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The map label for this gene is ldc [H]

Identifier: 119945152

GI number: 119945152

Start: 1737267

End: 1738445

Strand: Direct

Name: ldc [H]

Synonym: Ping_1416

Alternate gene names: 119945152

Gene position: 1737267-1738445 (Clockwise)

Preceding gene: 119945151

Following gene: 119945153

Centisome position: 38.1

GC content: 43.77

Gene sequence:

>1179_bases
ATGCTGACGCAACCACTAAAATATTATTCACAGTCTACTTTTGAGCGTATTTGTGCGAAGGCAAAAGAGGTTGAAACCCC
CTTTGTCATCATAGACAGTGCCACTGTTGAAGATCATTTTGATGCATTGAGGAACAATTTTCCCTGGGCGGAAATCTATT
ATGCTTTAAAGGCAAATCCTGCTCATGAAATTATTGATATTGTTAATAATAAAGAGGGGGGATTTGATCTTGCCTCTACC
TATGAGCTTGACCGGGTAATCTCCCATGGTACTGATCCGGATCTTATCAGTTATGGCAATACCATCAAAAAACGGGCAGA
TATTAAATATTTTTATGATGCCGGCATAAGAATGTTTGTTACTGATTCAGATGCTGATCTGGCCAATATTGCCGCCATGG
CGCCCGGTGCTAAAGTTTACGTCCGTATTCTTACGGAAGGCAACTTGACCGCTGACTGGCCGCTGTCGCGTAAATTTGGC
TGCCAGCCTGATATGGCAATGGATCTTCTGGTCAAAGCTCAAAAACTGGGTTTAGAACCTTATGGTGTTTCATTTCATGT
CGGCTCGCAACAACGTGATATTGGTGCCTGGGATGGGGCGATTGCGACGGTGAAAGTTATTTTTGAACGTCTTAAATCAG
AAAATAATATTGAATTACAGATGATTAATATGGGGGGAGGTTTTCCTGCTCAGTATATTCATCAGACTAATACTTTAGCA
GTCTATGCGGCAGAAATTCAGCGTTTTCTGATTGAGGATTTCGGTGCAACACTGCCGCGCATTATTCTTGAGCCGGGCCG
TTCCTTAGTCGCTAATGCGGGGATCCTGGTGACTGAAGTGGTGCAGGTTTCACGTAAGAGTAATACTGCGCTACATCGCT
GGGTATATACCGATGTTGGGCTGTTTTCTGGAATGATAGAAACCCTTGGGGAGGCGATTAAATATCCGTTATATTGCGAA
ACCTCCTCGCCAGGCACGGGGGAGGAATCTGAAGAAGTGGTCATCGCAGGGCCTACCTGTGATAGCGCTGATATTTTGTA
TGAGGATTATAAATACCGACTACCGCATAGCTTGAAAGAAGGAGACCGGCTTTTTTGGTTTTCAACGGGGGCTTATACCA
CCTCTTATAGTGCGGTTGAATTTAACGGATTCCCGCCATTAAAATCCTATTTTGTATAA

Upstream 100 bases:

>100_bases
GCCGCAAAAAAATCAAATAAATGGCAAAGACACTGTATAACTAGTCTGTTTTTAACCCGCATAAATGAACTCGGATTTGG
TATTCATAAAGGAGCAAACC

Downstream 100 bases:

>100_bases
TCAGAAAACAGCTGGCGGTTTTTTTATACAGCGCACGAAAAGGGAGATATGCGGGTGACTGCATCCAGTATATAATCAAA
TTTTTTGTTTAGCACTGAGC

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MLTQPLKYYSQSTFERICAKAKEVETPFVIIDSATVEDHFDALRNNFPWAEIYYALKANPAHEIIDIVNNKEGGFDLAST
YELDRVISHGTDPDLISYGNTIKKRADIKYFYDAGIRMFVTDSDADLANIAAMAPGAKVYVRILTEGNLTADWPLSRKFG
CQPDMAMDLLVKAQKLGLEPYGVSFHVGSQQRDIGAWDGAIATVKVIFERLKSENNIELQMINMGGGFPAQYIHQTNTLA
VYAAEIQRFLIEDFGATLPRIILEPGRSLVANAGILVTEVVQVSRKSNTALHRWVYTDVGLFSGMIETLGEAIKYPLYCE
TSSPGTGEESEEVVIAGPTCDSADILYEDYKYRLPHSLKEGDRLFWFSTGAYTTSYSAVEFNGFPPLKSYFV

Sequences:

