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The map label for this gene is dapA

Identifier: 119945556

GI number: 119945556

Start: 2260001

End: 2260882

Strand: Direct

Name: dapA

Synonym: Ping_1860

Alternate gene names: 119945556

Gene position: 2260001-2260882 (Clockwise)

Preceding gene: 119945554

Following gene: 119945557

Centisome position: 49.57

GC content: 40.82

Gene sequence:

>882_bases
ATGTTAACAGGCAGTATAGTCGCACTCGTGACACCCATGGATAAAACCGGTGAAATTGATTTCCTTACCTTAAAACAACT
TGTAGAATTTCATATAAAATCTGGCACCGCTGCTATCGTCGCTGTTGGTACTTCTGGGGAATCAGCAACATTAGATGTTG
ATACCCACGCAAAAGTGGTGATAAAAGCGCTGGAGTTTGCAGATGGACGCATTCCCATTATTGCGGGAAATGGTGCAAAT
TCAACCTCAGAAGCTGTTTTGTTAAGTAAACGTTTTGCCGATAGCGGCATTATAGCGGGCCTTAACGTCACTCCCTATTA
CAACAAACCTACCCAAGAGGGCCTGTTTCAACACTTTAAAGCTATTGCGGAGTCCTGTGATTTACCGCAAATATTGTACA
ATGTCCCTGGTCGAACATCTGTTGATATGTTGCCGGAAACCGTTGCGCGTCTTTCTAAAATAAAAAATATTATTGGCATC
AAAGAAGCCACGGGTGATTTAAATCGTCTTGCGGATATTAAAGCCTTAGTTGCTGATGATTTTGCTTTATACAGTGGTGA
TGATGCGACCGGATGTGATTTTCTTCTTCAGGGCGGACATGGTGTTATTTCTGTTACCACTAATATCGCGCCGGTTGAAA
TGGCTAAAATGTGTGAATATGCATTAAGCGGCCAGGCTGATTTAGCTAAAAAAATAGATAATCAGTTAGCGCCCGTGCAT
AAATATTTATTTATCGAATCTAATCCAATTCCGGTAAAATGGGCCTGTGCAGAAATGGGATTATTACCTTCTGCTGACTG
TCGTTTGCCATTAATGATGTTAGATAAAAAATATCAGCCGATTGTCCGTAACGCCTTAATTGAAGCTAAACTAATTTCAT
GA

Upstream 100 bases:

>100_bases
TCTTATTTTTGCTTTAAGAAGTTGAATCTATCCGCTTTATTGCTTGTTTTTAAGTGCATGCAAAAGTAACATTGATGAAC
TAATAAAGAGGAGCTTTAAG

Downstream 100 bases:

>100_bases
GCAAATTCTATAAATCAGGCCGGGTAACAACAGCCGTTATTGTTGCTTTATCGTTAAGTGCTTGTGCGCGTTTTGATGCC
AGAACACAAGCAAATGGTGA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MLTGSIVALVTPMDKTGEIDFLTLKQLVEFHIKSGTAAIVAVGTSGESATLDVDTHAKVVIKALEFADGRIPIIAGNGAN
STSEAVLLSKRFADSGIIAGLNVTPYYNKPTQEGLFQHFKAIAESCDLPQILYNVPGRTSVDMLPETVARLSKIKNIIGI
KEATGDLNRLADIKALVADDFALYSGDDATGCDFLLQGGHGVISVTTNIAPVEMAKMCEYALSGQADLAKKIDNQLAPVH
KYLFIESNPIPVKWACAEMGLLPSADCRLPLMMLDKKYQPIVRNALIEAKLIS

Sequences:

>Translated_293_residues
MLTGSIVALVTPMDKTGEIDFLTLKQLVEFHIKSGTAAIVAVGTSGESATLDVDTHAKVVIKALEFADGRIPIIAGNGAN
STSEAVLLSKRFADSGIIAGLNVTPYYNKPTQEGLFQHFKAIAESCDLPQILYNVPGRTSVDMLPETVARLSKIKNIIGI
KEATGDLNRLADIKALVADDFALYSGDDATGCDFLLQGGHGVISVTTNIAPVEMAKMCEYALSGQADLAKKIDNQLAPVH
KYLFIESNPIPVKWACAEMGLLPSADCRLPLMMLDKKYQPIVRNALIEAKLIS
>Mature_293_residues
MLTGSIVALVTPMDKTGEIDFLTLKQLVEFHIKSGTAAIVAVGTSGESATLDVDTHAKVVIKALEFADGRIPIIAGNGAN
STSEAVLLSKRFADSGIIAGLNVTPYYNKPTQEGLFQHFKAIAESCDLPQILYNVPGRTSVDMLPETVARLSKIKNIIGI
KEATGDLNRLADIKALVADDFALYSGDDATGCDFLLQGGHGVISVTTNIAPVEMAKMCEYALSGQADLAKKIDNQLAPVH
KYLFIESNPIPVKWACAEMGLLPSADCRLPLMMLDKKYQPIVRNALIEAKLIS

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=234, Percent_Identity=26.4957264957265, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI13540533, Length=288, Percent_Identity=26.3888888888889, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=59.9315068493151, Blast_Score=370, Evalue=1e-104,
Organism=Escherichia coli, GI87082415, Length=217, Percent_Identity=31.7972350230415, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789620, Length=280, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786463, Length=218, Percent_Identity=28.8990825688073, Blast_Score=98, Evalue=6e-22,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_PSYIN (A1SVX2)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943236.1
- ProteinModelPortal:   A1SVX2
- SMR:   A1SVX2
- STRING:   A1SVX2
- GeneID:   4625243
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1860
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- PhylomeDB:   A1SVX2
- BioCyc:   PING357804:PING_1860-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31389; Mature: 31389

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 161-161 BINDING 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTGSIVALVTPMDKTGEIDFLTLKQLVEFHIKSGTAAIVAVGTSGESATLDVDTHAKVV
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCHHHHH
IKALEFADGRIPIIAGNGANSTSEAVLLSKRFADSGIIAGLNVTPYYNKPTQEGLFQHFK
HHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEECCEECCCCCCCHHHHHHHHHH
AIAESCDLPQILYNVPGRTSVDMLPETVARLSKIKNIIGIKEATGDLNRLADIKALVADD
HHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCC
FALYSGDDATGCDFLLQGGHGVISVTTNIAPVEMAKMCEYALSGQADLAKKIDNQLAPVH
EEEECCCCCCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCE
KYLFIESNPIPVKWACAEMGLLPSADCRLPLMMLDKKYQPIVRNALIEAKLIS
EEEEEECCCCCEEEEHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHEECC
>Mature Secondary Structure
MLTGSIVALVTPMDKTGEIDFLTLKQLVEFHIKSGTAAIVAVGTSGESATLDVDTHAKVV
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCHHHHH
IKALEFADGRIPIIAGNGANSTSEAVLLSKRFADSGIIAGLNVTPYYNKPTQEGLFQHFK
HHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEECCEECCCCCCCHHHHHHHHHH
AIAESCDLPQILYNVPGRTSVDMLPETVARLSKIKNIIGIKEATGDLNRLADIKALVADD
HHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCC
FALYSGDDATGCDFLLQGGHGVISVTTNIAPVEMAKMCEYALSGQADLAKKIDNQLAPVH
EEEECCCCCCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCE
KYLFIESNPIPVKWACAEMGLLPSADCRLPLMMLDKKYQPIVRNALIEAKLIS
EEEEEECCCCCEEEEHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA