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The map label for this gene is envZ [H]

Identifier: 119945945

GI number: 119945945

Start: 2776271

End: 2777713

Strand: Reverse

Name: envZ [H]

Synonym: Ping_2285

Alternate gene names: 119945945

Gene position: 2777713-2776271 (Counterclockwise)

Preceding gene: 119945946

Following gene: 119945944

Centisome position: 60.92

GC content: 38.18

Gene sequence:

>1443_bases
ATGATGGTTTATTTGCGCTTATTGTTCAGATCATTAGTTTCCCGTATGTTATTGCTGACGATGGTATCGGTTATCGTCGC
ACAAGCCATGAGCAGTTTTTTTTGGGTAAATCAGTTTGCCGAAAGTGAAGAAAAATCACTGCTGCTTAATGCTAATAATT
TAGCTGAAAATGCCTTAAGCACTGTTTCATTTTTTCAAGATTTGCCCCTGCAATACCGTTATCTGGCGTTACAGCAACTT
CGAGATTTAGGTGGTAGCCGTTTTTTTGTGTCGTTAAACAGTGAACTTATCAACATCAATCCGATCGCGGCCAGTGGGTT
AAAAAGTGAGATTATAAAAACTGTTAAGGATGTACTCAGGCGAAGAATTTCAACGGAAAAAAAATTGCACATAGAATTTT
CACATCCAGATAATTTACACGTATTAAAAAATGATATTTTATTAAAAAATTTACCACCTTCCTGGGGGGCTTATTCTTTG
ATTATTCCTTCCGTTAAACCACCCGTTTTAGTGATGCAGGTTGAAATGGCTGAGAATGAGTGGCTTTATCTGGCGGCTAT
TTTACCTCCTCCTTATTTGCTTTCACAAAACTCAATTATATCAACTCAACAGATCATTACGCTGGTTTTTACTACCTTTA
TTTTACTTATCTTTATCTCTTTATTCTTTTTTTGGCAAACCAGACCCCTAAAACAGTTGGCTCTGGCGGTGTCTGAAATG
AGTATTGATTTATACCAGAAACCCCTTAAGGAAGAGGGAGCTTCTGAAATAGTGATGGCGACACGCGCATTTAATCGCAT
GCAGCAAAAATTACAGCGCTATATTCAAGATCGTGAAGTGTTATTCCGCTCTATTTCTCATGATTTAAAAACGCCTATTA
CCCGGTTACGATTGCGCGTGGAATTATTGAATAATGAAAAAAAAATAGTCGCCTTTAATCACGATTTAGACGATTTAGAA
ATGTTGGTTAAGGGGGCATTACAAACGGTCAAAGATACTGATATTCATGAAAATATCCAGTCAGTTGATGTGCTGAAATT
ATTAGAGCAGATAAGTAGTTCACAACCCGATCAAATAGAGATTATCTCCGGGGAAATTGCCCCTTATCGCGGTAAGCCTC
TGGCGTTAAAACGCTGTCTTTCTAACTTAATAGATAATGGGGTTAAGTATGGTCATTCAGTAAAGGTTTACCTTACGGAC
AGTGATGAAAGTTTGCAGCTTTTAATTCAAGATAATGGTCCGGGTATTCCAGTTAAAGAACTTCAGAATATATTTACGCC
GTATCGCCGTTTACATTATGACCAGCAGGGCCATGGTCTTGGGCTCGGTATTGCGCGTAATATTATTCATGCACATAACG
GTCAGCTGCATCTTATTAATCGGGATCAGGGCGGTTTGGAGGTGATCATCACCTTACCAAGAATTTACAAGTCTAATTTA
TGA

Upstream 100 bases:

>100_bases
TAAATCACCAAAAATCATAAAAACGATCCGCGGTGCCGGATATGTCTTTATCGCCGATGTTAATGAAAAAAATTAATATT
TTTAGTCATGCAGGATTAAT

Downstream 100 bases:

>100_bases
TAAAGCGGGATGCTGAGATGAAATGTTTAATTTTACTGGCAGCTCTTTTATGCGCTGTCAATGTTTATGCGGCAGAAGTC
GAGGTGCTTCACTGGTGGAC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MMVYLRLLFRSLVSRMLLLTMVSVIVAQAMSSFFWVNQFAESEEKSLLLNANNLAENALSTVSFFQDLPLQYRYLALQQL
RDLGGSRFFVSLNSELININPIAASGLKSEIIKTVKDVLRRRISTEKKLHIEFSHPDNLHVLKNDILLKNLPPSWGAYSL
IIPSVKPPVLVMQVEMAENEWLYLAAILPPPYLLSQNSIISTQQIITLVFTTFILLIFISLFFFWQTRPLKQLALAVSEM
SIDLYQKPLKEEGASEIVMATRAFNRMQQKLQRYIQDREVLFRSISHDLKTPITRLRLRVELLNNEKKIVAFNHDLDDLE
MLVKGALQTVKDTDIHENIQSVDVLKLLEQISSSQPDQIEIISGEIAPYRGKPLALKRCLSNLIDNGVKYGHSVKVYLTD
SDESLQLLIQDNGPGIPVKELQNIFTPYRRLHYDQQGHGLGLGIARNIIHAHNGQLHLINRDQGGLEVIITLPRIYKSNL

Sequences:

>Translated_480_residues
MMVYLRLLFRSLVSRMLLLTMVSVIVAQAMSSFFWVNQFAESEEKSLLLNANNLAENALSTVSFFQDLPLQYRYLALQQL
RDLGGSRFFVSLNSELININPIAASGLKSEIIKTVKDVLRRRISTEKKLHIEFSHPDNLHVLKNDILLKNLPPSWGAYSL
IIPSVKPPVLVMQVEMAENEWLYLAAILPPPYLLSQNSIISTQQIITLVFTTFILLIFISLFFFWQTRPLKQLALAVSEM
SIDLYQKPLKEEGASEIVMATRAFNRMQQKLQRYIQDREVLFRSISHDLKTPITRLRLRVELLNNEKKIVAFNHDLDDLE
MLVKGALQTVKDTDIHENIQSVDVLKLLEQISSSQPDQIEIISGEIAPYRGKPLALKRCLSNLIDNGVKYGHSVKVYLTD
SDESLQLLIQDNGPGIPVKELQNIFTPYRRLHYDQQGHGLGLGIARNIIHAHNGQLHLINRDQGGLEVIITLPRIYKSNL
>Mature_480_residues
MMVYLRLLFRSLVSRMLLLTMVSVIVAQAMSSFFWVNQFAESEEKSLLLNANNLAENALSTVSFFQDLPLQYRYLALQQL
RDLGGSRFFVSLNSELININPIAASGLKSEIIKTVKDVLRRRISTEKKLHIEFSHPDNLHVLKNDILLKNLPPSWGAYSL
IIPSVKPPVLVMQVEMAENEWLYLAAILPPPYLLSQNSIISTQQIITLVFTTFILLIFISLFFFWQTRPLKQLALAVSEM
SIDLYQKPLKEEGASEIVMATRAFNRMQQKLQRYIQDREVLFRSISHDLKTPITRLRLRVELLNNEKKIVAFNHDLDDLE
MLVKGALQTVKDTDIHENIQSVDVLKLLEQISSSQPDQIEIISGEIAPYRGKPLALKRCLSNLIDNGVKYGHSVKVYLTD
SDESLQLLIQDNGPGIPVKELQNIFTPYRRLHYDQQGHGLGLGIARNIIHAHNGQLHLINRDQGGLEVIITLPRIYKSNL

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=279, Percent_Identity=31.5412186379928, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=27.7777777777778, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1787894, Length=310, Percent_Identity=29.0322580645161, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=29.8701298701299, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1788393, Length=283, Percent_Identity=24.0282685512367, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787374, Length=296, Percent_Identity=27.027027027027, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786783, Length=303, Percent_Identity=24.4224422442244, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790551, Length=274, Percent_Identity=24.4525547445255, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789403, Length=296, Percent_Identity=26.0135135135135, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=282, Percent_Identity=25.177304964539, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=25.3164556962025, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082128, Length=247, Percent_Identity=26.7206477732794, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54786; Mature: 54786

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVYLRLLFRSLVSRMLLLTMVSVIVAQAMSSFFWVNQFAESEEKSLLLNANNLAENALS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHH
TVSFFQDLPLQYRYLALQQLRDLGGSRFFVSLNSELININPIAASGLKSEIIKTVKDVLR
HHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCHHHCCHHHHHHHHHHHHHH
RRISTEKKLHIEFSHPDNLHVLKNDILLKNLPPSWGAYSLIIPSVKPPVLVMQVEMAENE
HHHCCCCEEEEEECCCCCCEEEECCEEECCCCCCCCCEEEEECCCCCCEEEEEEEECCCC
WLYLAAILPPPYLLSQNSIISTQQIITLVFTTFILLIFISLFFFWQTRPLKQLALAVSEM
EEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SIDLYQKPLKEEGASEIVMATRAFNRMQQKLQRYIQDREVLFRSISHDLKTPITRLRLRV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
ELLNNEKKIVAFNHDLDDLEMLVKGALQTVKDTDIHENIQSVDVLKLLEQISSSQPDQIE
HHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEE
IISGEIAPYRGKPLALKRCLSNLIDNGVKYGHSVKVYLTDSDESLQLLIQDNGPGIPVKE
EEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCCCCHHH
LQNIFTPYRRLHYDQQGHGLGLGIARNIIHAHNGQLHLINRDQGGLEVIITLPRIYKSNL
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEHHHHCCCC
>Mature Secondary Structure
MMVYLRLLFRSLVSRMLLLTMVSVIVAQAMSSFFWVNQFAESEEKSLLLNANNLAENALS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHH
TVSFFQDLPLQYRYLALQQLRDLGGSRFFVSLNSELININPIAASGLKSEIIKTVKDVLR
HHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCHHHCCHHHHHHHHHHHHHH
RRISTEKKLHIEFSHPDNLHVLKNDILLKNLPPSWGAYSLIIPSVKPPVLVMQVEMAENE
HHHCCCCEEEEEECCCCCCEEEECCEEECCCCCCCCCEEEEECCCCCCEEEEEEEECCCC
WLYLAAILPPPYLLSQNSIISTQQIITLVFTTFILLIFISLFFFWQTRPLKQLALAVSEM
EEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SIDLYQKPLKEEGASEIVMATRAFNRMQQKLQRYIQDREVLFRSISHDLKTPITRLRLRV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
ELLNNEKKIVAFNHDLDDLEMLVKGALQTVKDTDIHENIQSVDVLKLLEQISSSQPDQIE
HHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEE
IISGEIAPYRGKPLALKRCLSNLIDNGVKYGHSVKVYLTDSDESLQLLIQDNGPGIPVKE
EEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCCCCHHH
LQNIFTPYRRLHYDQQGHGLGLGIARNIIHAHNGQLHLINRDQGGLEVIITLPRIYKSNL
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]