Click here to switch to the map view.

The map label for this gene is gcvA [H]

Identifier: 119945976

GI number: 119945976

Start: 2815707

End: 2816603

Strand: Direct

Name: gcvA [H]

Synonym: Ping_2316

Alternate gene names: 119945976

Gene position: 2815707-2816603 (Clockwise)

Preceding gene: 119945974

Following gene: 119945985

Centisome position: 61.75

GC content: 38.91

Gene sequence:

>897_bases
ATGCAAAAACTACCTGTTTTAAGCCATCTACGCACTTTTGTAACTGCCGCTAAAACAGGTAGCTTTGCCAATACAGCGAT
TAAATTATGCATCACTCCTGCTGCAGTAAGCCAGCACATACGTCAGTTAGAAAATCAACTTAAAAGTATTTTATTTGAGC
GTTCTAAACGGGGTGTTTGTCTGACCCAAGCAGGCATCCAATACCGTGTTTTTGCCGAAAAAGCACTTGATAACCTAAGG
CAGGGGCAGCATTGTCTTAATCAACTCAAGAACCAACAATACTTTACTATCAGAGCATTCCCTTCCGTGGCCAGTAAATG
GTTAATGCCAAAAATAATTCAATTTATGGACCTTAATCCTGACCTTGAAATTCGACTTGAAGCAAGTCATGCAAAAGTTG
ATTTTGATAACAGTGACACAGATGCCTGCATTAGCTTTGGTCATCAAGACTACCCAAATGAAGAGGCTGTTCTATTATTC
AACGACAGTGTATCTTTGGTAGCAAGCCCACTTTTGCTTCAACAACTTCCTCATGGTCATCACCTTGATACACTGCTTCA
GCAACCTTTGATTCAGATAGATTGGGGCCACTTTAATCGTTTTTTACCCGATTGGGAAAATTGGTTAAAACTGGCGGGTT
ATAAAGATATTAGTTTCAAAAAAGGCCCTCAATTTAATTTATCCAGCCTGGCTATTGAAGCGGCAGTGCAAGGAAAAGGA
CTTTTATTAGGACAAGAATCACTTATTCAGGATGAACTTAAATCTGGGAAATTAATACAAGTATGCGATATTTCTTTGCC
TTTAGAGCGCCCATATTACCTTGTTTATCCCAAGCGAACATTAGCTAACCCTCAGGCTATTAATTTTTTCAAACAACTTA
TAGCTAAAACAGGTTAG

Upstream 100 bases:

>100_bases
CTTAACAATAAAATCATGTTAAATCTATGCTAATAAGTTAGGATAACAAGCTAAAAAAAACGAACTATCTCATTAAAATC
ACAATACAATAGGTTATTAA

Downstream 100 bases:

>100_bases
GTCACAACAAGGCATTCACACCATCAAAAAGACGGGACACCTAAACCTTTTGCAGGTTAATGGGCTGGAAATGGCTCTTT
GCGACTTTCGACTGCTCAGT

Product: transcriptional regulator, substrate-binding of LysR family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MQKLPVLSHLRTFVTAAKTGSFANTAIKLCITPAAVSQHIRQLENQLKSILFERSKRGVCLTQAGIQYRVFAEKALDNLR
QGQHCLNQLKNQQYFTIRAFPSVASKWLMPKIIQFMDLNPDLEIRLEASHAKVDFDNSDTDACISFGHQDYPNEEAVLLF
NDSVSLVASPLLLQQLPHGHHLDTLLQQPLIQIDWGHFNRFLPDWENWLKLAGYKDISFKKGPQFNLSSLAIEAAVQGKG
LLLGQESLIQDELKSGKLIQVCDISLPLERPYYLVYPKRTLANPQAINFFKQLIAKTG

Sequences:

>Translated_298_residues
MQKLPVLSHLRTFVTAAKTGSFANTAIKLCITPAAVSQHIRQLENQLKSILFERSKRGVCLTQAGIQYRVFAEKALDNLR
QGQHCLNQLKNQQYFTIRAFPSVASKWLMPKIIQFMDLNPDLEIRLEASHAKVDFDNSDTDACISFGHQDYPNEEAVLLF
NDSVSLVASPLLLQQLPHGHHLDTLLQQPLIQIDWGHFNRFLPDWENWLKLAGYKDISFKKGPQFNLSSLAIEAAVQGKG
LLLGQESLIQDELKSGKLIQVCDISLPLERPYYLVYPKRTLANPQAINFFKQLIAKTG
>Mature_298_residues
MQKLPVLSHLRTFVTAAKTGSFANTAIKLCITPAAVSQHIRQLENQLKSILFERSKRGVCLTQAGIQYRVFAEKALDNLR
QGQHCLNQLKNQQYFTIRAFPSVASKWLMPKIIQFMDLNPDLEIRLEASHAKVDFDNSDTDACISFGHQDYPNEEAVLLF
NDSVSLVASPLLLQQLPHGHHLDTLLQQPLIQIDWGHFNRFLPDWENWLKLAGYKDISFKKGPQFNLSSLAIEAAVQGKG
LLLGQESLIQDELKSGKLIQVCDISLPLERPYYLVYPKRTLANPQAINFFKQLIAKTG

Specific function: Not known, the gcv operon regulated by the E.coli homolog does not exist in H.influenzae, so it probably acts as a transcriptional regulator on some other operon [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789173, Length=279, Percent_Identity=28.673835125448, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786448, Length=287, Percent_Identity=31.7073170731707, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788706, Length=276, Percent_Identity=28.9855072463768, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787589, Length=295, Percent_Identity=26.1016949152542, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1789440, Length=266, Percent_Identity=30.4511278195489, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI157672245, Length=166, Percent_Identity=31.3253012048193, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081978, Length=272, Percent_Identity=26.4705882352941, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI145693193, Length=297, Percent_Identity=24.5791245791246, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786401, Length=272, Percent_Identity=24.2647058823529, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790208, Length=171, Percent_Identity=30.4093567251462, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33723; Mature: 33723

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLPVLSHLRTFVTAAKTGSFANTAIKLCITPAAVSQHIRQLENQLKSILFERSKRGVC
CCCCHHHHHHHHHHHHHCCCCHHHHEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LTQAGIQYRVFAEKALDNLRQGQHCLNQLKNQQYFTIRAFPSVASKWLMPKIIQFMDLNP
EEECCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHCCCC
DLEIRLEASHAKVDFDNSDTDACISFGHQDYPNEEAVLLFNDSVSLVASPLLLQQLPHGH
CEEEEEECCCEEEECCCCCHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCC
HLDTLLQQPLIQIDWGHFNRFLPDWENWLKLAGYKDISFKKGPQFNLSSLAIEAAVQGKG
CHHHHHHCCCEEEECHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCE
LLLGQESLIQDELKSGKLIQVCDISLPLERPYYLVYPKRTLANPQAINFFKQLIAKTG
EEECHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCHHHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQKLPVLSHLRTFVTAAKTGSFANTAIKLCITPAAVSQHIRQLENQLKSILFERSKRGVC
CCCCHHHHHHHHHHHHHCCCCHHHHEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LTQAGIQYRVFAEKALDNLRQGQHCLNQLKNQQYFTIRAFPSVASKWLMPKIIQFMDLNP
EEECCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHCCCC
DLEIRLEASHAKVDFDNSDTDACISFGHQDYPNEEAVLLFNDSVSLVASPLLLQQLPHGH
CEEEEEECCCEEEECCCCCHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCC
HLDTLLQQPLIQIDWGHFNRFLPDWENWLKLAGYKDISFKKGPQFNLSSLAIEAAVQGKG
CHHHHHHCCCEEEECHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCE
LLLGQESLIQDELKSGKLIQVCDISLPLERPYYLVYPKRTLANPQAINFFKQLIAKTG
EEECHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCHHHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]