Click here to switch to the map view.

The map label for this gene is purE [H]

Identifier: 119945722

GI number: 119945722

Start: 2494010

End: 2494489

Strand: Direct

Name: purE [H]

Synonym: Ping_2048

Alternate gene names: 119945722

Gene position: 2494010-2494489 (Clockwise)

Preceding gene: 119945710

Following gene: 119945723

Centisome position: 54.7

GC content: 46.88

Gene sequence:

>480_bases
ATGAATAAACATAAAGTCGCGATCATCATGGGTTCTCAATCAGACTGGCCTGTCTTGCGCCAAGCAACCACCCTGCTTAA
GGAGTTTGGTATCCCTTTTGAAGCGATGGTGATATCTGCTCATCGAACACCACAACGATTATATGAGTTCACCAAGTCAG
CTGAAAATAACTATAGCGTGATCATCGCAGGTGCAGGTGGAGCAGCTCACCTACCTGGAATGACAGCAGCACTCACTTGT
GTTCCAGTGATTGGCGTTCCTGTGCAAAGCAAAGCACTCAAAGGCATGGATAGTTTGTTATCTATTGTTCAGATGCCAAA
AGGTGTTGCTGTGGCGACGCAAGCAATTGGCGAAGCGGGCGCATTTAATGCAGGCTTATTAGCGGCTCAGTTTCTGGCAA
TCCACGATTCAAAATTGCAAAGCAAAGTAAAAGCATGGCGCCAGCAGCAAACTGAGAGCATTGCTTGGGAGGTGGAATAA

Upstream 100 bases:

>100_bases
ATATCGAGAAGTCAGCGTTAGGGATCGACTTCTCCTTTAACGTACTGATTTACATTCCAAACCACAGCGTAATAACACAA
TGGATAATAGGGTAATAACA

Downstream 100 bases:

>100_bases
TGCGAATCGCCATTGTCGGTTGTGGCCAGCTCTCTCGTATGATGGCCCTCGCGGGGCTGCCTCTGGGCATTCAATTTAGC
TTTATTCACGATGATAAAAG

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MNKHKVAIIMGSQSDWPVLRQATTLLKEFGIPFEAMVISAHRTPQRLYEFTKSAENNYSVIIAGAGGAAHLPGMTAALTC
VPVIGVPVQSKALKGMDSLLSIVQMPKGVAVATQAIGEAGAFNAGLLAAQFLAIHDSKLQSKVKAWRQQQTESIAWEVE

Sequences:

>Translated_159_residues
MNKHKVAIIMGSQSDWPVLRQATTLLKEFGIPFEAMVISAHRTPQRLYEFTKSAENNYSVIIAGAGGAAHLPGMTAALTC
VPVIGVPVQSKALKGMDSLLSIVQMPKGVAVATQAIGEAGAFNAGLLAAQFLAIHDSKLQSKVKAWRQQQTESIAWEVE
>Mature_159_residues
MNKHKVAIIMGSQSDWPVLRQATTLLKEFGIPFEAMVISAHRTPQRLYEFTKSAENNYSVIIAGAGGAAHLPGMTAALTC
VPVIGVPVQSKALKGMDSLLSIVQMPKGVAVATQAIGEAGAFNAGLLAAQFLAIHDSKLQSKVKAWRQQQTESIAWEVE

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=58.4415584415584, Blast_Score=152, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6324702, Length=155, Percent_Identity=52.9032258064516, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16999; Mature: 16999

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKHKVAIIMGSQSDWPVLRQATTLLKEFGIPFEAMVISAHRTPQRLYEFTKSAENNYSV
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHCCCCCCEE
IIAGAGGAAHLPGMTAALTCVPVIGVPVQSKALKGMDSLLSIVQMPKGVAVATQAIGEAG
EEEECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
AFNAGLLAAQFLAIHDSKLQSKVKAWRQQQTESIAWEVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECC
>Mature Secondary Structure
MNKHKVAIIMGSQSDWPVLRQATTLLKEFGIPFEAMVISAHRTPQRLYEFTKSAENNYSV
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHCCCCCCEE
IIAGAGGAAHLPGMTAALTCVPVIGVPVQSKALKGMDSLLSIVQMPKGVAVATQAIGEAG
EEEECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
AFNAGLLAAQFLAIHDSKLQSKVKAWRQQQTESIAWEVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]