>Translated_392_residues
MLTQPLKYYSQSTFERICAKAKEVETPFVIIDSATVEDHFDALRNNFPWAEIYYALKANPAHEIIDIVNNKEGGFDLAST
YELDRVISHGTDPDLISYGNTIKKRADIKYFYDAGIRMFVTDSDADLANIAAMAPGAKVYVRILTEGNLTADWPLSRKFG
CQPDMAMDLLVKAQKLGLEPYGVSFHVGSQQRDIGAWDGAIATVKVIFERLKSENNIELQMINMGGGFPAQYIHQTNTLA
VYAAEIQRFLIEDFGATLPRIILEPGRSLVANAGILVTEVVQVSRKSNTALHRWVYTDVGLFSGMIETLGEAIKYPLYCE
TSSPGTGEESEEVVIAGPTCDSADILYEDYKYRLPHSLKEGDRLFWFSTGAYTTSYSAVEFNGFPPLKSYFV
>Mature_392_residues
MLTQPLKYYSQSTFERICAKAKEVETPFVIIDSATVEDHFDALRNNFPWAEIYYALKANPAHEIIDIVNNKEGGFDLAST
YELDRVISHGTDPDLISYGNTIKKRADIKYFYDAGIRMFVTDSDADLANIAAMAPGAKVYVRILTEGNLTADWPLSRKFG
CQPDMAMDLLVKAQKLGLEPYGVSFHVGSQQRDIGAWDGAIATVKVIFERLKSENNIELQMINMGGGFPAQYIHQTNTLA
VYAAEIQRFLIEDFGATLPRIILEPGRSLVANAGILVTEVVQVSRKSNTALHRWVYTDVGLFSGMIETLGEAIKYPLYCE
TSSPGTGEESEEVVIAGPTCDSADILYEDYKYRLPHSLKEGDRLFWFSTGAYTTSYSAVEFNGFPPLKSYFV

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=382, Percent_Identity=30.1047120418848, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI16506287, Length=370, Percent_Identity=27.027027027027, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI22538418, Length=356, Percent_Identity=26.123595505618, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI21361583, Length=356, Percent_Identity=26.123595505618, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1789203, Length=406, Percent_Identity=23.8916256157635, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562780, Length=377, Percent_Identity=32.0954907161804, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI25141365, Length=368, Percent_Identity=23.9130434782609, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322664, Length=382, Percent_Identity=30.6282722513089, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24586472, Length=381, Percent_Identity=27.2965879265092, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24586474, Length=373, Percent_Identity=26.5415549597855, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 43700; Mature: 43700

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTQPLKYYSQSTFERICAKAKEVETPFVIIDSATVEDHFDALRNNFPWAEIYYALKANP
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCHHHEEEEECCCC
AHEIIDIVNNKEGGFDLASTYELDRVISHGTDPDLISYGNTIKKRADIKYFYDAGIRMFV
HHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCHHHHHCCEEEEEECCEEEEE
TDSDADLANIAAMAPGAKVYVRILTEGNLTADWPLSRKFGCQPDMAMDLLVKAQKLGLEP
ECCCCCHHHHHHCCCCCEEEEEEEECCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCC
YGVSFHVGSQQRDIGAWDGAIATVKVIFERLKSENNIELQMINMGGGFPAQYIHQTNTLA
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHCCCCEE
VYAAEIQRFLIEDFGATLPRIILEPGRSLVANAGILVTEVVQVSRKSNTALHRWVYTDVG
EEHHHHHHHHHHHHCCHHHHHHHCCCCHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
LFSGMIETLGEAIKYPLYCETSSPGTGEESEEVVIAGPTCDSADILYEDYKYRLPHSLKE
HHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCC
GDRLFWFSTGAYTTSYSAVEFNGFPPLKSYFV
CCEEEEEECCCCEEEEEEEEECCCCCHHHHCC
>Mature Secondary Structure
MLTQPLKYYSQSTFERICAKAKEVETPFVIIDSATVEDHFDALRNNFPWAEIYYALKANP
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCHHHEEEEECCCC
AHEIIDIVNNKEGGFDLASTYELDRVISHGTDPDLISYGNTIKKRADIKYFYDAGIRMFV
HHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCHHHHHCCEEEEEECCEEEEE
TDSDADLANIAAMAPGAKVYVRILTEGNLTADWPLSRKFGCQPDMAMDLLVKAQKLGLEP
ECCCCCHHHHHHCCCCCEEEEEEEECCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCC
YGVSFHVGSQQRDIGAWDGAIATVKVIFERLKSENNIELQMINMGGGFPAQYIHQTNTLA
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHCCCCEE
VYAAEIQRFLIEDFGATLPRIILEPGRSLVANAGILVTEVVQVSRKSNTALHRWVYTDVG
EEHHHHHHHHHHHHCCHHHHHHHCCCCHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
LFSGMIETLGEAIKYPLYCETSSPGTGEESEEVVIAGPTCDSADILYEDYKYRLPHSLKE
HHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCC
GDRLFWFSTGAYTTSYSAVEFNGFPPLKSYFV
CCEEEEEECCCCEEEEEEEEECCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]