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The map label for this gene is lolE [H]

Identifier: 119945861

GI number: 119945861

Start: 2678172

End: 2679413

Strand: Reverse

Name: lolE [H]

Synonym: Ping_2201

Alternate gene names: 119945861

Gene position: 2679413-2678172 (Counterclockwise)

Preceding gene: 119945862

Following gene: 119945848

Centisome position: 58.76

GC content: 39.05

Gene sequence:

>1242_bases
ATGTTTCGCCCTTTATTAATTTTTATCGGCCTGCGATATAGTAAGGCTAAACATAAAAATAAGTTTGTTTCTTTTATTTC
TATGGCCTCCATATTGGGTATCGCGCTTGGGGTGACTGCATTAATTGTCGGCCTGTCGGCAATGAATGGTTTTGAAAAGG
CATTACGTGATCAGATGTTAGCTGTTATTCCTCATGCAGAGTTAGAAACAGTCAATGGTAGCTTTGAAAATCTGGACAGT
TCCTTAAAACAAGTCAGGCATCATCCCGGTGTTATTGCCGCAAGCCCGTACATTATGCTGAATGGTTTATTGCAAAAAGA
TGATCAAATAAAAGCGTTGCAAATTAGAGCGATAGCCCCGAAAAGTGAAAGGGATGTGACAGCTGTTGAGCATTATATAA
AAGGCGGAGGCTGGGAGTTATTAAAAACGGGGCAGCGTTCAATCGTATTAGGTAAAAGTGTTGCACTGAAGCTTGCTATG
AAGATAGGTGACTCGTTAACATTAATATTGCCGCAAGAGGGTGGACAACAATTAAAATCTCCTCGTAAAATAAAGCTCAC
CTTAGTGGGGTTATTTGAAATGGGAGGGCAGTTAGATAACGCCCTTGGTTTTATGCATATCGACGATGCCAAACAAATAT
TGGGACTCGACAGTGCGAATGGGATTGCTTTTAAAGTAGCGGATATATTAGATGCACAAACATTAGCACGGGACGTGGGT
TATAGTCTTAATGATTATCTGTATATAAAAAGCTGGATCACCAGCCAGGGTTATTTATATCAAGATATTCAGATGGTTAA
ATCTTTAATGTATGTCATTTTATTGCTGGTTATCGCCGTTGCCTGTTTTAATATTGTATCTACTCTGGTGATGGCCGTTA
ATGAAAAAAGAGGCGACATTGCTATTTTAAAAACCATGGGGGCCTCAAAATGGTTGTTACGCGGTATATTCATCGTGCAG
GGGGCATTTAATGGTCTGGTAGGTTGTCTTTTAGGTGCTGCTATCGGTATTTTTATTGCCTTAAATTTGACCGATATTGT
TAAATTTATAGAAACTGTCATCGGCCATAAATTCTTATCGGGTGATGTTTATTTTATAGATTTTTTACCCTCACATTTAA
TTTATGAGCAAGTTATTGTTGTGACTGTTGCCGCTTTTTTTATGAGTGTGTTATCTACTCTATATCCCGCTTGGCGGGCA
AGTAAGATCCAGCCTGCATTGGAACTAGGATTTGCTCATTAG

Upstream 100 bases:

>100_bases
CGGGGACTGCTTTTGTGGTAGTGACTCATGATCAACAGTTAGCCAATAAATTAACGCGTCAGGAACATATGAACAGTGGT
GTGTTACAGGGAAAGGTATA

Downstream 100 bases:

>100_bases
TTGAATTGCTAAGCTTAAAAAATAGAGCGTTAGTAATATATGATCAGCAACTGCATTGGAACTGGGATTTGCTCATTAGC
TGAATTGTTAAGCTTAAAAA

Product: lipoprotein releasing system, transmembrane protein, LolC/E family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MFRPLLIFIGLRYSKAKHKNKFVSFISMASILGIALGVTALIVGLSAMNGFEKALRDQMLAVIPHAELETVNGSFENLDS
SLKQVRHHPGVIAASPYIMLNGLLQKDDQIKALQIRAIAPKSERDVTAVEHYIKGGGWELLKTGQRSIVLGKSVALKLAM
KIGDSLTLILPQEGGQQLKSPRKIKLTLVGLFEMGGQLDNALGFMHIDDAKQILGLDSANGIAFKVADILDAQTLARDVG
YSLNDYLYIKSWITSQGYLYQDIQMVKSLMYVILLLVIAVACFNIVSTLVMAVNEKRGDIAILKTMGASKWLLRGIFIVQ
GAFNGLVGCLLGAAIGIFIALNLTDIVKFIETVIGHKFLSGDVYFIDFLPSHLIYEQVIVVTVAAFFMSVLSTLYPAWRA
SKIQPALELGFAH

Sequences:

>Translated_413_residues
MFRPLLIFIGLRYSKAKHKNKFVSFISMASILGIALGVTALIVGLSAMNGFEKALRDQMLAVIPHAELETVNGSFENLDS
SLKQVRHHPGVIAASPYIMLNGLLQKDDQIKALQIRAIAPKSERDVTAVEHYIKGGGWELLKTGQRSIVLGKSVALKLAM
KIGDSLTLILPQEGGQQLKSPRKIKLTLVGLFEMGGQLDNALGFMHIDDAKQILGLDSANGIAFKVADILDAQTLARDVG
YSLNDYLYIKSWITSQGYLYQDIQMVKSLMYVILLLVIAVACFNIVSTLVMAVNEKRGDIAILKTMGASKWLLRGIFIVQ
GAFNGLVGCLLGAAIGIFIALNLTDIVKFIETVIGHKFLSGDVYFIDFLPSHLIYEQVIVVTVAAFFMSVLSTLYPAWRA
SKIQPALELGFAH
>Mature_413_residues
MFRPLLIFIGLRYSKAKHKNKFVSFISMASILGIALGVTALIVGLSAMNGFEKALRDQMLAVIPHAELETVNGSFENLDS
SLKQVRHHPGVIAASPYIMLNGLLQKDDQIKALQIRAIAPKSERDVTAVEHYIKGGGWELLKTGQRSIVLGKSVALKLAM
KIGDSLTLILPQEGGQQLKSPRKIKLTLVGLFEMGGQLDNALGFMHIDDAKQILGLDSANGIAFKVADILDAQTLARDVG
YSLNDYLYIKSWITSQGYLYQDIQMVKSLMYVILLLVIAVACFNIVSTLVMAVNEKRGDIAILKTMGASKWLLRGIFIVQ
GAFNGLVGCLLGAAIGIFIALNLTDIVKFIETVIGHKFLSGDVYFIDFLPSHLIYEQVIVVTVAAFFMSVLSTLYPAWRA
SKIQPALELGFAH

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=408, Percent_Identity=45.5882352941176, Blast_Score=373, Evalue=1e-104,
Organism=Escherichia coli, GI1787360, Length=420, Percent_Identity=30, Blast_Score=165, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925
- InterPro:   IPR011926 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45198; Mature: 45198

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRPLLIFIGLRYSKAKHKNKFVSFISMASILGIALGVTALIVGLSAMNGFEKALRDQML
CCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVIPHAELETVNGSFENLDSSLKQVRHHPGVIAASPYIMLNGLLQKDDQIKALQIRAIAP
HHCCCCHHHHCCCCHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCEEEEEEEEECC
KSERDVTAVEHYIKGGGWELLKTGQRSIVLGKSVALKLAMKIGDSLTLILPQEGGQQLKS
CCCCCHHHHHHHHCCCCHHHHHCCCCEEEECHHHHHHHHHHCCCCEEEEEECCCCHHHCC
PRKIKLTLVGLFEMGGQLDNALGFMHIDDAKQILGLDSANGIAFKVADILDAQTLARDVG
CCEEEEEEEEHHHHCCCHHHHHCEEEECCHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHC
YSLNDYLYIKSWITSQGYLYQDIQMVKSLMYVILLLVIAVACFNIVSTLVMAVNEKRGDI
CCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
AILKTMGASKWLLRGIFIVQGAFNGLVGCLLGAAIGIFIALNLTDIVKFIETVIGHKFLS
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHC
GDVYFIDFLPSHLIYEQVIVVTVAAFFMSVLSTLYPAWRASKIQPALELGFAH
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCCC
>Mature Secondary Structure
MFRPLLIFIGLRYSKAKHKNKFVSFISMASILGIALGVTALIVGLSAMNGFEKALRDQML
CCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVIPHAELETVNGSFENLDSSLKQVRHHPGVIAASPYIMLNGLLQKDDQIKALQIRAIAP
HHCCCCHHHHCCCCHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCEEEEEEEEECC
KSERDVTAVEHYIKGGGWELLKTGQRSIVLGKSVALKLAMKIGDSLTLILPQEGGQQLKS
CCCCCHHHHHHHHCCCCHHHHHCCCCEEEECHHHHHHHHHHCCCCEEEEEECCCCHHHCC
PRKIKLTLVGLFEMGGQLDNALGFMHIDDAKQILGLDSANGIAFKVADILDAQTLARDVG
CCEEEEEEEEHHHHCCCHHHHHCEEEECCHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHC
YSLNDYLYIKSWITSQGYLYQDIQMVKSLMYVILLLVIAVACFNIVSTLVMAVNEKRGDI
CCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
AILKTMGASKWLLRGIFIVQGAFNGLVGCLLGAAIGIFIALNLTDIVKFIETVIGHKFLS
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHC
GDVYFIDFLPSHLIYEQVIVVTVAAFFMSVLSTLYPAWRASKIQPALELGFAH
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10783239 [H]