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The map label for this gene is pyrD

Identifier: 119945959

GI number: 119945959

Start: 2793737

End: 2794747

Strand: Reverse

Name: pyrD

Synonym: Ping_2299

Alternate gene names: 119945959

Gene position: 2794747-2793737 (Counterclockwise)

Preceding gene: 119945960

Following gene: 119945958

Centisome position: 61.29

GC content: 39.27

Gene sequence:

>1011_bases
ATGTTTTATCAAATTATGCGCAGTTTTTTATTTATGTTAAATCCTGAAAAAGCCCATGACTTTTCAATCAAACAATTAAA
GTTAACCCAGGGCACTGCCTTAGATTTTATCTATCGTCAGAGGGTCCAGCAAAGACCAGTGCAGGTCATGGGTTTAACTT
TTCCAAATTCAGTGGGTTTGGCTGCGGGTTTAGATAAAAATGGCGAATGTATTGATGCCTTCGGCGCAATGGGTTTTGGG
CATATTGAAGTGGGTACGGTAACTCCCGTTGCACAGCCCGGTAATGAATCTCCACGTATGTTCAGAGTATTGGAATCTGA
CGGTATTATTAACCGTATGGGCTTTAATAATGAGGGTGTCGAAAATTTAATTAAGAATGTGAAAGAAAGTAATTTCAAAG
GTGTTATTGGTATTAACATAGGTAAAAATTTCTCAACACCGGTGGAACAGGGAAAAGAAGATTATTTGTTATGCATGGAT
AAAGTTTATCCTTATGCCGATTACATTGCGGTTAATATTTCTTCACCTAATACGCCCGGATTACGTTCGCTACAGTATGG
TGATGCACTGAATGAATTGCTTGCTGCGCTCAAAATACGTCAAGCTGAACTGCAAGTTAAATACAATAAATATGTGCCAA
TTGCCTTAAAAATTGCACCGGATCTCAGTGACCAGGAGATTGTCTCAATCGCCAAATCATTGCTCGAATACAAAATTGAC
GGTTTAATTGCGACTAATACTACCCTTGATCGTGACATGGTTAAAGGTATGTCGCATGCAGGTGAGGCGGGTGGTTTAAG
CGGCCGTCCTTTGCAAAATAAAAGTACCGCTGTGATTGCAAAATTTGCCGCGCAATTAAAAGGAGAGATTCCCATTATTG
GCGTGGGTGGCATTGATAATGTGATTGCTGCCAAAGAGAAAATACAAGCAGGTGCAAGTTTAGTGCAGATCTATTCCGGT
TTTATCTACCATGGCCCTCAATTAGTTAAAAATATTGTCAATAATATTTAA

Upstream 100 bases:

>100_bases
GGTATAGCTAACTTATATGATTTTATTGTTTTTGTTTAACAGATACAGAGTACAATAAATACAATATTATTTTATCCACT
TTTTATGAAAGGTTTTACTT

Downstream 100 bases:

>100_bases
TTTATAATACCGCTCTGTTTGTGCAGAGCAGTGATAGGTGAAAGTGACTTTGTGTAAAAAAACGCATCGAATAATTGATT
TTAGACCGCAAGCAAATTGG

Product: dihydroorotate oxidase

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MFYQIMRSFLFMLNPEKAHDFSIKQLKLTQGTALDFIYRQRVQQRPVQVMGLTFPNSVGLAAGLDKNGECIDAFGAMGFG
HIEVGTVTPVAQPGNESPRMFRVLESDGIINRMGFNNEGVENLIKNVKESNFKGVIGINIGKNFSTPVEQGKEDYLLCMD
KVYPYADYIAVNISSPNTPGLRSLQYGDALNELLAALKIRQAELQVKYNKYVPIALKIAPDLSDQEIVSIAKSLLEYKID
GLIATNTTLDRDMVKGMSHAGEAGGLSGRPLQNKSTAVIAKFAAQLKGEIPIIGVGGIDNVIAAKEKIQAGASLVQIYSG
FIYHGPQLVKNIVNNI

Sequences:

>Translated_336_residues
MFYQIMRSFLFMLNPEKAHDFSIKQLKLTQGTALDFIYRQRVQQRPVQVMGLTFPNSVGLAAGLDKNGECIDAFGAMGFG
HIEVGTVTPVAQPGNESPRMFRVLESDGIINRMGFNNEGVENLIKNVKESNFKGVIGINIGKNFSTPVEQGKEDYLLCMD
KVYPYADYIAVNISSPNTPGLRSLQYGDALNELLAALKIRQAELQVKYNKYVPIALKIAPDLSDQEIVSIAKSLLEYKID
GLIATNTTLDRDMVKGMSHAGEAGGLSGRPLQNKSTAVIAKFAAQLKGEIPIIGVGGIDNVIAAKEKIQAGASLVQIYSG
FIYHGPQLVKNIVNNI
>Mature_336_residues
MFYQIMRSFLFMLNPEKAHDFSIKQLKLTQGTALDFIYRQRVQQRPVQVMGLTFPNSVGLAAGLDKNGECIDAFGAMGFG
HIEVGTVTPVAQPGNESPRMFRVLESDGIINRMGFNNEGVENLIKNVKESNFKGVIGINIGKNFSTPVEQGKEDYLLCMD
KVYPYADYIAVNISSPNTPGLRSLQYGDALNELLAALKIRQAELQVKYNKYVPIALKIAPDLSDQEIVSIAKSLLEYKID
GLIATNTTLDRDMVKGMSHAGEAGGLSGRPLQNKSTAVIAKFAAQLKGEIPIIGVGGIDNVIAAKEKIQAGASLVQIYSG
FIYHGPQLVKNIVNNI

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=348, Percent_Identity=40.8045977011494, Blast_Score=232, Evalue=3e-61,
Organism=Escherichia coli, GI1787177, Length=336, Percent_Identity=63.0952380952381, Blast_Score=462, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17509475, Length=324, Percent_Identity=40.7407407407407, Blast_Score=225, Evalue=2e-59,
Organism=Drosophila melanogaster, GI281361352, Length=341, Percent_Identity=41.0557184750733, Blast_Score=242, Evalue=2e-64,
Organism=Drosophila melanogaster, GI17137316, Length=341, Percent_Identity=41.0557184750733, Blast_Score=242, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_PSYIN (A1SX25)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943639.1
- ProteinModelPortal:   A1SX25
- SMR:   A1SX25
- STRING:   A1SX25
- GeneID:   4624617
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_2299
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- PhylomeDB:   A1SX25
- BioCyc:   PING357804:PING_2299-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 36671; Mature: 36671

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 175-175

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYQIMRSFLFMLNPEKAHDFSIKQLKLTQGTALDFIYRQRVQQRPVQVMGLTFPNSVGL
CHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEEECCCCCCC
AAGLDKNGECIDAFGAMGFGHIEVGTVTPVAQPGNESPRMFRVLESDGIINRMGFNNEGV
EECCCCCCCHHHHHHCCCCCEEEECEECCCCCCCCCCCCEEEEECCCCCEEECCCCCCCH
ENLIKNVKESNFKGVIGINIGKNFSTPVEQGKEDYLLCMDKVYPYADYIAVNISSPNTPG
HHHHHHHHHCCCCEEEEEECCCCCCCHHHCCCCCEEEEHHHHCCCCCEEEEEECCCCCCC
LRSLQYGDALNELLAALKIRQAELQVKYNKYVPIALKIAPDLSDQEIVSIAKSLLEYKID
CCCCHHHHHHHHHHHHHHHHHHHEEEEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHHC
GLIATNTTLDRDMVKGMSHAGEAGGLSGRPLQNKSTAVIAKFAAQLKGEIPIIGVGGIDN
CEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCH
VIAAKEKIQAGASLVQIYSGFIYHGPQLVKNIVNNI
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MFYQIMRSFLFMLNPEKAHDFSIKQLKLTQGTALDFIYRQRVQQRPVQVMGLTFPNSVGL
CHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEEECCCCCCC
AAGLDKNGECIDAFGAMGFGHIEVGTVTPVAQPGNESPRMFRVLESDGIINRMGFNNEGV
EECCCCCCCHHHHHHCCCCCEEEECEECCCCCCCCCCCCEEEEECCCCCEEECCCCCCCH
ENLIKNVKESNFKGVIGINIGKNFSTPVEQGKEDYLLCMDKVYPYADYIAVNISSPNTPG
HHHHHHHHHCCCCEEEEEECCCCCCCHHHCCCCCEEEEHHHHCCCCCEEEEEECCCCCCC
LRSLQYGDALNELLAALKIRQAELQVKYNKYVPIALKIAPDLSDQEIVSIAKSLLEYKID
CCCCHHHHHHHHHHHHHHHHHHHEEEEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHHC
GLIATNTTLDRDMVKGMSHAGEAGGLSGRPLQNKSTAVIAKFAAQLKGEIPIIGVGGIDN
CEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCH
VIAAKEKIQAGASLVQIYSGFIYHGPQLVKNIVNNI
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA