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The map label for this gene is thrS

Identifier: 119945879

GI number: 119945879

Start: 2700524

End: 2702431

Strand: Reverse

Name: thrS

Synonym: Ping_2219

Alternate gene names: 119945879

Gene position: 2702431-2700524 (Counterclockwise)

Preceding gene: 119945880

Following gene: 119945878

Centisome position: 59.27

GC content: 40.46

Gene sequence:

>1908_bases
ATGCCCATTATTACTCTACCCGACGGTAATCAACGTCAATTCGATAACACTACCTCAATAATGGAAATCGCTGCCGATAT
CGGCCCCGGTCTTGCCAAAGCATGTATTGCCGGACGTGTTGACGGTCAGTTAGTTGATGCATGTGATCCTATTGAGAAAG
ATGCTAATATTGCCATTATTACCGCAAAAGATGACCAAGGTTTAGAAATTTTACGTCACTCATGTGCGCATCTTTTAGGG
CATGCCATTAAGCAGCTTTATCCTAATGCTAAGATGGCTATTGGTCCGACGATTGAAAATGGCTTTTATTACGATATTGA
TCTTGATGTCACGATCAATGATGATGAATTGGCAAAAATTGCTAAGCGTATGAACGAATTAGTGAAAACTAATTATACTG
TGGTTAAAGAAAAAGTTTCGGTAGAAGAAGCAAAAGCGCTTTTCAAAGAGCGTGGTGAGAGCTATAAATTAGAGATTCTT
GAAGGTATTCACCCTGATGATCGTCCCGGGTTATACCATCATGAAGAATATATTGATATGTGCCGAGGCCCACATGTGCC
GGTAATGAAATTCTGTCAATATTTTAAACTGATGAAGGTCTCAGGCGCATATTGGCGCGGCAATTCAGATAATAAAATGT
TACAACGAATTTATGGCACCGCTTGGGCTGACAAAAAACAACTTAATGCGTATTTAAAACGTCTTGAAGAAGCAGCCAAA
CGTGACCATCGTAAAATTGGTAAACAGTTAGACTTGTATCATATGCAGGAAGAAGCCCCAGGTATGGTTTTTTGGCATAG
TAATGGCTGGACAATTTATCGAGAACTTGAAAAATATGTGCGTGAACAAACGGAAGCTTATGACTACCAAGAAGTAAAAG
CGCCGCAAATACTGGATCGTGCTCTTTGGGAAAAATCGGGACATTGGGGTAAATACAAAGACAATATGTTCTGTACCAGC
TCTGAAAATCGAGACTATGCGATTAAACCCATGAACTGCCCCGGACATTTACAAATCTTCAATCAGGGACTGAAATCGTA
TCGCGATTTGCCACTGCGCATGGCCGAGTTTGGCTCTTGTCACCGTAACGAGCCGTCCGGCTCATTACACGGTTTAATGC
GTGTACGTGCTTTTACTCAGGATGATGCCCATATCTTCTGCACGGAAGAACAAATTCTTGACGAAGTATCTGCTTGTATT
CAGATGGTATTTGAATGTTACAAAACCTTTGGTTTTGATGATATTGCTGTCAAACTATCTACCCGCCCAGATCAACGAGT
GGGCGATGATGCGACTTGGGATAAGGCCGAAGCGGCTTTGGCTAATGCATTAACCACAAATAATATCAATTATGGTGTAC
TGCCGGGTGAAGGGGCTTTTTATGGGCCTAAAATCGAATTTACTTTATATGATTGTTTAGGTCGTGGGTGGCAATGTGGT
ACAATTCAACTAGATTTTTCAATGCCAGGTCGTTTAGACGCTTCTTTTGTTGGTGAAGATAATGAACGACATACACCGGT
TATGATTCACCGAGCTATTTTAGGTTCTTTAGAACGTTTTATTGGTATTCTAACTGAAGAGTATGCTGGCGTTTATCCGA
CATGGTTATCACCAAAACAGGTGGTGGTGATGAATATTACCGATAAACAGTCTGCTTTTGTCGACGAAGTTGTAAATAAA
TTAAAAAAATCAGGCATTAGAGCCATTTCGGACTTGAGAAATGAGAAGATAGGCTTTAAAATCCGTGAGCATACATTAAA
ACGTGTTCCGTATTTACTTGTCATCGGTGATCAAGAAGTCGAAGCTGGTGAAGTTGCTGTAAGAACTCGTAAAGGTGATG
ATTTAGGTAAATTCAAAGTAGACGATTTTGCCGCTTATATTAAAGAAGAAATCATCACACGCCGTTAA

Upstream 100 bases:

>100_bases
GGCGCTTTTAATGAGCGTTATATTCCTTTAAAATGCGCATCTTATTTATCAATTATACAAATGCTTTTTGGTTGGAAGCA
TCACTGTGAGGAAATACAGC

Downstream 100 bases:

>100_bases
ATTTATTAGGAGGATTGGTTATAAAAGGTGCAAAAAAAGCCCCACAACAGGGCAATAAACATCGTTTGAATGATGAGATC
ACCGGGACTGAAGTGCGTCT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 635; Mature: 634

Protein sequence:

>635_residues
MPIITLPDGNQRQFDNTTSIMEIAADIGPGLAKACIAGRVDGQLVDACDPIEKDANIAIITAKDDQGLEILRHSCAHLLG
HAIKQLYPNAKMAIGPTIENGFYYDIDLDVTINDDELAKIAKRMNELVKTNYTVVKEKVSVEEAKALFKERGESYKLEIL
EGIHPDDRPGLYHHEEYIDMCRGPHVPVMKFCQYFKLMKVSGAYWRGNSDNKMLQRIYGTAWADKKQLNAYLKRLEEAAK
RDHRKIGKQLDLYHMQEEAPGMVFWHSNGWTIYRELEKYVREQTEAYDYQEVKAPQILDRALWEKSGHWGKYKDNMFCTS
SENRDYAIKPMNCPGHLQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRAFTQDDAHIFCTEEQILDEVSACI
QMVFECYKTFGFDDIAVKLSTRPDQRVGDDATWDKAEAALANALTTNNINYGVLPGEGAFYGPKIEFTLYDCLGRGWQCG
TIQLDFSMPGRLDASFVGEDNERHTPVMIHRAILGSLERFIGILTEEYAGVYPTWLSPKQVVVMNITDKQSAFVDEVVNK
LKKSGIRAISDLRNEKIGFKIREHTLKRVPYLLVIGDQEVEAGEVAVRTRKGDDLGKFKVDDFAAYIKEEIITRR

Sequences:

>Translated_635_residues
MPIITLPDGNQRQFDNTTSIMEIAADIGPGLAKACIAGRVDGQLVDACDPIEKDANIAIITAKDDQGLEILRHSCAHLLG
HAIKQLYPNAKMAIGPTIENGFYYDIDLDVTINDDELAKIAKRMNELVKTNYTVVKEKVSVEEAKALFKERGESYKLEIL
EGIHPDDRPGLYHHEEYIDMCRGPHVPVMKFCQYFKLMKVSGAYWRGNSDNKMLQRIYGTAWADKKQLNAYLKRLEEAAK
RDHRKIGKQLDLYHMQEEAPGMVFWHSNGWTIYRELEKYVREQTEAYDYQEVKAPQILDRALWEKSGHWGKYKDNMFCTS
SENRDYAIKPMNCPGHLQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRAFTQDDAHIFCTEEQILDEVSACI
QMVFECYKTFGFDDIAVKLSTRPDQRVGDDATWDKAEAALANALTTNNINYGVLPGEGAFYGPKIEFTLYDCLGRGWQCG
TIQLDFSMPGRLDASFVGEDNERHTPVMIHRAILGSLERFIGILTEEYAGVYPTWLSPKQVVVMNITDKQSAFVDEVVNK
LKKSGIRAISDLRNEKIGFKIREHTLKRVPYLLVIGDQEVEAGEVAVRTRKGDDLGKFKVDDFAAYIKEEIITRR
>Mature_634_residues
PIITLPDGNQRQFDNTTSIMEIAADIGPGLAKACIAGRVDGQLVDACDPIEKDANIAIITAKDDQGLEILRHSCAHLLGH
AIKQLYPNAKMAIGPTIENGFYYDIDLDVTINDDELAKIAKRMNELVKTNYTVVKEKVSVEEAKALFKERGESYKLEILE
GIHPDDRPGLYHHEEYIDMCRGPHVPVMKFCQYFKLMKVSGAYWRGNSDNKMLQRIYGTAWADKKQLNAYLKRLEEAAKR
DHRKIGKQLDLYHMQEEAPGMVFWHSNGWTIYRELEKYVREQTEAYDYQEVKAPQILDRALWEKSGHWGKYKDNMFCTSS
ENRDYAIKPMNCPGHLQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRAFTQDDAHIFCTEEQILDEVSACIQ
MVFECYKTFGFDDIAVKLSTRPDQRVGDDATWDKAEAALANALTTNNINYGVLPGEGAFYGPKIEFTLYDCLGRGWQCGT
IQLDFSMPGRLDASFVGEDNERHTPVMIHRAILGSLERFIGILTEEYAGVYPTWLSPKQVVVMNITDKQSAFVDEVVNKL
KKSGIRAISDLRNEKIGFKIREHTLKRVPYLLVIGDQEVEAGEVAVRTRKGDDLGKFKVDDFAAYIKEEIITRR

