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The map label for this gene is envZ [H]

Identifier: 119945112

GI number: 119945112

Start: 1692154

End: 1693233

Strand: Reverse

Name: envZ [H]

Synonym: Ping_1373

Alternate gene names: 119945112

Gene position: 1693233-1692154 (Counterclockwise)

Preceding gene: 119945113

Following gene: 119945101

Centisome position: 37.14

GC content: 38.8

Gene sequence:

>1080_bases
TTGATTGCCCCAAGTCAAATAAAAGATATTCGTATTGTCTCAGTTAAAAGTGAACAACTAGATGTGGGCATGAGTAAAAT
GCATGCAATGCTCAGTGACAATCCGATGCATAAAAAAATGAACAATAGCTATAACTTACAATTAACAGGCTCTATTTTAT
TAGCAAATCAGCACTGGTTAAATTTTAATTCTGCCATTGATGAAAAAATAGTACAGCTCCCGCTAAAAGCGGTTATTTTA
GTCTTTGTTTTCACCCTGCTAATTCTTATCAGTATGACCTGGACGGTAAAGCGCGCATTAAGGCCGATTGACGAATTAGC
CGTTGCTGCCAACAAAGTCGGCAGCGAACGGAATTTTAAAGCTCTCCCCGTTATTGGACCGAGTGAAGTGATACCCACTA
TTATTGCGTTTAATAAAATGCAATCTAACCTCTCTAAATTCATTAATGATCGCACTAAAATGTTGTCTGCGATATCACAT
GACTTGAAAACGCCTTTGACCAGTTTACGGTTACGACTTGAGTTTATAGCGCCAGGCGAGGATCAGGCCAGAATGCTTGA
TACGATTGCACAGATGGAAGAAATGCTGAAAGCCACGTTAGCGTTTTCAAAAAGTAATTGGCAGAGAGAGGAGAAGCAGG
AGACGGAGATAGTGAGTTTATTAACCACTATTTGTGACGATTATCGTGATCGCGGCATCAACATTCAATTAAAAAGTCAT
AACAAATTGGTTTTCCGTTTATGGCCTATCGCATTTCGCCGCGTTATTGAAAATTTAGTTAATAACAGTATTGCTCACGG
GAAAGATCTTCAAGGTAACCTGGATATCACTATTGAAGCTCTTTTGACCAGTGGAATCTTGACAATTTATGTAAGAGATA
CTGGCAGGGGAATAGATAAAAGTCAGTTTAAAGAGGTCATTAAACCCTTTGTTCGTTTAGATAAAGCACGTGGTACCCAA
AATTCGAGTGTTGGTTTGGGGCTGGCAATTACCCATAGTATTATAGAAGAACATGGCGGTAAATTAACCTTTAACAATCA
AAAGATGGGTGGCCTGGAAGTCAAGATTACATTGTCTTAA

Upstream 100 bases:

>100_bases
TTATCAGCGCAAGCCAAGGCGTGGGCTTTGACTTGTCACTGGATCGCAAGCCAATAGTGATCGAAAATAAAAAAACCTTT
TATCAAAGAAACTGCACGAC

Downstream 100 bases:

>100_bases
AAGTAATAGTATTGATTTTACCAAGCATCAATAAATAGAAAACCATCAGATTTGGTATTTAAATTTTTAGAAAGGAATAT
AAAGTCATAGAAAGCTATTT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MIAPSQIKDIRIVSVKSEQLDVGMSKMHAMLSDNPMHKKMNNSYNLQLTGSILLANQHWLNFNSAIDEKIVQLPLKAVIL
VFVFTLLILISMTWTVKRALRPIDELAVAANKVGSERNFKALPVIGPSEVIPTIIAFNKMQSNLSKFINDRTKMLSAISH
DLKTPLTSLRLRLEFIAPGEDQARMLDTIAQMEEMLKATLAFSKSNWQREEKQETEIVSLLTTICDDYRDRGINIQLKSH
NKLVFRLWPIAFRRVIENLVNNSIAHGKDLQGNLDITIEALLTSGILTIYVRDTGRGIDKSQFKEVIKPFVRLDKARGTQ
NSSVGLGLAITHSIIEEHGGKLTFNNQKMGGLEVKITLS

Sequences:

>Translated_359_residues
MIAPSQIKDIRIVSVKSEQLDVGMSKMHAMLSDNPMHKKMNNSYNLQLTGSILLANQHWLNFNSAIDEKIVQLPLKAVIL
VFVFTLLILISMTWTVKRALRPIDELAVAANKVGSERNFKALPVIGPSEVIPTIIAFNKMQSNLSKFINDRTKMLSAISH
DLKTPLTSLRLRLEFIAPGEDQARMLDTIAQMEEMLKATLAFSKSNWQREEKQETEIVSLLTTICDDYRDRGINIQLKSH
NKLVFRLWPIAFRRVIENLVNNSIAHGKDLQGNLDITIEALLTSGILTIYVRDTGRGIDKSQFKEVIKPFVRLDKARGTQ
NSSVGLGLAITHSIIEEHGGKLTFNNQKMGGLEVKITLS
>Mature_359_residues
MIAPSQIKDIRIVSVKSEQLDVGMSKMHAMLSDNPMHKKMNNSYNLQLTGSILLANQHWLNFNSAIDEKIVQLPLKAVIL
VFVFTLLILISMTWTVKRALRPIDELAVAANKVGSERNFKALPVIGPSEVIPTIIAFNKMQSNLSKFINDRTKMLSAISH
DLKTPLTSLRLRLEFIAPGEDQARMLDTIAQMEEMLKATLAFSKSNWQREEKQETEIVSLLTTICDDYRDRGINIQLKSH
NKLVFRLWPIAFRRVIENLVNNSIAHGKDLQGNLDITIEALLTSGILTIYVRDTGRGIDKSQFKEVIKPFVRLDKARGTQ
NSSVGLGLAITHSIIEEHGGKLTFNNQKMGGLEVKITLS

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=309, Percent_Identity=27.831715210356, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787894, Length=283, Percent_Identity=29.3286219081272, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=25.5555555555556, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1790551, Length=287, Percent_Identity=26.8292682926829, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=29.2792792792793, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788393, Length=242, Percent_Identity=23.9669421487603, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787374, Length=290, Percent_Identity=25.5172413793103, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=219, Percent_Identity=25.1141552511416, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1786783, Length=290, Percent_Identity=20.3448275862069, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 40341; Mature: 40341

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAPSQIKDIRIVSVKSEQLDVGMSKMHAMLSDNPMHKKMNNSYNLQLTGSILLANQHWL
CCCCCCCCCEEEEEECCHHHHCCHHHHHHHHCCCCHHHHCCCCEEEEEEEEEEEECCCCC
NFNSAIDEKIVQLPLKAVILVFVFTLLILISMTWTVKRALRPIDELAVAANKVGSERNFK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCE
ALPVIGPSEVIPTIIAFNKMQSNLSKFINDRTKMLSAISHDLKTPLTSLRLRLEFIAPGE
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCCC
DQARMLDTIAQMEEMLKATLAFSKSNWQREEKQETEIVSLLTTICDDYRDRGINIQLKSH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
NKLVFRLWPIAFRRVIENLVNNSIAHGKDLQGNLDITIEALLTSGILTIYVRDTGRGIDK
CEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHCCEEEEEEECCCCCCCH
SQFKEVIKPFVRLDKARGTQNSSVGLGLAITHSIIEEHGGKLTFNNQKMGGLEVKITLS
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEC
>Mature Secondary Structure
MIAPSQIKDIRIVSVKSEQLDVGMSKMHAMLSDNPMHKKMNNSYNLQLTGSILLANQHWL
CCCCCCCCCEEEEEECCHHHHCCHHHHHHHHCCCCHHHHCCCCEEEEEEEEEEEECCCCC
NFNSAIDEKIVQLPLKAVILVFVFTLLILISMTWTVKRALRPIDELAVAANKVGSERNFK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCE
ALPVIGPSEVIPTIIAFNKMQSNLSKFINDRTKMLSAISHDLKTPLTSLRLRLEFIAPGE
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCCC
DQARMLDTIAQMEEMLKATLAFSKSNWQREEKQETEIVSLLTTICDDYRDRGINIQLKSH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
NKLVFRLWPIAFRRVIENLVNNSIAHGKDLQGNLDITIEALLTSGILTIYVRDTGRGIDK
CEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHCCEEEEEEECCCCCCCH
SQFKEVIKPFVRLDKARGTQNSSVGLGLAITHSIIEEHGGKLTFNNQKMGGLEVKITLS
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]