated: 50762; Mature: 50762

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00110 PYRUVATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRTKIVTTLGPATDRDNNLEKIIAAGANMVRMNFSHGEAIDHVRRANEVREIAARLGK
CCCCEEEEEEECCCCCCCCCHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
DVAIMGDLQGPKIRVSTFKDNKIILVVGDKFTLDSDIEKGQGDQQAVGLDYKTLPQEVVA
CEEEEECCCCCEEEEEEECCCEEEEEECCCEEECCCHHCCCCCCCEECCCHHHCCHHHHC
GDLLLLDDGRVQLQVENVLGNKVNTVVTIGGPLSNNKGINKKGGGLSAAALTPKDKKDII
CCEEEEECCEEEEEEEHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCHHHEE
TAAEIGCDYLAVSFPRNGADLHYARRLAIEAGCNAKIVAKVERAEAVETQEALEEIILAS
EHHHCCCCEEEEECCCCCCCHHHHHHEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHC
DVVMVARGDLGVEIGDARLVGVQKNMIRTARRLNRVVITATQMMESMVSSPMPTRAEVMD
CEEEEEECCCCEEECCEEEEEHHHHHHHHHHHHCEEEEEHHHHHHHHHCCCCCCHHHHHH
VANAVLDGTDAVMLSGETAAGDYPVETVKAMSEVCLGAEKHPSINISKNRMECTFDDPTE
HHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCEEEEEECCCHH
ALAITAMFAANHTNGIKAIVALTATGTTALLMSRLSSGLPIFALSSNPQTLSYCALYRGV
HEEEEEEEECCCCCCEEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCC
TPIKFNSNASNNLVFTGAAIETLKEAGYLQKGDLIIITHGDNHYAGSTNTCKIVTV
CEEEECCCCCCCEEEECHHHHHHHHCCCEECCCEEEEECCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MLRRTKIVTTLGPATDRDNNLEKIIAAGANMVRMNFSHGEAIDHVRRANEVREIAARLGK
CCCCEEEEEEECCCCCCCCCHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
DVAIMGDLQGPKIRVSTFKDNKIILVVGDKFTLDSDIEKGQGDQQAVGLDYKTLPQEVVA
CEEEEECCCCCEEEEEEECCCEEEEEECCCEEECCCHHCCCCCCCEECCCHHHCCHHHHC
GDLLLLDDGRVQLQVENVLGNKVNTVVTIGGPLSNNKGINKKGGGLSAAALTPKDKKDII
CCEEEEECCEEEEEEEHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCHHHEE
TAAEIGCDYLAVSFPRNGADLHYARRLAIEAGCNAKIVAKVERAEAVETQEALEEIILAS
EHHHCCCCEEEEECCCCCCCHHHHHHEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHC
DVVMVARGDLGVEIGDARLVGVQKNMIRTARRLNRVVITATQMMESMVSSPMPTRAEVMD
CEEEEEECCCCEEECCEEEEEHHHHHHHHHHHHCEEEEEHHHHHHHHHCCCCCCHHHHHH
VANAVLDGTDAVMLSGETAAGDYPVETVKAMSEVCLGAEKHPSINISKNRMECTFDDPTE
HHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCEEEEEECCCHH
ALAITAMFAANHTNGIKAIVALTATGTTALLMSRLSSGLPIFALSSNPQTLSYCALYRGV
HEEEEEEEECCCCCCEEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCC
TPIKFNSNASNNLVFTGAAIETLKEAGYLQKGDLIIITHGDNHYAGSTNTCKIVTV
CEEEECCCCCCCEEEECHHHHHHHHCCCEECCCEEEEECCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1732206; 1859631; 8439398 [H]