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=606, Percent_Identity=39.4389438943894, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI38202255, Length=614, Percent_Identity=39.413680781759, Blast_Score=451, Evalue=1e-126,
Organism=Homo sapiens, GI20070344, Length=654, Percent_Identity=35.1681957186544, Blast_Score=390, Evalue=1e-108,
Organism=Escherichia coli, GI1788013, Length=635, Percent_Identity=72.2834645669291, Blast_Score=1001, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=196, Percent_Identity=26.530612244898, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71984192, Length=626, Percent_Identity=40.0958466453674, Blast_Score=470, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI71984184, Length=626, Percent_Identity=40.0958466453674, Blast_Score=469, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6322112, Length=627, Percent_Identity=38.2775119617225, Blast_Score=444, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322654, Length=395, Percent_Identity=37.2151898734177, Blast_Score=292, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24583842, Length=634, Percent_Identity=39.7476340694006, Blast_Score=475, Evalue=1e-134,
Organism=Drosophila melanogaster, GI28574141, Length=634, Percent_Identity=39.7476340694006, Blast_Score=475, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24583839, Length=634, Percent_Identity=39.7476340694006, Blast_Score=475, Evalue=1e-134,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_PSYIN (A1SWU5)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943559.1
- ProteinModelPortal:   A1SWU5
- SMR:   A1SWU5
- STRING:   A1SWU5
- GeneID:   4623856
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_2219
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   FHPKGMV
- PhylomeDB:   A1SWU5
- BioCyc:   PING357804:PING_2219-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 72314; Mature: 72183

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIITLPDGNQRQFDNTTSIMEIAADIGPGLAKACIAGRVDGQLVDACDPIEKDANIAII
CCEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEECCCCCCCCCCCEEEE
TAKDDQGLEILRHSCAHLLGHAIKQLYPNAKMAIGPTIENGFYYDIDLDVTINDDELAKI
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCEECCCEEEEEEEEEEECHHHHHHH
AKRMNELVKTNYTVVKEKVSVEEAKALFKERGESYKLEILEGIHPDDRPGLYHHEEYIDM
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCCCCCCCHHHHHH
CRGPHVPVMKFCQYFKLMKVSGAYWRGNSDNKMLQRIYGTAWADKKQLNAYLKRLEEAAK
HCCCCCCHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RDHRKIGKQLDLYHMQEEAPGMVFWHSNGWTIYRELEKYVREQTEAYDYQEVKAPQILDR
HHHHHHCCHHHHHHHHCCCCCEEEEECCCEEHHHHHHHHHHHHHHHCCHHHCCHHHHHHH
ALWEKSGHWGKYKDNMFCTSSENRDYAIKPMNCPGHLQIFNQGLKSYRDLPLRMAEFGSC
HHHHCCCCCCCCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCCC
HRNEPSGSLHGLMRVRAFTQDDAHIFCTEEQILDEVSACIQMVFECYKTFGFDDIAVKLS
CCCCCCHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
TRPDQRVGDDATWDKAEAALANALTTNNINYGVLPGEGAFYGPKIEFTLYDCLGRGWQCG
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEECCEEEEEEHHHHCCCEEEE
TIQLDFSMPGRLDASFVGEDNERHTPVMIHRAILGSLERFIGILTEEYAGVYPTWLSPKQ
EEEEECCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
VVVMNITDKQSAFVDEVVNKLKKSGIRAISDLRNEKIGFKIREHTLKRVPYLLVIGDQEV
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEEEECCCCC
EAGEVAVRTRKGDDLGKFKVDDFAAYIKEEIITRR
CCCCEEEEECCCCCCCCEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PIITLPDGNQRQFDNTTSIMEIAADIGPGLAKACIAGRVDGQLVDACDPIEKDANIAII
CEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEECCCCCCCCCCCEEEE
TAKDDQGLEILRHSCAHLLGHAIKQLYPNAKMAIGPTIENGFYYDIDLDVTINDDELAKI
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCEECCCEEEEEEEEEEECHHHHHHH
AKRMNELVKTNYTVVKEKVSVEEAKALFKERGESYKLEILEGIHPDDRPGLYHHEEYIDM
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCCCCCCCHHHHHH
CRGPHVPVMKFCQYFKLMKVSGAYWRGNSDNKMLQRIYGTAWADKKQLNAYLKRLEEAAK
HCCCCCCHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RDHRKIGKQLDLYHMQEEAPGMVFWHSNGWTIYRELEKYVREQTEAYDYQEVKAPQILDR
HHHHHHCCHHHHHHHHCCCCCEEEEECCCEEHHHHHHHHHHHHHHHCCHHHCCHHHHHHH
ALWEKSGHWGKYKDNMFCTSSENRDYAIKPMNCPGHLQIFNQGLKSYRDLPLRMAEFGSC
HHHHCCCCCCCCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCCC
HRNEPSGSLHGLMRVRAFTQDDAHIFCTEEQILDEVSACIQMVFECYKTFGFDDIAVKLS
CCCCCCHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
TRPDQRVGDDATWDKAEAALANALTTNNINYGVLPGEGAFYGPKIEFTLYDCLGRGWQCG
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEECCEEEEEEHHHHCCCEEEE
TIQLDFSMPGRLDASFVGEDNERHTPVMIHRAILGSLERFIGILTEEYAGVYPTWLSPKQ
EEEEECCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
VVVMNITDKQSAFVDEVVNKLKKSGIRAISDLRNEKIGFKIREHTLKRVPYLLVIGDQEV
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEEEECCCCC
EAGEVAVRTRKGDDLGKFKVDDFAAYIKEEIITRR
CCCCEEEEECCCCCCCCEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA